Patents Assigned to University of Kentucky Research Foundation
  • Patent number: 12030877
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: July 9, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Patent number: 12019081
    Abstract: A compound and a method of detecting CLN3 are provided. The compound includes a heavy isotope labeled CLN3 proteotypic peptide. The method includes i) selecting a CLN3 proteotypic peptide that exhibits linear behavior in the mass spectrometer; ii) generating a stable isotope labeled standard; iii) spiking known amounts of the stable isotope labeled standard into a sample to form a spiked sample; iv) determining retention times and establishing calibration curves using the spiked sample; and v) detecting unlabeled selected CLN3 proteins in the sample.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: June 25, 2024
    Assignees: University of Kentucky Research Foundation, New York University
    Inventors: Qingjun Wang, Beatrix M. Ueberheide
  • Patent number: 11999676
    Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: June 4, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Linda P. Dwoskin, David Watt, Jon Thorson, Mark Leggas, Kip Guy, Jared Hammill, Stefan Kwiatkowski, Derong Ding, Guangrong Zheng, Peter Anthony Crooks, Na-Ra Lee
  • Patent number: 11999960
    Abstract: The present invention provides a method for increasing the sucrose ester content of a tobacco plant or tobacco cell culture, the method comprising modifying said tobacco plant or tobacco cell culture by inhibiting the activity or expression of a diterpene synthesis gene. The present invention also provides for the use of a diterpene synthesis gene for increasing the sucrose ester content of a tobacco plant or tobacco cell culture, as well as tobacco cells, tobacco plants, tobacco plant propagation materials, harvested leaves, processed tobaccos, or tobacco products obtainable in accordance with the invention.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: June 4, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: George Wagner, Antoaneta Borissova Mahaylova-Kroumova, Guiliang Tang, Erming Wang
  • Patent number: 11998547
    Abstract: The present disclosure relates to compounds and compositions that inhibit the NLRP3 inflammasome, for example, a compound according to formula I wherein R1 is C1-4 alkyl; and R2 is H or C1-4 alkyl, provided that when R2 is H. R1 is not CH3. Also disclosed are methods for treating multiple sclerosis using the compounds and compositions.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: June 4, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Jayakrishna Ambati, Benjamin Fowler, Kameshwari Ambati
  • Patent number: 11999803
    Abstract: Unique compounds useful for inhibiting a proteasome in a cell, pharmaceutical compositions and methods of their use are provided herein.
    Type: Grant
    Filed: February 14, 2023
    Date of Patent: June 4, 2024
    Assignee: University of Kentucky Research Foundation
    Inventor: Kyung Bo Kim
  • Patent number: 11987564
    Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: May 21, 2024
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, The United States Government as respresented by the Department of Veterans Affairs, The University of Kentucky Research Foundation
    Inventors: George Richard Uhl, Ian M. Henderson, Wei Wang, Thomas Prisinzano
  • Patent number: 11986464
    Abstract: Methods of treating or reducing risk of aneurysm, reducing cardiovascular risk, reducing serum cholesterol, reducing serum triglycerides, and/or reducing atherosclerotic plague in a subject involve administering to the subject an effective amount of a 5HT3R antagonist.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: May 21, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Lisa Cassis, Sean Thatcher, Yasir Alsiraj, Mark Ensor, Eric Blalock
  • Patent number: 11984046
    Abstract: A surgical skills training model has an elongated body including muscle, fascia, subcutaneous tissue, connective tissue and skin mimicking layers. The fascia and connective tissue layer are made from a material having a stretch direction that is aligned with a longitudinal axis of the muscle layer and the body of the model.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: May 14, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Samuel G. Powdrill, DeShana Collett
  • Patent number: 11980687
    Abstract: A composition and method for treating a subject following myocardial infarction are provided. The composition includes a non-PEGylated liposome. The method includes administering a non-PEGylated liposome to a subject in need thereof following myocardial infarction.
