Abstract: The present invention provides monoclonal antibodies that recognize polio virus receptor (PVR) and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
February 2, 2021
Assignees:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., UNIVERSITY OF RUEKA FACULTY OF MEDICINE RIJEKA, CROATIA
Inventors:
Ofer Mandelboim, Noa S. Kaynan, Pinchas Tsukerman, Stipan Jonjic