Abstract: A neutron imaging system, including: a plurality of Li-III-VI2 semiconductor crystals arranged in an array, wherein III represents a Group III element and VI represents a Group VI element; and electronics operable for detecting and a charge in each of the plurality of crystals in the presence of neutrons and for imaging the neutrons. Each of the crystals is formed by: melting the Group III element; adding the Li to the melted Group III element at a rate that allows the Li and Group III element to react, thereby providing a single phase Li-III compound; and adding the Group VI element to the single phase Li-III compound and heating. Optionally, each of the crystals is also formed by doping with a Group IV element activator.
Type:
Grant
Filed:
March 31, 2014
Date of Patent:
April 25, 2017
Assignees:
Consolidates Nuclear Security, LLC, Fisk University
Abstract: An axial flow blood pump comprises: an impeller (2) that rotates around an axis and is provided with axial flow blades on the peripheral surface thereof, a permanent magnet inside the impeller (2), and a dynamic bearing or a pivot bearing; a first casing (5) that surrounds the peripheral surface of the impeller (2) and is provided with an intake port (11); an annular fixed element (6) that generates a rotating magnetic field in the impeller (2) and can be fitted onto the outer surface of the first casing (5); an outlet port (12); a second casing (3) that is provided with guide vanes (diffusers) (31) in the inner surface thereof; and a socket member (4) that is fittably and securely mounted onto the outer peripheral surface of the second casing (3) and is provided with a joining portion that can join with the fixed element (6).
Type:
Grant
Filed:
December 26, 2013
Date of Patent:
April 25, 2017
Assignee:
National University Corporation Kobe University
Abstract: Methods and apparatus are provided for beamforming and information feedback are provided. Signals for beams to be transmitted through corresponding antenna ports, are generated. The beams are formed by precoding the signals with beamforming vectors. The beams are sorted into a number of resource reuse groups based on a resource that is to be shared. The beams are transmitted, using resources allocated per group, to a receiver. Feedback information is generated on at least one antenna port, based on the received beams. The feedback information is transmitted to the transmitter. A beam is selected having a greatest gain for a transmitter using the feedback information. A transmission resource is allocated for the selected beam.
Type:
Grant
Filed:
December 27, 2012
Date of Patent:
April 25, 2017
Assignees:
Samsung Electronics Co., Ltd, Industry-Academic Cooperation Foundation, Korean National University of Transportation
Inventors:
Hyojin Lee, Cheol Mun, Kiil Kim, Younsun Kim, Juho Lee, Joonyoung Cho
Abstract: Compositions comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with one or more of CTACK protein, TECK protein, MEC protein and functional fragments thereof and/or an isolated nucleic acid molecule that encodes a protein selected from the group consisting of: CTACK, TECK, MEC and functional fragments thereof are disclosed. Methods of inducing an immune response, including methods of inducing mucosal immune responses, in an individual against an immunogen, using such compositions are disclosed.
Type:
Grant
Filed:
October 28, 2011
Date of Patent:
April 25, 2017
Assignee:
The Trustees of the University of Pennsylvania
Abstract: Substituted indole derivatives of formula (I) wherein the radicals have e.g. the following meaning: R1 is hydrogen, —C1-6-alkyl, R2 is hydrogen, —C1-6-alkyl or cycloC3-12-alkyl; R3 is —OR R4 is hydrogen or halogen, R5 is hydrogen, —C1-6-alkyl R6 is hydrogen, —C1-6-alkyl R is hydrogen or —C1-6-alkyl; X is a group —C(O)CH2— or —CH?CH—; R7 is hydrogen are potent inhibitors of Abeta peptide polymerization and can be used for the treatment of e.g. Alzheimers disease or ocular disorders.
Abstract: Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus contains an added or substituted component that improves (1) the peptide's binding affinity to C3 or its fragments, (2) the peptide's solubility in aqueous liquids, (3) the peptide's plasma stability, (4) the peptide's in vivo retention and/or (5) the peptide's bioavailability, as compared with an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed.
