Patents Assigned to University of Iowa Research Foundation
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Patent number: 11814526Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.Type: GrantFiled: December 12, 2022Date of Patent: November 14, 2023Assignee: University of Iowa Research FoundationInventors: Elise Lin Cheng, C. Allan Guymon, Marian R. Hansen, Braden Leigh
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Patent number: 11806382Abstract: The invention provides a method and kits for inhibiting integrin ?9?1 activity comprising contacting integrin ?9?1 or a binding partner of integrin ?9?1 with an isolated anti-integrin ?9 inhibitor, wherein the integrin ?9?1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin ?9?1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.Type: GrantFiled: November 18, 2020Date of Patent: November 7, 2023Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Anil K. Chauhan, Nirav A. Dhanesha
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Patent number: 11808961Abstract: The disclosure relates to a composite comprising a metal film having a first major surface and opposed second major surface, at least a portion of the metal film having a sheet resistance of at least 15 ?/sq, an optical transmittance of at least 60% within the visible spectrum, and tunable bandpass filtering effect in the THz frequency range; a dielectric substrate comprising a first major surface and opposed second major surface; the metal film first major surface located on at least a portion of the dielectric substrate first major surface. The disclosure also relates to methods of making such composites and articles comprising such composites.Type: GrantFiled: January 10, 2020Date of Patent: November 7, 2023Assignee: University of Iowa Research FoundationInventors: Hongtao Ding, Qinghua Wang
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Patent number: 11804076Abstract: Embodiments of the present systems and methods may provide techniques that may provide the capability to autonomously and automatically identify cases of suspected abuse, which may then be subject to follow up review and action. For example, in an embodiment, a system for identifying potential physical abuse in a location may comprise at least one video camera provided at the location and a computer system comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor to cause the computer system to perform: receiving video data from the at least one video camera, identifying potential physical abuse from the video data, the identification being to within a predetermined confidence level, and transmitting information indicating that a potential human threat has been identified.Type: GrantFiled: October 2, 2020Date of Patent: October 31, 2023Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Karim Abdel-Malek, Kimberly Farrell, Rajan M. Bhatt, Daniel L. Clay
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Publication number: 20230328942Abstract: A metal alloy is provided which includes by weight percentage of the metal alloy, 28 to 55 percent copper, 45 to 63 percent nickel, and 4 to 10 percent iron. The metal alloy may be weight percentage 28 percent copper, 62 percent nickel, and 10 percent iron. The metal alloy may be formed into a foil which may have a thickness of 100 ?m or less or 50 ?m or less. A magnetic field instrument may include a magnetometer core body formed from one or more layers of the foil. The magnetometer core body may be a ring core or a racetrack core. The magnetic field instrument may further include a sense winding and may further include a drive winding. The magnetic field instrument may be a fluxgate magnetometer.Type: ApplicationFiled: March 21, 2022Publication date: October 12, 2023Applicants: University of Iowa Research Foundation, The University of British ColumbiaInventors: David M Miles, Saul Brian Barry Narod
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Patent number: 11775902Abstract: A prevention and safety management system utilizes a non-intrusive imaging sensor (e.g. surveillance cameras, smartphone cameras) and a computer vision system to record videos of workers not wearing sensors. The videos are analyzed using a deep machine learning algorithm to detect kinematic activities (set of predetermined body joint positions and angles) of the workers and recognizing various physical activities (walk/posture, lift, push, pull, reach, force, repetition, duration etc.). The measured kinematic variables are then parsed into metrics relevant to workplace ergonomics, such as number of repetitions, total distance travelled, range of motion, and the proportion of time in different posture categories. The information gathered by this system is fed into an ergonomic assessment system and is used to automatically populate exposure assessment tools and create risk assessments.Type: GrantFiled: April 11, 2022Date of Patent: October 3, 2023Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Stephen Baek, Nathan B. Fethke, Jean Robillard, Joseph A. V. Buckwalter, Pamela Villacorta
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Patent number: 11771412Abstract: An eyelid flipper tool is used to flip a patient's eyelid to gain access to the patient's meibomian gland lands and gland openings. The eyelid flipper tool has a concave end and a convex end connected by a center section. The concave end has a concave edge with a concave end width, a concave radius, and a curvature. The convex end of the eyelid flipper tool has a convex edge with a convex end up with, a convex end radius, and a curvature. The radii of the concave end and the convex end and the curvature of the ends are dimensioned to conform to the curvature of the eyelids or the globe of a patient's eye.Type: GrantFiled: November 8, 2017Date of Patent: October 3, 2023Assignee: University of Iowa Research FoundationInventor: Christine Sindt
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Patent number: 11751786Abstract: The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health via pressure. Certain implementations are directed to patients who require daily catheterization. The various embodiments have at least one tube coupled to a catheter, a pressure sensor and a processor. Further implementations feature an optional pump and measure volume. Certain embodiments include a digital device with a software application capable of displaying the monitored readings.Type: GrantFiled: April 29, 2020Date of Patent: September 12, 2023Assignee: University of Iowa Research FoundationInventors: Christopher Cooper, Ryan Steinberg, Lewis Thomas, Clifford Curry, Eric Pahl, Sanam Zarei, Kayla Jones
