Patents Assigned to University of Notre Dame du Lac
  • Patent number: 10270547
    Abstract: A system and method for detection of complex sinusoidal signals. The method can include obtaining a set of complex-valued samples of one or more signals, in the presence of unknown noise, using a plurality of sensors. The presence of ? candidate complex sinusoids can be assumed. Then, ? candidate complex sinusoids in the set of complex-valued samples can be estimated. The method can include comparing a measurement of the energy of the ? estimated candidate complex sinusoids with a threshold value. Based on the comparison, a determination can be made whether to assume a different number of candidate complex sinusoids and repeat the estimation and the comparison steps, or to specify the estimated ? candidate complex sinusoids as detected complex sinusoids. The threshold value can be determined using a penalty value which reduces the probability of overestimating the number of complex sinusoids.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: April 23, 2019
    Assignee: University of Notre Dame du Lac
    Inventors: Thomas G. Pratt, Farzad Talebi
  • Patent number: 10259788
    Abstract: Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 16, 2019
    Assignee: University of Notre Dame du Lac
    Inventors: William F. Schneider, Joan F. Brennecke, Edward J. Maginn, Elaine Vazquez, Burcu Gurkan, Erica Price, Brett Goodrich
  • Patent number: 10264525
    Abstract: Systems and methods for performing energy efficient communication. A transceiver for use in a point-to-point packet-based communication link with packet erasures is described. The transceiver can include a data source to provide bits of data for transmission to a remote device. The transceiver can map the bits of data to symbols in a constellation according to a modulation scheme and can provide the symbols on one or more subcarriers. The transceiver can include co-located orthogonally polarized antenna elements or spatially separated antenna elements or both. The symbols can be transmitted in packets via one or more of the antenna elements. The transceiver can determine a metric of average transmit energy per bit successfully decoded, and not erased, at the remote device and can adjust transmission powers at the antenna elements to reduce the average transmit energy per successfully decoded and unerased bit.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: April 16, 2019
    Assignee: University of Notre Dame du Lac
    Inventors: Thomas G. Pratt, Jun Chen
  • Patent number: 10253013
    Abstract: The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 9, 2019
    Assignee: University of Notre Dame du Lac
    Inventors: Mayland Chang, Shahriar Mobashery
  • Patent number: 10247720
    Abstract: Disclosed are methods, compositions, and devices for an integrated, heterogenerous ion-exchange membrane-based plastic microfluidic biochip platform that can be used to detect multiple diagnostic markers present in real samples. Its various components can be easily integrated in a modular fashion for different applications. Automated control allows sequential and dynamic activation of different components on the chip. The integrated platform consists of three units and is designed to execute the following functions: (i) separation of the target biomolecules from the real sample, (ii) localizing and concentrating the targeted molecules at a specific location in the microfluidic chip, and (iii) detection of the targeted molecules using hybridization/docking events against a complementary ssDNA oligoprobe sequence or a specific antibody.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: April 2, 2019
    Assignee: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Zdenek Slouka, Satyajyoti Senapati, Sunny S. Shah, Hsueh-Chia Chang
  • Patent number: 10190271
    Abstract: A structural plane is presented for forming a variable depth structure constructed of adjustable modules. Each module is formed of four links connected with revolute joints. The modules are connected at adjacent lateral joints and by upper and lower chords connecting the upper and lower revolute joints of the modules. The ultimate lateral joints of the modules at each end are connected to each end of the structural plane. The adjustable module and other components can form two- and three-hinged arches made of standard rolled steel sections.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: January 29, 2019
    Assignees: University of Notre Dame du Lac, HNTB Corporation
    Inventors: Ashley P. Thrall, Yao Wang, Theodore P. Zoli, III
  • Publication number: 20190016909
    Abstract: A method for fabricating nanostructured polymeric materials based on a combination of inkjet printing and template synthesis. Layer-by-layer assembled nanotubes can be synthesized in a polycarbonate track-etched (PCTE) membrane by printing poly(allylamine hydrochloride) (PAH) and poly(styrenesulfonate) (PSS) sequentially. By changing the printing conditions, polymeric nanotubes or nanowires can be prepared by printing poly(vinyl alcohol) (PVA) in a PCTE template. Inkjet printing paired with template synthesis can be used to generate patterns comprised of chemically distinct nanomaterials. Thin polymeric films of layer-by-layer assembled PAH and PSS can be printed on a PCTE membrane. Inkjet printing paired with template synthesis can also be used to prepare functional mosaic membranes, such as charge mosaic membranes comprising polyelectrolytes of different charges to pattern positively charged or negatively-charged domains, respectively, on the surface of the template.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 17, 2019
    Applicant: University of Notre Dame du Lac
    Inventors: William A. PHILLIP, Siyi Qu, Sherwood BENAVIDES, Peng GAO, Feng GAO
  • Publication number: 20190004010
