Abstract: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
March 21, 2000
Assignee:
University of North Carloina at Chapel Hill
Inventors:
Forrest K. Ferrari, Xiao Xiao, Richard Jude Samulski