Patents Assigned to University of Washington Center for Commercialization
-
Patent number: 11596786Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.Type: GrantFiled: January 11, 2021Date of Patent: March 7, 2023Assignees: Cochlear Limited, University of Washington Center for CommercializationInventors: Frank Risi, Colin Irwin, Jay T. Rubinstein, Felipe Santos, James O. Phillips
-
Patent number: 10888696Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is still enough to avoid damage to the anatomical structures.Type: GrantFiled: January 2, 2019Date of Patent: January 12, 2021Assignees: COCHLEAR LIMITED, UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATIONInventors: Frank Risi, Colin Irwin, Jay T. Rubinstein, Felipe Santos, James O. Phillips
-
Patent number: 10421789Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.Type: GrantFiled: March 4, 2019Date of Patent: September 24, 2019Assignees: University of Washington, Center for Commercialization, The Scripps Research Institute, International AIDS Vaccine InitiativeInventors: Po-Ssu Huang, Joseph Graham Jardine, Sergey V. Menis, William Ray Schief, Neil P. King
-
Patent number: 10347857Abstract: A hybrid organic-inorganic thin film is provided. The hybrid organic-inorganic thin film comprising: an organic-phase comprising a porous organic nanostructure comprised of an interpenetrating network having at least one dimension between 0.1 and 100 nm; and an inorganic phase at least partially distributed within the porosity of the organic phase. In a first aspect, the organic phase has a first band gap and the inorganic phase has a second band gap different from the first band gap. A method of producing an organic-inorganic energy harvesting device and a device therefrom comprising the hybrid organic-inorganic thin film is provided.Type: GrantFiled: November 23, 2016Date of Patent: July 9, 2019Assignees: THE BOEING COMPANY, UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATIONInventors: Marvi A. Matos, Alpana N. Ranade, Danilo C. Pozzo
-
Patent number: 10221217Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.Type: GrantFiled: December 22, 2015Date of Patent: March 5, 2019Assignees: University of Washington, Center for Commercialization, The Scripps Research Institute, International AIDS Vaccine InitiativeInventors: Po-Ssu Huang, Joseph Graham Jardine, Sergey V. Menis, William Ray Schief, Neil P. King
-
Patent number: 9945831Abstract: According to one aspect, the invention relates to an aquatic sample analysis system adapted for in situ use. The system includes an incubation chamber having an optically clear portion and forming an opening for receiving a fluidic sample and apparatus for sealing the opening. The system also includes a sensor for sensing at least one parameter associated with the sample inside the chamber, a control module in communication with the sensor, and a power source.Type: GrantFiled: July 24, 2015Date of Patent: April 17, 2018Assignees: Woods Hole Oceanographic Institution, University of Washington Center for CommercializationInventors: Benjamin A. S. Van Mooy, Richard G. Keil
-
Publication number: 20150376645Abstract: In some embodiments the present disclosure provides a composition for targeted alteration of a DNA sequence and methods of altering the targeted DNA sequence using the composition. In some embodiments such a composition comprises a MiniVector comprising a nucleic acid sequence template for homology-directed repair, alteration, or replacement of the targeted DNA sequence within a cell in vivo or in vitro, where the MiniVector lacks both a bacterial origin of replication and an antibiotic selection gene, and wherein the Mini Vector has a size up to about 2,500 base pairs.Type: ApplicationFiled: May 30, 2013Publication date: December 31, 2015Applicants: BAYLOR COLLEGE OF MEDICINE, UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATIONInventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, JR., Nancy Maizel, Olivier Humbert
-
Patent number: 9089692Abstract: A vestibular stimulation array is disclosed having one or more separate electrode arrays each operatively adapted for implantation in a semicircular canal of the vestibular system, wherein each separate electrode array is dimensioned and constructed so that so that residual vestibular function is preserved. In particular, the electrode arrays are dimensioned such that the membranous labyrinth is not substantially compressed. Furthermore, the electrode array has a stop portion to limit insertion of the electrode array into the semi-circular canal and is stiff enough to avoid damage to the anatomical structures.Type: GrantFiled: May 28, 2010Date of Patent: July 28, 2015Assignees: COCHLEAR LIMITED, UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATIONInventors: Frank Risi, Colin Irwin, Jay T Rubinstein, Felipe Santos, James O Phillips
-
