Abstract: A variable gain amplifier utilizing positive feedback and time-domain calibration includes an integration phase and a regeneration phase. A current source provides a bias current that increases linearity in the integration phase and reduces common-mode voltage dependence. The circuit includes a timing control loop, wherein a variable gain of a residue amplifier is proportional to a first time that a timing control loop signal is kept high, as determined by an on or off status of respectively paired inverter assemblies each having an input voltage determined by an amplifier output voltage during the regeneration phase. A strong-arm latch structure acts as a positive feedback latch until the first time is de-asserted.

Abstract: A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.

Abstract: An electrochromic device comprises (i) a conductive layer, (ii) an electrochromic material, on the conductive layer, (iii) an electrolyte, on the electrochromic material, and (iv) a counter-electrode, on the electrolyte. The conductive layer has a surface roughness factor (SRF) of at least 10, and the conductive layer comprises a semi-metal.

Abstract: A method of treating heart failure in a patient is disclosed that includes implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, and activating the device to deliver electrical stimulation to the spinal cord.

Abstract: Briefly, the present disclosure relates to a nanocomposite thermoelectric energy converter comprising a composite thin film inorganic semiconductor having carbonized polymer nano-clusters and the net of polymer nano-fibers included within. The carbonized polymer nano-clusters and nano-fibers improve the thermoelectric figure of merit ZT by increasing electrical conductivity and decreasing thermal conductivity. The converter may be fabricated by a dual beam pulsed laser deposition process. A first laser beam evaporates a target comprising the materials of the inorganic semiconductor. A second laser beam evaporates the polymer using a matrix assisted target for depositing the polymer concurrently with the semiconductor deposition to yield the composite film. The lasers may be separately controlled to determine the resulting composition. The converter may be deposited on rigid or flexible substrates for a wide range of applications.

Abstract: A time-based decision feedback equalizer (TB-DFE) circuit may include a voltage-to-time converter configured to convert a communication signal into a time-based signal. A timing of when an edge of the time-based signal occurs is indicative of a voltage level of the communication signal. The circuit may include a plurality of delay circuits arranged to process the time-based signal in series to generate a delay data signal. The delay circuits may adjust the timing of when the edge of the time-based signal occurs, and a corresponding time delay introduced by each of the delay circuits may be based on a respective weighting factor applied to one or more samples of an output digital signal previously generated by the TB-DFE circuit. A phase detector may compare a timing of an edge of the delay data signal with a reference clock signal and generate the output digital signal based on the comparison.

Abstract: Carbon nanotube membranes that are flexible, non-fragile, stable at high temperatures, superhydrophobic, have submicrometer openings, and are resistant to delamination and corrosive conditions are provided. The carbon nanotube membranes comprise carbon nanotubes grown on a microporous, metal substrate, e.g. silver, quartz fiber filter, and HAST. Methods of fabricating the carbon nanotubes are also provided.

Abstract: The present invention provides a gas-liquid separator/connector having three concentric tube device made such that flow of fluids from a ESP enters the bottom and are diverted into the largest of the three concentric tubes located as the outside tube. The relatively large space between the inside tube and the outside tube allows for the gas to separate from the liquid. The gas continues to rise to the surface in the tubing-casing annulus. The liquid now can enter by gravity the third tube that is placed outside the inner tube (the tubing) and the large external tube. This third concentric tube is not as long as the large outer tube and is connected at the bottom to become the entrance to the pump intake for the beam pump or PCP. The pump intake for the beam pump or PCP is a part of the smallest inner tube of the connector.

Abstract: Systems and methods for monitoring rotating machinery are disclosed. Transmitter and receiver antennas can be provided with access to the rotating machinery. At least one receiver signal resulting from at least one transmitter signal that has propagated through a portion of the rotating machinery can be obtained. A first signal pair can be formed from a first receiver signal and a first transmitter signal, or from first and second receiver signals obtained from spatially-separated receiver antennas, or from first and second receiver signals which are attributable to different transmitter signals. Amplitude and phase information of a plurality of frequency components for each signal in the first signal pair can be determined. A set of comparison values for the first signal pair can be determined by comparing respective frequency component phases or respective frequency component amplitudes. A characteristic of the rotating machinery can then be analyzed using the comparison values.

Abstract: A transparent emissive device is provided. The device may include one or more OLEDs having an anode, a cathode, and an organic emissive layer disposed between the anode and the cathode. In some configurations, the OLEDs may be non-transparent. The device may also include one or more locally transparent regions, which, in combination with the non-transparent OLEDs, provides an overall device transparency of 5% or more.

Abstract: A series of fluorine-containing bisphosphonic acids in which an alkylamine side chain is added, a series of fluorine-containing bisphosphonic acids in which an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom is added, to the carbon atom of P—C(F)—P, and a series of fluorine-containing bisphosphonate derivatives in which the acid moiety thereof is esterified by an alkoxymethyl group such as POM group, n-butanoyloxymethyl (BuOM) group and the like, that is, the fluorine-containing bisphosphonic acid and fluorine-containing bisphosphonate derivative represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, can efficiently induce proliferation of peripheral blood ?? T cells that express V?2V?2 T cell receptor having superior cytotoxicity against tumor cells and virus infected cells, immunize tumor cells and virus infected cells, and can induce cytotoxicity by ?? T cells.

Abstract: The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels.

Abstract: Micro-windmills, micro-systems including micro-windmills, and methods of forming the same are described. The micro-systems with a micro-windmill are configured to withstand wind pressures and environmental conditions and can be used for various applications.

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.

Abstract: The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique gene expression profiles in children with regressive autism spectrum disorder (ASD) and ileocolitis.

Abstract: A method of providing an image Completely Automatic Public Turing test to tell Computers and Humans Apart (CAPTCHA), and a server thereof. The method includes: outputting an image CAPTCHA including a plurality of images including a determination object image; receiving an image selection from the image CAPTCHA; determining whether a test of the image CAPTCHA is passed, based on the received image selection; and determining what the determination object image means. The images include a first group of images used to determine whether an accessing party passes the image CAPTCHA test and a second group of images unused to determine whether the accessing party passes the image CAPTCHA test. The second group includes the determination object image. The determining of the pass of the image CAPTCHA test is performed by selecting an image representing a correct or incorrect answer from the first group.

Abstract: Disclosed herein are lithographic systems and methods. For example, disclosed herein are methods comprising illuminating a first location of a plasmonic substrate with electromagnetic radiation; wherein the electromagnetic radiation comprises a wavelength that overlaps with at least a portion of the plasmon resonance energy of the plasmonic substrate; and wherein the plasmonic substrate is in thermal contact with a liquid sample comprising a plurality of particles; thereby: generating a bubble at a location in the liquid sample proximate to the first location of the plasmonic substrate, the bubble having a gas-liquid interface with the liquid sample; trapping at least a portion of the plurality of particles at the gas-liquid interface of the bubble and the liquid sample; and depositing at least a portion of the plurality of particles on the plasmonic substrate at the first location.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: A process for producing a metal foam. The process includes mechanically working a metallic powder such that oxide particles are finely dispersed within a metallic matrix of the metallic particles that make up the metallic powder. The mechanically worked metallic powder is then annealed in a reducing atmosphere, which in turn reduces the oxide particles within the metallic particles such that H2O gas molecules (steam) are formed within the metallic matrix and intraparticle porosity is produced.

Abstract: Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.