Patents Assigned to University of South Florida (A Florida Non-Profit Corporation)
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Publication number: 20170283344Abstract: In some embodiments, a system for producing liquid fuel from landfill gas includes a tri-reformer that receives landfill gas and produces synthesis gas having a H2:CO ratio of approximately 2:1, and a Fischer-Tropsch synthesis (FTS) reformer that receives the synthesis gas from the tri-reformer and produces liquid fuel.Type: ApplicationFiled: September 17, 2013Publication date: October 5, 2017Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: John N. Kuhn, Babu Joseph, Devin Walker, Syed Ali Gardezi, Timothy Roberge
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Publication number: 20170219564Abstract: Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.Type: ApplicationFiled: April 18, 2017Publication date: August 3, 2017Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Subhra Mohapatra, Shyam S. Mohapatra
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Patent number: 9458086Abstract: Modified stilbenoids and formulations thereof are provided. The modified stilbenoids can include one or more amino or amino-alkyl substituents. The formulation can be for the treatment or prevention of obesity and the modified stilbenoid present in an effective amount to alleviate or prevent the onset of one or more symptoms of obesity. Methods of making the modified stilbenoids and formulations thereof are provided. Methods are provided for treating a subject with a modified stilbenoid in an effective amount to alleviate or prevent one or more symptoms associated with diabetes, cardiovascular disease, high blood pressure, deep vein thrombosis, osteoarthritis, obstructive sleep apnea, cancer, and non-alcoholic fatty liver disease. The administration of the modified stilbenoids can result in decreased levels of PKC?II, PKC?VIII, substantially unaltered expression of PKC?I; a decreased number of adipocytes; increased weight and/or fat loss; or a combination thereof.Type: GrantFiled: July 2, 2014Date of Patent: October 4, 2016Assignees: University of South Florida (A Florida Non-Profit Corporation), The United States of America as Represented by the Department of Veterans Affairs Office of General Counsel—PSG IV (024)Inventors: Niketa A. Patel, Rekha S. Patel, Kirpal S. Bisht
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Patent number: 9319253Abstract: Various methods and systems are provided for edge windowing of orthogonal frequency division multiplexing (OFDM) systems. In one example, among others, a method includes obtaining an edge windowing portion by reducing a cyclic prefix size for a quantity of edge subcarriers in an OFDM symbol and reducing side lobes by applying a windowing function to the edge subcarriers. In another example, a device includes a separator capable of dividing subcarriers of an OFDM symbol into first and second subcarrier groups, a first CP adder capable of obtaining a windowing portion by adjusting a cyclic prefix size of the first subcarrier group, and a first windower capable of reducing side lobes by applying a windowing function to the first subcarrier group. In another example, a method includes determining a RMS delay spread of a mobile station and scheduling a subcarrier based at least in part upon the RMS delay spread.Type: GrantFiled: November 19, 2012Date of Patent: April 19, 2016Assignee: UNIVERSITY OF SOUTH FLORIDA (A FLORIDA NON-PROFIT CORPORATION)Inventors: Alphan Sahin, Huseyin Arslan
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Publication number: 20150080409Abstract: Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.Type: ApplicationFiled: October 31, 2014Publication date: March 19, 2015Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Roman Manetsch, Lindsey Neil Shaw, Kurt Steven Van Horn, Whittney Nicole Burda
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Publication number: 20150064116Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.Type: ApplicationFiled: September 28, 2012Publication date: March 5, 2015Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Subhra Mohapatra, Chunyan Wang
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Publication number: 20150051466Abstract: In one embodiment, an implantable biosensor includes a sense antenna comprising a silicon carbide substrate and a radiating electrode formed on the substrate.Type: ApplicationFiled: March 12, 2013Publication date: February 19, 2015Applicants: University of South Florida (A Florida Non-Profit Corporation), Office of Enterpreneurship and Technology TransferInventors: Shamima Afroz, Sylvia Wilson Thomas, Stephen E. Saddow, Gokhan Mumcu, Erdem Topsakal
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Publication number: 20150035615Abstract: In one embodiment, a vertical microcoaxial interconnect includes a dielectric substrate having a top side and a bottom side, an inner conductor extending through the substrate from its top side to its bottom side, an outer conductor that extends through the substrate from its top side to its bottom side, the outer conductor surrounding the inner conductor, a signal line extending to the inner conductor without contacting the outer conductor, and a ground line extending to the outer conductor without contacting the inner conductor or the signal line.Type: ApplicationFiled: October 7, 2013Publication date: February 5, 2015Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Justin Boone, Subramanian Krishnan, Shekhar Bhansali
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Publication number: 20150024967Abstract: Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.Type: ApplicationFiled: July 31, 2014Publication date: January 22, 2015Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Subhra Mohapatra, Shyam S. Mohapatra
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Publication number: 20140370510Abstract: Provided herein is a method of modulating an APC peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated polypeptide and administering an HDACi to the APC. Also provided herein is a method of identifying an HDACi-associated peptide comprising administering an HDACi to an APC, isolating the polypeptide from an APC MHC molecule binding cleft, and identifying the polypeptide.Type: ApplicationFiled: February 20, 2013Publication date: December 18, 2014Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: George Blanck, Kevin Jeremiah Cronin
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Patent number: 8906918Abstract: Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.Type: GrantFiled: March 22, 2013Date of Patent: December 9, 2014Assignee: University of South Florida (A Florida Non-Profit Corporation)Inventors: Roman Manetsch, Lindsey Neil Shaw, Kurt Steven Van Horn, Whittney Nicole Burda
