Patents Assigned to University of Utah Research Foundation
  • Patent number: 10358655
    Abstract: A non-natural modified CMV promoter is provided. Such a promoter can include a promoter nucleotide sequence that is at least 80% homologous to a sequence selected from the group consisting of SEQ ID 01, SEQ ID 02, SEQ ID 03, SEQ ID 04, SEQ ID 05, SEQ ID 06, SEQ ID 07, and compliments thereof.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: July 23, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Wesley I. Sundquist, Eiji Morita, Jun Arii
  • Patent number: 10359552
    Abstract: An optical filter may reduce the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to cells in the human eye in certain wavelengths, such as 480 nm and 590 nm, and a visual spectral response of the human eye. The optical filter may disrupt the isomerization of melanopsin in the human eye reducing the availability of the active isoform, whereas the attenuation of light weighted across the action potential spectrum of the active isoform attenuates the phototransduction cascade leading to photophobic responses. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light in certain wavelengths, and to transmit more than a second amount of light weighted across the visual spectral response. Methods of use and methods of manufacturing optical filters are also described.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: July 23, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Steven M. Blair, Bradley Jay Katz
  • Patent number: 10351903
    Abstract: Methods are provided for nucleic acid analysis. In an illustrative method, allele amplification bias is used to amplify preferentially a target nucleic acid that is present in a low allele fraction.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: July 16, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Luming Zhou, Robert Andrew Palais
  • Patent number: 10350169
    Abstract: Therapeutic compositions are disclosed which contain a therapeutic agent and a bile acid or bile acid conjugate. The compositions can be absorbed via enterohepatic circulation. The compositions include a cationic moiety and an anionic polymer, which are coupled through electrostatic interactions. The therapeutic compositions can be used for the treatment of diseases or disorders.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 16, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: You Han Bae, Yong-Kyu Lee, Md Nurunnabi, Hee Sook Hwang, Dongsub Kwag
  • Patent number: 10353034
    Abstract: A method for producing an image of a subject using a magnetic resonance imaging (MRI) system includes acquiring a series of echo signals by sampling k-space along radial lines that each pass through the center of k-space. Each projection of the radial lines is divided into multiple echoes and successive projections are spaced by a predetermined angular distance. The series of echo signals are reconstructed into a plurality of images, wherein each image corresponds to a distinct echo signal.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: July 16, 2019
    Assignees: Siemens Healthcare GmbH, University of Utah Research Foundation
    Inventors: Bradley Drake Bolster, Jr., Dennis L. Parker, Allison Payne, Bryant Svedin
  • Patent number: 10350160
    Abstract: The present technology provides intravaginal devices designed to deliver lubricants to the vagina for a sustained period of time. The intravaginal devices include a first segment comprising an outer surface and a lumen containing a lubricant, wherein the first segment is configured to deliver the contents of the lumen to the outer surface, and the first segment comprises a polymer selected from the group consisting of a hydrophilic, semi-permeable elastomer and a hydrophobic elastomer. The lubricant may be an aqueous lubricant. The present technology further provides an intravaginal device including a solid first segment that includes a hydrophilic semi-permeable elastomer, an outer surface and an aqueous lubricant, wherein the first segment is configured to deliver the aqueous lubricant to the outer surface.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: July 16, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION, THE
    Inventors: Patrick F. Kiser, R. Tyler McCabe, Margaret N. Kiser, Theodore Henry Albright
  • Publication number: 20190209606
    Abstract: Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.
