Patents Assigned to University of Utah Research Foundation
  • Patent number: 11911583
    Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
    Type: Grant
    Filed: August 15, 2020
    Date of Patent: February 27, 2024
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Dustin Williams, Nicholas Ashton
  • Patent number: 11911584
    Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
    Type: Grant
    Filed: August 15, 2020
    Date of Patent: February 27, 2024
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Dustin Williams, Nicholas Ashton
  • Patent number: 11911442
    Abstract: Disclosed are methods of treating obesity or an obesity-related condition comprising administering an effective amount of soluble (pro)renin receptor (sPRR) to a subject that is obese or having an obesity-related condition. In some instances, obesity-related conditions can be, but are not limited to, steatosis, hyperglycemia, insulin resistance, chronic renal disease. Disclosed are methods of reducing body weight comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating fatty liver in a subject comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating a fluid and electrolyte disorder comprising administering an effective amount of sPRR to a subject diagnosed with a fluid and electrolyte disorder.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: February 27, 2024
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Tianxin Yang
  • Publication number: 20240052313
    Abstract: The disclosure relates to a chondrogenic cell sheet comprising at least two layers of confluent chondrogenically differentiated cells, wherein the cell sheet is prepared from mesenchymal stem cells (MSCs), and wherein the chondrogenically differentiated cells on the basal side of the cell sheet express adhesion molecules. The disclosure also relates to a method of preparing a chondrogenic cell sheet comprising: a) culturing MSCs on temperature responsive cultureware until confluent to form a cell sheet; b) detaching the cell sheet by temperature reduction and allowing the cell sheet to contract, forming a contracted cell sheet; c) contacting the contracted cell sheet with a culture surface; and d) treating the contracted cell sheet on the culture surface with chondrogenic medium and culturing to form a chondrogenic cell sheet. Methods of using the chondrogenic cell sheets to repair cartilage tissue or treat joint disease are also disclosed.
    Type: Application
    Filed: October 7, 2020
    Publication date: February 15, 2024
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Teruo Okano, Kyungsook Kim, Hallie Thorp, David W. Grainger, Travis Maak
  • Patent number: 11896240
    Abstract: A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Zackery Evans, T. Wade Fallin, Travis G. Maak, Charles L. Saltzman
  • Publication number: 20240024005
    Abstract: A bone screw may be insertable into a bone. The bone screw may have a distal member with bone-engaging threads, a proximal member configured to slidably engage the distal member, and a tension member with a proximal end coupled to the proximal member, and a distal end coupled to the distal member such that, in response to motion of the distal member away from the proximal member, the tension member elongates and urges the distal member to move toward the proximal member.
    Type: Application
    Filed: September 30, 2023
    Publication date: January 25, 2024
    Applicant: University of Utah Research Foundation
    Inventors: Colin S. GREGERSEN, T. Wade FALLIN, Charles L. SALTZMAN, Chase HAGMAN
  • Patent number: 11875482
    Abstract: Technology is described for methods and systems for imaging an object (110). The method can include an image sensor (116) exposed to light (114) from an object (110) without passing the light through an image modification element. Light intensity of the light (114) can be stored as data in a medium. The image data can be analyzed at a processor (902) as a reconstructed image of the object (110).
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: January 16, 2024
    Assignee: University of Utah Research Foundation
    Inventors: Rajesh Menon, Ganghun Kim, Kyle Isaacson
  • Publication number: 20230404601
    Abstract: A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.
    Type: Application
    Filed: December 1, 2022
    Publication date: December 21, 2023
    Applicant: University of Utah Research Foundation
    Inventors: Zackery EVANS, T. Wade FALLIN, Travis G. MAAK, Charles L. SALTZMAN
  • Publication number: 20230390401
    Abstract: Bioorthogonal molecules are disclosed and described. A bioorthogonal a molecule having a structure according to: where R2, R3, and R4 are independently selected from H, a substituted or unsubstituted C1-C4 alkyl or alkylene group, a substituted or unsubstituted aryl, COOR9, COR9, CONR9R10, CN, CF3, SO2R9, or a tether molecule; R1 is —R5, —OCOR6, —COR7, or —R8; R5 is —R8, —OH, or tosyl; R6 is a nitrophenyl ether or —R8; R7 is —R8; R8 is a payload or a molecular linker to a payload; and R9 and R10 are independently selected from H or a substituted or unsubstituted C1-C4 alkyl or alkene group.
    Type: Application
    Filed: July 10, 2023
    Publication date: December 7, 2023
    Applicant: University of Utah Research Foundation
    Inventors: Raphael Franzini, Julian Tu
  • Patent number: 11833188
    Abstract: The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: December 5, 2023
    Assignees: UNIVERSITY OF UTAH RESEARCH FOUNDATION, TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Joshua Schiffman, Avi Schroeder, Lisa Abegglen
  • Patent number: 11834708
    Abstract: Methods, devices, and kits are provided for performing PCR in <20 seconds per cycle, with improved efficiency and yield.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: December 5, 2023
    Assignee: University of Utah Research Foundation
    Inventors: Carl T. Wittwer, Jared Steven Farrar
  • Patent number: 11822110
    Abstract: Technology is described for methods and systems for a diffractive optic device (525) for holographic projection. The diffractive optic device can include a lens (535) configured to convey a hologram. The lens (535) further comprises a patterned material (510) formed with an array of cells having a non-planar arrangement of cell heights extending from a surface of the patterned material. The lens further optionally comprises a filling material (530) to fill gaps on both surfaces of the patterned material.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: November 21, 2023
    Assignee: University of Utah Research Foundation
    Inventor: Rajesh Menon
  • Publication number: 20230357724
    Abstract: The disclosure provides a human umbilical cord mesenchymal stem cell sheet comprising one or more layers of confluent human umbilical cord mesenchymal stem cells (hUC-MSCs). The disclosure also provides method for producing hUC-MSC sheets comprising culturing hUC-MSCs in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support.
