Patents Assigned to University of Virginia Patent Foundation
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Patent number: 11567062Abstract: A computer-implemented method for providing a real-time estimate of glycosylated hemoglobin (HbA1c) of a patient from a self-monitoring blood glucose (SMBG) measurement, and tracking changes in average glycemia of said patient over time is disclosed.Type: GrantFiled: June 8, 2016Date of Patent: January 31, 2023Assignee: University of Virginia Patent FoundationInventors: Boris P. Kovatchev, Marc D. Breton
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Publication number: 20230027709Abstract: The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and SAS1R co-localized to oocytes and to acrosomes of acrosome-reacted sperm. Interactions between mSLLP1 and SAS1R were demonstrated by far-western analysis, in a yeast two-hybrid system under stringent selection conditions, and by immunoprecipitation of SAS1R by anti-mSLLP1 as well as the converse. Purified recombinant SAS1R was found to have protease activity, to inhibit fertilization in-vitro, and to induce an immune response in females.Type: ApplicationFiled: November 16, 2020Publication date: January 26, 2023Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: John C. HERR, Monika SACHDEV, Arabinda MANDAL
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Publication number: 20230025608Abstract: A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.Type: ApplicationFiled: February 8, 2021Publication date: January 26, 2023Applicants: University of Virginia Patent Foundation, The University of BirminghamInventors: Donald F. Hunt, Jeffrey Shabanowitz, Stacy Alyse Malaker, Victor H. Engelhard, Angela L. Ambakhutwala, Kara L. Cummings, Rebecca C. Obeng, Mark Cobbold
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Publication number: 20230010671Abstract: The present application provides compositions and methods for preparing and using “heavy” nucleotide derivatives of thymidine or uridine by replacing the oxygen atom attached to one or more of positions with non-radioactive oxygen-18 (18O), administering it to a subject to target a tumor including incorporation into tumor cell DNA, and then treating the tumor with proton beam therapy to transmutate the 18O to 18F, resulting in a break of the new fluorine-phosphorous bond. This chemical event destabilizes ribose-phosphate DNA back-bone and base pairing thus produce single- and double strand breaks, clusters lesions that can lead to irreparable DNA damage and enhanced tumor cell killing. The atomic, chemical, and physical aspects result in the use of lower radiation doses and significantly alter acute and late morbidity of radiotherapy. Heavy thymidine and heavy uridine derivatives labeled with 18O have been made and tested.Type: ApplicationFiled: June 27, 2022Publication date: January 12, 2023Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, HAMPTON UNIVERSITYInventors: Tyvin A. RICH, Dongfeng PAN, Mahendra D. CHORDIA
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Publication number: 20230001055Abstract: Provided are compositions that can be employed for generating microporous gel systems. In some embodiments, the compositions include at least one sub-population of soft hydrogel microparticles with a Youngs modulus of less than 50 kPa and at least one sub-population of stiff hydrogel microparticles with a Young's modulus of greater than 90 kPa. Also provided are methods for generating the compositions, methods for treating bone and/or cartilage defects in subject using the disclosed compositions, methods for treating osteoarthritis using the disclosed compositions, and methods for providing orthopedic implants to subjects.Type: ApplicationFiled: December 7, 2020Publication date: January 5, 2023Applicant: University of Virginia Patent FoundationInventors: Donald Richieri Griffin, Blaise N. Pfaff, Nicholas J. Cornell, Brent R. DeGeorge, JR.
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Patent number: 11541101Abstract: Methods and compositions for modulating transforming growth factor-beta (TGF?) biological activity in a vertebrate subject in need thereof. The methods involve administering to the vertebrate subject an effective amount of a substance capable of modulating activity of LEMD3 in the vertebrate subject to thereby modulate TGF? biological activity in the vertebrate subject.Type: GrantFiled: October 9, 2019Date of Patent: January 3, 2023Assignees: University of Virginia Patent Foundation, Emory UniversityInventors: Thomas H. Barker, Leandro Moretti, Dwight M. Chambers
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Patent number: 11540749Abstract: The disclosed embodiments provide systems and methods for predicting presence of one or more neurological deficits. The system may include a microphone, a camera, one or more memory devices storing instructions, and one or more processors configured to execute the instructions to extract audio information including a period density entropy coefficient and a mel frequency cepstral coefficient from an audio feed received from the microphone. Additionally, the instructions may cause the processor to determine position and depth information of eye movement from a video feed received from the camera and detect features of interest including facial landmarks, spatial orientation of limbs, and positional information of limb movements from the video feed. The one or more processors may further extract the features of interest from the video feed and process the extracted features of interest by aligning the extracted features of interest to a common reference.Type: GrantFiled: January 22, 2019Date of Patent: January 3, 2023Assignee: University of Virginia Patent FoundationInventors: Omar Uribe, Mark McDonald, Andrew M. Southerland, Gustavo Rohde, Yan Zhuang
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Patent number: 11538675Abstract: The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed.Type: GrantFiled: June 5, 2017Date of Patent: December 27, 2022Assignees: University of Virginia Patent Foundation, Thermo Finnigan LLCInventors: Donald F. Hunt, Ann M. English, Scott A. Ugrin, Dina L. Bai, Jeffrey Shabanowitz, John Edward Philip Syka
