Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.

Abstract: Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability.

Abstract: An electric power system or power grid is optimized using a computer-implemented tool the represents in computer memory the optimization function and at least one constraint, which the processor operates upon using a linear programming solver algorithm. The constraints are represented in memory as data structures that include both real and reactive power terms, corresponding to at least one of a power flow model and a transmission line model. The transmission line model is represented using a piecewise linear representation. The power flow model may also include for each node in the power system a real power loss term representing transmission line loss allocated to that node.

Abstract: A bidirectional DC-DC converter includes a series circuit of a first winding of a first reactor, a second reactor, and a first switch connected to both ends of a first DC power source, a series circuit of a second switch and a second DC power source connected to both ends of the first switch, a series circuit of a second winding of the first reactor, a third reactor, a first selector switch, and a first diode connected to both ends of a series circuit of the second reactor and the first switch, a series circuit of a second selector switch, a second diode, and the second DC power source connected to both ends of a series circuit of the first selector switch and first diode, and a controller turning on/off the switches and the selector switches.

Abstract: The present invention relates to a method for determining the presence of anti-Tr antibodies in a subject comprising the steps of obtaining a sample from said subject testing the presence of said antibodies in said sample by addition of DNER protein or an antigenic part thereof and checking whether said DNER protein is bound by any antibodies in said sample Such an assay is useful for the diagnosis of paraneoplastic cerebellar degeneration that is associated with Hodgkin lymphoma, or, more generally, to type patients suffering from cerebellar ataxia. Also comprised in the invention is a kit for performing such an assay.

Abstract: Various embodiments of the present disclosure pertain to nanocomposites for detecting hydrocarbons in a geological structure. In some embodiments, the nanocomposites include: a core particle; a polymer associated with the core particle; a sulfur-based moiety associated with the polymer; and a releasable probe molecule associated with the core particle, where the releasable probe molecule is releasable from the core particle upon exposure to hydrocarbons. Additional embodiments of the present disclosure pertain to methods of detecting hydrocarbons in a geological structure by utilizing the nanocomposites of the present disclosure.

Abstract: The invention discloses a culture method for Antrodia cinnamomea to elevate the amounts and types of the bioactive components in Antrodia cinnamomea through controlling the wavelength and intensity of the light. Furthermore, the modification of the environmental factors such as water content, composition and relative amount of the culture medium, and the culture temperature are capable of increasing the amounts and types of the bioactive components in Antrodia cinnamomea.

Abstract: Buddleja ‘Pink Micro Chip’ is a new and distinct variety of butterfly bush that has the following unique combination of desirable features that are outstanding in a new variety. 1. ‘Pink Micro Chip’ has low vigor resulting in very dwarf stature. 2. ‘Pink Micro Chip’ is asexually propagated using softwood or semi-hardwood cuttings. 3. ‘Pink Micro Chip’ demonstrates a dense, spreading growth habit. 4. ‘Pink Micro Chip’ is lacking male flower parts (anthers), resulting in male (pollen) sterility. 5. “Pink Micro Chip’ produces female structures that are essentially sterile, resulting in lack of seed formation. 6. ‘Pink Micro Chip’ has red-purple flower color.

Abstract: Devices incorporating a single to a few-layer MoS2 channels in combination with optimized substrate, dielectric, contact and electrode materials and configurations thereof, exhibit light emission, photoelectric effect, and superconductivity, respectively.

Abstract: The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.

Abstract: There is provided a method of treating a condition in a subject in need characterized at least in part by abnormal, uncontrolled, undesirable or pathological ocular neovascularization. The method includes administering to the patient an effective amount of an interfering agent that inhibits the expression of MCPIP.

Abstract: An autostereoscopic display system includes a display including a plurality of addressable pixels. Each of the plurality of pixels includes two or more sub-pixels. The display is adapted to have n views in the horizontal direction wherein n is an integer greater than or equal to 2. A native pixel density of the display in the horizontal direction divided by n is greater than 75% of a native pixel density in the vertical direction. The system further includes a view selector that, for each of two or more viewing perspectives, makes one of the views visible and a multiplexer system in operative connection with the display. The multiplexer system is adapted to controllably shift light horizontally from at least one of the plurality of pixels.

Abstract: This invention relates to asphalt compositions. The invention provides a sulfur rubber asphalt binder composition that includes a base asphalt having a softening point, elemental sulfur, and a crumb rubber material. The crumb rubber material is combined with the base asphalt and the elemental sulfur to create the sulfur rubber asphalt binder composition. The crumb rubber material is present in the sulfur rubber asphalt binder in an amount effective to increase the softening point as compared to the softening point of the base asphalt.

Abstract: A fluid analysis method is provided. A gradient distribution of a first scalar property of a calibration fluid in a space is obtained. A calibration schlieren image of the calibration fluid is acquired and processed to obtain an intensity distribution of the calibration schlieren image. The gradient distribution of the first scalar property of the calibration fluid in the space is mapped to the intensity distribution of the calibration schlieren image, so as to obtain a corresponding relation between the gradients of the first scalar property and the intensities. A test schlieren image of a test fluid is acquired and processed to obtain intensity distribution of the test schlieren image. The intensity distribution of the test schlieren image is converted to the gradient distribution of the first scalar property of the test fluid according to the corresponding relation. Moreover, a fluid analysis system is also provided.

Abstract: Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treating patients to alleviate symptoms of the disease, prevent or delay its onset, or inhibit its progression. The inventions are based on the discovery that persons with a genome having a deletion of the CFHR-1 and/or CFHR-3 gene, which normally lie on human chromosome 1 between DNA encoding CFH and CFHR-4, are at reduced risk of developing AMD, and elevated risk of developing vascular disease such as aneurysm.

Abstract: The present invention relates, in-general, to Human immunodeficiency virus (HIV), and in particular to a carbohydrate-based vaccine for HIV and to methods of making and using same.

Abstract: A computer-implemented method includes receiving a request to search for other users who are associated with at least a threshold level of similarity to the requesting user; accessing information indicative of a patient profile of the requesting user; determining one or more attributes of the requesting user; searching a data repository for information indicative of a user associated with one or more attributes corresponding to at least one of the one or more attributes of the requesting user; identifying, based on searching, a user associated with one or more attributes corresponding to at least one of the one or more attributes of the requesting user; determining that the one or more corresponding attributes of the identified user satisfy the threshold level of similarity; and transmitting information indicative of the identified user, with the transmitted information specifying the identified user as being a peer of the requesting user.

Abstract: An ultra-wideband low-noise amplifier circuit with low power consumption includes a cascode amplifier circuit module and an output combining circuit module. The cascode amplifier circuit module receives an input signal, and outputs a first output signal and a second output signal. The output combining circuit module receives the first output signal and the second output signal, and applies respective phase shifts to the first output signal and the second output signal for reducing a phase difference between the first output signal and the second output signal, so as to obtain a combined output signal.

Abstract: The present invention provides embryonic stem cells obtainable from an embryo of an immunodeficient mouse which is deficient in both Rag2 and Jak3 genes by culture in the presence of a GSK3 inhibitor and an MEK inhibitor, as well as a transgenic mouse, which is created with the use of these embryonic stem cells.

Abstract: In one embodiment, an implantable biosensor includes a sense antenna comprising a silicon carbide substrate and a radiating electrode formed on the substrate.