Patents Assigned to University of Toronto Innovations.Foundation
  • Patent number: 6455590
    Abstract: Methods and kits for treament of glaucoma are disclosed. In general, the methods of the invention include administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: September 24, 2002
    Assignee: University of Toronto Innovations.Foundation
    Inventor: William G. Tatton
  • Patent number: 6034896
    Abstract: A flash E.sup.2 PROM cell having source and drain regions disposed in a substrate, a channel region intermediate to the source and drain regions, a tunnel dielectric layer overlying the channel region, a floating gate overlying the tunnel dielectric layer, an inter-poly dielectric layer overlying the floating gate, and a control gate overlying the inter-poly dielectric layer. The flash E.sup.2 PROM cell further having a highly doped p.sup.+ pocket implant covering a portion of the cell width and adjacent to at least one of the drain and source regions. The flash E.sup.2 PROM cell is comprised of two sections butted together. The portion (width-wise) that is covered by the highly doped p.sup.+ pocket implant is referred to as a program section. The remaining portion (width-wise) not covered by the highly doped p.sup.+ pocket implant resembles a conventional flash E.sup.2 PROM cell and is referred to as a sense section. The highly doped p.sup.+ pocket implant and the n.sup.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: March 7, 2000
    Assignee: The University of Toronto, Innovations Foundation
    Inventors: Jeewika Chandanie Ranaweera, Ivan Kalastirsky, Elvira Gulersen, Wai Tung Ng, Clement Andre T. Salama
  • Patent number: 6001976
    Abstract: A purified DNA molecule comprises a DNA sequence of approximately 15.1 kb coding for normal or mutant RYR1 protein having a molecular weight of approximately 564,740 daltons. The DNA molecule has an endonuclease restriction map of FIG. 1 and a sequence of FIG. 2.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: December 14, 1999
    Assignee: University of Toronto Innovations Foundation and University of Guelph
    Inventors: David H. MacLennan, Peter J. O'Brien
  • Patent number: 5981598
    Abstract: Methods and kits for treament of glaucoma are disclosed. In general, the methods of the invention include administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: November 9, 1999
    Assignee: The University of Toronto Innovations Foundation
    Inventor: William G. Tatton
  • Patent number: 5866629
    Abstract: Tissue infiltrating primer formulations and methods of using such formulations, e.g., in the dental or medical fields, are described. The formulations of the invention include an effective amount of a tissue infiltrating agent and a primer. The tissue infiltrating primer formulations provide enhanced penetration of a biomaterial into a target substrate, e.g. hard tissues, when compared to their non-tissue infiltrating primer formulation counterparts.
    Type: Grant
    Filed: December 5, 1995
    Date of Patent: February 2, 1999
    Assignee: The University of Toronto Innovations Foundation
    Inventors: Paul Joseph Santerre, Keith Titley, Robert Chernecky, Phillip Watson
  • Patent number: 5783606
    Abstract: Methods and kits for treatment of glaucoma are disclosed. In general, the methods of the invention include administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: July 21, 1998
    Assignee: The University of Toronto Innovations Foundation
    Inventor: William G. Tatton
  • Patent number: 5730784
    Abstract: Hydrogen Sulfide is substantially completely removed from a gas stream in a two-stage operation. Hydrogen Sulfide is first partially oxidized to sulfur dioxide and the sulfur dioxide reacted with part of the remaining hydrogen sulfide while the hydrogen sulfide not so reacted is subsequently oxidized, thereby removing all of the hydrogen sulfide from the gas stream.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 24, 1998
    Assignees: The University of Toronto Innovations Foundation, Apollo Environmental Systems Corp.