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Publication number: 20220401580Abstract: Provided are nucleotide sequences encoding polypeptides with ribonuclease III activity, wherein the nucleotide sequences have been modified to reduce their regulation by miRNAs. In some embodiments, the nucleotide sequences are at least 50% and as much as 100% identical to SEQ ID NO: 20 or SEQ ID NO: 22, and/or encode polypeptides that are at least 90% percent identical to SEQ ID NO: 23. Also provided are vectors and host cells that include the nucleotide sequences, methods for expressing the nucleotide sequences in cells, tissues, and organs, which in some embodiments can be in the eye of a subject in need thereof, methods for preventing and/or treating development of diseases or disorders and/or for restoring undesirably low DICER1 expression using the nucleotide sequences, and pharmaceutical compositions that have the presently disclosed nucleotide sequences.Type: ApplicationFiled: November 12, 2020Publication date: December 22, 2022Applicants: University of Virginia Patent Foundation, University of Utah Research FoundationInventors: Jayakrishna Ambati, Bradley David Unti Gelfand, Balamurali K. Ambati, Hironori Uehara
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Publication number: 20220386965Abstract: Embodiment relate to a system for developing a model to classify continuous glucose monitoring (CGM) data. The system includes a processor and computer memory having instructions stored thereon that when executed will cause the processor to determine whether two CGM profiles match based on a similarity of shapes of the two CGM profiles, each CGM profile including a data set of CGM measurements. The processor designates two matching CGM profiles as a CGM profile pair. The processor transforms the CGM profile pair into a motif. The processor labels the motif as a labelled motif based on a clinical characteristic. The processor recursively repeats the determine, designate and transform steps of a CGM profile pairing process until a finite set of motifs is created, which includes the labelled motif as a classified data point. The processor monitor, analyzes, or influences a concentration of glucose levels in a fluid.Type: ApplicationFiled: June 1, 2022Publication date: December 8, 2022Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Boris P. KOVATCHEV, Benjamin LOBO
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Publication number: 20220392632Abstract: A system or method for compressing continuous glucose monitor (CGM) data for a subject and/or a technician, clinician, or for use with an interventional device. The system or method configures the CGM data to allow the subject, technician, clinician, or interventional device to take a physical action in response to receiving a transmission to improve the safety and/or efficacy of therapy for the subject.Type: ApplicationFiled: November 13, 2020Publication date: December 8, 2022Applicant: University of Virginia Patent FoundationInventors: Ke Wang, Leon S. Farhi, Boris P. Kovatchev
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Publication number: 20220387567Abstract: Compositions that include anti-cancer, anti-tumor, and anti-microbial infection peptides are provided. In some embodiments, the compositions include 1-10 or more synthetic peptides that are between 8 and 50 amino acids long and include an amino acid sequence as disclosed herein.Type: ApplicationFiled: March 23, 2020Publication date: December 8, 2022Applicants: University of Virginia Patent Foundation, The University of Birmingham, The General Hospital CorporationInventors: Donald F. Hunt, Jeffrey Shabanowitz, Keira Mahoney, Jennifer G. Abelin, Mohammad Ovais Azizzanjani, Paisley Trantham Myers, Stacy Alyse Malaker, Andrew Norris, Jennifer Hitchcock, Xi Peng, Negin Ghafourian, Mark Cobbold, Sarah Penny, Nico Buettner, James M. Heather
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Publication number: 20220380408Abstract: Provided are peptides that based on the amino acid sequences LDPAKDCGDQKYAY (SEQ ID NO: 1) and LDPSKDCGDPKYAY (SEQ ID NO: 2), optionally wherein the peptide includes an N-terminal stearate modification. Also provided are method for using the disclosed peptides for inhibiting neointima formation in mammals, methods for inhibiting division and/or proliferation of vascular smooth muscle cells, and uses of the disclosed peptides for treating cardiovascular diseases and/or disorder associated with undesirable vascular SMC proliferation, which in some embodiments can re-late to inhibiting neointima formation in a mammal.Type: ApplicationFiled: July 27, 2020Publication date: December 1, 2022Applicant: University of Virginia Patent FoundationInventors: Scott R. Johnstone, Brant E. Isakson
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Patent number: 11512072Abstract: The present disclosure provides azetidine compounds of Formula I and their pharmaceutically acceptable salts, their compositions, and methods for their use in determining azetidine compound binding to proteins. The azetidine compounds are useful as probes, for monitoring diacylglycerol kinase activity, and for identifying druggable targets.Type: GrantFiled: April 19, 2019Date of Patent: November 29, 2022Assignee: University of Virginia Patent FoundationInventors: Ku-Lung Hsu, Rebecca L. McCloud
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Patent number: 11512002Abstract: Disclosed herein are methods for the preparation of porous metal oxide materials, including metal oxide xerogels and metal oxide aerogels. Methods for preparing porous metal oxide materials can comprise (i) reacting a metal alkoxide with water in the presence of a catalyst system to form a partially hydrolyzed sol, (ii) contacting the partially hydrolyzed sol with a base catalyst and a non-aqueous solvent to form a precursor gel; and (iii) drying the precursor gel to form the porous metal oxide material. The catalyst system employed in step (i) comprises a combination of a weak acid and a strong acid.Type: GrantFiled: April 18, 2019Date of Patent: November 29, 2022Assignee: University of Virginia Patent FoundationInventors: Jong Ho Sonn, Pamela M. Norris