    Type: Application
    Filed: September 14, 2017
    Publication date: July 11, 2019
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Hamidreza GHANDEHARI, Siam OOTTAMASATHIEN, Mark Martin JENSEN, Joseph CAPPELLO, Wanjian JIA, Glenn D. PRESTWICH
  • Patent number: 10348306
    Abstract: Resistive random access memory (RRAM) based multiplexers and field programmable gate arrays (FPGAs) are provided. The RRAM-based multiplexers and FPGAs include a 4T1R programming structure to program the RRAMs. The programming structure includes two programming transistors connected between the power supply and the top electrode of the RRAM and two programming transistors connected between the power supply and the bottom electrode of the RRAM. The programming transistors are used to set and rest the RRAMs. In the RRAM-based multiplexer programming transistors connected to the bottom electrodes are shared between a plurality of RRAMs. The shared programming transistors and an output inverter of the RRAM are provided in a deep N-well of the RRAM-based multiplexer. The programming transistors connected to the top electrodes of the RRAMs and a plurality of input inverters are provided in a regular well of the RRAM-based multiplexer.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: July 9, 2019
    Assignees: University of Utah Research Foundation, Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Pierre-Emanuel Gaillardon, Xifan Tang, Gain Kim, Giovanni De Micheli, Edouard Giacomin
  • Patent number: 10329435
    Abstract: An electrothermal coating can include a nanostructure mixture randomly dispersed in a polymer matrix with more than one type of low-dimensional nanostructure. These types of low-dimensional nanostructures can include a combination of a nanospheroid plus one or both of a linear nanostructure and a planar nanostructure. Useful conductivity is achieved, while concentration of the mixed nanostructures is within the cured polymer composite coating being below the percolation limit of each individual carbon nanostructure type, alone, within an identical polymer matrix.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 25, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Feng Lui, Chao Hui
  • Patent number: 10310994
    Abstract: A sequential asynchronous system and a method for operating the same. The method includes operating a first asynchronous finite state machine at a first clock rate and operating a second asynchronous finite state machine at a second clock rate. The method also includes generating, with fork logic, a fork request based on a first state of the first asynchronous finite state machine and receiving, with join logic, the fork request from the fork logic. The method further includes receiving, with the join logic, a communication request from the second asynchronous finite state machine based on a second state of the second asynchronous finite state machine and initiating, with the join logic, a state transition of the second asynchronous finite state machine. The method also includes providing, with the join logic, a join acknowledgement to the fork logic upon completion of the state transition.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 4, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Kenneth S. Stevens, Dipanjan Bhadra
  • Patent number: 10293153
    Abstract: An implantable medical device can include an electrode substrate electrically connected to at least one electrode. The device can have a pseudoporous surface across the electrode substrate and electrode. This surface can result in a real surface area (RSA) greater than the geometric surface area (GSA) of the device. The pseudoporous surface can be a macroporous surface enabling a charge injection capacity greater than 1 mC/cm2 while minimizing rejection of the device by surrounding tissue in chronic implant applications. The electrode can be a thin layer of conductive material, such as platinum or another metal, conformally deposited on the pseudoporous surface of the electrode substrate. A method of making the implantable device can include forming the device having an electrode substrate and at least one electrode electrically coupled to the electrode substrate, and forming a pseudoporous surface on the electrode substrate and electrode.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: May 21, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Sandeep Negi, Rajmohan Bhandari
  • Patent number: 10296030
    Abstract: An operating configuration for a power system during a particular time period may be derived from a net load forecast for the power system during the particular time period. The operating configuration may be based on characteristics of power generation units (PGUs) available within the power system (e.g., power generators). The characteristics of a PGU may include a generation trajectory for the PGU that defines, inter alia, power generated by the PGU as the PGU ramps up power production within the power system. The generation trajectory of PGUs may be evaluated in view of the net load forecast to ensure that adequate power resources are available within the power system and avoid ramping scarcity conditions.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: May 21, 2019
    Assignees: University of Utah Research Foundation, Arizona Board of Regents for and on behalf of Arizona State University
    Inventors: Masood Parvania, Anna Scaglione
