Abstract: The present invention relates to a method for the real-time identification of seizures in an Electroencephalogram (EEG) signal. The method provides for patient-independent seizure identification by use of a multi-patient trained generic Support Vector Machine (SVM) classifier. The SVM classifier is operates on a large feature vector combining features from a wide variety of signal processing and analysis techniques. The method operates sufficiently accurately to be suitable for use in a clinical environment. The method may also be combined with additional classifiers, such a Gaussian Mixture Model (GMM) classifier, for improved robustness, and one or more dynamic classifiers such as an SVM using sequential kernels for improved temporal analysis of the EEG signal.

Abstract: An optical circuit breaker includes a main optical transmission path including an optical coupler, a delay line and a protection device, and a parallel protection path configured to receive a tapped portion of a signal provided to the main optical transmission path and generate a reference signal based on the tapped portion. The protection device may be configured to be triggered to prevent an overpower condition from passing through the optical circuit breaker responsive to the reference signal exceeding a user selectable threshold. The delay line may be configured to have a longer delay than a time it takes for the protection device to be triggered via the parallel protection path.

Abstract: A method for multi-user CAx editing includes monitoring an operational state of a processor of a first CAx client, receiving, at a communication filter of the first CAx client, a first remote operation to be executed by the first CAx client in a CAx environment, populating the first remote operation to a queue formed in a memory structure in response to a determination that the operational state of the processor of the first CAx client is executing a local operation when the first remote operation is received, and executing the first remote operation in the CAx environment on the first CAx client in response to a determination that the operational state of the processor of the first CAx client is idle. A computer program product such as a computer readable medium and a computer system corresponding to the above method are also disclosed herein.

Abstract: A method for creating a nanostructure surface, comprises creating a nanostructure master having a surface being the negative of a shape that, when illuminated with a predefined illumination, provides a unique optical pattern; and creating nanostructure molds from the nanostructure master, wherein each nanostructure mold has a negative of the master surface which, when illuminated with the predefined illumination, provides the unique optical pattern, which may be a hologram. A nanotag may incorporate an image for identification and a unique pattern that can be identified for authentication.

Abstract: Generalized transfer functions are available to mathematically derive the more relevant central blood pressure waveform from a more easily measured radial blood pressure waveform. However, these transfer functions are population averages and therefore may not adapt well to variations in pulse pressure amplification (ratio of radial to central pulse pressure). An adaptive transfer function was developed. First, the transfer function is represented in terms of the wave travel time and wave reflection coefficient parameters of an arterial model. Then, the model parameters are estimated from only the radial blood pressure waveform by exploiting the frequent observation that central blood pressure waveforms exhibit exponential diastolic decays.

Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.

Abstract: An energy storage-combined cooling, heating and power (S-CCHP) system for a building receives energy from a source, for example an intermittent source, and stores the energy in first and second high temperature energy storage (HTES) units. A Brayton cycle using the first HTES unit produces hot and pressurized air that is further heated in the second HTES unit. The heated air drives a turbine to generate electricity for the building. A portion of the compressed air from the Brayton cycle is diverted to a hot water heat exchanger, then to another turbine to produce electricity to the building. The hot water heat exchanger heats water for the building and the other turbine exhaust cools water for building cooling. Heat exchangers are strategically placed to optimize the thermal efficiency of the cycle. In some embodiments the heat transfer fluid is humidified to improve thermal energy transfer properties.

Abstract: This invention provides a process for sequencing single-stranded DNA or RNA by employing a nanopore and modified nucleotides.

Abstract: The present invention provides methods for treating or alleviating one or more symptoms of depression and/or anxiety in a subject comprising administering an effective amount of an NCAM peptide mimetic to the subject. The symptoms of depression and/or anxiety are typically observed in or associated with a neurological condition. The present invention also provides methods for treating a neurological condition such as a psychiatric disorder in a subject comprising administering an effective amount of an NCAM peptide mimetic to the subject.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.

Abstract: A pulsed beam of NIR excitation light is projected into a sample (345) at an oblique angle and scanned by a scanning element through a volume in the sample. 2-photon excitation excites fluorescence within the sample. The fluorescence is imaged onto an intermediate image plane that remains stationary regardless of the orientation of the scanning element. The image is captured by a linear array of light detecting elements (392) or a linear portion of a rectangular array. At any given position of the scanning element, the linear array (or portion) images all depths simultaneously. A plurality of images are captured for each of a plurality of different orientations of the scanning element. The orientation of the scanning element is controlled to move in a two dimensional pattern, which causes the beam of excitation light to sweep out a three dimensional volume within the sample.

