Abstract: The present invention provides for dominant negative mutations of Arabidopsis REDUCING WALL ACETYLATION (RWA).

Abstract: Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may contain a fluorophore or may be conjugated to a fluorophore in order to prepare a fluorescent probe for use in high throughput screening methods to identify new modulators of glucocerebrosidase activity via fluorescence polarization.

Abstract: Embodiments of the invention leverage mobile proliferation to enable laypersons to initiate a timely and effective emergency response in case of an emergency, such as a medical emergency, e.g., cardiac event. Mobile apps are made available as part of an organization's overall response plan and program, allowing bystanders of emergency events to easily initiate notification of trained responders, for example in their facility, in a timely manner commensurate with the type of emergency specific to their facility. More particularly, embodiments of the invention use mobile applications to alert certified first trainees to respond to the scene of the emergency.

Abstract: The present invention provides for a genetically modified host cell comprising a 2-pyrrolidone synthase, or an enzymatically active fragment thereof, heterologous to the host cell.

Abstract: Methods of producing particles of fiber and resin from fiber-resin composite materials are disclosed. The particles may be combined with a resin system and optionally combined with fillers, binders or reinforcements to produce new cured solid composite products.

Abstract: The presently disclosed subject matter relates to enhanced dry-cooling systems and methods. More specifically, the presently disclosed subject matter relates to enhanced dry-cooling systems for increasing power plant efficiency and output. One embodiment of the present disclosure is directed to dry-cooling system for increasing power plant efficiency and output. The dry-cooling system comprises an air-cooled condenser and an air cooling system in fluid communication with the air-cooled condenser.

Abstract: Described herein is a continuous process for modifying the properties of polyester and polyester based fibers, such as a poly(butylene terephthalate) (PBT) fiber, comprising subjecting the PBT fiber to alkaline hydrolysis, and optionally further comprising functionalizing the PBT fiber by solution grafting such as fluorination. The alkaline hydrolysis and optionally subsequent functionalization such as fluorination process can be continuous, following the melt blowing/spinning or spun-bonding process. Also described is a nonwoven PBT fiber mat obtained by the surface modification process. Further described is a filtration device comprising the nonwoven PBT fiber mat.

Abstract: Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.

Abstract: The present invention relates to miR145, miR132, miR212, and the genes or gene products regulated by these miRNAs. miR145 is downregulated in cells infected with HCMV. This downregulation modulates expression of miR145 target genes, including IRS-1. Transfection of cells with a miR145 agent, such as a miR145 mimetic, reduces HCMV replication and protein expression. miR132 and miR212 are upregulated in cells infected with HCMV. This upregulation modulates expression of miR132 and miR212 target genes, including MeCP2 and RICS. Transfection of cells with a miR132 and/or a miR212 antagonist reduces HCMV replication and protein expression. Accordingly, the invention provides methods of attenuating HCMV replication by modulating, for example, miR145, miR132, and/or miR212, and targets thereof. Also provided are methods of detecting an HCMV infection, and compositions and kits useful for attenuating HCMV replication.

Abstract: Disclosed is a use of the Chinese medicine composition and Dianxianning in the preparation of a medicament for preventing or treating Alzheimer's disease. As indicated by the experiments, the Chinese medicine composition and Dianxianning have a significant inhibiting effect on palsy phenotype in pathological models of animals with Alzheimer's disease, and this indicates that the Chinese medicine composition and Dianxianning can be used to prevent or treat Alzheimer's disease.

Abstract: A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.

Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.

Abstract: Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port defined from an exterior of the base to each of the wells, each fluid port being spaced above the base sheet by a distance sufficient to introduce a material above a matrix deposited on the base sheet in the wells; and a cover having a pair of spaced apart well covering portions that are each disposed above a respective one of the one spaced apart wells of the base body when the cover is covering the upper surface of the base body and having a gas passage defined between the spaced apart well covering portions and at least one gas port defined from an exterior of the cover to each of the well covering portions.

Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.

Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Abstract: The various embodiments herein provide a Uniform Circular Displaced Sensor Array (UC-DSA) system and method for measuring/estimating Direction of Arrival (DOA) of a wireless signal. The UC-DSA system comprises at least a set of two circular antenna arrays. The two circular antenna arrays have a number of elements. A Radio frequency (RF) receiver captures a wireless signal incident on a circular antenna array. A Direction of Arrival (DOA) estimator processes a received input signal and a Triangulation system provides the exact location of the source of the wireless signal. The two circular antenna arrays with the same number of elements are placed on different radii, and are shifted to have equal separation between inner elements and outer elements.

Abstract: An optical system is provided having a laser configured to generate light having a first laser spectrum with a first linewidth, a waveform generator configured to produce a noise waveform, and an electro-optic phase modulator in optical communication with the laser and in electrical communication with the waveform generator. The electro-optic phase modulator is configured to receive the light having the first laser spectrum, to receive the noise waveform, and to respond to the noise waveform by modulating the light to produce light having a second laser spectrum with a second linewidth broader than the first linewidth.

Abstract: The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to restore the stratum granulosum and stratum corneum and treat a dermatological disease, such as, for instance atopic dermatitis. More specifically it provides terpenes and terpenoids such as monoterpenoids, sesquiterpenes and norisoprenoids as ingredients that work to restore and thicken the stratum granulosum and stratum corneum and treat a dermatological disease. Terpenes and terpenoid compounds support the cell proliferation, cell differentiation, growth of skin, skin tissue and keratinocytes by upregulating genes for loricrin filaggrin, caspase 14, hornerin and other late cornified envelope components and vascular endothelial growth factor (VEGF) and downregulation of matrix metalloproteinases. Both terpenes and terpenoids may be applied topically or orally at oral or topical concentrations from about 0.

Abstract: A version of the invention comprises a device for controlling or interfacing with a computer or other form of communicable machine based on the pyroelectric effect, and includes at least one optically- and infrared- (IR-) transparent graphene electrode.

Abstract: The present disclosure provides a device for evaluating a mechanical property of a material. The device comprises a sensing layer that has a contact surface for contacting a surface area of the material. The sensing layer has a property or dimension that is pressure sensitive. The device also comprises a detector arranged to detect electromagnetic radiation that propagates through at least the sensing layer. The device is arranged such that, when the contact surface of the sensing layer is in contact with the surface area of the material and a load is applied on at least a portion of the surface area of the material, the detected electromagnetic radiation can be used to determine stress within a portion of the sensing layer, the determined stress being indicative of the mechanical property of the material.