Publication number: 20150203827Abstract: Fusion proteins comprising a tafazzin peptide and a cellular permeability peptide are disclosed. The tafazzin peptide may be coupled to the permeability peptide through a polypeptide linker. Methods of making and using the fusion proteins are also disclosed. For example, the disclosed fusion proteins may be used to treat a patient having a disorder associated with a tafazzin deficiency or a remodeled cardiolipin deficiency (e.g., Barth syndrome). Additionally, the disclosed fusion proteins may be used in prophylaxis against developing a disorder associated with a tafazzin deficiency or a remodeled cardiolipin deficiency in a patient at risk of developing such a disorder.Type: ApplicationFiled: January 22, 2015Publication date: July 23, 2015Applicant: University of Washington Center for CommercializationInventors: Michael T. Chin, Wei-Ming Chien, Ana Dinca
-
Publication number: 20150030561Abstract: Presently disclosed are methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist.Type: ApplicationFiled: May 15, 2012Publication date: January 29, 2015Applicants: GENZYME CORP., UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATIONInventors: David C. Dale, Gary J. Bridger, Frank J. Hsu
-
Patent number: 8726827Abstract: Systems and methods for compensating for compressibility and thermal expansion coefficient mismatch in buoyancy controlled or buoyancy-driven underwater vehicles are disclosed herein. An underwater vehicle configured in accordance with one embodiment of the disclosure, for example, can include a hull and a compartment carried by the hull and at least partially flooded with a first liquid having similar properties as a surrounding liquid into which the hull is configured to be deployed. The first liquid has a first compressibility and thermal expansion coefficient. The underwater vehicle can further include a compressibility and thermal expansion coefficient compensation system comprising a container filled or at least partially filled with a compressible liquid comprising silicone in the compartment. The compressible liquid has a second compressibility higher than the first compressibility and second thermal expansion coefficient higher than the first thermal expansion coefficient.Type: GrantFiled: February 22, 2013Date of Patent: May 20, 2014Assignee: University of Washington Center for CommercializationInventor: Charles C. Eriksen
-
Patent number: 8696360Abstract: The current application is directed to developing and administering subject-appropriate ITAs. The various to developing and administering subject-appropriate ITAs evaluate many aspects of ITA content, content presentation, and administration with regard to particular categories of test subjects in order to develop subject-appropriate ITAs (“SAITAs”) and to administer SAITAs appropriately to the categories of test subjects for which the tests are developed. Aspects of SAITA presentation and administration that are evaluated include input devices, presentation formats, presentation language, presentation media, colors used in presentation of tutorials and stimuli, words, pictures, and symbols used in a presentation of tutorials and stimuli, the pace and length of various portions of SAITAs, human vs. computer administration of SAITAs, presentation of feedback to test subjects during SAITAs, ITAs and many other aspects of ITA content, content presentation, and administration.Type: GrantFiled: October 4, 2011Date of Patent: April 15, 2014Assignee: University of Washington Center for CommercializationInventors: Dario Cvencek, Andrew Meltzoff, Anthony G. Greenwald, Craig Harris
-
Publication number: 20140094682Abstract: A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.Type: ApplicationFiled: December 3, 2013Publication date: April 3, 2014Applicant: University of Washington, Center for CommercializationInventors: Jessica Foley, Shahram Vaezy, James Little
-
Publication number: 20140056868Abstract: In some embodiments the present disclosure provides a composition for targeted alteration of a DNA sequence and methods of altering the targeted DNA sequence using the composition. In some embodiments such a composition comprises a MiniVector comprising a nucleic acid sequence template for homology-directed repair, alteration, or replacement of the targeted DNA sequence within a cell in vivo or in vitro, where the MiniVector lacks both a bacterial origin of replication and an antibiotic selection gene, and wherein the MiniVector has a size up to about 2,500 base pairs.Type: ApplicationFiled: May 30, 2013Publication date: February 27, 2014Applicants: University of Washington Center for Commercialization, Baylor College of MedicineInventors: Lynn E. Zechiedrich, Jonathan Fogg, Daniel James Catanese, JR., Erol Bakkalbasi, Nancy Maizel, Olivier Humbert
-