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Publication number: 20220373627Abstract: Methods, computing devices, and magnetic resonance imaging systems that improve image quality in turbo spiral echo (TSE) imaging are disclosed. With this technology, a TSE pulse sequence is generated that includes a series of radio frequency (RF) refocusing pulses to produce a corresponding series of nuclear magnetic resonance (NMR) spin echo signals. A gradient waveform including a plurality of segments is generated. The plurality of segments collectively comprise a spiral ring retraced in-out trajectory. During an interval adjacent to each of the series of RF refocusing pulses, a first gradient pulse is generated according to the gradient waveform. The first gradient pulses encode the NMR spin echo signals. An image is then constructed from digitized samples of the NMR spin echo signals obtained based at least in part on the encoding.Type: ApplicationFiled: April 28, 2022Publication date: November 24, 2022Applicant: University of Virginia Patent FoundationInventors: Zhixing Wang, Steven P. Allen, Xue Feng, John P. Mugler, III, Craig H. Meyer
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Publication number: 20220362177Abstract: Provided are methods for treating diseases, disorders, and conditions associated with undesirable cellular proliferation in subjects in need thereof. In some embodiments, the methods include administering to a subject in need thereof a therapeutically effective amount of a composition comprising, consisting essentially of, or consisting of a chemotherapeutic agent and a short chain ceramide. Also provided are methods for increasing total ceramide levels in cells, for increasing long chain ceramide to a very long chain ceramide ratios in cells, methods for enhancing apoptosis of cells, for prognosing subjects with diseases, disorders, and conditions associated with undesirable cellular proliferation with respect to treatments, for increasing sensitivities of drug-resistant tumor and/or cancer cells to chemotherapeutics, and compositions that have one or more short chain ceramides and one or more chemotherapeutically active agents.Type: ApplicationFiled: October 16, 2020Publication date: November 17, 2022Applicant: University of Virginia Patent FoundationInventors: Mark Kester, Tye Deering, Thomas P. Loughran, JR., Todd E. Fox, Pedro Filipe Da Costa Pinheiro, David J. Feith
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Publication number: 20220357416Abstract: Methods, computing devices, and MRI systems that reduce artifacts produced by Maxwell gradient terms in TSE imaging using non-rectilinear trajectories are disclosed. With this technology, a RF excitation pulse is generated to produce transverse magnetization that generates a NMR signal and a series of RF refocusing pulses to produce a corresponding series of NMR spin-echo signals. An original encoding gradient waveform comprising a non-rectilinear trajectory is modified by adjusting a portion of the original encoding gradient waveform or introducing a zero zeroth-moment waveform segment at end(s) of the original encoding gradient waveform. During an interval adjacent to each of the series of RF refocusing pulses a first gradient pulse is generated. At least one of the first gradient pulses is generated according to the modified gradient waveform. An image is constructed from generated digitized samples of the NMR spin-echo signals obtained.Type: ApplicationFiled: April 28, 2022Publication date: November 10, 2022Applicant: University of Virginia Patent FoundationInventors: John P. Mugler, III, Craig H. Meyer, Adrienne Campbell, Rajiv Ramasawmy, Josef Pfeuffer
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Publication number: 20220347144Abstract: Provided are methods for preventing and/or reducing weight gain in subjects. In some embodiments, the methods include administering an effective amount of a composition that includes a long chain fatty acid of at least 22 carbons and/or a derivative thereof to prevent and/or reduce weight gain in the subject. In some embodiments, the long chain fatty acid is a monounsaturated omega 9 fatty acid, which in some embodiments is nervonic acid or a derivative thereof. Also provided are methods for preventing and/or reducing the development of obesity in subjects, for inhibiting reduction of very-long chain sphingolipids in subjects, for increasing content of one or more ceramides while simultaneously decreasing content of one or more C20-C26 ceramides in subjects, and for reducing blood glucose levels resulting from consumption of high fat diets in subjects.Type: ApplicationFiled: September 28, 2020Publication date: November 3, 2022Applicant: University of Virginia Patent FoundationInventors: Todd E. Fox, Mark Kester
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Publication number: 20220330876Abstract: A system for classifying cardiac rhythms is disclosed. The system includes one or more processors, one or more computer-readable tangible storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include first program instructions times between heartbeats. The program instructions further comprise second program instructions to segment the time series into a plurality of segments. The program instructions further comprise third program instructions to calculate a plurality of parameters corresponding to each of the 30-second segments. The program instructions further comprise fourth program instructions to analyze the obtained data and the calculated parameters using a plurality of multivariable algorithms for rhythm classification.Type: ApplicationFiled: July 5, 2022Publication date: October 20, 2022Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: J. Randall MOORMAN, Douglas E. LAKE