Patents Assigned to University of Kentucky Research Foundation
  • Patent number: 10975412
    Abstract: A method is described for the identification of multi-subunit biocomplex drug targets. The method includes identifying a target that performs a biological function, wherein the target comprises one or more subunits, wherein a minimum number of the one or more subunits is inactivated to inhibit the biological function. The method includes selecting a drug that binds specifically to each subunit of the one or more subunits with a target probability. The method describes a relationship between inhibition efficiency of the drug and total number of the one or more subunits using a binomial distribution, wherein the inhibition efficiency comprises a probability that the delivered drug blocks the biological function. The method includes confirming empirically the relationship using an experimental target. The method includes administering the drug to the target to treat a multi-drug resistant disease, wherein the target comprises a biological complex in a mammalian subject.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 13, 2021
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Peixuan Guo, Dan Shu
  • Patent number: 10954201
    Abstract: Compounds for use as electrolyte in a non-aqueous redox battery are provided, including an N-substituted phenothiazine compound according to the formula: R? is alkyl and R is selected from alkyl, aryl, alkylaryl, alkoxyaryl, alkylcarboxyl, arylcarbonyl, haloalkyl, perfluoroalkyl, glycol, polyether, haloaryl, a negative electrolyte, a polymerizable unit, and a polymer.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: March 23, 2021
    Assignee: University of Kentucky Research Foundation
    Inventors: Susan A. Odom, Aman Preet Kaur, Matthew D. Casselman, N. Harsha Attanayake
  • Publication number: 20210045310
    Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
    Type: Application
    Filed: April 28, 2020
    Publication date: February 18, 2021
    Applicant: University of Kentucky Research Foundation
    Inventors: Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
  • Patent number: 10900357
    Abstract: A ventilation system for an underground mine includes a blowing curtain, a passive regulator in a shape of an airfoil and an airflow ventilation source. The passive regulator is positioned in the air path adjacent a discharge end of the blowing curtain.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: January 26, 2021
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Andrzej M. Wala, Todor P. Petrov
  • Patent number: 10892525
    Abstract: Compounds for use as photoredox catalysts and as redox shuttles in a rechargeable battery having a high-voltage cathode providing overcharge protection capabilities are provided, including a compound according to the formula: wherein R is selected from the group consisting of alkyl, aryl, alkylaryl, alkoxyaryl, alkylcarboxyl, aryl carbonyl, haloalkyl, perfluoroalkyl, glycols, haloaryl, a negative electrolyte, and a polymer.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 12, 2021
    Assignee: University of Kentucky Research Foundation
    Inventors: Susan A. Odom, Aman Preet Kaur, Corrine F. Elliott
  • Patent number: 10883962
    Abstract: Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 5, 2021
    Assignees: University of Kentucky Research Foundation, Clemson University Research Foundation
    Inventors: Guigen Zhang, Samuel Bearden
  • Patent number: 10875890
    Abstract: Disclosed herein are peptide inhibitors of AniA. Pharmaceutical compositions are also disclosed that include one or more peptide inhibitors of AniA and/or nucleic acids encoding the same. The pharmacological inhibition of AniA should disable anaerobic respiration and augment the ability of existing antimicrobials to clear the pathogen. Thus, also disclosed are methods of inhibiting and/or treating infection from N. gonorrhoeae.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: December 29, 2020
    Assignees: Oregon State University, The University of Kentucky Research Foundation
    Inventors: Aleksandra Sikora, Konstantin V. Korotkov
  • Patent number: 10868534
    Abstract: An adiabatic logic-in-memory based complementary metal-oxide-semiconductor/magnetic-tunnel-junction (ALiM CMOS/MTJ) circuit utilizes an adiabatic logic based pre-charged sense amplifier (PCSA) to recover energy from its output load capacitors. The ALiM CMOS/MTJ includes a non-volatile magnetic-tunnel-junction (MTJ) based memory. The ALiM CMOS/MTJ also includes a dual rail complementary metal-oxide-semiconductor (CMOS) logic that performs logic operations in association with the MTJ, and thereby generates logic outputs based on logic inputs. The ALiM CMOS/MTJ also includes the adiabatic PCSA, which is operatively coupled to the dual rail CMOS logic. The adiabatic logic based PCSA includes PCSA circuitry for which an input is a multi-phase power clock, and a charge recovery circuit having the output load capacitors. The charge recovery circuit is operatively coupled to the PCSA circuitry such that the ALiM CMOS/MTJ circuit uses the power clock to recover energy from the output load capacitors.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: December 15, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Himanshu Thapliyal, S. Dinesh Kumar
  • Patent number: 10864212
    Abstract: The present disclosure relates to compositions and methods for treating retinal damage and/or retinal degradation. More specifically, this disclosure relates to methods for treating degradation of the retinal pigment epithelium by administering compositions comprising a nucleoside and/or a nucleoside or nucleotide reverse transcriptase inhibitor.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: December 15, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Jayakrishna Ambati, Benjamin Fowler
  • Patent number: 10854911
    Abstract: Compounds for use in a rechargeable battery are provided, including a compound according to the formula: wherein R1 and R9 are independently selected from the group consisting of H, alkyl, aryl, perfluoroaryl, perfluoroalkyl, alkylaryl, alkoxyaryl, alkylcarboxyl, aryl carbonyl, haloalkyl, perfluoroalkyl, glycols, haloaryl, a negative electrolyte, and a polymer, so long as when R1 is H, R9 is not H; and R10 is selected from the group consisting of methyl, alkyl, aryl, alkylaryl, alkoxyaryl, alkylcarboxyl, aryl carbonyl, haloalkyl, perfluoroalkyl, perfluoroaryl, glycols, haloaryl, an oligomer, and a polymer.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 1, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Susan A. Odom, Chad Risko, Matthew D. Casselman, Corrine F. Elliott, N. Harsha Attanayake, Subrahmanyam Modekrutti
  • Patent number: 10842422
    Abstract: A low-cost compact fiberless diffuse speckle contrast flowmeter includes a small laser diode and a 2-dimensional imaging device such as a charge coupled device (CCD) or complementary metal oxide semiconductor (CMOS) for directly contacting the tissue and measuring a parameter such as blood flow in a deep/thick volume of tissue (up to 10 mm depth). The small laser diode is fixed at a certain distance (0 to 20 mm) from the imaging device and directly contacts the tissue. Light emitted from the laser diode penetrates through the tissue and reflects back to the imaging device without passing through any lenses or fibers. One or more additional laser diodes may be added for producing light at different wavelengths, and the combination of measurements taken by the imaging device at the different wavelengths allows for measuring additional parameters, such as both blood flow and blood oxygenation.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 24, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Guoqiang Yu, Chong Huang, Jeffrey Todd Hastings
  • Patent number: 10828381
    Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to RNA nanoparticles and RNA dendrimers, and methods of disease diagnosis and treatments using the RNA nanostructure and RNA dendrimers.
