Abstract: An embodiment of the invention is directed to a composition comprising a luminescent noble metal nanoparticle, wherein the surface of the noble metal nanoparticle is coated with a ligand, and wherein the noble metal nanoparticle is about 2 nm to 5 nm in diameter and further wherein a portion of the noble metal is present as its radioactive isotope. In an embodiment of the invention, the radioactive isotope is present at a concentration of up to 2% w/w of the noble metal.
Type:
Application
Filed:
August 28, 2013
Publication date:
April 10, 2014
Applicant:
The Board of Regents of the University of Texas System
Abstract: A braking system for hybrid vehicle may include a brake pedal, a pedal stroke sensor detecting stroke of the brake pedal and outputting corresponding signal, a brake control unit receiving the signal of the pedal stroke sensor, a driving wheel caliper braking a driving wheel according to control of the brake control unit, a regenerative braking unit including a motor/generator which generates electric energy according to control of the brake control unit in braking of the driving wheel, a master cylinder connected with the brake pedal and operated by the brake pedal, and a driven wheel caliper braking a driven wheel according to operation of the master cylinder.
Type:
Application
Filed:
December 12, 2012
Publication date:
April 10, 2014
Applicants:
Research & Business Foundation, Sungkyunkwan University, Hyundai Motor Company
Inventors:
Byoung Soo Yoo, Hyun-Soo Kim, Ji-Weon Ko
Abstract: The application describes methods for accurately evaluating whether thyroid test samples, especially indeterminate thyroid samples, are benign or malignant.
Type:
Application
Filed:
September 20, 2013
Publication date:
April 10, 2014
Applicant:
Cornell University
Inventors:
Xavier M. Keutgen, Thomas J. Fahey, III, Olivier Elemento, Rasa Zarnegar
Abstract: The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS.
Type:
Application
Filed:
April 12, 2013
Publication date:
April 10, 2014
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
Daniel J. ABRAMS, Raymond BUNCH, Tom ANCHORDOQUY, Karen E. STEVENS
Abstract: An aspect of the invention relates to a golf swing analyzing apparatus, comprising: a first arithmetic section operating to use an output from a first inertial sensor and an output from a second inertial sensor to calculate a first energy amount, the first inertial sensor being attached to a portion of an upper body of a golfer, the second inertial sensor being attached to a golf club, the first energy amount being generated in the upper body of the golfer; a second arithmetic section operating to use the output from the first inertial sensor and the output from the second inertial sensor to calculate a second energy amount transferred to the golf club from the upper body of the golfer; and a processing section calculating an energy transferring ratio of an energy transferred from the upper body of the golfer to the golf club based on a ratio of the second energy amount to the first energy amount.
Abstract: A method includes generating, from an integrated oscillator circuit, an oscillating output signal and generating, by an integrated power amplifier (PA) circuit, an amplified oscillating output signal based on the oscillating output signal. The method further includes receiving, by integrated receiver amplifier circuit, an electron spin resonance (ESR) signal from biological samples that include a magnetic species and generating, by the integrated receiver amplifier circuit, an amplified ESR signal based on the received ESR signal. The method further includes receiving, by the integrated receiver amplifier circuit, an electron spin resonance (ESR) signal from magnetic nanoparticles that are loaded with drugs or attached to human cells.
Type:
Application
Filed:
September 30, 2013
Publication date:
April 10, 2014
Applicant:
William Marsh Rice University
Inventors:
Xuebei Yang, Charles Chen, Payam Seifi, Aydin Babakhani
Abstract: The present invention includes compositions and methods for using an anionic surfactant composition for treating a hydrocarbon-bearing formation or a reservoir, of formula (I): wherein R1 and R2 are identical or different and may independently be alkyl, alkenyl, alkynyl, alkylene, aryl, propylene oxide, ethylene oxide or hydrogen groups in a straight or branched chain with 16 or more carbon atoms, X1 and X2 are identical or different and are selected from the group consisting of phosphate, sulfate, carboxylate, sulfonate or other suitable anionic groups, S is a spacer group selected from short or long arkyl, alkenyl, alkynyl, alkylene, stilbene, polyethers, and other suitable aliphatic or aromatic groups comprising 2 to 12 carbon atoms.
Type:
Application
Filed:
August 9, 2013
Publication date:
April 10, 2014
Applicant:
Board of Regents, The University of Texas System
Abstract: The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
Type:
Application
Filed:
December 11, 2013
Publication date:
April 10, 2014
Applicant:
University of Virginia Patent Foundation
Inventors:
Robert Hendel, William B. Stilley, Shannon P. Williams
Abstract: The present invention provides compositions and methods for inducing a CAR mediated trans-signal in a T cell. The trans-signaling CAR T cells comprise a first CAR having a first signaling module and a second CAR having a distinct second signaling module. The present invention also provides cells comprising a plurality of types of CARs, wherein the plurality of types of CARs participate in trans-signaling to induce T cell activation.
