Patents Assigned to University of Tennessee Research Foundation
  • Patent number: 10407343
    Abstract: Red mud-based geopolymer compositions and methods of their preparation are described. The red mud-based geopolymer compositions can be cured at ambient temperatures using alkaline solutions of relatively low alkaline compound concentration compared to other geopolymer compositions. In particular, the use of a red mud previously utilized in a flue gas desulfurization process can provide high strength geopolymer compositions.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: September 10, 2019
    Assignees: University of Tennessee Research Foundation, Hebei Research Institute of Construction and Geotechnical Investigation Co., Ltd.
    Inventors: Qingke Nie, Wei Hu, Baoshan Huang, Tao Ai, Qiang He, Xiang Shu
  • Patent number: 10391472
    Abstract: A fiber useful in the absorption of metal ions from aqueous solutions, the fiber comprising a polyolefin backbone having a diameter of at least 1 micron and having covalently appended on its surface halogen atoms and vinyl-addition polymeric grafts functionalized with metal-binding groups, such as at least one functional group selected from carboxylate, keto, aldo, amino, imino, nitrile, amido, oxime, amidoxime, imide dioxime, and hydroxamate groups. The vinyl-addition polymeric grafts may also be further functionalized with hydrophilic groups different from the metal-binding groups, wherein the hydrophilic groups may be selected from carboxylate, sulfone, sulfonate, phosphonate, alkylammonium, iminium, amide, pyrrolidone, and polyalkyleneglycol groups. Also described are methods for producing the functionalized fibers, and methods for using the functionalized fiber, particularly in extracting metal ions from metal-containing solutions.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: August 27, 2019
    Assignees: UT-Battelle, LLC, University of Tennessee Research Foundation
    Inventors: Sheng Dai, Suree Brown, Tomonori Saito
  • Patent number: 10390543
    Abstract: Provided are methods for processing milk using one or more procedures that include at least one high pressure treatment, such as High Pressure Jet Processing at a hydrostatic pressure of at least 400 MPa. Food additives and food products that contain processed milk components are also provided, and may be dairy or non-dairy products.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 27, 2019
    Assignees: The Penn State Research Foundation, University of Tennessee Research Foundation
    Inventors: Federico Miguel Harte, Marta Corzo Martinez, Maneesha S. Mohan
  • Patent number: 10377945
    Abstract: Mixed halide scintillation materials of the general formula AB(1-y)MyX?wX?(3-w), where 0?y?1, 0.05?w?1, A may be an alkali metal, B may be an alkali earth metal, and X? and X? may be two different halogen atoms, and of the general formula A(1-y)BMyX?wX?(3-w), where 0?y?1, 0.05?w?1, A maybe an alkali metal, B may be an alkali earth metal, and X? and X? are two different halogen atoms. The scintillation materials of formula (1) include a divalent external activator, M, such as Eu2+ or Yb2+. The scintillation materials of formula (2) include a monovalent external activator, M, such as Tl+, Na+ and In+.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Luis Stand, Charles L. Melcher, Mariya Zhuravleva, Hua Wei
  • Patent number: 10381656
    Abstract: An electrode includes a proton conducting electrolyte phase, an electronic conducting phase, and a metal or metal alloy catalyst in contact with each of the phases. The electronic conducting phase is infiltrated with the proton conducting electrolyte phase such that the phases form a solid nanocomposite with bulk electronic conductivity.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: August 13, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Alexander B. Papandrew, Ramez A. Elgammal
  • Patent number: 10371740
    Abstract: A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; performing a recurrence quantification analysis on the received data to identify a predetermined number of sensors, from the plurality of sensors, that are closest to the disturbance; constructing a plurality of minimum-volume-enclosing ellipsoids based on and enclosing the data received from the identified sensors; extracting one or more parameters from the plurality of minimum-volume-enclosing ellipsoids; inputting the one or more parameters into a multivariate-random-forest regression algorithm to determine the location of the disturbance and a power mismatch corresponding to the disturbance; and presenting, on one or more display units, the determined location of the disturbance and the determined power mismatch.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: August 6, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Yi Cui, Feifei Bai, Wenxuan Yao, Yong Liu, Ling Wu, Yilu Liu
  • Patent number: 10369133
    Abstract: Here provided are new immunosuppressive compounds and novel therapeutics for improving tissue transplantation.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: August 6, 2019
    Assignee: THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Duane Douglas Miller, Charles Ryan Yates, Jayaprakash Pagadala, Ram Mahato, Hao Wu
  • Patent number: 10372148
    Abstract: A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; determining, with one or more processors, for each sensor, an extremum of the data corresponding to the sensor; interpolating, with the one or more processors, the extrema; and presenting, on one or more display units, a location corresponding to a global maximum of the interpolated extrema as the location of the disturbance. The method may further include, if a difference between the largest extremum and each of remaining extremum is greater than a predetermined threshold, skipping the interpolating step and the presenting step, and presenting a location of the sensor corresponding to the largest extremum as the location of the disturbance.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: August 6, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Shutang You, Dao Zhou, Ling Wu, Yilu Liu
  • Patent number: 10351768
    Abstract: Mixed halide scintillation materials of a first general formula A4B(1-y)MyX?6(1-z)X?6z and a second general formula A(4-y)BMyX?6(1-z)X?6z are disclosed. In the general formulas, A is an alkali metal, B is an alkaline earth metal, and X? and X? are two different halogen atoms. Scintillation materials of the first general formula include a divalent external activator M such as Eu2+ or Yb2+ or a trivalent external activator M such as Ce3+. Scintillation materials of the second general formula include a monovalent external activator M such as In+, Na+, or Tl+ or a trivalent external activator such as Ce3+.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: July 16, 2019
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Luis Stand, Mariya Zhuravleva, Kan Yang, Charles L. Melcher, Adam Coleman Lindsey
  • Patent number: 10314771
    Abstract: An oral composition is provided comprising crosslinked polyvinylpyrrolidone (PVP) and xylitol. The xylitol and the crosslinked PVP are in a ratio of about 5:1, and the oral composition is in the form of a lozenge or lollipop. Methods are also provided.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 11, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Mojdeh Dehghan, Daranee Versluis, Hassan Almoazen
  • Patent number: 10314797
    Abstract: This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: June 11, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Yali He
  • Publication number: 20190168170
    Abstract: An electrochemical device includes an anode, a cathode, and a separator interposed between the anode and cathode. The separator includes an anion conductive membrane having a porous substrate having hydrophilic moieties bonded thereto to increase water availability in a vicinity of ionogenic sites contributing to conductivity of the membrane in a presence of aqueous phases imbibed therein.
