Abstract: This invention relates to improving delivery of agents (e.g., one or more nanoparticles) to the central nervous system.

Abstract: A method, system and devices to selectively control modal vibrations in an elastic panel with a number of force actuators distributed throughout the surface of the elastic panel to excite/depress the response of one or more vibrational resonant modes included in a prescribed subset. The force actuators are disposed such that prescribed modal excitation/depression may be realized when the actuators are driven by a common source signal.

Abstract: Ultrasound imaging at high spatial resolution that makes use of both magnitude and phase of echoes in an image reconstruction process that applies unique constraints to a fitting of echoes from the object of interest to echoes from an array of known scatterers.

Abstract: The present invention relates to isolated peptides suitable for disrupting an epithelial barrier, transepithelial dmg or vaccine formulations, drug delivery vehicles for delivering these formulations, and methods of using of these formulations for disrupting an epithelial barrier.

Abstract: An ultrasound study in which the reflected echoes are analyzed to determine a physical characteristic of scatterers within the volume of interest, the acoustic attenuation within the volume of interest, and the echo amplitude. These data are used to diagnose the disease state and the progression of disease.

Abstract: A GRIN optic having an optical axis (z-direction) and a GRIN profile varying in the x and y-directions, the profile having one or more discontinuities extending in the x-y direction. The discontinuities may form a non-closed shape or have a non-smooth rectilinear shape. The GRIN optic may have plane-parallel surfaces. A method of designing a GRIN optic which includes mapping discretized elements in the light output specification to array elements of a linear GRIN array elements, identifying for each array element, a base refractive index n0, a gradient magnitude ?, and a gradient direction ?G capable of directing a beamlet from the light source to a corresponding location in the light output specification, and constructing a piecewise-continuous freeform GRIN profile of the GRIN optic by integrating the discrete linear GRIN array elements into a continuous refractive index profile.

Abstract: The present invention relates to methods of treating female reproductive tract irritation (such as pain and pruritus) or/and inflammation.

Abstract: Systems and methods for assessing multi-layer structures in which a spectrum array is generated from low coherence interferometry and input into a statistical estimator, which determines the thickness and layer number based on the inputted spectrum and other information, including information about a source intensity noise, Poisson noise, and dark noise associated with the low coherence interferometry.

Abstract: A device, system and method for the detection and screening of plastic microparticles in a sample is disclosed. A nanoporous silicon nitride membrane is used to entrap plastic microparticles contained in the sample. The sample may be a water sample, an air sample, or other liquid or gas sample. The entrapped plastic microparticles are then heated or otherwise processed on the nanoporous silicon nitride membrane. An imaging system observes the nanoporous silicon nitride membrane with tic entrapped plastic microparticles to determine the type and quantity of the various plastic microparticles that are entrapped on the membrane.

Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical tissues is performed in combination with corneal lenticular surgery to achieve overall desired vision corrections.

Abstract: A hybrid integrated thermal sensor device includes a magnetic tunnel junction (MTJ) device electrically coupled in series with at least one CMOS transistor and disposed between a voltage rail terminal and a ground terminal. An output terminal is electrically coupled to a drain of the at least one CMOS transistor. The MTJ operates in an anti-parallel state and the output terminal provides a voltage indicative of a temperature of the MTJ device based on an MTJ antiparallel resistance. A distributed sensor network for real-time thermal mapping of an integrated circuit (IC) is also described.

Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or ocular tissues is performed to address various types of vision correction.

Abstract: An integrated optical device includes a substrate. A waveguide includes a lithium niobate. A TiO2 coating is disposed at least in part over a longitudinal surface of the waveguide as a coated waveguide supported by the substrate. A silicon oxide substantially can cover and surround the waveguide in cross section over a longitudinal direction of said waveguide as an optical cladding. A method for substantially eliminating optical damage in lithium niobate devices is also described.

Abstract: The invention relates to novel compositions managing or inhibiting blood clotting and related uses.

Abstract: The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.

Abstract: A method to image an in vivo object in an eye includes illuminating an object in the eye by a light source; configuring one or more detectors to receive light from a conjugate plane behind a confocal plane of the object, the conjugate plane acting as a light screen; receiving at the one or more detectors a backscattered light from the light source which has been refracted at least in part by the object before being backscattered from the light screen to provide a detector data; and processing the detector data over a time period by a computer to generate information about the object.

Abstract: This invention relates to methods to determine vaccine candidate strains that can be used to induce broadly cross-reactive immunity against pathogens, related vaccines, and related methods.

Abstract: The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.

Abstract: Disclosed is a sensor chip for detecting a target molecule in a sample. The sensor chip includes a substrate having a surface and a layer of hydrogel particles immobilized on the substrate surface at two or more locations on the surface, wherein the hydrogel particles at a first location comprise a plurality of first probe molecules bound to the particles and the hydrogel particles at a second location comprise a plurality of second probe molecules bound to the particles. Systems that include the sensor chip, as well as methods of preparing and using the sensor chip, are also disclosed.

Abstract: The invention provides methods and kits for rapid and inexpensive detection of hyposmia or anosmia, diminishment or loss of the sense of smell. Sudden onset of diminishment or loss of the sense of smell is an early sign of infection with SARS-CoV-2, the causative agent of COVID-19; detecting the sudden onset of diminishment or loss of the sense of smell can therefore be used to rapidly screen a population for persons who should undergo diagnostic testing for a SARS-CoV-2 infection, and more generally to screen persons for olfactory disorders.