Type:
Grant
Filed:
September 7, 2012
Date of Patent:
April 25, 2017
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
John D. Lambris, Hongchang Qu, Daniel Ricklin
Abstract: Novel organic compounds comprising ligands with deuterium substitution are provided. In particular, the compound is an iridium complex comprising methyl-d3 substituted ligands. The compounds may be used in organic light emitting devices to provide devices having improved color, efficiency and lifetime.
Type:
Grant
Filed:
August 6, 2013
Date of Patent:
April 25, 2017
Assignee:
Universal Display Corporation
Inventors:
Chuanjun Xia, James Fiordeliso, Raymond Kwong
Abstract: Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosing dementia such as mild cognitive impairment and Alzheimer's disease.
Type:
Grant
Filed:
February 26, 2010
Date of Patent:
April 25, 2017
Assignee:
Emory University
Inventors:
Yevgeny E. Agichtein, Elizabeth A. Buffalo, Dmitry Lagun, Cecelia Manzanares, Stuart Zola
Abstract: Hypotonic formulations were evaluated for delivering water-soluble drugs and for drug delivery with muco-inert (that is, non-adhesive) mucus-penetrating nanoparticles (MPP). Hypotonic formulations markedly increased the rate at which drugs and MPP reached the epithelial surface, including deep into the vaginal folds. Minimally hypotonic formulations, preferably ranging from 20-220 mOsm/kg, provided rapid and uniform delivery of MPP to the entire vaginal surface, with minimal risk of epithelial toxicity. Data also show that there is a higher osmolality in the colon, such that vehicles with an osmolality above that of blood plasma (generally considered isotonic at ˜300 mOsm/kg), still lead to improvements in distribution in the colon due to rapid, osmotically-induced fluid absorption. The range for improved colon distribution with a hypotonic vehicle in the colon is ˜20 mOsm/kg-450 mOsm/kg.
Type:
Grant
Filed:
July 12, 2016
Date of Patent:
April 25, 2017
Assignee:
The Johns Hopkins University
Inventors:
Laura Ensign, Richard Cone, Justin Hanes
Abstract: This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.
Type:
Grant
Filed:
November 12, 2014
Date of Patent:
April 25, 2017
Assignees:
The Charles Stark Draper Laboratory, Inc., The University of South Florida
Inventors:
Anilkumar Harapanahalli Achyuta, Javier Cuevas, Shivshankar Sundaram, Chris Katnik
Abstract: Biomaterial compositions that include an isolated heparosan polymer are disclosed, as well as kits containing such biomaterial compositions and methods of producing and using such biomaterial compositions.
Type:
Grant
Filed:
October 22, 2013
Date of Patent:
April 25, 2017
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: The present invention relates to novel compounds for modulating US28 receptor activity and methods for their use in preventing or treating US28 receptor-mediated disorders or conditions.
Type:
Grant
Filed:
September 23, 2013
Date of Patent:
April 25, 2017
Assignees:
University of Central Florida Research Foundation, Inc., Friedrich Alexander University
Abstract: The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition.
Type:
Grant
Filed:
November 4, 2016
Date of Patent:
April 25, 2017
Assignee:
Yale University
Inventors:
Craig M. Crews, Hyun Seop Tae, Ashley R. Schneekloth, Taavi Neklesa, Thomas Sundberg
Abstract: A method for making carbon nanotube film includes providing a first patterned carbon nanotube array and a second patterned carbon nanotube array having a predetermined pattern including a rectangle, a first triangle, and a second triangle. A carbon nanotube film is pulled out from a vertex angle of the first triangle of the first patterned carbon nanotube array, until carbon nanotubes of the base side of the second triangle of the first patterned carbon nanotube array are pulled. A carbon nanotube film preform is pulled out from a vertex angle of the first triangle of the second patterned carbon nanotube array and connecting the carbon nanotube film preform to the base side of the second triangle of the first patterned carbon nanotube array. The carbon nanotube film is continuing pulled out.