    Type: Application
    Filed: July 27, 2017
    Publication date: June 6, 2019
    Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Thomas ZAWODZINSKI, Shane FOISTER
  • Patent number: 10308685
    Abstract: Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 4, 2019
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Jonathan S. Wall, Timothy E. Sparer, Stephen J. Kennel
  • Patent number: 10301285
    Abstract: The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: May 28, 2019
    Assignees: GTX, INC., UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Duane D. Miller, Jianjun Chen, James T. Dalton, Chien-Ming Li, Sunjoo Ahn, Wei Li
  • Patent number: 10300037
    Abstract: This invention is directed to substituted acylanilide compounds and uses thereof in treating muscular dystrophies such as Duchenne muscular dystrophy and Becker muscular dystrophy and in improving or preserving lung function and cardiac function in a subject suffering from Duchenne muscular dystrophy.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: May 28, 2019
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: James T. Dalton, Thamarai Ponnusamy, Ramesh Narayanan
  • Publication number: 20190144387
    Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
    Type: Application
    Filed: September 5, 2018
    Publication date: May 16, 2019
    Applicant: University of Tennessee Research Foundation
    Inventors: Ramesh NARAYANAN, Duane D. MILLER, Thamarai PONNUSAMY, Dong-Jin HWANG, Yali HE
  • Patent number: 10255684
    Abstract: Systems and methods for correcting motion during medical imaging involve using a detector to track annihilation photons produced by one of (i) external emitting sources placed onto a body of a person being imaged or (ii) an object of interest in the body. Motion information is generated based on the tracking. A motion-corrected image is formed from recorded image data, using the motion information.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: April 9, 2019
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Dustin R. Osborne, Dongming Hu, Sang Hyeb Lee
  • Patent number: 10248675
    Abstract: A circuit element of a multi-dimensional dynamic adaptive neural network array (DANNA) may comprise a neuron/synapse select input functional to select the circuit element to function as one of a neuron and a synapse. In one embodiment of a DANNA array of such circuit elements, (wherein a circuit element may be digital), a destination neuron may be connected to a first neuron by a first synapse in one dimension a second destination neuron may be connected to the first neuron by a second synapse in a second dimension to form linked columns and rows of neuron/synapse circuit elements. In one embodiment, the rows and columns of circuit elements have read registers that are linked together by signal lines and clocked and controlled so as to output columnar data to an output register when a neuron/synapse data value is stored in the read register.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: April 2, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: J. Douglas Birdwell, Mark E. Dean, Catherine Schuman
  • Patent number: 10221355
    Abstract: Metal halide scintillators are described. More particularly, the scintillators include Tl and/or In-based ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A is an alkali metal, such as Li, Na, K, Rb, Cs or any combination thereof; B is an alkali earth metal, such as Be, Mg, Ca, Sr, Ba or any combination thereof; X is a halide, such as Cl, Br, I, F or any combination thereof; some or all of A has been replaced by Tl and/or In, and some or all of B has been replaced by another dopant, such as Eu, Ce, Tb, Yb, and Pr. Radiation detectors comprising the metal halide scintillators are also described.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: March 5, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Luis Stand, Mariya Zhuravleva, Charles L. Melcher
  • Publication number: 20190060280
    Abstract: This invention is directed to selective androgen receptor degrader (SARD) compounds pharmaceutical compositions and uses thereof in treating early prostate cancer, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
    Type: Application
    Filed: May 16, 2018
    Publication date: February 28, 2019
    Applicant: University of Tennessee Research Foundation
    Inventors: Ramesh NARAYANAN, Duane D. MILLER, Thamarai PONNUSAMY, Dong-Jin HWANG, Yali HE