    Inventors: James W. Smith, David Todd R. Ellenor, John N. Harbinson
  • Patent number: 5708061
    Abstract: Insoluble particulate materials, which may be in solid or liquid form, are dispersed in a continuous non-aqueous phase and the dispersion rendered stable and resistant to phase separation by an in-situ stabilization procedure involving the formation of chemical bonds among the stabilizer components and to dispersed phases to form a network surrounding the particles which is compatible with the continuous phase. The invention has particular application for the formation of stabilized polyolefin-modified bitumen compositions for paving and other applications.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 13, 1998
    Assignee: University of Toronto Innovations Foundation
    Inventors: Simon Hesp, Zhizhong Liang, Raymond T. Woodhams
  • Patent number: 5705564
    Abstract: Insoluble particulate materials, which may be in solid or liquid form, are dispersed in a continuous non-aqueous phase and the dispersion rendered stable and resistant to phase separation by an in-situ stabilization procedure involving the formation of chemical bonds among the stabilizer components and to dispersed phases to form a network surrounding the particles which is compatible with the continuous phase. The invention has particular application for the formation of stabilized polyolefin-modified bitumen compositions for paving and other applications.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: January 6, 1998
    Assignee: The University of Toronto Innovations Foundation
    Inventors: Zhi-Zhong Liang, Raymond T. Woodhams
  • Patent number: 5616698
    Abstract: The present invention provides improved syntheses of oligosacchairdes. In accordance with preferred embodiments, anomeric specificity in such syntheses can be attained using polymer-supported liquid synthetic design with certain novel diether linkers. The present invention also provides novel strategies for capping imcompletely glycosylated hydroxyls.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: April 1, 1997
    Assignee: University of Toronto Innovations Foundation
    Inventors: Jiri J. Krepinsky, Stephen P. Douglas, Dennis M. Whitfield
  • Patent number: 5585005
    Abstract: Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from gas streams by oxidation in aqueous chelated transition metal solution in a agitated flotation cell. The same principal may be employed with other procedures in which a gaseous phase is dispersed in a liquid phase to effect an interaction between components present in such phases, for example, to treat or strip or react a component of the liquid phase.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 17, 1996
    Assignees: University of Toronto Innovations Foundation, Apollo Environmental Systems Corp.
    Inventors: James W. Smith, David T. R. Ellenor, John N. Harbinson
  • Patent number: 5527475
    Abstract: The parameters of a gas-liquid contact apparatus for the removal of a component of a gas stream in which an impeller-apertured shroud combination is immersed in a liquid phase to which the gas stream is fed at a gas flow rate of Q. The structural and operating parameters of the apparatus are quantified to provide a Shear Effectiveness Index (SEI) value of from about 1 to about 10 and an Effective Shear Index (ESI) value of from about 1 to about 2500.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 18, 1996
    Assignees: The University of Toronto Innovations Foundation, Appollo Environmental Systems Corp.
    Inventors: James W. Smith, David T. R. Ellenor, John N. Harbinson
  • Patent number: 5520818
    Abstract: Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from gas streams by oxidation in aqueous chelated transition metal solution in a modified agitated flotation cell. The same principal may be employed in other procedures in which a gaseous phase is dispersed in a liquid phase to effect an interaction between components present in such phases. A gas-liquid contact apparatus, generally a combined chemical reactor and solid product separation device, comprising such modified agitated flotation cell is also described. In order to effect mass transfer and rapid reaction gas bubbles containing hydrogen sulfide and oxygen are formed by rotating an impeller at a blade tip velocity of at least about 350 in/sec. to achieve the required shear.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: May 28, 1996
    Assignees: The University of Toronto Innovations Foundation, Apollo Environmental Systems Corp.
    Inventors: James W. Smith, David T. R. Ellenor, John N. Harbinson
  • Patent number: 5500130
    Abstract: Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from gas streams by oxidation in aqueous chelated transition metal solution in a modified agitated flotation cell. The same principal may be employed in other procedures in which a gaseous phase is dispersed in a liquid phase to effect an interaction between components present in such phases. A gas-liquid contact apparatus, generally a combined chemical reactor and solid product separation device, comprising such modified agitated flotation cell is also described. In order to effect mass transfer and rapid reaction gas bubbles containing hydrogen sulfide and oxygen are formed by rotating an impeller at a blade tip velocity of at least about 350 in/sec. to achieve the required shear.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 19, 1996
    Assignee: The University of Toronto Innovations Foundation and Apollo Environmental Systems Corp.
    Inventors: James W. Smith, David T. R. Ellenor, John N. Harbinson
  • Patent number: 5500135
    Abstract: Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from gas streams by oxidation in aqueous chelated transition metal solution in a modified agitated flotation cell. The same principal may be employed in other procedures in which a gaseous phase is dispersed in a liquid phase to effect an interaction between components present in such phases. A gas-liquid contact apparatus, generally a combined chemical reactor and solid product separation device, comprising such modified agitated flotation cell is also described. In order to effect mass transfer and rapid reaction gas bubbles containing hydrogen sulfide and oxygen are formed by rotating an impeller at a blade tip velocity of at least about 350 in/sec. to achieve the required shear.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 19, 1996
    Assignees: The University of Toronto Innovations Foundation, Apollo Environmental Systems Corp.