Type:
Grant
Filed:
June 12, 2015
Date of Patent:
April 25, 2017
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Abstract: An apparatus and method for controlling a terminal is provided. A terminal control apparatus may set a virtual display space in an outer circumferential portion of the terminal and map at least one file to the virtual display space. Through this, a display region of the terminal may be expanded to an outer circumferential region of the terminal.
Type:
Grant
Filed:
March 26, 2010
Date of Patent:
April 25, 2017
Assignees:
Samsung Electronics Co., Ltd., Board of Trustees of the Leland Stanford Junior University
Inventors:
Joon Ah Park, Abhay Sukumaran, Katherine Murray, Won-Chul Bang, Clifford Nass, Sung Ho Park
Abstract: Certain embodiments of the invention provide a compound of formula (I): A-X—Y—Z—R1??(I), or a salt thereof, wherein A, X, Y, Z and R1 have any of the values defined in the specification, and methods of use thereof. For example, certain embodiments of the invention provide a method for inhibiting atherosclerosis or atherosclerotic development in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
September 8, 2015
Date of Patent:
April 25, 2017
Assignee:
Rutgers, The State University of New Jersey
Inventors:
Kathryn E. Uhrich, Prabhas Moghe, Dalia Abdelhamid, Li Gu, Yingyue Zhang
Abstract: A condensed cyclic compound is represented by Formula 1, and an organic light-emitting device includes the condensed cyclic compound. The organic light-emitting device includes a first electrode, a second electrode facing the first electrode, and an organic layer. The organic layer includes an emission layer and the condensed-cyclic compound.
Type:
Grant
Filed:
July 28, 2014
Date of Patent:
April 25, 2017
Assignees:
Samsung Display Co., Ltd., Pusan National University Industry—University Cooperation Foundation
Inventors:
Sung-Wook Kim, Myeong-Suk Kim, Jin-Soo Hwang, Sam-Il Kho, Hong-Suk Suh
Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.
Type:
Grant
Filed:
June 29, 2016
Date of Patent:
April 25, 2017
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ada Shuk Yan Poon, Alexander Jueshyan Yeh, Yuji Tanabe, John Ho, Sanghoek Kim
Abstract: A charge pump (CP) that operates at low input voltage with high power conversion efficiency is disclosed. A first embodiment provides a negative CP used for controlling load switches of a voltage doubler. Using a negative CP extends the operating region below ground to relieve the power delivery limitation of the CP. A second embodiment provides a low power adaptive dead-time circuit, which has several dead-time signals having different lengths of dead-times and selects one according to the input voltage level. A low input voltage detector in the adaptive dead-time circuit is used to determine which dead-time should be used. A third embodiment provides a switching body bias used for the low input voltage CP. The switching body bias uses both forward and reverse body bias applied to the CP to minimize reverse current and maximize power transfer. The first, second, and third embodiments can be used together or independently.
Type:
Grant
Filed:
February 5, 2015
Date of Patent:
April 25, 2017
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Jungmoon Kim, Kwok Tai Philip Mok, Chulwoo Kim
Abstract: A phased array RF coil module and an imaging apparatus using the same can receive a magnetic resonance signal generated from a target object at high receive sensitivity and improve a signal to noise ratio. The phased array RF coil module includes at least one first phased array RF coil unit generating a magnetic field having a component horizontal with the surface of a target object and a second phased array RF coil unit formed horizontally with the surface of the target object and generating a magnetic field having a component vertical to the surface of the target object. The imaging apparatus using the phased array RF coil module is a magnetic resonance imaging apparatus.
Type:
Grant
Filed:
October 30, 2013
Date of Patent:
April 25, 2017
Assignees:
Samsung Electronics Co., Ltd., University-Industry Cooperation Group of Kyung Hee University