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Publication number: 20140336239Abstract: Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223 polynucleotides that can be used to modulate differentiation of MDSCs. Increased differentiation of a MDSC population, or cells within an MDSC population, can be achieved by increasing the miR-142 and/or miR-223 polynucleotides in a MDSC.Type: ApplicationFiled: December 3, 2012Publication date: November 13, 2014Applicant: University of South Florida (A florida Non-Profit Corporation)Inventors: Shyam S. Mohapatra, Srinivas Nagaraj Bharadwaj, Subhra Mohapatra
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Patent number: 8881639Abstract: In one embodiment, hybrid body armor includes a ballistic fabric and a plurality of small ballistic plates arranged in a tightly packed array over the ballistic fabric.Type: GrantFiled: May 29, 2012Date of Patent: November 11, 2014Assignee: University of South Florida (A Florida Non-Profit Corporation)Inventors: Daniel Jeffrey Miller, Autar Krishen Kaw
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Publication number: 20140330123Abstract: A sonic window includes a body sized and configured to close an opening formed through the cranium, wherein at least a part of the body is made of a sonically transparent material through which ultrasonic waves can pass.Type: ApplicationFiled: May 2, 2014Publication date: November 6, 2014Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Jotham Charles Manwaring, Kim Herbert Manwaring
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Patent number: 8784832Abstract: The disclosure provides compositions that are useful for eliciting a strain-transcending immune response in an animal or human directed against the blood-stage of the malarial parasite Plasmodium vivax. The compositions are based on the ligand domain of Plasmodium vivax Duffy binding protein (PvDBPII). Polar charged polymorphic residues within the dominant strain-specific B-cell epitope were mutated to uncharged residues (e.g. serine, alanine and threonine). This DEKnull variant of PvDBPII produced in bacteria can be purified and refolded in vitro to mimic conformation and erythrocyte binding function of native DBPII. Immunogenicity of DEKnull was confirmed by administration to mice. Compared to the naturally-occurring, strain variant DBPII, DEKnull elicits antibodies that are more broadly reactive with different strain variants of DBPII and enhances production of functional inhibitory antibodies to the shared protective epitopes of native DBPII.Type: GrantFiled: August 20, 2012Date of Patent: July 22, 2014Assignee: University of South Florida (A Florida Non-Profit Corporation)Inventors: John H. Adams, Francis B. Ntumngia, Jesse L. Schloegel, Samantha J. Barnes, Amy M. McHenry, Patchanee Chootong
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Publication number: 20140080885Abstract: Embodiments of the present disclosure provide methods of treating a traumatic brain injury with an agent. In particular, embodiments of the present disclosure provide for methods of treating a traumatic brain injury using an agent such as (±)-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine or an isomer, a tautomer, or a prodrug thereof, or pharmaceutically acceptable salt each of these.Type: ApplicationFiled: September 13, 2013Publication date: March 20, 2014Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Keith R. Pennypacker, Shyam S. Mohapatra
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Publication number: 20140004039Abstract: Embodiments of the present disclosure provide for RGD mimetic ?-AApeptide compounds, ?-AApeptide compounds capable of binding an RGD binding site on integrin ?v?3, linear ?-AApeptide compounds, cyclic ?-AApeptide compounds and multimeric RGD mimetic ?-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic ?-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.Type: ApplicationFiled: June 18, 2013Publication date: January 2, 2014Applicants: Wisconsin Alumni Research Foundation, University of South Florida (A Florida Non-Profit Corporation)Inventors: Jianfeng Cai, Youhong Niu, Weibo Cai, Hao Hong
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Publication number: 20130243867Abstract: Provided herein is a micelle composition comprising a polyethylene glycol (PEG), a DC-cholesterol, and a dioleoylphosphatidyl-ethanolamine (DOPE) and either or both a pharmaceutical compound core and a polynucleotide coating. Also provided herein is a method of administering one or more compounds to a cell comprising administering to the cell a micelle composition comprising 1) PEG-PE, a DC-cholesterol, and DOPE, and 2) the one or more compounds, wherein the compounds are selected from the group consisting of a polynucleotide and a pharmaceutical composition. Further provided are methods for detecting the micelle composition.Type: ApplicationFiled: February 22, 2013Publication date: September 19, 2013Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Mark Christian Howell, Suraj Kishore Dixit, Chunyan Wang
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Publication number: 20130217045Abstract: Provided herein is a method for diagnosing Alzheimer's disease in a subject comprising detecting an increase in an amyloidogenic A?1-17 antibody in the subject as compared to a control. Further provided herein is a method for testing efficacy of an Alzheimer's disease treatment in a subject comprising detecting a decrease in an amyloidogenic A?1-17 antibody in the subject as compared to prior to the treatment.Type: ApplicationFiled: February 15, 2013Publication date: August 22, 2013Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Jun Tan, Demian Obregon, Huayan Hou, Juan Deng
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Publication number: 20130087673Abstract: In one embodiment, a system for applying reinforcement material to an existing structure includes a work rail adapted to be temporarily secured to a bottom surface of the structure, adhesive applying apparatus supported by the work rail, the adhesive applying apparatus being adapted to form an adhesive layer on the bottom surface of the structure adjacent the work rail, and reinforcement material applying apparatus supported by the work rail, the reinforcement material applying apparatus being adapted to apply reinforcement material to the adhesive layer formed on the bottom surface of the structure.Type: ApplicationFiled: September 4, 2012Publication date: April 11, 2013Applicant: University of South Florida (A Florida Non-Profit Corporation)Inventors: Austin Gray Mullins, Rajan Sen, Danny Winters