Patents Assigned to University of Massachusetts at Lowell
  • Publication number: 20220054389
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Application
    Filed: March 8, 2021
    Publication date: February 24, 2022
    Applicant: University of Massachusetts Lowell
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Patent number: 11174336
    Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: November 16, 2021
    Assignee: University of Massachusetts Lowell
    Inventors: Rudolf Faust, Umaprasana Ojha
  • Patent number: 10576034
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: March 3, 2020
    Assignee: University of Massachusetts Lowell
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Patent number: 10532019
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: January 14, 2020
    Assignee: University of Massachusetts Lowell
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Patent number: 10016364
    Abstract: The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased Tmax, increased CmaX3 and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated dispersion medium. This is unlike current nanoparticulate composition methods that mix an insoluble compound with an unheated dispersion medium. Further, these nanoemulsions are observed to be bacterial-resistant and stable to extremes in both temperature and pH changes.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: July 10, 2018
    Assignee: University of Massachusetts Lowell
    Inventors: Robert James Nicolosi, Thomas Wilson
  • Patent number: 9631042
    Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 25, 2017
    Assignees: BOSTON SCIENTIFIC SCIMED, INC., THE UNIVERSITY OF MASSACHUSETTS LOWELL
    Inventors: Mark Boden, Marlene C. Schwarz, Frederick H. Strickler, Rudolf Faust, Umaprasana Ojha, Tomoya Higashihara
  • Patent number: 9574043
    Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: February 21, 2017
    Assignee: University of Massachusetts Lowell
    Inventors: Rudolf Faust, Umaprasana Ojha
  • Patent number: 9506029
    Abstract: The present invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydrogel materials, apparatus and methods for several non-invasive techniques of maintaining optimal or near-optimal nutrient and pH levels in cell cultures.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: November 29, 2016
    Assignee: University of Massachusetts Lowell
    Inventors: Daniel Schmidt, Emmanuelle Reynaud, Peter Gaines
  • Patent number: 9486408
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: November 8, 2016
    Assignee: University of Massachusetts Lowell
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Patent number: 9434867
    Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: September 6, 2016
    Assignee: University of Massachusetts Lowell
    Inventor: Daniel Schmidt
  • Publication number: 20160075923
    Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.
    Type: Application
    Filed: September 21, 2015
    Publication date: March 17, 2016
    Applicant: University of Massachusetts Lowell
    Inventor: Daniel Schmidt
  • Patent number: 9173970
    Abstract: The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: November 3, 2015
    Assignees: University of Massachusetts Lowell, NovaPlast Corporation
    Inventors: Stephen McCarthy, Jeffrey Weinzweig
  • Patent number: 9139690
    Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: September 22, 2015
    Assignee: University of Massachusetts Lowell
    Inventor: Daniel Schmidt
  • Patent number: 8999431
    Abstract: Metal flakes, an organic metal precursor, an organic solvent and either no binder, or a volatile or a thermally decomposable binder are combined to form a paste. The paste is deposited in a circuit pattern on a substrate and the circuit pattern is cured. While curing, the organic metal precursor decomposes to leave an electrically conductive path, and the printed circuit is thus formed. A precursor to an electrically conductive circuit material includes an organic metal precursor, metal microparticles, and an organic solvent. The method can be employed to form printed circuits, for a variety of electrical, electronic and sensing application, such as crack detection in ceramic, plastics, concrete, wood, fabric, leather, rubber or paper and composite materials.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: April 7, 2015
    Assignee: University of Massachusetts Lowell
    Inventors: Ramaswamy Nagarajan, Sharavanan Balasubramaniam, Julie Chen, Joey Mead
  • Patent number: 8962785
    Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: February 24, 2015
    Assignee: University of Massachusetts Lowell
    Inventors: Rudolf Faust, Umaprasana Ojha
  • Publication number: 20150018223
    Abstract: This invention provides methods and kits for the detection of tau-associated neurodegenerative diseases, such as Alzheimer's disease, prior to the onset of clinical symptoms. The method generally involves determining the amount of one or more tau protein isoforms in a biological sample relative to a suitable control, where an altered amount of the tau isoform(s) relative to the control identifies the presence of a tau-associated neurodegenerative disease. Such methods can also be applied more generally for the detection of tau abnormalities in any biological sample.
    Type: Application
    Filed: January 28, 2011
    Publication date: January 15, 2015
    Applicant: UNIVERSITY OF MASSACHUSETTS LOWELL
    Inventors: Garth F. Hall, Wonhee Kim, Sangmook Lee
  • Patent number: 8911760
    Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: December 16, 2014
    Assignees: Boston Scientific Scimed, Inc., The University of Massachusetts Lowell
    Inventors: Mark Boden, Marlene C. Schwarz, Frederick H. Strickler, Rudolf Faust, Umaprasana Ojha, Tomoya Higashihara
  • Patent number: 8870871
    Abstract: The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: October 28, 2014
    Assignee: University of Massachusetts Lowell
    Inventors: Stephen McCarthy, Jeffrey Weinzweig
  • Publication number: 20140099342
    Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.
    Type: Application
    Filed: October 9, 2012
    Publication date: April 10, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS LOWELL
    Inventors: Jonathan Edelson, Robert Nicolosi
  • Publication number: 20140088289
    Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 27, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS LOWELL
    Inventor: Daniel Schmidt