Patents Assigned to University of Tennessee Research Corporation
  • Patent number: 6146724
    Abstract: A laminate which includes a barrier layer of OAUGDP bonded silicon oxide and a cellulosic or thermoplastic base layer. A process for applying same. A package container which includes the laminate.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: November 14, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventor: John Reece Roth
  • Patent number: 6127185
    Abstract: The present invention relates to an instrument and methods for determining stability of oils and fats. The instrument includes a sample reaction vessel for containing a sample of an oil or fat, a moisturized gas source operably connected to the vessel for contacting a moisturized gas with the sample, a compound trap containing water operably connected to the vessel to contact the moisturized gas from the vessel with the water, and an automatic data acquisition and control system for monitoring the electrical conductivity of the water. The method is carried out by heating an oil or a fat, contacting the oil or fat with a moisturized gas, contacting the moisturized gas with water to form a trap solution, measuring the electrical conductivity of the trap solution, and determining the stability of the oil or fat.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: October 3, 2000
    Assignee: University of Tennessee Research Corporation
    Inventors: Sharon L. Melton, Hung-Wei Lin
  • Patent number: 6106659
    Abstract: Continuous-feed plasma treater systems are designed to treat continuous substrates, such as webs or films, by continuously feeding the substrates through an enclosure having a plasma discharge that alters the substrate's surface properties in some desirable fashion. According to the present invention, the enclosure has one or more electrode assemblies that generate plasma discharges at working-gas pressures ranging from moderate pressures (e.g., rough vacuums as low as about 10 Torr) to high pressures (e.g., about one Atmosphere). The electrode assemblies are driven by power supplies that excite the electrode assemblies in either an RF resonant excitation mode or a pulsed voltage excitation mode.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: August 22, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: Paul Spence, John Lynch
  • Patent number: 6099282
    Abstract: The present invention relates to a die for use in textile processes involving nonwoven melt blown fabrics. In a melt blown process, molten polymer resin is injected into a melt blown die and ejected from the die in the form of filaments. The present invention is directed to an improved die nosepiece comprising a multiplicity of adjacent holes offset with respect to each other at an angle greater than or equal to 5.degree. and less than 90.degree., through which resin filaments are ejected.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: August 8, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventor: Mancil W. Milligan
  • Patent number: 6100047
    Abstract: The invention provides methods for identifying compounds and compositions useful in the regulation of weight, the treatment of obesity, diabetes and other insulin resistance-related disorders hypertension, cardiovascular disease and the like. The methods comprise the use of adipocytes and predipocytes in assays and screens for compounds or compositions of interest. The present invention recognizes the presence of the sulfonylurea receptor in adipocytes and its utility in identifying compounds and in treating obesity and other insulin resistance-related disorders. The methods of the invention also provide for identifying novel calcium channels or other calcium regulatory channels that are selectively expressed in human adipocytes as compared to human preadipocytes and for screening adipocytes for compounds that selectively antagonize calcium. These compounds may be used in the treatment of obesity and diabetes and other insulin resistance-related disorders.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: August 8, 2000
    Assignees: Zen Bio, Inc., The University of Tennessee Research Corporation
    Inventors: William O. Wilkison, Michael B. Zemel, Naima Moustaid-Mousse
  • Patent number: 6096217
    Abstract: The present invention comprises a supported liquid membrane carrier liquid with a dielectric constant between approximately 20 and 32, more particularly between 22 and 28, and preferably about 24, and the use of that carrier liquid in a supported liquid membrane device to extract one or more chemical species from a feed liquid. The invention further comprises such a device where a temperature gradient is maintained between any of the feed, carrier, or strip liquids. In another embodiment of the invention, any of the feed, carrier, or strip liquids are conditioned, for example, by passing the liquids through a purifier, or replacing lost carrier liquid. In another embodiment of the invention, two or more devices are connected in series or parallel.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: August 1, 2000
    Assignees: Lockheed Martin Energy Research Corporation, Commodore Separation Technologies, Inc., The University of Tennessee Research Corporation
