Abstract: Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). Indirubin derivatives (IRDs) potently reduce the viabilities of various cancer cells and affect kinase activities. IRDs disclosed herein provide new therapeutics for cancer and conditions regulated by the kinase activities.

Abstract: The present invention relates to the discovery of a high titer hybrid-virus vector that gives rise to high titer virus like vesicles (VLVs) that can be used as a vaccine. The invention includes compositions and methods of generating an evolved hybrid-virus vector vaccine and selecting high titer VLVs, methods of treating and/or preventing or immunizing against, a specific disease or disorder, and methods of inducing a memory T cell and B cell immune response in a subject administered the VLV composition produced thereby. Furthermore, the invention encompasses a pharmaceutical composition for vaccinating a subject as well as a high titer protein expression system.

Abstract: A smart beverage container may be used to monitor user hydration. The container has at least one sensor for sensing an amount of liquid within the container. The liquid is monitored over time to determine an amount of liquid consumed by a user, and feedback is provided to the user indicating whether the user's liquid consumption is within a desired range according to a predefined profile of consumption. Such feedback may include information for indicating when the user is to consume additional liquid in order to remain in compliance with a desired liquid consumption regimen, as well as reminders to take additional liquid or warn the user if too much liquid had been consumed.

Abstract: A biological information measuring apparatus includes a radiation emitting unit configured to emit radiation to a subject, a biomagnetic field detector configured to detect a biomagnetic field on the subject, and a radiation sensitive material having sensitivity to the radiation, having enough size for enabling radiography of an examination target of the subject, and being nonmagnetic. The radiation sensitive material is arranged between an examination region where the examination target of the subject is to be positioned and the biomagnetic field detector.

Abstract: In some embodiments, a method of ameliorating diastolic dysfunction may include positioning at least a distal end of a system for cutting a trabeculae carneae in a left ventricle of a human heart. The system may include an elongated member, a grip, an engaging portion, and a cutting device. A second end of the engaging portion may turn in upon the engaging portion towards a first end of the engaging portion while still allowing trabeculae carneae to enter through an opening between the first and second ends. The cutting device may be positioned within an inner diameter of the engaging portion. The method may include positioning at least one trabeculae carneae in the inner diameter of the engaging portion. The method may include severing the at least one trabeculae carneae. The method may include increasing left ventricular compliance of the human heart.

Abstract: The present invention provides a method of hydraulically fracturing a well penetrating an subterranean formation by optimizing the spacing of fractures along a wellbore to form a complex network of hydraulically connected fractures by identifying a deviated wellbore in a subterranean formation; introducing a series of fractures in the deviated wellbore, wherein the series of fractures comprising at least a first fracture, a second fracture, a third fracture and a fourth fracture each separated by a non-uniformed and an increased spacing distance such that the spacing distance from each adjacent fracture in the series of fractures is at an increased distance; and forming one or more complex fractures extending from the series of fractures to form a complex fracture network.

Abstract: The present invention relates to diagnostic methods, reagents, and kits for detecting and diagnosing Early Stage Parkinson's disease.

Abstract: A emitter is formed of a thin-film membrane disposed within a cavity so as to provide a output beam. The emitter may be configured to obtain broadband light. The emitter may enhance the emissivity of light over a broad spectral band.

Abstract: A transparent luminescent solar concentrator is provided. In another aspect, a luminescent solar concentrator absorbs outside of visible light and emits outside of visible light. A further aspect of a luminescent solar concentrator employs nanocrystal clusters embedded in a polymeric matrix. In still another aspect, a unique ligand and luminophore host pairing is used for a solar concentrator.

Abstract: The dielectric barrier discharge ionization detector includes: a dielectric tube through which a plasma generation gas is passed; a high-voltage electrode formed on the outer wall of the dielectric tube; two ground electrodes and formed on the outer wall of the dielectric tube, with the high-voltage electrode in between; a voltage supplier for applying AC voltage between the high-voltage electrode and each ground electrode to generate electric discharge within the dielectric tube and thereby generate plasma from the plasma generation gas; and a charge-collecting section for detecting an ion current formed by ionized sample-component gas produced by the plasma. The distance between one ground electrode and the high-voltage electrode is longer than a discharge initiation distance between these two electrodes, while the distance between the other ground electrode and the high-voltage electrode is shorter than the discharge initiation distance between these two electrodes.