Type:
Application
Filed:
October 2, 2013
Publication date:
April 10, 2014
Applicant:
The Trustees of the University of Pennsylvania
Abstract: Disclosed is a method for early diagnosis of liver cancer. The method comprises the steps of:(A) providing a sample obtained from a subject; (B) assessing the expression level of four subtypes of ?-mannosidase genes consisting of MAN1C1 in the sample; (C) comparing the expression level of ?-mannosidase genes in the sample with a normal control; and (D) determining whether the subject having a risk of suffering liver cancer in accordance with the result of step (C); wherein while the MAN1C1 expression level of the sample is lower than that in the normal control, the subject is determined to have a risk of suffering liver cancer. Additionally, while MAN1A1, MAN1A2 and MAN1B1 expression levels in the sample are higher than those in control group, the subject is determined to suffer from liver cancer and has a risk of metastasis. In the future, MAN1C1 can be applied to early diagnosis of liver cancer and metastasis, suppression of liver metastasis, and screening agents for treating liver cancer.
Abstract: A method and device are disclosed for inducing mechanical stress in a cellular sample to evaluate mechanotransduction in the cellular sample. In one embodiment, the mechanical stress is induced by generating a microcavitation bubble in the cellular sample using a pulsed energy. The microcavitation bubble creates a microtsunami, which provides a transient, impulsive mechanical stress on the cellular sample, forming a gradient of effects at distances away from the microcavitation bubble.
Type:
Application
Filed:
October 4, 2013
Publication date:
April 10, 2014
Applicant:
The Regents of The University of California
Inventors:
Elliot L. Botvinick, Vasan Venugopalan, Jonathan Compton, Amy Hellman
Abstract: An electronic device includes a silicon carbide layer having a first conductivity type and a main junction adjacent a surface of the silicon carbide layer, and a junction termination region at the surface of the silicon carbide layer adjacent the main junction. Charge in the junction termination region decreases with lateral distance from the main junction, and a maximum charge in the junction termination region may be less than about 2×1014 cm?2.
Type:
Application
Filed:
December 11, 2013
Publication date:
April 10, 2014
Applicants:
The University of South Carolina, Cree, Inc.
Inventors:
Qingchun Zhang, Anant K. Agarwal, Tangali S. Sudarshan, Alexander Bolotnikov
Abstract: The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt.-% of the acyl-groups of said diglycerides are eicoapentaenoic acid (EPA) groups and/or docasahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
Type:
Application
Filed:
December 10, 2013
Publication date:
April 10, 2014
Applicant:
The Trustees of Columbia University in the City of New York
Abstract: A device includes an excitation coil, a detector coil, and a processing circuit. The excitation coil is aligned about a volume. The excitation coil is configured to carry a first and second biasing current and generate a magnetic field in the volume. The detector coil is configured to generate an electrical signal based on a detected field within the volume. The detected field is based on the magnetic field. The processing circuit is configured to generate data based on the electrical signal.
Abstract: A solid carrier sprayer apparatus, including a solid carrier container, a liquid container, a solid carrier spreading apparatus, and a liquid application apparatus is provided. The solid carrier spreading apparatus can be coupled to receive solid carrier from the solid carrier container, and is configured to drop the received solid carrier substantially evenly over an area of ground. The liquid application apparatus can be coupled to receive liquid from the liquid container, and is configured to spray received liquid substantially evenly over the received solid carrier, such that the liquid is sprayed substantially evenly over the received solid carrier before the solid carrier is dropped substantially evenly over the area of ground. Methods of using a solid carrier sprayer apparatus are also discussed.
Type:
Application
Filed:
December 10, 2013
Publication date:
April 10, 2014
Applicant:
Board of Trustees of Michigan State University
Inventors:
A. Ronald Detweiler, Gary Zehr, Joseph Vargas
Abstract: Systems for untethered sensing and recording of activity of one or more electrically excitable cells in a target region includes at least one untethered probe. Each untethered probe includes at least one signal detector, configured to electrically couple to the target region, measure the activity of the one or more electrically excitable cells, and produce an electrical signal in response to the activity of the one or more electrically excitable cells, and at least one light source, electrically coupled to the at least one signal detector, to receive the electrical signal and emit a light signal representing the activity of the one or more electrically excitable cells. Methods for untethered sensing and recording of activity of one or more electrically excitable cells in a target region are also provided.
Type:
Application
Filed:
December 12, 2013
Publication date:
April 10, 2014
Applicant:
The Trustees of Columbia University in the City of New York
Inventors:
Dirk R. Englund, Aurel A. Lazar, Chaitanya Rastogi, Yevgeniy B. Slutskiy
Abstract: The present invention provides a rapid-acting, blood arginine level-increasing oral preparation containing citrulline or a salt thereof and arginine or a salt thereof as active ingredients. The rapid-acting, blood arginine level-increasing oral preparation of the present invention can rapidly and effectively increase blood arginine level after ingestion, and can rapidly provide an arginine ingestion effect.
Type:
Application
Filed:
December 12, 2013
Publication date:
April 10, 2014
Applicants:
National University Corporation Nagoya University, Kyowa Hakko Bio Co., Ltd.
Inventors:
Masayuki OCHIAI, Koji MORISHITA, Toshio HAYASHI
Abstract: In one general aspect, a non-transitory computer-readable storage medium can be configured to store instructions that when executed cause a processor to perform a process. The process can include receiving an indicator configured to trigger movement of a representation of a first portion of data and a representation of a second portion of data in a direction toward a boundary where the boundary is oriented with respect to a display area. The process can also include modifying a position of the representation of the first portion of data with respect to a position of the representation of second portion of data in response to the indicator.
Type:
Application
Filed:
October 4, 2013
Publication date:
April 10, 2014
Applicant:
Brigham Young University
Inventors:
William Arthur Barrett, Ryan Thomas Cheatham