Abstract: Ferromagnetic materials are disclosed that comprise at least one Dirac half metal material. In addition, Dirac half metal materials are disclosed, wherein the material comprises a plurality of massless Dirac electrons. In addition, ferromagnetic materials are disclosed that includes at least one Dirac half metal material, wherein the material comprises a plurality of massless Dirac electrons, wherein the material exhibits 100% spin polarization, and wherein the plurality of electrons exhibit ultrahigh mobility. Spintronic devices and heterostructures are also disclosed that include a Dirac half metal material.

Abstract: Described herein is a chelator for radiolabels (e.g., 89Zr) for targeted PET imaging that is an alternative to DFO. In certain embodiments, the chelator for 89Zr is the ligand, 3,4,3-(LI-1,2-HOPO) (“HOPO”), which exhibits equal or superior stability compared to DFO in chemical and biological assays across a period of several days in vivo. As shown in FIG. 1, the HOPO is an octadentate chelator that stabilizes chelation of radiolabels (e.g., 89Zr). A bifunctional ligand comprising p-SCN-Bn-HOPO is shown in FIG. 4 and FIG. 5. Such a bifunctional ligand can eliminate (e.g., 89Zr) loss from the chelate in vivo and reduce uptake in bone and non-target tissue. Therefore, the bifunctional HOPO ligand can facilitate safer and improved PET imaging with radiolabeled antibodies.

Abstract: The present application discloses a terahertz based self-feedback system for detecting atmospheric high-risk chemical. In the system, a detecting device is configured to detect information of an atmospheric high-risk chemical. A mechanical adjusting device is configured to adjust a height and an orientation of the detecting device to obtain the information at different heights and orientations. A mobile carrying device is configured to drive the detecting device to move to obtain the information of the atmospheric high-risk chemical at different locations. A processing device is configured to process the information and feedback an instruction to adjust the height and the orientation of the detecting device and control the mobile carrying device to move. The processing device is also configured for imaging the information of the atmospheric high-risk chemical. The present application also discloses terahertz based methods for detecting a distribution and a leakage source of the atmospheric high-risk chemical.

Abstract: The invention provides kinase substrates and methods comprising their use.

Abstract: Interferon-?-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C—X—C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed.

Abstract: Disclosed herein is Brunner's Gland Stem/Progenitor Cells (BGSCs) having phenotypic traits of endodermal stem cells and positive for pluripotency markers, and methods of isolating them from the human duodenum. Moreover, the present disclosure provides that BGSCs are easily isolated from duodenum from human donors, can be expanded in culture or induced to differentiate towards hepatic and pancreatic lineages and could represent a cell source for clinical programs of regenerative medicine.

Abstract: A method for treating a microbial infection, especially pneumonia, comprising administering an aqueous-ethanol extract of Thymus or Boswellia or a composition containing the extract. Aqueous-ethanol extracts of Thymus and/or Boswellia.

Abstract: The present disclosure describes two click reactions to sequentially polymerize and then functionalize hydrogel microparticles to provide therapeutic agent-functionalized crosslinked hydrogel microparticles. The two click reactions have one common reactive group, and are non-interfering with respect to one another. The therapeutic agents can be released from the hydrogel microparticles over time as the hydrogel degrades, or the therapeutic agents can be released from the hydrogel microparticles by enzymatic degradation or hydrolysis. In some embodiments, the biological function of the therapeutic agents can be preserved or enhanced when covalently bound to the hydrogel microparticles. The present disclosure also provides methods for the production of hydrogel cell culture substrates. The methods overcome the hurdle of protein functionalization through the implementation of an advanced but simple chemical strategy that involves modifying a protein of interest with chemical groups (e.g.

Abstract: Disclosed embodiments concern a composition comprising a diatom frustule and two or more photocatalytic nanoparticles dispersed on the surface of the frustule. Also disclosed are embodiments of a method for making the composition. The nanoparticles are dispersed such that they are separate and not in physical contact with each other. An average distance between the nanoparticles may be from greater than 0 nm to 100 nm. The nanoparticles may comprise a dopant material. Paint compositions comprising the diatom frustule compositions are also contemplated. The diatom frustule composition may be useful for removing and/or degrading volatile organic compounds, such as those present in the atmosphere.