Patent number: 8611189Abstract: A water pillow for coupling acoustic energy into tissue. The pillow is configured to conform to a transducer to facilitate coupling of ultrasound energy. The pillow includes a pouch that accommodates the transducer to enable a snug fit between the pillow and the transducer. The pillow includes a liquid inlet and outlet to facilitate liquid circulation for cooling, is biocompatible, has a low attenuation, is conformal to the shape of the transducer, facilitates use of an adjustable pressure to achieve various standoffs, includes an integral pouch to facilitate an interference fit to the transducer, facilitates water circulation for cooling, is sterilizable, and is disposable. Either the surface of the pillow adapted to conform to a tissue interface, or the surface of the pillow adapted to conform to the transducer, or both, can include pores configured to weep liquid to facilitate acoustic coupling of the pillow with the transducer and/or tissue.Type: GrantFiled: September 16, 2005Date of Patent: December 17, 2013Assignee: University of Washington Center for CommercializationInventors: Shahram Vaezy, Thuc Nghi Nguyen, Vesna Zderic, Jessica Foley
-
Publication number: 20130269782Abstract: A hybrid organic-inorganic thin film is provided. The hybrid organic-inorganic thin film comprising: an organic-phase comprising a porous organic nanostructure comprised of an interpenetrating network having at least one dimension between 0.1 and 100 nm; and an inorganic phase at least partially distributed within the porosity of the organic phase. In a first aspect, the organic phase has a first band gap and the inorganic phase has a second band gap different from the first band gap. A method of producing an organic-inorganic energy harvesting device and a device therefrom comprising the hybrid organic-inorganic thin film is provided.Type: ApplicationFiled: March 14, 2013Publication date: October 17, 2013Applicants: UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION, THE BOEING COMPANYInventors: Marvi A. Matos, Alpana N. Ranade, Danilo C. Pozzo
-
Patent number: 8545820Abstract: Compositions containing metal ions bound into a titanate are described which have demonstrated an ability to suppress bacterial growth of a number of organisms associated with periodontal disease and caries.Type: GrantFiled: July 14, 2011Date of Patent: October 1, 2013Assignees: Savannah River Nuclear Solutions, LLC, University of Washington Center for CommercializationInventors: David T. Hobbs, Mark C. Elvington, John Wataha, Whasun O. Chung, R. Bruce Rutherford, Daniel C. Chan
-
Publication number: 20130109012Abstract: The present technology relates generally to devices to expose cells to fluid shear forces and associated systems and methods. In particular, several embodiments are directed toward devices to expose cells to fluid shear forces in order to measure changes in internal cell forces. In some embodiments, a fluidic device includes a flow unit configured to induce fluid flow through the device. The device further includes a fluid channel configured to accept a biological sample dispersed on an array of flexible structures. The flow unit can be configured to induce disturbed and/or laminar flow in the fluid channel. The device can further include optical or magnetic detection means configured to measure a degree of deflection of one or more flexible structures in the array.Type: ApplicationFiled: October 29, 2012Publication date: May 2, 2013Applicant: University of Washington Center for CommercializationInventor: University of Washington Center for Commercializ
-
Patent number: 8381672Abstract: Systems and methods for compensating for compressibility and thermal expansion coefficient mismatch in buoyancy controlled or buoyancy-driven underwater vehicles are disclosed herein. An underwater vehicle configured in accordance with one embodiment of the disclosure, for example, can include a hull and a compartment carried by the hull and at least partially flooded with a first liquid having similar properties as a surrounding liquid into which the hull is configured to be deployed. The first liquid has a first compressibility and thermal expansion coefficient. The underwater vehicle can further include a compressibility and thermal expansion coefficient compensation system comprising a container filled or at least partially filled with a compressible liquid comprising silicone in the compartment. The compressible liquid has a second compressibility higher than the first compressibility and second thermal expansion coefficient higher than the first thermal expansion coefficient.Type: GrantFiled: June 2, 2010Date of Patent: February 26, 2013Assignee: University of Washington Center for CommercializationInventor: Charles C. Eriksen
-
Patent number: 8349761Abstract: A catalyst material for use at elevated temperatures is provided. The material can include a plurality of fibers and a plurality of particles supported on the fibers. In addition, a porous layer can cover the plurality of particles and allow for process fluid to come into contact with the particles, and yet retard sintering of the particles at elevated temperatures is present. The plurality of fibers can be a plurality of nanofibers which may or may not be oxide nanofibers. The particles can be metallic nanoparticles and the porous layer can be a porous oxide layer.Type: GrantFiled: July 27, 2010Date of Patent: January 8, 2013Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., University of Washington Center for Commercialization, Washington UniversityInventors: Younan Xia, Charles Taylor Campbell, Yunqian Dai, Byungkwon Lim, Benjamin Alan Grayson, Paul T. Fanson