    Inventors: James W. Smith, David T. R. Ellenor, John N. Harbinson
  • Patent number: 5444095
    Abstract: The present invention relates to the use of deprenyl or derivatives or analogues of deprenyl to rescue damaged nerve cells in an animal; to pharmaceutical compositions containing deprenyl adapted for such use; and, to methods for the treatment of disorders of the nervous system by rescuing damaged nerve cells.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: August 22, 1995
    Assignee: University of Toronto, Innovations Foundation
    Inventors: William G. Tatton, Carol E. Greenwood
  • Patent number: 5413765
    Abstract: Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from gas streams by oxidation in aqueous chelated transition metal solution in a modified agitated flotation cell. The same principle may be employed with other procedures in which a gaseous phase is dispersed in a liquid phase to effect an interaction between components present in such phases. A gas-liquid contact apparatus, generally a combined chemical reactor and solid product separation device, comprising such modified agitated flotation cell also is described. In order to effect efficient mass transfer and rapid reaction, gas bubbles containing hydrogen sulfide and oxygen are formed by rotating an impeller at a blade tip velocity of at least about 350 in/sec. to achieve the required shear.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: May 9, 1995
    Assignees: Apollo Environmental Systems Corp., University of Toronto Innovations Foundation
    Inventors: James W. Smith, David T. R. Ellenor, John N. Harbinson
  • Patent number: 5413907
    Abstract: A method for isolating a cDNA specific for the human ryanodine receptor is disclosed. The gene is associated with malignant hyperthermia, a hypermetabolic syndrome triggered primarily by inhalation anesthetics. The cDNA can be cloned and expressed in a recombinant plasmid or phage. The cDNA, or fragments thereof, is used as diagnostic probes for individuals at risk for malignant hyperthermia using restriction fragment length polymorphism analysis. The cDNA is that sequenced in FIG. 2 of this specification.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: May 9, 1995
    Assignees: The University of Toronto Innovations Foundation, HSC Research and Development Limited Partnership, The Toronto Hospital
    Inventors: Ronald G. Worton, David H. MacLennan, Beverley A. Britt
  • Patent number: 5407646
    Abstract: Hydrogen sulfide or other gaseous component is removed from a gas stream containing the same by distribution of the gas stream in the form of fine bubbles by a rotary impeller and stationary shroud arrangement at a submerged location in an aqueous iron or other transition metal chelate solution, or other suitable catalyst, contained in an enclosed reaction vessel. Sulfur particles, or other insoluble phase product, of narrow particle size range formed in the reaction are floated off from the iron chelate solution. An oxygen-containing gas stream also is distributed in the form of fine bubbles by a separate rotary impeller and stationary shroud arrangement at a separate submerged location in the iron chelate solution. The second submerged location generally is separated from the first by a baffle extending downwardly in the reaction vessel from a top closure towards a bottom closure.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: April 18, 1995
    Assignee: The University of Toronto Innovations Foundation
    Inventors: James W. Smith, Nim Y. Lee
  • Patent number: 5366698
    Abstract: Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from gas streams by oxidation in aqueous chelated transition metal solution in a modified agitated flotation cell. A gas-liquid contact apparatus, generally a combined chemical reactor and solid product separation device, comprising such modified agitated flotation cell also is described. In order to effect efficient mass transfer and rapid reaction, gas bubbles containing hydrogen sulfide and oxygen are formed by rotating an impeller at a blade tip velocity of at least about 350 in/sec. to achieve the required shear. To assist in the reaction, a surrounding shroud has a plurality of openings, generally of aspect ratio of approximately 1, of equal diameter and arranged in uniform pattern, such as to provide a gas flow therethrough less than about 0.02 lb/min/opening in the shroud.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: November 22, 1994
    Assignees: The University of Toronto, Innovations Foundation, Apollo Environmental Systems Inc.
    Inventors: James W. Smith, David T. R. Ellenor, John N. Harbinson