    Type: Application
    Filed: January 15, 2020
    Publication date: November 9, 2023
    Applicant: University of Utah Research Foundation
    Inventors: Teruo Okano, Kyungsook Kim, David Grainger
  • Patent number: 11801307
    Abstract: Disclosed herein, are antibody-polymer-drug conjugates. The conjugate comprises a targeting moiety, one or more polymers, and one or more therapeutic agents. Also described herein, are compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: October 31, 2023
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Jiyuan Yang, Jindrich Kopecek, Libin Zhang, Yixin Fang
  • Patent number: 11801079
    Abstract: A tether assembly may be attached to a bone to correct a rotational deformity. The bone may have a growth plate that separates a first section of the bone from a second section of the bone. The tether assembly may have a tether member with a first end, a second end, and a central portion extending between the first end and the second end. The first end may have a closed outer wall that defines and fully bounds a first aperture. The second end may have an open outer wall that defines and partially bounds a second aperture. The open outer wall may define a slot in communication with the second aperture. The first and second ends may be securable to the first and second sections of the bone via coupling members inserted through the first and second apertures and anchored in the first and second sections, respectively.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: October 31, 2023
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Zackery Evans, T. Wade Fallin, Peter M. Stevens
  • Patent number: 11774453
    Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: October 3, 2023
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Andrew S. Dixon, Shawn Owen
  • Publication number: 20230293771
    Abstract: The disclosure provides a chondrocyte cell sheet comprising one or more layers of confluent cells comprising chondrocytes and chondroprogenitor cells. Methods of generating cartilage tissue in a subject are also provided. The disclosure also provides a method for producing chondrocyte cell sheets comprising culturing chondrocytes and chondroprogenitor cells in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support.
    Type: Application
    Filed: July 16, 2021
    Publication date: September 21, 2023
    Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION, ORGANIZATION OF CELL SHEET TISSUE ENGINEERING REGENERATIVE MEDICINE INITIATIVES
    Inventors: Mimi Egami, David Grainger, Kyungsook Kim, Makoto Kondo, Travis Maak, Teruo Okano, Hideaki Sakai
  • Patent number: 11761919
    Abstract: A system for low power chemical sensing can include a voltage shift unit which receives a voltage signal from a chemical sensor unit. The voltage signal can be determined by a concentration of an analyte. The voltage shift unit can transform the voltage signal to an input voltage signal, and send the input voltage signal to a plurality of frequency selective surface (FSS) units of an FSS array. The FSS array can communicate a radio frequency (RF) signal in an Institute of Electrical and Electronics Engineers (IEEE) S band with a resonant frequency based on the input voltage to provide the concentration of the analyte.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: September 19, 2023
    Assignees: University of Utah Research Foundation, The Penn State Research Foundation
    Inventors: Benjamin R. Bunes, Leonard Cardillo, Douglas Later, Ling Zang, Douglas H. Werner, Ronald Jenkins, Micah D. Gregory
  • Patent number: 11762131
    Abstract: A variable focus optical device (100) can include first optically transparent membrane (102) and a second membrane (104) that at least partially define a chamber (106) retaining an optically transparent liquid. A transparent piston (110) is attached to the second membrane (104). At least one actuator (112a-c) is operatively coupled to the transparent piston (110) and configured to move to change a focal length of the variable focus optical device (100) via actuation of the transparent piston (110). Three curved bimorph actuators (112a-c) can surround and be coupled to the piston (110) for actuation of the piston (110) to generate a plano-convex or plano-concave lens via the membranes (102, 104). A smart eyeglasses system includes a pair of variable focus optical devices (100), an object distance sensor, a battery, optional eye-tracking camera(s), and a microcontroller, collectively used for purposes of sensing distance of objects and adjusting said focal length via the variable focus optical devices (100).
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: September 19, 2023
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Carlos Mastrangelo, Nazmul Hasan, Kim Hanseup
  • Patent number: 11752203
    Abstract: An isolated and purified peptide, neonatal NET-inhibitory Factor (nNIF), is disclosed. Methods for treatment of and prophylaxis against inflammatory disorders are also disclosed, including methods of treatment of and prophylaxis against inflammatory disorders comprising administering NET-inhibitory peptides (NIPs), which may be a nNIF, a pharmaceutically acceptable salt of a nNIF, a nNIF analog, a pharmaceutically acceptable salt of a nNIF analog, a nNIF-Related Peptide (nNRP), including the nNRP, Cancer-Associated SCM-Recognition, Immune Defense Suppression, and Serine Protease Protection Peptide (CRISPP), a pharmaceutically acceptable salt of a nNRP, a nNRP analog, or a pharmaceutically acceptable salt of a nNRP analog, to an individual.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: September 12, 2023
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Christian Con Yost, Guy A. Zimmerman, Andrew S. Weyrich