    Inventors: Srinivas Kilambi, Bruce A. Moyer, R. Bruce Robinson, Peter V. Bonnesen
  • Patent number: 6090469
    Abstract: A staple fiber web is disclosed which contains pleats having staple fibers which are commingled with staple fibers from adjoining pleats. The commingling permits denser packing of pleats on the web and increases filtering efficiency and stability of the web. Methods of manufacturing the pleated staple fiber web are disclosed.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: July 18, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: Larry C. Wadsworth, Oldrich Jirsak, Peter Ping-yi Tsai
  • Patent number: 6086769
    Abstract: The present invention comprises a supported liquid membrane carrier liquid with a dielectric constant between approximately 20 and 32, more particularly between 22 and 28, and preferably about 24, and the use of that carrier liquid in a supported liquid membrane device to extract one or more chemical species from a feed liquid. The invention further comprises such a device where a temperature gradient is maintained between any of the feed, carrier, or strip liquids. In another embodiment of the invention, any of the feed, carrier, or strip liquids are conditioned, for example, by passing the liquids through a purifier, or replacing lost carrier liquid. In another embodiment of the invention, two or more devices are connected in series or parallel.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: July 11, 2000
    Assignees: Commodore Separation Technologies, Inc., Lockheed Martin Energy Research Corporation, The University of Tennessee Research Corporation
    Inventors: Srinivas Kilambi, Bruce A. Moyer, R. Bruce Robinson, Peter V. Bonnesen
  • Patent number: 6083355
    Abstract: Continuous-feed plasma treater systems are designed to treat continuous substrates, such as webs or films, by continuously feeding the substrates through an enclosure having a plasma discharge that alters the substrate's surface properties in some desirable fashion. The plasma discharges are generated by one or more electrode assemblies housed within the enclosure. In general, the plasma treater systems of the present invention have one or more cylinder-sleeve electrode assemblies and/or one or more cylindrical cavity electrode assemblies. A cylinder-sleeve electrode assembly comprises a cylinder electrode and a sleeve electrode positioned with its concave face facing and substantially parallel to the cylinder electrode to form an annular gap between the outer surface of the cylinder electrode and the inner surface of the sleeve electrode.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: July 4, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventor: Paul Spence
  • Patent number: 6074818
    Abstract: Improvements to nucleic acid fingerprinting are disclosed. The method generates profiles of increased fidelity characteristic of the nucleic acids analyzed. Novel primers and other means are taught. Useful products are disclosed.
    Type: Grant
    Filed: October 20, 1993
    Date of Patent: June 13, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: Gustavo Caetano-Anolles, Brant J. Bassam, Peter M. Gresshoff
  • Patent number: 6071957
    Abstract: The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: June 6, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: Duane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
  • Patent number: 6063386
    Abstract: A recombinant multivalent hybrid protein vaccine against multiple serotypes of group A streptococci that may result in rheumatic fever. The vaccine can also evoke other protective antibodies of the mucosal type DNA sequences e.g. genes which encode the necessary amino acids that carry our the desired epitopes. A method of vaccination against streptococcal infections and compositions for carrying out the same.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: May 16, 2000
    Assignee: University of Tennessee Research Corporation
    Inventors: James B. Dale, James W. Lederer
  • Patent number: 6059935
    Abstract: Two methods and corresponding electrode designs are provided for the generation of a plasma, for example, at or about one atmosphere. Using these methods, various webs, films and three-dimensional objects are beneficially treated in a reduced amount of time. A first method utilizes a repetitive, asymmetric voltage pulse to generate a plasma discharge between two electrodes. An asymmetric voltage pulse is used to generate a discharge in which a substrate can be exposed predominately to either positive or negative plasma species depending on the voltage polarity used. A second method uses the gap capacitance of an electrode pair and an external inductor in shunt to form a resonant LC circuit. The circuit is driven by a high power radio frequency source operating at 1 to 30 MHz to generate a uniform discharge between the electrode pair. Both methods have temperature controlled discharge surfaces with supply gas temperature, humidity and flow rate control.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: May 9, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventor: Paul D. Spence
  • Patent number: 6037490
