Patents Assigned to University of Massachusetts at Lowell
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Publication number: 20220054389Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: March 8, 2021Publication date: February 24, 2022Applicant: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Patent number: 11174336Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.Type: GrantFiled: December 6, 2019Date of Patent: November 16, 2021Assignee: University of Massachusetts LowellInventors: Rudolf Faust, Umaprasana Ojha
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Patent number: 10576034Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: GrantFiled: October 7, 2016Date of Patent: March 3, 2020Assignee: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Patent number: 10532019Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: GrantFiled: July 7, 2017Date of Patent: January 14, 2020Assignee: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Patent number: 10016364Abstract: The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased Tmax, increased CmaX3 and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated dispersion medium. This is unlike current nanoparticulate composition methods that mix an insoluble compound with an unheated dispersion medium. Further, these nanoemulsions are observed to be bacterial-resistant and stable to extremes in both temperature and pH changes.Type: GrantFiled: January 12, 2015Date of Patent: July 10, 2018Assignee: University of Massachusetts LowellInventors: Robert James Nicolosi, Thomas Wilson
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Patent number: 9631042Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.Type: GrantFiled: November 12, 2014Date of Patent: April 25, 2017Assignees: BOSTON SCIENTIFIC SCIMED, INC., THE UNIVERSITY OF MASSACHUSETTS LOWELLInventors: Mark Boden, Marlene C. Schwarz, Frederick H. Strickler, Rudolf Faust, Umaprasana Ojha, Tomoya Higashihara
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Patent number: 9574043Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.Type: GrantFiled: January 12, 2010Date of Patent: February 21, 2017Assignee: University of Massachusetts LowellInventors: Rudolf Faust, Umaprasana Ojha
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Patent number: 9506029Abstract: The present invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydrogel materials, apparatus and methods for several non-invasive techniques of maintaining optimal or near-optimal nutrient and pH levels in cell cultures.Type: GrantFiled: December 30, 2011Date of Patent: November 29, 2016Assignee: University of Massachusetts LowellInventors: Daniel Schmidt, Emmanuelle Reynaud, Peter Gaines
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Patent number: 9486408Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: GrantFiled: October 9, 2012Date of Patent: November 8, 2016Assignee: University of Massachusetts LowellInventors: Jonathan Edelson, Robert Nicolosi
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Patent number: 9434867Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.Type: GrantFiled: September 21, 2015Date of Patent: September 6, 2016Assignee: University of Massachusetts LowellInventor: Daniel Schmidt
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Publication number: 20160075923Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.Type: ApplicationFiled: September 21, 2015Publication date: March 17, 2016Applicant: University of Massachusetts LowellInventor: Daniel Schmidt
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Patent number: 9173970Abstract: The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.Type: GrantFiled: October 3, 2014Date of Patent: November 3, 2015Assignees: University of Massachusetts Lowell, NovaPlast CorporationInventors: Stephen McCarthy, Jeffrey Weinzweig
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Patent number: 9139690Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.Type: GrantFiled: April 27, 2012Date of Patent: September 22, 2015Assignee: University of Massachusetts LowellInventor: Daniel Schmidt
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Patent number: 8999431Abstract: Metal flakes, an organic metal precursor, an organic solvent and either no binder, or a volatile or a thermally decomposable binder are combined to form a paste. The paste is deposited in a circuit pattern on a substrate and the circuit pattern is cured. While curing, the organic metal precursor decomposes to leave an electrically conductive path, and the printed circuit is thus formed. A precursor to an electrically conductive circuit material includes an organic metal precursor, metal microparticles, and an organic solvent. The method can be employed to form printed circuits, for a variety of electrical, electronic and sensing application, such as crack detection in ceramic, plastics, concrete, wood, fabric, leather, rubber or paper and composite materials.Type: GrantFiled: December 1, 2009Date of Patent: April 7, 2015Assignee: University of Massachusetts LowellInventors: Ramaswamy Nagarajan, Sharavanan Balasubramaniam, Julie Chen, Joey Mead
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Patent number: 8962785Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.Type: GrantFiled: November 20, 2012Date of Patent: February 24, 2015Assignee: University of Massachusetts LowellInventors: Rudolf Faust, Umaprasana Ojha
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Publication number: 20150018223Abstract: This invention provides methods and kits for the detection of tau-associated neurodegenerative diseases, such as Alzheimer's disease, prior to the onset of clinical symptoms. The method generally involves determining the amount of one or more tau protein isoforms in a biological sample relative to a suitable control, where an altered amount of the tau isoform(s) relative to the control identifies the presence of a tau-associated neurodegenerative disease. Such methods can also be applied more generally for the detection of tau abnormalities in any biological sample.Type: ApplicationFiled: January 28, 2011Publication date: January 15, 2015Applicant: UNIVERSITY OF MASSACHUSETTS LOWELLInventors: Garth F. Hall, Wonhee Kim, Sangmook Lee
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Patent number: 8911760Abstract: The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.Type: GrantFiled: December 30, 2009Date of Patent: December 16, 2014Assignees: Boston Scientific Scimed, Inc., The University of Massachusetts LowellInventors: Mark Boden, Marlene C. Schwarz, Frederick H. Strickler, Rudolf Faust, Umaprasana Ojha, Tomoya Higashihara
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Patent number: 8870871Abstract: The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.Type: GrantFiled: April 13, 2007Date of Patent: October 28, 2014Assignee: University of Massachusetts LowellInventors: Stephen McCarthy, Jeffrey Weinzweig
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Publication number: 20140099342Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.Type: ApplicationFiled: October 9, 2012Publication date: April 10, 2014Applicant: UNIVERSITY OF MASSACHUSETTS LOWELLInventors: Jonathan Edelson, Robert Nicolosi
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Publication number: 20140088289Abstract: An epoxy resin is provided that includes a diglycidyl ether of a substituted cycloaliphatic diol or bis-thiol, and a thermoset epoxy polymer is provided employing the same. The epoxy resin is bisphenol A free, and capable of forming thermoset epoxy polymers with fewer associated health and environmental concerns than conventional epoxies based on phenolic compounds.Type: ApplicationFiled: April 27, 2012Publication date: March 27, 2014Applicant: UNIVERSITY OF MASSACHUSETTS LOWELLInventor: Daniel Schmidt