  • Patent number: 10290370
    Abstract: Embodiments are directed to extracting specified data items from narrative text. In one scenario, a computer system accesses narrative textual information which includes data items that are to be identified and extracted. The computer system identifies specified data items in the narrative textual information that are to be extracted from the narrative textual information. The computer system then filters the identified data items to remove false positive identifications. The false positive filtering includes classifying the identified data items as specified data items, so that classified data items are identified as true positive items that are to be extracted from the narrative textual information. The computer system further extracts, from the narrative textual information, those filtered data items that were classified as being true positive items.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: May 14, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Stéphane Michael Meystre, Óscar Ferrández Escamez
  • Patent number: 10290387
    Abstract: Methods for precise and predictable modification of previously synthesized nanocrystals. The methods rely on the solubility behavior of crystalline materials to provide for controlled reversal of the nanocrystal growth process (i.e., dissolution). A method for post-synthesis modification of colloidal nanocrystals includes (1) providing a first nanocrystal having a first size and a first shape, (2) forming a reaction mixture that includes the nanocrystal, at least one ligand capable of binding to at least one component of the nanocrystal, at least one solvent, and an inert gas atmosphere, and (3) modifying the size and/or shape of the nanocrystal in the reaction mixture for a period of time at a temperature in a range from about 100° C. to about 240° C. so as to produce at least a second nanocrystal having a second size and/or a second shape.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: May 14, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Michael Hans Risbud Bartl, Jacqueline T. Siy
  • Patent number: 10281627
    Abstract: Implementations of the present invention relate to apparatuses, systems, and methods for blocking, attenuating, or filtering neuroactive wavelengths of the visible light spectrum and reducing or preventing the symptoms affiliated with exposure to those wavelengths. Nanoparticles of a predetermined composition, size, and structure are dispersed in a host medium to create an optical notch filter, thereby attenuating only a narrow range of the visible spectrum.
    Type: Grant
    Filed: November 15, 2014
    Date of Patent: May 7, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Steven M. Blair, Pradeep Kasinadhuni, Steve McDaniel, Bradley Jay Katz
  • Patent number: 10279044
    Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.
    Type: Grant
    Filed: May 29, 2016
    Date of Patent: May 7, 2019
    Assignees: Purdue Research Foundation, University of Utah Research Foundation
    Inventors: Stewart Andrew Low, Philip S. Low, Christopher Galliford, Jindrich Kopecek, Jiyan Yang
  • Patent number: 10282687
    Abstract: An optimal operating configuration for a power system may be derived from a continuous-time model of generation and ramping constraints of power generation units available within the power system. The optimal operating configuration may be leveraged to calculate a valuation metric for power generated by the power generating units. The valuation metric may include costs incurred by the power generating units due to ramping events. In addition, incremental generation and ramping cost metrics may be used to identify power generation units to use in responding to short-term load variations. Power generating units may be selected based, at least in part, on the incremental ramping costs of the power generating units.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: May 7, 2019
    Assignee: University of Utah Research Foundation
    Inventor: Masood Parvania
  • Patent number: 10279047
    Abstract: Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: May 7, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Young-Wook Won, David A. Bull, Amit N. Patel
  • Patent number: 10273246
    Abstract: In one aspect, the invention relates to substituted 5H-[1,2,5]oxadiazolo [3?,4?:5,6]pyrazino[2,3-b]indole analogs, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and A methods of treating disorders, e.g., various tumors and cancers, associated with a ?-catenin/T-cell factor interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: April 30, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Haitao Ji, Yongqiang Zhang, Min Zhang, Jonathan L. Catrow
  • Patent number: 10271914
    Abstract: An adapter system can include a set of adapters operably adapted to a set of microsurgical tools. Each adapter in the set of adapters can be formed for a complimentary surgical tool in the set of surgical tools. Each adapter can have a setback feature designed to orient a corresponding tool tip at a common tip distance. An adapter receptacle can include a joint or joints having a rotary motion and/or translation mechanism and a setback stop feature.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: April 30, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Manikantan Nambi, Jacob J. Abbott, Paul S. Bernstein