Patents Assigned to University of Sydney
  • Publication number: 20200123113
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Application
    Filed: September 10, 2019
    Publication date: April 23, 2020
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle
  • Publication number: 20200085919
    Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant(ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.
    Type: Application
    Filed: December 21, 2017
    Publication date: March 19, 2020
    Applicant: The University of Sydney
    Inventors: Theerthankar Das Ashish Kumar, Jim Manos, Gregory Stuart Whiteley, Trevor Owen Glasbey
  • Publication number: 20190367583
    Abstract: The invention relates to the treatment of stroke and related diseases, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the cleavage of fibrinogen by thrombin.
    Type: Application
    Filed: December 15, 2017
    Publication date: December 5, 2019
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Richard J. PAYNE, Shaun Phillip JACKSON, Pedro Jose BARBOSA PEREIRA
  • Patent number: 10450277
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 22, 2019
    Assignees: The Salk Institute for Biological Studies, University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
  • Publication number: 20190282514
    Abstract: The invention relates to terpenes and uses thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: September 19, 2019
    Applicant: The University of Sydney
    Inventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
  • Patent number: 10376589
    Abstract: The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localized manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 13, 2019
    Assignee: The University of Sydney
    Inventors: Brian Stanley Hawkett, Trevor William Hambley, Nicole Sarah Bryce, Thi Thuy Binh Pham, Nirmesh Jain
  • Patent number: 10369156
    Abstract: Provided herein are pharmaceutical compositions that are useful for the treatment of hypertension comprising an angiotensin II receptor blocker, a diuretic, a calcium channel blocker, and a beta-blocker, wherein the dose of each component is below the lowest dose approved for the treatment of hypertension for the component.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 6, 2019
    Assignees: THE GEORGE INSTITUTE FOR GLOBAL HEALTH, THE UNIVERSITY OF SYDNEY
    Inventors: Anthony Rodgers, Clara Chow
  • Publication number: 20190194105
    Abstract: A method for treating cancer can include administering a therapeutically effective amount of a compound of formula (Ia): or pharmaceutically acceptable salts or solvates thereof, wherein R1a, R1b, R1c, R1d, R2, and R3 are as defined, and A----B is selected from CH?CH, CH?CH(CH2)pCH2, or CH2—CH2(CH2)pCH2, and where p is 1 or 2.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 27, 2019
    Applicant: The University of Sydney
    Inventors: Colin Charles Duke, Van Hoan Tran, Rujee Kyokajee Duke
  • Patent number: 10300783
    Abstract: The invention relates to a vehicle including a chassis and a pair of wheels supported in spaced apart relationship by the chassis for rotation about a common axis. A pair of drive modules is associated with the respective wheels. The drive modules and the chassis are connected for rotation as a sub-assembly relative to the wheels about the common axis with the centre of mass of the sub-assembly below the common axis in a static equilibrium position. Each of the drive modules is housed substantially within the respective wheel.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: May 28, 2019
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Mark Calleija, Salah Sukkarieh
  • Patent number: 10301268
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 28, 2019
    Assignees: The Salk Institute for Biological Studies, University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
  • Patent number: 10238667
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: March 26, 2019
    Assignees: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ning Ding, Michael Downes, Christopher Liddle, Ronald M. Evans, Nanthakumar Subramaniam
  • Publication number: 20190084939
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Application
    Filed: November 27, 2018
    Publication date: March 21, 2019
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle
  • Publication number: 20190070220
    Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.
    Type: Application
    Filed: July 7, 2016
    Publication date: March 7, 2019
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: David Gottlieb, Leighton Clancy
  • Patent number: 10196335
    Abstract: Prenylated stilbene compounds and the use of such compounds in the treatment of diseases and medical disorders, for example cancer, skin ageing, inflammation, bacterial or fungal infection and immunosuppression.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: February 5, 2019
    Assignee: The University of Sydney
    Inventors: Colin Charles Duke, Van Hoan Tran, Rujee Kyokajee Duke
  • Publication number: 20180273478
    Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).
    Type: Application
    Filed: January 29, 2016
    Publication date: September 27, 2018
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Lenka Munoz, Fadi Maged Shokry Gurgis, Mia Akerfeldt, Michael Kassiou
  • Patent number: 10084542
    Abstract: A microwave photonic notch filter comprising: a modulator to modulate an optical signal with an electrical signal to generate a first sideband and a second sideband; a configurable optical processor to generate a modified optical signal by adjusting the power of the sidebands to achieve a power difference between first sideband and second sideband and by producing an antiphase relationship between light within two sidebands corresponding to the selected frequency band; an optical resonance to adjust the power of the first sideband of the modified optical signal corresponding to the selected frequency band by a resonance power adjustment to generate a resonance output signal; an optical-to-electrical converter to generate a copy of the electrical signal with suppressed frequency components within the selected frequency band; and a control unit to re-configure the configurable optical processor to adjust the power difference between two sidebands towards the resonance power adjustment.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 25, 2018
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: David Albert Immanuel Marpaung, Mattia Pagani, Shayan Shahnia
  • Publication number: 20180243469
    Abstract: Disclosed herein are biocompatible materials useful for tissue regeneration and repair, wherein the bioactive polymer may be in the form of a hydrogel, for example a thermoresponsive hydrogel. This bioactive polymer and a resulting hydrogel, may be used for the regeneration of bone tissue. Accordingly, also disclosed herein are methods of treating a bone defect in a mammal, the methods comprising administering a therapeutically effective amount of a hydrogel formed by the bioactive polymer to the mammal to treat the bone defect.
    Type: Application
    Filed: August 31, 2016
    Publication date: August 30, 2018
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Ali Fathi, Fariba Dehghani, Anthony Weiss, Suzannne Mithieux
  • Publication number: 20180244590
    Abstract: The present invention provides a method of stabilizing a nitrate-based explosive through the use of a NOx scavenger. The present invention further provides a blasting agent including ammonium nitrate and a NOx scavenger. The present invention further provides for a method of blasting adapted for use in reactive and/or elevated temperature ground.
    Type: Application
    Filed: September 1, 2016
    Publication date: August 30, 2018
    Applicant: The University of Sydney
    Inventors: James Kenneth Beattie, Alex Masato Djerdjev, Brian Stanley Hawkett, Chiara Neto, Pramith Priyananda
  • Publication number: 20180221089
    Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.
    Type: Application
    Filed: June 10, 2016
    Publication date: August 9, 2018
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20180163457
    Abstract: A pump-out tube for evacuating a space between two sheets of glass, the pump out tube being receivable in a hole formed in at least one of the sheets of glass, the pump out tube formed as a separate element comprising a tubular member and a seal formed around the tube.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 14, 2018
    Applicant: The University of Sydney
    Inventors: Cenk Kocer, Tom Vu, Clara Thao Hoang Tran