Patents Assigned to University of Iowa Research Foundation
  • Patent number: 11814526
    Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.
    Type: Grant
    Filed: December 12, 2022
    Date of Patent: November 14, 2023
    Assignee: University of Iowa Research Foundation
    Inventors: Elise Lin Cheng, C. Allan Guymon, Marian R. Hansen, Braden Leigh
  • Patent number: 11806382
    Abstract: The invention provides a method and kits for inhibiting integrin ?9?1 activity comprising contacting integrin ?9?1 or a binding partner of integrin ?9?1 with an isolated anti-integrin ?9 inhibitor, wherein the integrin ?9?1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin ?9?1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: November 7, 2023
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Anil K. Chauhan, Nirav A. Dhanesha
  • Patent number: 11808961
    Abstract: The disclosure relates to a composite comprising a metal film having a first major surface and opposed second major surface, at least a portion of the metal film having a sheet resistance of at least 15 ?/sq, an optical transmittance of at least 60% within the visible spectrum, and tunable bandpass filtering effect in the THz frequency range; a dielectric substrate comprising a first major surface and opposed second major surface; the metal film first major surface located on at least a portion of the dielectric substrate first major surface. The disclosure also relates to methods of making such composites and articles comprising such composites.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: November 7, 2023
    Assignee: University of Iowa Research Foundation
    Inventors: Hongtao Ding, Qinghua Wang
  • Patent number: 11804076
    Abstract: Embodiments of the present systems and methods may provide techniques that may provide the capability to autonomously and automatically identify cases of suspected abuse, which may then be subject to follow up review and action. For example, in an embodiment, a system for identifying potential physical abuse in a location may comprise at least one video camera provided at the location and a computer system comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor to cause the computer system to perform: receiving video data from the at least one video camera, identifying potential physical abuse from the video data, the identification being to within a predetermined confidence level, and transmitting information indicating that a potential human threat has been identified.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: October 31, 2023
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Karim Abdel-Malek, Kimberly Farrell, Rajan M. Bhatt, Daniel L. Clay
  • Publication number: 20230328942
    Abstract: A metal alloy is provided which includes by weight percentage of the metal alloy, 28 to 55 percent copper, 45 to 63 percent nickel, and 4 to 10 percent iron. The metal alloy may be weight percentage 28 percent copper, 62 percent nickel, and 10 percent iron. The metal alloy may be formed into a foil which may have a thickness of 100 ?m or less or 50 ?m or less. A magnetic field instrument may include a magnetometer core body formed from one or more layers of the foil. The magnetometer core body may be a ring core or a racetrack core. The magnetic field instrument may further include a sense winding and may further include a drive winding. The magnetic field instrument may be a fluxgate magnetometer.
    Type: Application
    Filed: March 21, 2022
    Publication date: October 12, 2023
    Applicants: University of Iowa Research Foundation, The University of British Columbia
    Inventors: David M Miles, Saul Brian Barry Narod
  • Patent number: 11775902
    Abstract: A prevention and safety management system utilizes a non-intrusive imaging sensor (e.g. surveillance cameras, smartphone cameras) and a computer vision system to record videos of workers not wearing sensors. The videos are analyzed using a deep machine learning algorithm to detect kinematic activities (set of predetermined body joint positions and angles) of the workers and recognizing various physical activities (walk/posture, lift, push, pull, reach, force, repetition, duration etc.). The measured kinematic variables are then parsed into metrics relevant to workplace ergonomics, such as number of repetitions, total distance travelled, range of motion, and the proportion of time in different posture categories. The information gathered by this system is fed into an ergonomic assessment system and is used to automatically populate exposure assessment tools and create risk assessments.
    Type: Grant
    Filed: April 11, 2022
    Date of Patent: October 3, 2023
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Stephen Baek, Nathan B. Fethke, Jean Robillard, Joseph A. V. Buckwalter, Pamela Villacorta
  • Patent number: 11771412
    Abstract: An eyelid flipper tool is used to flip a patient's eyelid to gain access to the patient's meibomian gland lands and gland openings. The eyelid flipper tool has a concave end and a convex end connected by a center section. The concave end has a concave edge with a concave end width, a concave radius, and a curvature. The convex end of the eyelid flipper tool has a convex edge with a convex end up with, a convex end radius, and a curvature. The radii of the concave end and the convex end and the curvature of the ends are dimensioned to conform to the curvature of the eyelids or the globe of a patient's eye.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 3, 2023
    Assignee: University of Iowa Research Foundation
    Inventor: Christine Sindt
  • Patent number: 11751786
    Abstract: The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health via pressure. Certain implementations are directed to patients who require daily catheterization. The various embodiments have at least one tube coupled to a catheter, a pressure sensor and a processor. Further implementations feature an optional pump and measure volume. Certain embodiments include a digital device with a software application capable of displaying the monitored readings.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: September 12, 2023
    Assignee: University of Iowa Research Foundation
    Inventors: Christopher Cooper, Ryan Steinberg, Lewis Thomas, Clifford Curry, Eric Pahl, Sanam Zarei, Kayla Jones
  • Publication number: 20230281493
    Abstract: A data-driven method for streamflow forecasting is provided. The method includes steps of measuring index velocity at an index velocity gaging station associated with a stream to provide index velocity data, simultaneously with measuring the index velocity, measuring water stage at the index velocity gaging station to provide stage data, and applying a data-driven model implemented using a computing device to the index velocity data and the stage data, the data-driven model further using historical index velocity data and historical stage data collected at the station to forecast at least one of magnitude and timing of a flood crest arrival during occurrence of a hydrological event. The index-velocity data and the stage data may be concurrently collected using a Horizontal Acoustic Doppler Current Profiler (HADCP). The method may further include generating using the computing device an alert in advance of flood crest.