    Type: Grant
    Filed: April 17, 2016
    Date of Patent: November 10, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Peixuan Guo, Hui Li, Wei Luo
  • Patent number: 10794830
    Abstract: A method of monitoring for the presence of an oxidizing chemical species in an aqueous or non-polar environment includes steps of exposing a structured compound semiconductor material to the oxidizing chemical species in the environment and detecting electromagnetic radiation emitted by the structured compound semiconductor material upon exposure to the oxidizing chemical species. The structured compound semiconductor material is a phytate scaffold material and a metal dopant.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: October 6, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventor: William L. Boatright
  • Patent number: 10793450
    Abstract: The invention is a capacitive, aka electrostatic, deionization apparatus and method that solves the problem of short lifetime of conventional capacitive deionization (CDI) and of membrane capacitive deionization (MCDI) devices and methods by shifting the Potential of Zero Charge of electrode surfaces through surface modifications. Such electrode surface modifications provide very long lifetime capacitive deionization devices and methods.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: October 6, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Xin Gao, Ayokunle Omosebi, James Richardson Landon, Kunlei Liu
  • Patent number: 10788426
    Abstract: A method of monitoring for the presence of a hydroperoxide in an aqueous or non-polar environment includes steps of exposing a structured compound semiconductor material with peroxidase activity to the hydroperoxide in the environment and detecting electromagnetic radiation emitted by the structured compound semiconductor material with peroxidase activity upon exposure to the hydroperoxide. The luminescence emitting semiconductor material with peroxidase activity consists of a primary semiconductor material with a dopant prepared on a phytate scaffold.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: September 29, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventor: William L. Boatright
  • Patent number: 10781446
    Abstract: The presently-disclosed subject matter relates to RNA-based composition and method to treat gastric cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a gastric cancer targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat gastric cancer in a subject having or at risk of having gastric cancer.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: September 22, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Peixuan Guo, Daxiang Cui, Dan Shu, Yi Shu, Chunlei Zhang
  • Patent number: 10773330
    Abstract: Methods and systems are provided herein for measuring 3D apparatus (e.g., manual tool or tool accessory) orientation. Example implementations use an auto-nulling algorithm that incorporates a quaternion-based unscented Kalman filter. Example implementations use a miniature inertial measurement unit endowed with a tri-axis gyro and a tri-axis accelerometer. The auto-nulling algorithm serves as an in-line calibration procedure to compensate for the gyro drift, which has been verified to significantly improve the estimation accuracy in three-dimensions, especially in the heading estimation.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: September 15, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Yuming Zhang, WeiJie Zhang
  • Patent number: 10772940
    Abstract: The presently-disclosed subject matter includes isolated polypeptides that comprise a butyrylcholinestrase (BChE) polypeptide and a second polypeptide. The BChE polypeptide as well as the second polypeptide can be variants and/or fragments thereof. The presently-disclosed subject matter also includes a pharmaceutical composition that comprises the present isolated polypeptide and a suitable pharmaceutical carrier. Further still, methods are provided for treating cocaine-induced conditions, and comprise administering the isolated polypeptide and/or pharmaceutical compositions thereof to an individual.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: September 15, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Hsin-Hsiung Tai, Xiabin Chen, Liu Xue, Shurong Hou
  • Patent number: 10755146
    Abstract: A computer-implemented process is disclosed for generating a labeled overhead image of a geographical area. A plurality of ground level images of the geographical area is retrieved. A ground level feature map is generated, via a ground level convolutional neural network, based on features extracted from the plurality of ground level images. An overhead image of the geographical area is also retrieved. A joint feature map is generated, via an overhead convolutional neural network based on the ground level feature map and features extracted from the plurality of ground level images. Geospatial function values at a plurality of pixels of the overhead image are estimated based on at least the joint feature map and the overhead image. The plurality of pixels of the overhead image is labeled according to the estimated geospatial function values.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: August 25, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Nathan Jacobs, Scott Workman
  • Patent number: 10738328
    Abstract: A method is provided for producing modified mutant yeast and the resulting yeast that can be used as a platform for terpene production. The method includes chemical mutagenesis to effect ergosterol dependent growth in yeast. Subsequently, these yeast are subjected to an erg9 knockout mutation to thereby produce ergosterol dependent growth/erg9 knockout mutation yeast cell lines. The resulting yeast are well suited for use in the production of terpenes.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: August 11, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joe Chappell, Xun Zhuang, Wu Shuiqin