    Type: Grant
    Filed: April 18, 2023
    Date of Patent: May 14, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Vincent J. Venditto, Ahmed Abdel-Latif, Ahmed Al-Darraji, Dave Feola, John C. Gensel
  • Patent number: 11976092
    Abstract: Disclosed herein are high Tm RNA nanostructures that can be composed of one or more modules or motifs to build RNA nanostructures with or without layers. The RNA nanostructures can have a core domain and three or more double-stranded arms and formulations thereof to conjugate high copy numbers of therapeutics, pH responsive or enzyme cleavable drug cargo. Also described herein is a design strategy for generation of synthetic RNA oligonucleotides that can self assemble into highly thermostable RNA structures. Also described herein are uses of the RNA nanostructures described herein.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: May 7, 2024
    Assignees: Ohio State Innovation Foundation, University of Kentucky Research Foundation
    Inventors: Peixuan Guo, Mario Vieweger, Xin Li, Sijin Guo, Hongran Yin, Xijun Piao, Yi Shu, Dan Shu, Mehdi Rajabi
  • Patent number: 11964172
    Abstract: A quality assurance device for a medical accelerator includes a housing having an inner radioluminescent layer adapted to provide a visual indication when contacted with invisible radiation generated by the medical accelerator. In addition, the quality assurance device includes one or more cameras located within the housing and adapted to image the inner radioluminescent layer of the housing including the visual indication.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: April 23, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Janelle A. Molloy, Dennis A. Cheek, Quan Chen
  • Patent number: 11964028
    Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to RNA nanoparticles and RNA dendrimers, and methods of disease diagnosis and treatments using the RNA nanostructure and RNA dendrimers.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: April 23, 2024
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Peixuan Guo, Hui Li, Wei Luo
  • Patent number: 11938443
    Abstract: A hybrid post-combustion carbon dioxide capture system for capturing carbon dioxide from a flue gas includes a compressor adapted to produce a compressed flue gas stream, a membrane-based carbon dioxide separation unit configured to receive a first portion of the compressed flue gas stream from the compressor, and an aqueous-based carbon dioxide capture unit configured to receive a second portion of the compressed flue gas stream from the compressor whereby the compressed flue gas stream is processed in parallel by the membrane-based carbon dioxide separation unit and the aqueous-based carbon dioxide capture unit.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: March 26, 2024
    Assignee: University of Kentucky Research Foundation
    Inventor: Kunlei Liu
  • Patent number: 11932557
    Abstract: Methods for detecting and extracting plastic contaminants within a water sample, which involve introducing the water sample to a hydrophobic deep eutectic solvent, are provided.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: March 19, 2024
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Jian Shi, Wenqi Li, Jameson Hunter, Yuxuan Zhang, Qing Shao
  • Patent number: 11932897
    Abstract: A method of making curcuminoids in a mammalian cell. The method of making a curcuminoid in a mammalian cell includes expressing one or more enzymes in the mammalian cell, the enzymes being selected from the group consisting of tyrosine ammonia lyase (TAL), 4-coumaroyl-CoA ligase (4CL1), curcuminoid synthase (CUS), diketide-CoA synthase (DCS), curcumin synthase (CURS1), 4-coumarate 3-hydroxylase (C3H), caffeoyl-CoA 3-O-methyltransferase (CCoAMT), and acetyl-CoA carboxylase (ACC). The expressing of the one or more enzymes converts a starting material, such as tyrosine or ferulic acid, to the curcuminoid. Also provided herein are therapeutic uses for the curcuminoid made in a mammalian cell.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: March 19, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Logan W. Warriner, Daniel W. Pack
  • Patent number: 11920039
    Abstract: Derivatized malachite green leuco dyes for use in radio-chromic systems are described. The dyes have the following structure: in which Ar is a substituted phenyl or thiophene ring in which at least one substitution of the Ar ring is not ortho to the bond between the ring and the linking carbon, and in which R1, R2, R3, and R4 are independently selected from methyl, alkyl, or alkyl halide. The systems include the dyes in conjunction with an activator, e.g., a halogenated activator, and a carrier, e.g., a fluid carrier or an encapsulating polymeric matrix.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: March 5, 2024
    Assignees: Battelle Savannah River Alliance, LLC, University of Kentucky Research Foundation
    Inventors: Aaron L. Washington, II, John T. Bobbitt, III, John E. Anthony, Brent Peters, James C. Nicholson
  • Patent number: 11890490
    Abstract: A quality assurance device for a medical accelerator includes a housing having an inner radioluminescent layer adapted to provide a visual indication when contacted with invisible radiation generated by the medical accelerator. In addition, the quality assurance device includes one or more passive optical components within the housing adapted to deliver an image of the inner radioluminescent layer of the housing including the visual indication to one or more cameras located outside of the housing.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: February 6, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Janelle A. Molloy, Dennis A. Cheek, Quan Chen
  • Patent number: 11883409
    Abstract: Therapeutic uses P2X7 inhibition and inhibition of IRAK1 and/or IRAK4, methods protecting a cell, and screening methods for identifying inhibitors are described herein.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: January 30, 2024
    Assignee: University of Kentucky Research Foundation
    Inventor: Jayakrishna Ambati
  • Patent number: 11857914
    Abstract: An apparatus for removing an acid gas from a feed gas stream includes an absorber and an electrochemical regenerator. The absorber is adapted for separating the acid gas from the feed gas feed stream using a lean carbon capture solvent. The electrochemical regenerator is connected to the absorber and adapted for (a) regenerating the carbon capture solvent and (b) generating hydrogen gas. A method for removing acid gas from a feed gas stream includes steps of separating, delivering, releasing, generating and returning.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: January 2, 2024
    Assignee: University of Kentucky Research Foundation
    Inventors: Ayokunle Omosebi, Xin Gao, Reynolds Frimpong, Kunlei Liu