Patents Assigned to University of Iowa Research Foundation
  • Patent number: 11298338
    Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, and one or more anti-cancer therapies.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 12, 2022
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Fenghuang Zhan, Ivana Frech, Guido Tricot
  • Publication number: 20220098648
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Application
    Filed: October 5, 2021
    Publication date: March 31, 2022
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Howswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliott Burghardt, Karen Clark
  • Patent number: 11288808
    Abstract: Disclosed are systems and methods for image segmentation using convolutional networks. Image data comprising an image hypervolume can be received. The image hypervolume can be provided to a trained convolutional neural network (CNN). The CNN can output a segmentation of the image hypervolume.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: March 29, 2022
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael Abramoff, Xiaodong Wu
  • Publication number: 20220072092
    Abstract: The invention provides compositions, kits and methods to treat a hyperproliferative disorder with an agent that increases expression of MCR1 and an MCR1 ligand. The invention also provides a method of treating drug-resistant melanoma, comprising administering an MCR1 ligand to a patient in need thereof. The present invention also provides in certain embodiments a melanoma-targeting conjugate comprising Formula I. T-L-X wherein T is a MCR1 ligand, L is a linker, and X an anti-cancer composition, for the therapeutic treatment of a hyperproliferative disorder. The present invention also provides methods, kits, and uses of the conjugate of Formula I.
    Type: Application
    Filed: November 19, 2021
    Publication date: March 10, 2022
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael K. Schultz, Frances L. Johnson, Somya Kapoor, Dongyoul Lee, Mengshi Li, Molly Martin
  • Patent number: 11241576
    Abstract: The present embodiment is an implantable device capable of controlling cochlear implant electrode insertion and positioning. The embodiment uses an implanted mechanical positioning unit to advance position and monitor an electrode array. The device can be controlled via an external controller to reposition or advance an electrode array at any point after implantation with no surgical re-intervention. A cochlear implant electrode array whose position can be advanced and modified over time to best fit a patient's evolving hearing pattern would improve functional outcomes and significantly expand the candidacy range for cochlear implantation to include patients with substantial residual hearing.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: February 8, 2022
    Assignee: University of Iowa Research Foundation
    Inventors: Marlan R. Hansen, Christopher Kaufmann
  • Publication number: 20220036974
    Abstract: A method for pooled sample testing for a target substance using compressed sensing includes receiving a plurality of individual samples, determining a mixing matrix for a plurality of pooled sample mixtures to create by mixing portions of selected ones of the plurality of individual samples, and determining an allocation matrix for the plurality of pooled samples, wherein the allocation matrix allocations portions of each of the plurality of pooled samples for each test, performing mixing to create the plurality of pooled sample mixtures based on the mixing matrix and the allocation matrix, performing quantitative tests on the plurality of pooled sample mixtures so as to estimate an amount of the target substance contained within each of the plurality of pooled sample mixtures, and decoding results of the quantitative tests to determine quantitative estimates of amount of the target substance in each of the plurality of individual samples.
    Type: Application
    Filed: July 28, 2021
    Publication date: February 3, 2022
    Applicants: University of Iowa Research Foundation, The Penn State Research Foundation
    Inventors: Weiyu Xu, Xiaodong Wu, Jirong Yi, Raghu Mudumbai, Myung Cho
  • Publication number: 20220012890
    Abstract: An automated method for segmentation includes steps of receiving at a computing device an input image representing at least one surface and performing by the computing device image segmentation on the input image based on a graph surface segmentation model with deep learning. The deep learning may be used to parameterize the graph surface segmentation model.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 13, 2022
    Applicant: University of Iowa Research Foundation
    Inventors: Xiaodong Wu, Leixin Zhou, John M Buatti, Hui Xie
  • Patent number: 11222993
    Abstract: Methods and a device for cascading broadband emission are described. An example device can comprise a substrate, a bottom contact layer above at least a portion of the substrate, and a plurality of emission regions above the bottom contact layer. The plurality of emission regions can be disposed one above another. Each of the plurality of emission regions can be configured with different respective band gaps to emit radiation of different wavelengths. The device can comprise a plurality of tunnel junctions. Each of the tunnel junctions can be disposed between at least two corresponding emission regions of the plurality of emission regions. The device can comprise a top contact layer above the plurality of emission regions.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 11, 2022
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: John P. Prineas, Dennis Norton, Thomas F. Boggess, Russell J. Ricker
  • Publication number: 20210401562
    Abstract: A Descemet Membrane Endothelial Keratoplasty (DMEK) holder for placement within a vial for supporting a corneal tissue inserter is provided. The DMEK holder includes a top and an opposite bottom, at least one support member extending between the top and the bottom, with a bottom portion of the at least one support member sized and shaped to fit against a bottom inner surface of the vial to thereby support the corneal tissue inserter within the vial, and a first annular member having an opening sized and shaped such that a bottom end of the corneal tissue inserter is insertable through the opening and the first annular member separates the corneal tissue inserter from an inner surface of the vial and positions the corneal tissue inserter within the vial away from inner surfaces of the vial to thereby improve retrieval of the corneal tissue inserter by a surgeon.