    Type: Application
    Filed: February 27, 2023
    Publication date: September 7, 2023
    Applicant: University of Iowa Research Foundation
    Inventor: Marian Muste
  • Publication number: 20230264043
    Abstract: A method for needle position optimization for prostate brachytherapy for use with a radiation delivery device configured to use a plurality of needles inserted into a prostate of a patient includes obtaining imagery of the prostate of the patient, generating a needle pool for prostate brachytherapy treatment of the patient based on the imagery of the prostate of the patient, and determining at a computing device an optimum prostate brachytherapy treatment plan for the patient by iteratively removing needles from the needle pool by forming and computationally solving a convex optimization problem wherein the convex optimization problem uses a quadratic dosimetric penalty function, dwell time regularization by total variation, and block sparsity regularization term.
    Type: Application
    Filed: February 17, 2023
    Publication date: August 24, 2023
    Applicant: University of Iowa Research Foundation
    Inventors: Xiaodong Wu, Weiyu Xu, Jirong Yi
  • Publication number: 20230263164
    Abstract: The invention provides a compound of formula (I): wherein X, Y Z, R1, R2, and X+ have any of the values described in the specification. The compounds are useful to increase plant growth and/or to increase harvest yield.
    Type: Application
    Filed: August 30, 2021
    Publication date: August 24, 2023
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Ned B. Bowden, Justin M. CARTER, Eric M. BROWN, Nimesh RANASINGHE, Arjun PAUDEL, Erin E. IRISH
  • Patent number: 11730799
    Abstract: A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: August 22, 2023
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRS
    Inventors: David M. Lubaroff, Delbert L. Harris
  • Patent number: 11713795
    Abstract: The invention includes systems having a cover attached to a frame, and a transmission unit with a rotational device connected to or part of the frame. The cover is mechanically connected to the at least one rotational device. A vibration dampening unit mechanically connected to the transmission unit such that translational movement (e.g. vertical movements) of the cover causes rotational movement of the rotational device. The rotational movement is, in turn, transmitted to the vibration dampening unit via the transmission unit. Preferably, the vibration dampening unit is a passive unit and also a resistance force modulated vibration dampening unit.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: August 1, 2023
    Assignees: ActiBioMotion, LLC, University of Iowa Research Foundation
    Inventors: Salam Rahmatalla, Eric C. Frick, Charles W. Harris, Jr., Varun Chalasani
  • Publication number: 20230225326
    Abstract: The invention provides a compound of formula I: wherein X, Y, Z, R?, R2, and X+ have any of the values described in the specification. The compounds are useful to increase plant growth and/or to increase harvest yield.
    Type: Application
    Filed: February 28, 2023
    Publication date: July 20, 2023
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Ned B. Bowden, Justin M. CARTER, Eric M. BROWN, Nimesh RANASINGHE, Arjun PAUDEL, Erin E. IRISH
  • Patent number: 11702672
    Abstract: A method of preparing a chimeric virus comprising bocavirus capsid protein (VP) and a recombinant adeno-associated (AAV) viral genome, and isolated mutant bocavirus genomes, are provided.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: July 18, 2023
    Assignees: University of Iowa Research Foundation, University of Kansas
    Inventors: Ziying Yan, John F. Engelhardt, Jianming Qiu
  • Publication number: 20230202843
    Abstract: The invention provides a method for preparing an actinide metal peroxide from a corresponding actinide metal oxide under solid reaction conditions.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 29, 2023
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Tori M. FORBES, Dmytro V. KRAVCHUK
  • Patent number: 11684679
    Abstract: An isolated recombinant parvovirus vector comprising a synthetic enhancer comprising plurality of enhancer sequences operably linked to a promoter, and methods of using the vector, are provided.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: June 27, 2023
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Ziying Yan
  • Patent number: 11680079
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: June 20, 2023
    Assignees: University of Iowa Research Foundation, The United States Government As Represented By The Department of Veteran Affairs
    Inventors: Paloma H. Giangrande, Francis Miller, Kevin Urak
  • Patent number: 11661600
    Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: May 30, 2023
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Christopher Ahern, John D. Lueck
  • Patent number: 11638522
    Abstract: The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline, and myocardial infarct.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: May 2, 2023
    Assignees: University of Iowa Research Foundation, United States Government as Represented by the Department of Veterans Affairs
    Inventors: Michael D. Abramoff, Meindert Niemeijer, Xiayu Xu, Milan Sonka, Joseph M. Reinhardt