Abstract: A CO2 adsorbent that includes MIL-100(Fe) and various amounts of carbon nanotubes that are dispersed therein, and a method of capturing CO2 with a CO2 adsorbent that includes an adsorbent matrix of a zeolite and/or a metal organic framework and carbon nanotubes that are dispersed within the adsorbent matrix. Various embodiments of the CO2 adsorbent and the method of capturing CO2 are also provided.

Abstract: The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.

Abstract: A suspension system for a vehicle may include a knuckle rotatably supporting a wheel and a plurality of arms connecting the knuckle with a vehicle body wherein an arm among the plurality of arms may be a virtual link formed by a virtual link module and a point at which the virtual link applies a constraint force to the knuckle may be formed at a virtual space.

Abstract: A method and apparatus for equalization in a communication system. The method includes receiving an input of a block of symbols, filtering the input in the frequency domain, calculating an error factor in the time domain based on the filtered input, updating tap weights of the equalizer in the frequency domain using circular correlation based on the error factor and the conjugate of the input in the frequency domain, and outputting the filtered input.

Abstract: A two-step switching method of circuit switch can be used in a charge pump circuit of a phase locked loop circuit. In the method, a first type switch and a second type switch which have the same sizes and are opposite in type, are provided. The first type switch and second type switch continuously receive an input current, and the input current is kept at a low current state in a first stage before the first type switch and the second type switch are turned on. In a second stage, the first type switch and the second type switch are turned on, the input current is gradually adjusted to a target current state, and the input current of the target current state is gradually supplied to an external circuit. The present method can reduce noise generated by the external circuit, reduce power loss, and offset charge injection.

Abstract: A modular planar interconnect device for a solid oxide fuel cell includes a planar interconnect body, a pair of upper shielding plates, and a pair of lower shielding plates. The upper shielding plates are configured to be respectively fitted between front and rear boundary wall surfaces of a first inlet region of the planar interconnect body and between front and rear boundary wall surfaces of a first outlet region of the planar interconnect body. The lower shielding plates are configured to be respectively fitted between right and left boundary wall surfaces of a second inlet region of the planar interconnect body and between right and left boundary wall surfaces of a second outlet region of the planar interconnect body.

Abstract: A method of localizing portable apparatus (200) obtains: a stored experience data set comprising a set of connected nodes; captured location representation data provided by at least one sensor associated with the portable apparatus, and a current pose estimate of the portable apparatus within the environment. The pose estimate is used to select a candidate set of the nodes that contain a potential match for the captured location representation data. The pose estimate is used to obtain a set of paths from path memory data, each said path comprising a set of said nodes previously traversed in the environment under similar environmental/visual conditions. The set of paths is used to refine the candidate set. The captured location representation data and the refined candidate set of nodes is compared in order to identify a current pose of the portable apparatus within the environment.

Abstract: Methods, systems, and devices are disclosed for implementing magnetoencephalography (MEG) source imaging. In one aspect, a method includes determining a covariance matrix based on sensor signal data in the time domain or frequency domain, the sensor signal data representing magnetic-field signals emitted by a brain of a subject and detected by MEG sensors in a sensor array surrounding the brain, defining a source grid containing source locations within the brain that generate magnetic signals, the source locations having a particular resolution, in which a number of source locations is greater than a number of sensors in the sensor array, and generating a source value of signal power for each location in the source grid by fitting the selected sensor covariance matrix, in which the covariance matrix is time-independent based on time or frequency information of the sensor signal data.

Abstract: Systems and methods for asset monitoring utilize a network, one or more data servers, one or more asset-monitoring modules, and one or more beacon modules to monitor assets deployed across a facility. The systems and methods are asset-agnostic and are able to provide statistical forecasts and degradation model for each asset monitored. The systems and methods may further apply real-time regression, including Bayesian updating techniques to provide real-time corrections to forecasts and degradation models.

Abstract: The measuring cup includes numerous embodiments configured for a user to precisely determine the cup contents without need to lift the cup to one's eye level or to lower the eye level to the level of the cup contents. The various embodiments include folding cups; cups having transparent passages in the wall; cups having adjustably positionable bottoms; cups having level indicator rods in the cup interior extending upward from the cup bottom; cups having one or more filaments extending across the cup interior; cups having rigid level indicators spanning the cup interior; cups having adjustably positionable level indicator tabs therein; cups having buoyant level indicator tabs adjustably positionable in the cup interior; and cups having removable clip-on scales extending down along the interior of the cup wall, the scales having a plurality of attachment points for the removable attachment of a level indicator tab at a desired attachment point.