    Abstract: The invention provides a capillary isoelectric focusing (cIEF) system based on a sandwich injection method for automated chemical mobilization. This system was coupled with an electrokinetically pumped nanoelectrospray interface to a mass spectrometer. The nanoelectrospray emitter employed an acidic sheath electrolyte. To realize automated focusing and mobilization, a plug of ammonium hydroxide was first injected into the capillary, followed by a section of mixed sample and ampholyte. As focusing progressed, the NH3H2O section was titrated to lower pH buffer by the acidic sheath buffer. Chemical mobilization started automatically once the ammonium hydroxide was consumed by the acidic sheath flow electrolyte.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 3, 2019
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Norman DOVICHI, Guijie ZHU, Liangliang SUN
  • Publication number: 20180363054
    Abstract: Current procedures for the analysis of sexual assault kits are labor intensive, time consuming and deliver a success rate lower than 40%. This has resulted in rape kit backlogs of thousands. The primary challenge crime laboratories face in analyzing these cases is the separation of purified male DNA from the mixture of primarily female DNA from gynecological swabs. Effective elution of the sample from the swab and efficient separation of intact sperm cells from epithelial and other cellular debris, allow for a successful PCR amplification and short tandem repeat (STR) DNA analysis for perpetrator identification. The disclosure provides an effective and economically accessible technology for the separation of male and female cells and DNA, for example, from a gynecological swab by capillary zone electrophoresis (CZE).
    Type: Application
    Filed: June 20, 2018
    Publication date: December 20, 2018
    Applicant: University of Notre Dame du Lac
    Inventors: Sarah LUM, Norman DOVICHI, Bonnie JASKOWSKI HUGE, Carlos Gusti GARTNER
  • Publication number: 20180354944
    Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo [1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
    Type: Application
    Filed: February 5, 2018
    Publication date: December 13, 2018
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Marvin J. MILLER, Garrett C. MORASKI, Lowell D. MARKLEY, George E. DAVIS
  • Patent number: 10100889
    Abstract: A brake disc rotor or stator is manufactured with slots in the interior face of the disc. A paste comprised of a fine powder of a carbide-forming metal along with fine carbon powder, suspended in an organic binder, is applied to the force-bearing areas in the rotor slot faces or the stator slot faces. The disc is then placed into a furnace in a nitrogen atmosphere and heated to the ignition temperature. When the furnace reaches the ignition temperature, a combustion reaction begins that creates a molten liquid ceramic material on the slot face. Upon cooling, the resulting brake disc has a tough, hard, abrasion-resistant ceramic surface on the portion of the brake disc slot that bears pressure.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: October 16, 2018
    Assignees: Honeywell International Inc., The University of Notre Dame Du Lac
    Inventors: Allen H. Simpson, Mark L. La Forest, Gregory Vanderheyden, Alexander Mukasyan
  • Patent number: 10086331
    Abstract: Disclosed herein are methods for CO2 capture that use phase change ionic liquids (PCILs) to remove the CO2 from flue gas or other gas streams containing CO2. PCILs have high CO2 uptake and form a liquid PCIL-CO2 complex when they react with C( )2. When the liquid PCIL-CO2 complex is heated to regenerate the solid PCIL material by removing the carbon dioxide, part of the heat needed to release the CO2 can be supplied by the heat of fusion of the PCIL as it solidifies. Utilization of the heat of fusion of the PCIL to assist in its own regeneration can substantially reduce the parasitic energy loss associated with post-combustion CO2 capture.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 2, 2018
    Assignee: University of Notre Dame du Lac
    Inventors: Joan F. Brennecke, Edward J. Maginn, William F. Schneider
  • Patent number: 10087463
    Abstract: The present invention provides a method for transforming an insect genome that has a much enhanced transformation frequency. The vectors and plasmids employed in the method are further described as transposition vectors that include a minimal amount of nucleotide sequence homologous to a 5? region and a 3? region of a native piggyBac nucleic acid sequence. The transformed cells or embryos may also be developed into transgenic organisms. Disclosed are minimal piggyBac-based plasmid constructs that comprises a minimal nucleic acid sequence homologous to a 5? end of a piggyBac nucleic acid sequence (about 60-80 bp, particularly 66 bp) and a relatively long (300 to about 380 bp, particularly 311 bp or 378 bp) continuous nucleic acid sequence homologous to a 3? end of a piggyBac native nucleic acid sequence. Methods employing these constructs include the use of a helper plasmid.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: October 2, 2018
    Assignee: University of Notre Dame Du Lac
    Inventors: Malcolm J. Fraser, Xu Li
  • Publication number: 20180272008
    Abstract: Embodiments of the present disclosure provide a nanoparticle based platform, and nanoallergens for identifying, evaluating and studying allergen mimotopes as multiple copies of a single mimotope or various combinations on the same particle. The nanoparticle is extremely versatile and allows multivalent binding to IgEs specific to a variety of mimotopes, simulating allergen proteins. Nanoparticles can include various molecular ratios of components. For example, the nanoallergens can include about 0.1-40% mimotope-lipid conjugate and about 60-99.9% lipid. The mimotope-lipid conjugate includes a mimotope, a first linker, and lipid molecule. Nanoallergens can be used in in vitro and in vivo applications to identify a specific patient's sensitivity to a set of epitopes and predict a symptomatic clinical response, identify allergen epitopes through blind screening peptide sequences from allergen protein, and in a clinical application similar to a scratch test.