    Type: Application
    Filed: June 28, 2021
    Publication date: December 30, 2021
    Applicant: University of Iowa Research Foundation
    Inventors: Syed M. A. Muqsit Hashmi, Leela Raghava Jaidev Chakka, Aliasger K. Salem
  • Publication number: 20210378742
    Abstract: An apparatus and method of treatment of an animal using the apparatus are disclosed. The apparatus includes a scalpel, a laser included in the scalpel, and a visible light source included in the scalpel. The visible light source provides a visible targeting beam. The method of treatment includes activating a visible targeting beam in a laser scalpel. The visible targeting beam has an illumination intensity. The method further includes illuminating a tumor that includes cancerous cells and non-cancerous cells with the visible targeting beam, activating an invisible mid-infrared laser included in the scalpel to produce a laser spot at the tumor, and ablating the cancerous cells while leaving the non-cancerous cells substantially undamaged.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 9, 2021
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventor: Fatima Toor
  • Publication number: 20210369670
    Abstract: The invention provides the use of SWELL1 inhibitors and modulators for therapeutic use, e.g., to treat obesity and type 2 diabetes.
    Type: Application
    Filed: August 4, 2017
    Publication date: December 2, 2021
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventor: Rajan Sah
  • Publication number: 20210369742
    Abstract: The present invention provides in certain embodiments methods of inhibiting platelet function or thrombosis, inhibiting pyruvate kinase M2 (PKM2) dimerization, and/or treating a disease associated with thrombosis by administering a composition comprising a dimeric pyruvate kinase M2 (PKM2) inhibitor in a patient in need thereof.
    Type: Application
    Filed: May 26, 2021
    Publication date: December 2, 2021
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Anil Chauhan, Manasa K. Nayak
  • Patent number: 11179484
    Abstract: The invention provides compositions, kits and methods to treat a hyperproliferative disorder with an agent that increases expression of MCR1 and an MCR1 ligand. The invention also provides a method of treating drug-resistant melanoma, comprising administering an MCR1 ligand to a patient in need thereof. The present invention also provides in certain embodiments a melanoma-targeting conjugate comprising Formula (I): T-L-X wherein T is a MCR1 ligand, L is a linker, and X an anti-cancer composition, for the therapeutic treatment of a hyperproliferative disorder. The present invention also provides methods, kits and uses of the conjugate of Formula (I).
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: November 23, 2021
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael K. Schultz, Frances L. Johnson, Somya Kapoor, Dongyoul Lee, Mengshi Li, Molly Martin
  • Patent number: 11168120
    Abstract: The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: November 9, 2021
    Assignee: University of Iowa Research Foundation
    Inventor: Gregory S. Hageman
  • Publication number: 20210330693
    Abstract: Anti-heparanase compounds for the treatment of cancer are described. The anti-heparanase compounds are high affinity, synthetic glycopolymers that result in minimal anticoagulant activity. Stereoselective fluorinated forms of these compounds are also provided.
    Type: Application
    Filed: December 5, 2019
    Publication date: October 28, 2021
    Applicants: Wayne State University, Technion, Israel Institute of Technology, University of Iowa Research Foundation
    Inventors: Hien M. Nguyen, Ravi Sankar Loka, Eric Sletten, Israel Vlodavsky
  • Patent number: 11155882
    Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: October 26, 2021
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: James O. McNamara, Katie R. Flenker, Hyeon Kim, Alexander R. Howswill, Frank J. Hernandez, Mark Behlke, Lingyan Huang, Richard Owczarzy, Elliott Burghardt, Karen Clark
  • Patent number: 11159258
    Abstract: The invention addresses the problem of recovering an unknown signal from multiple records of brief duration which are presumed to contain the signal at mutually random delays in a background of independent noise. The scenario is relevant to many applications, among which are the recovery of weak transients from large arrays of sensors and the identification of recurring patterns through a comparison of sequential intervals within a single record of longer duration. A simple and practical approach is provided by solving this problem through higher-order spectra. Applying the method to the third-order spectrum, the bispectrum, leads to filters derived from cross bicoherence.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: October 26, 2021
    Assignee: University of Iowa Research Foundation
    Inventor: Christopher K. Kovach
  • Patent number: 11142775
    Abstract: Vectors having a nucleotide sequence having SEQ ID NO:1 or a nucleotide sequence having at least 85% identity to SEQ ID NO:1, or a portion thereof, that is capable of regulating bocaparvovirus replication, or vectors having the complement of the nucleotide sequence, and methods of using the vectors, are provided.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: October 12, 2021
    Assignees: University of Iowa Research Foundation, University of Kansas
    Inventors: Ziying Yan, John F. Engelhardt, Jianming Qiu, Zekun Wang
  • Publication number: 20210310807
    Abstract: A method for measuring elevation of an accumulating resource with a visually distinguishable intersecting object includes providing an electronic device comprising a camera and at least one position sensor, performing at least one survey by obtaining sensor readings while the camera is aimed at an intersection, determining an altitude and pitch angle of the camera using the sensor readings; and computing the elevation of the accumulating resource using the geolocation and pitch angle of the camera.
    Type: Application
    Filed: April 6, 2021
    Publication date: October 7, 2021
    Applicant: University of Iowa Research Foundation
    Inventors: Ibrahim Demir, Muhammed Yusuf Sermet
  • Patent number: 11136453
    Abstract: Composites comprising polymeric nanofibers, metal oxide nanoparticles, and optional surface-segregating surfactants and precursor compositions are disclosed. Also disclosed are nonwoven mats formed from the composites and methods of making and using the composites. The composites enable the deployment of nanostructured materials for water treatment within a self-contained membrane with high water fluxes, as well as a number uses.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: October 5, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: David Michael Cwiertny, Nosang Vincent Myung, Katherine Tanya Peter, Katherine Elizabeth Greenstein, Gene Francis Parkin