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Publication number: 20230281493Abstract: A data-driven method for streamflow forecasting is provided. The method includes steps of measuring index velocity at an index velocity gaging station associated with a stream to provide index velocity data, simultaneously with measuring the index velocity, measuring water stage at the index velocity gaging station to provide stage data, and applying a data-driven model implemented using a computing device to the index velocity data and the stage data, the data-driven model further using historical index velocity data and historical stage data collected at the station to forecast at least one of magnitude and timing of a flood crest arrival during occurrence of a hydrological event. The index-velocity data and the stage data may be concurrently collected using a Horizontal Acoustic Doppler Current Profiler (HADCP). The method may further include generating using the computing device an alert in advance of flood crest.Type: ApplicationFiled: February 27, 2023Publication date: September 7, 2023Applicant: University of Iowa Research FoundationInventor: Marian Muste
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Publication number: 20230264043Abstract: A method for needle position optimization for prostate brachytherapy for use with a radiation delivery device configured to use a plurality of needles inserted into a prostate of a patient includes obtaining imagery of the prostate of the patient, generating a needle pool for prostate brachytherapy treatment of the patient based on the imagery of the prostate of the patient, and determining at a computing device an optimum prostate brachytherapy treatment plan for the patient by iteratively removing needles from the needle pool by forming and computationally solving a convex optimization problem wherein the convex optimization problem uses a quadratic dosimetric penalty function, dwell time regularization by total variation, and block sparsity regularization term.Type: ApplicationFiled: February 17, 2023Publication date: August 24, 2023Applicant: University of Iowa Research FoundationInventors: Xiaodong Wu, Weiyu Xu, Jirong Yi
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Publication number: 20230263164Abstract: The invention provides a compound of formula (I): wherein X, Y Z, R1, R2, and X+ have any of the values described in the specification. The compounds are useful to increase plant growth and/or to increase harvest yield.Type: ApplicationFiled: August 30, 2021Publication date: August 24, 2023Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Ned B. Bowden, Justin M. CARTER, Eric M. BROWN, Nimesh RANASINGHE, Arjun PAUDEL, Erin E. IRISH
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Patent number: 11730799Abstract: A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer.Type: GrantFiled: June 29, 2021Date of Patent: August 22, 2023Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRSInventors: David M. Lubaroff, Delbert L. Harris
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Patent number: 11713795Abstract: The invention includes systems having a cover attached to a frame, and a transmission unit with a rotational device connected to or part of the frame. The cover is mechanically connected to the at least one rotational device. A vibration dampening unit mechanically connected to the transmission unit such that translational movement (e.g. vertical movements) of the cover causes rotational movement of the rotational device. The rotational movement is, in turn, transmitted to the vibration dampening unit via the transmission unit. Preferably, the vibration dampening unit is a passive unit and also a resistance force modulated vibration dampening unit.Type: GrantFiled: May 28, 2021Date of Patent: August 1, 2023Assignees: ActiBioMotion, LLC, University of Iowa Research FoundationInventors: Salam Rahmatalla, Eric C. Frick, Charles W. Harris, Jr., Varun Chalasani
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Publication number: 20230225326Abstract: The invention provides a compound of formula I: wherein X, Y, Z, R?, R2, and X+ have any of the values described in the specification. The compounds are useful to increase plant growth and/or to increase harvest yield.Type: ApplicationFiled: February 28, 2023Publication date: July 20, 2023Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Ned B. Bowden, Justin M. CARTER, Eric M. BROWN, Nimesh RANASINGHE, Arjun PAUDEL, Erin E. IRISH
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Patent number: 11702672Abstract: A method of preparing a chimeric virus comprising bocavirus capsid protein (VP) and a recombinant adeno-associated (AAV) viral genome, and isolated mutant bocavirus genomes, are provided.Type: GrantFiled: February 8, 2017Date of Patent: July 18, 2023Assignees: University of Iowa Research Foundation, University of KansasInventors: Ziying Yan, John F. Engelhardt, Jianming Qiu
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Publication number: 20230202843Abstract: The invention provides a method for preparing an actinide metal peroxide from a corresponding actinide metal oxide under solid reaction conditions.Type: ApplicationFiled: December 21, 2022Publication date: June 29, 2023Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Tori M. FORBES, Dmytro V. KRAVCHUK
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Patent number: 11684679Abstract: An isolated recombinant parvovirus vector comprising a synthetic enhancer comprising plurality of enhancer sequences operably linked to a promoter, and methods of using the vector, are provided.Type: GrantFiled: March 7, 2017Date of Patent: June 27, 2023Assignee: University of Iowa Research FoundationInventors: John F. Engelhardt, Ziying Yan
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Patent number: 11680079Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.Type: GrantFiled: April 13, 2020Date of Patent: June 20, 2023Assignees: University of Iowa Research Foundation, The United States Government As Represented By The Department of Veteran AffairsInventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
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Patent number: 11661600Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.Type: GrantFiled: November 2, 2018Date of Patent: May 30, 2023Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Christopher Ahern, John D. Lueck
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Patent number: 11638522Abstract: The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline, and myocardial infarct.Type: GrantFiled: March 26, 2018Date of Patent: May 2, 2023Assignees: University of Iowa Research Foundation, United States Government as Represented by the Department of Veterans AffairsInventors: Michael D. Abramoff, Meindert Niemeijer, Xiayu Xu, Milan Sonka, Joseph M. Reinhardt