    Type: Application
    Filed: September 26, 2016
    Publication date: September 27, 2018
    Applicant: University of Notre Dame du Lac
    Inventors: Zihni Basar BILGICER, Peter DEAK, Tanyel KIZILTEPE BILGICER, Jared Francis STEFANICK, Jonathan Darryl ASHLEY
  • Publication number: 20180265506
    Abstract: Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections.
    Type: Application
    Filed: September 19, 2016
    Publication date: September 20, 2018
    Applicant: UNIVERSITY OF NOTRE DAME DU LAC
    Inventors: Marvin J. MILLER, Garrett C. MORASKI
  • Publication number: 20180263909
    Abstract: The disclosure provides pharmaceutical compositions and method of using the compositions, wherein the compositions comprise liposomes that contain two or more anticancer drugs. In various embodiments the components of the liposomes can include a) a phospholipid, b) a pegylated lipid, c) an aqueous core, and d) at least one covalently-linked drug-conjugated lipid, an encapsulated drug, or a combination thereof, wherein the drug of the lipid-drug conjugate, encapsulated drug, or both, are anticancer drugs.
    Type: Application
    Filed: September 15, 2016
    Publication date: September 20, 2018
    Applicant: University Of Notre Dame du Lac
    Inventors: Zihni Basar BILGICER, Tanyel KIZILTEPE BILGICER, Jonathan Darryl ASHLEY
  • Publication number: 20180258461
    Abstract: Capillary electrophoresis fractionation of an environmental microbiota segregates high abundance microbes from lower abundance species, and results in a three-fold increase in the number of 16s rRNA OTUs that map to known species. However, most of the bacteria are found in a few wells, although reasonably large numbers of OTUs were found in over half the wells.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Applicant: University of Notre Dame du Lac
    Inventors: Norman Dovichi, Bonnie Jaskowski Huge, Matthew Champion
  • Publication number: 20180241634
    Abstract: Disclosed herein are systems, methods, and software for providing a network structure for a network. In one example, a method includes identifying an occurrence of a cascade amongst a plurality of nodes of the network. The method also includes determining respective activation times for each node of a plurality of activated nodes activated during the cascade. The method further includes, for each pairwise combination of activated nodes from the plurality of activated nodes, computing, based on the respective activation times, a connection probability that a pair of nodes from the plurality of activated nodes is connected by an edge. The method further includes mapping a true edge between two activated nodes of the plurality of activated nodes in the network based on computed connection probabilities for the each pairwise combination.
    Type: Application
    Filed: February 22, 2018
    Publication date: August 23, 2018
    Applicant: University of Notre Dame du Lac
    Inventor: Dervis Can Vural
  • Publication number: 20180237412
    Abstract: The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.
    Type: Application
    Filed: April 24, 2018
    Publication date: August 23, 2018
    Applicant: University of Notre Dame du Lac
    Inventors: Mayland CHANG, Shahriar MOBASHERY
  • Patent number: 10050027
    Abstract: First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is positioned contiguous to the first edge surface of the first integrated device. The interconnect structures disposed on the first integrated device are in physical contact with the interconnect structures disposed on the edge surface of the second integrated device so as to provide alignment for conveying at least one signal between the optical components on the first and second integrated devices.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: August 14, 2018
    Assignee: University of Notre Dame du Lac
    Inventors: Douglas C. Hall, Scott Howard, Anthony Hoffman, Gary H. Bernstein, Jason M. Kulick