Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.

Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.

Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.

Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.

Abstract: Prenylated stilbene compounds and the use of such compounds in the treatment of diseases and medical disorders, for example cancer, skin ageing, inflammation, bacterial or fungal infection and immunosuppression.

Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).

Abstract: A microwave photonic notch filter comprising: a modulator to modulate an optical signal with an electrical signal to generate a first sideband and a second sideband; a configurable optical processor to generate a modified optical signal by adjusting the power of the sidebands to achieve a power difference between first sideband and second sideband and by producing an antiphase relationship between light within two sidebands corresponding to the selected frequency band; an optical resonance to adjust the power of the first sideband of the modified optical signal corresponding to the selected frequency band by a resonance power adjustment to generate a resonance output signal; an optical-to-electrical converter to generate a copy of the electrical signal with suppressed frequency components within the selected frequency band; and a control unit to re-configure the configurable optical processor to adjust the power difference between two sidebands towards the resonance power adjustment.

Abstract: The present invention provides a method of stabilizing a nitrate-based explosive through the use of a NOx scavenger. The present invention further provides a blasting agent including ammonium nitrate and a NOx scavenger. The present invention further provides for a method of blasting adapted for use in reactive and/or elevated temperature ground.

Abstract: Disclosed herein are biocompatible materials useful for tissue regeneration and repair, wherein the bioactive polymer may be in the form of a hydrogel, for example a thermoresponsive hydrogel. This bioactive polymer and a resulting hydrogel, may be used for the regeneration of bone tissue. Accordingly, also disclosed herein are methods of treating a bone defect in a mammal, the methods comprising administering a therapeutically effective amount of a hydrogel formed by the bioactive polymer to the mammal to treat the bone defect.

Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.

Abstract: A needle insertion device configured to insert a needle into a lumen of a vessel of a subject, the insertion device comprising an insertion mechanism configured to insert the needle into the lumen of the vessel at high speed, in accordance with one or more predetermined parameters.

Abstract: A pump-out tube for evacuating a space between two sheets of glass, the pump out tube being receivable in a hole formed in at least one of the sheets of glass, the pump out tube formed as a separate element comprising a tubular member and a seal formed around the tube.

Abstract: An optical processing system providing a rapid optical response, the system including: a first optical material sensitive to an effective refractive index change under photon absorption; a first optical pump for optically pumping the first optical material at a first frequency so as to cause the first optical material to undergo an effective refractive index change by means of photon absorption; a second optical pump for optically pumping the first optical material at a second frequency so as to cause the first optical material to undergo a rapid second refractive index change by means of stimulated emission.

Abstract: This disclosure relates to preserving a quantum state in a quantum memory. A controller of the quantum memory determines based on a characteristic of noise that causes deterioration of the quantum state a dynamical decoupling base sequence. The duration of the base sequence is shorter than or equal to an access latency time of the quantum memory to allow access to the quantum state within the access latency time. Further, the deterioration of the quantum state is bounded to an upper deterioration limit when the base sequence is repeatedly applied to the quantum system. This provides acceptable access times while simultaneously allowing long term storage of data in the quantum state with low error rates. Repeatedly applying the base sequence to the quantum system will first yield an increasing deterioration but that deterioration will eventually reach the upper limit. As a result, over time the error rates will not exceed that upper limit and the quantum state is stable.

Abstract: The invention relates to the identification of antigens, including Mycobacterium sulphate assimilation pathway components such as CysD, for preventing and treating Mycobacterium infection, especially but not exclusively Mycobacterium tuberculosis infection; to expression systems including live Mycobacterium for expression of said antigens for prevention and treatment of said infection; and to use of said antigens and expression systems for prevention and treatment of said infection.

Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.

Abstract: Described herein is a computer implemented method for generating a probabilistic model usable to identify instances of a target feature in geophysical data sets stored on a memory device.

Abstract: In a gap retention member to be disposed between a pair of glass plates when a circumference of a gap formed between the pair of glass plates with their plate faces opposing each other is to be sealed to maintain the gap under a depressurized state, the gap retention member includes hard portions to contact the pair of glass plates respectively and a soft portion disposed between the hard portions and having a lower hardness than the hard portions, the soft portion being more susceptible to deformation based on a shearing force effective in the direction along the opposing faces of the glass plates than deformation based on a compressive force effective in a thickness direction perpendicular to the opposing faces of the glass plates.

Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.

Abstract: A planning system (201) for scheduling the operation of autonomous entities within a defined geographical region. The planning system operates at a region plan level (301) for strategic planning across the geographical region, at an operation plan level (302) for operations to be performed by autonomous entities in localized zones having operation-defined geographical boundaries, and at a task plan level (303) in which processing is undertaken in respect of specific tasks to be performed by the autonomous entities, in undertaking the operations.