    Abstract: Novel compounds which are useful for boron neutron capture therapy (BNCT) are disclosed. The compounds comprise a stable boron-containing group and an aminocycloalkane carboxylic acid group or a boronated acyclic hydrocarbon-linked amino carboxylic acid. Methods for synthesis of the compounds and for use of the compounds in BNCT are disclosed.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: March 14, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: George W. Kabalka, Rajiv R. Srivastava
  • Patent number: 6030906
    Abstract: The present invention relates to a planar consolidated multilayered nonwoven web comprising reduced pore sizes. The present invention also relates to a method for forming a planar consolidated multilayered nonwoven web which is elastic in the cross direction and which comprises a first and a second layer.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: February 29, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: Charles B. Hassenboehler, Larry C. Wadsworth
  • Patent number: 6019957
    Abstract: The present invention relates to a radiolabeled non-steroidal compound having the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3, are the same or different and are a radioactive or nonradioactive halogen, a nitro, a cyano, a carbamoyl, a hydrogen, a perfluoroalkyl, a haloalkylamido, an isothiocyanate, an azide, a diazocarbonyl, a substituted oxirane, or a .beta.-chloroethylamine;R.sub.4 is a hydrogen, an alkyl, or is joined to R.sub.5 ;R.sub.5 is a radioactive or nonradioactive halogen, a hydrogen, a hydroxy, an alkyl, a haloalkyl, an alkoxy, an acyloxy, an amino, an alkylamino, a thio, a thioalkyl, or is joined to R.sub.4 ;R.sub.6 is a hydrogen, an alkyl, a halogen, or a haloalkyl;A.sub.1 and A.sub.2 are the same or different, and each is a direct link or an alkylene;X.sub.1 is a radioactive or nonradioactive halogen, an oxygen, a sulfur, a sulphinyl, a sulphonyl, an amino, an alkylimino, or alkylene;R.sub.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: February 1, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: Duane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
  • Patent number: 6016227
    Abstract: This invention relates to an improved laser beam useful in material surface processing and an apparatus for producing the improved laser beam. The improved laser beam of the present invention comprises a power distribution that is more intense at the outer regions than in the central region. The invention includes an apparatus comprising a power spherical and cylindrical optical elements aligned to focus and/or shape a laser beam into a novel profile useful in material surface processing. The invention further includes a method of using this apparatus to focus and/or shape a laser beam for producing Laser Induced Surface Improvements, hereinafter referred to as "LISI".
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: January 18, 2000
    Assignee: The University of Tennessee Research Corporation
    Inventors: John A. Hopkins, Frederick A. Schwartz, Mary Helen McCay, Thurman Dwayne McCay, Narendra B. Dahotre, John Brice Bible
  • Patent number: 5990336
    Abstract: The synthesis and purification of zosteric acid is described. The specification describes methods for preparing p-coumaric acid, for preparing zosteric acid, and purifying zosteric acid. Zosteric acid is prepared from p-coumaric acid. Zosteric acid, however, need not be prepared by any particular method to be purified by a method of the invention. All three methods may be used in combination to prepare and purify zosteric acid.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: November 23, 1999
    Assignee: The University of Tennessee Research Corporation
    Inventor: Spiro D. Alexandratos
  • Patent number: 5990100
    Abstract: Pharmaceutical compositions and methods for use in the treatment of psoriasis, having isopropyl myristate as a first active ingredient and a different anti-psoriatic agent as a second active ingredient; preferably they are combined in the same pharmaceutical composition.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: November 23, 1999
    Assignees: Panda Pharmaceuticals, L.L.C., The University of Tennessee Research Corporation
    Inventors: E. William Rosenberg, Thomas M. Glenn, Robert B. Skinner, Jr., Patricia W. Noah
  • Patent number: 5985056
    Abstract: The present invention is directed toward a process for laser alloying of a workpiece and an apparatus for carrying out said process. The method embodiment of the present invention is directed toward a process for forming an alloy in the surface of a metal substrate comprising the steps of applying an alloy precursor material at a controlled rate to the surface of the substrate and then melting the surface and the precursor alloy material by the application of a laser beam in order to form an alloy of the precursor alloy material and the substrate. The method embodiment of the present invention further comprises the steps of measuring one or more parameters indicative of alloying depth, controlling the rate of precursor application in response to at least one of the measured parameters, and allowing the allow to solidify.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: November 16, 1999
    Assignee: The University of Tennessee Research Corporation
    Inventors: Thurman Dwayne McCay, Mary Helen McCay, Narendra B. Dahotre