Abstract: A method of measuring binding between hemoglobin and a microbe of interest includes: providing hemoglobin from a source of interest; contacting the hemoglobin with a microbe of interest; and measuring the binding affinity between the hemoglobin and the microbe, wherein the binding affinity is indicative of microbe virulence in the presence of the hemoglobin.

Abstract: A method of nanoimprinting a piezoelectric polymeric material includes: heating a surface of the piezoelectric polymeric material to an imprinting temperature greater than (Tc?25)° C. and less than Tc, in which Tc is the Curie temperature of the piezoelectric polymeric material; and pressing the heated surface of the piezoelectric polymeric material using a nanoimprinting template having a nanopillar structure so as to form the piezoelectric polymeric material with high aspect ratio nanopillars.

Abstract: Described herein are compounds and methods that prevent the viral infection of cells. The compounds and methods described herein minimize viral resistance and maximize the number of targeted viruses. Additionally, the compounds and methods minimize the toxicity toward uninfected cells.

Abstract: An ultrafast electron diffraction device for irradiating a sample with a bunch of electrons in an ultrashort pulse in order to perform an ultrafast analysis of the sample. The ultrafast electron diffraction device includes: a) a laser emitter for delivering an ultrashort pulse laser having a pulse width of not more than 1 ps onto a target which is a material for generating electrons at an intensity of not less than 1017 W/cm2; and b) a pulse compressor for rotating, in a magnetostatic field, a bunch of electrons generated from the target onto which the ultrashort pulse laser has been delivered so as to suppress the spread of the bunch of electrons in their traveling direction. The pulse compressor is composed of an entrance-side parallel-plate static magnet, one end of which is placed on the course of the bunch of electrons, and an exit-side parallel-plate static magnet.

Abstract: The gaming machine of the present invention provides a gaming machine that executes the processing of: determining, for each station, a normal game result based on a player card for the station; accepting via each input device an input for a side bet on a normal game in a station other than the station having this input device; determining, when a side bet is placed, a side game result according to the determined normal game result of the station as the side bet target; and offering a first payout based on the normal game result, and a second payout based on the side game result.

Abstract: The present invention relates to methods and compositions for preventing and/or treating various conditions in a patient, including for example, T-cell lymphoblastic leukemia and lymphoma as well as neurodegenerative diseases, such as for example, Alzheimer's disease. In one preferred embodiment of the invention, such methods include providing a patient with an effective amount of a combination of a NOTCH-1 inhibitor and glucocorticoid. The present invention further encompasses methods for increasing the efficacy of, and mitigating resistance to, glucocorticoids in the treatment of T-cell lymphoblastic leukemia and lymphoma, which generally include providing a patient with an effective amount of one or more NOTCH-1 inhibitors.

Abstract: The present invention relates to a population of antibodies enriched from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. Furthermore, the present invention relates to a method of enriching a population of antibodies from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. The present invention also relates to the population of antibodies of the invention for use in medicine, a pharmaceutical composition comprising the populations of antibodies of the invention and the use of the population of antibodies of the invention in the prevention and/or treatment of atherosclerosis, cancer and infections such as bacterial, viral or fungal infections.

Abstract: A laser system is provided which selectively excites Raman active vibrations in molecules. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and remote sensing.

Abstract: Methods and systems for measuring particles within a flow are provided. An aircraft transports a high volume sample rate holographic measurement instrument through a particle-containing volume of interest along a reference axis X (time). As the instrument moves relative to the volume of interest, the holographic measurement instrument transmits a collimated light beam across the volume of interest along an optical axis Z. The light beam interacts with particles contained within the volume of interest, and a high-speed, one-dimensional detector array detects incident light reflecting patterns of light intensity levels that are associated with the interaction between the light beam and the particles.

Abstract: The present invention discloses a multilevel resistive memory having large storage capacity, which belongs to a field of a fabrication technology of a resistive memory. The resistive memory includes an top electrode and a bottom electrode, and a combination of a plurality of switching layers and defective layers interposed between the top electrode and the bottom electrode, wherein, the top electrode and the bottom electrode are respectively contacted with a switching layer (a film such as Ta2O5, TiO2, HfO2), and the defective layers (metal film such as Ti, Au, Ag) are interposed between the switching layers. By using the present invention, a storage capacity of a resistive memory can be increased.

Abstract: A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample.

Abstract: Various applications are directed to a material stack having a strained active material therein. In connection with an embodiment, an active material (e.g. a semiconductor material) is at least initially and partially released from and suspended over a substrate, strained, and held in place. The release and suspension facilitates the application of strain to the semiconductor material.

Abstract: A master key (K2,2) inputted by an input unit is stored in a storage unit. A matrix generating unit generates key element matrices (M1-M3) with respect to each of split keys (eR2, eR1, eR3) obtained by a key dividing unit dividing the master key (K2,2). To each coordinate entry of the key element matrices (M1-M3), operation data that successively obtained by repeating a hash operation with a one-way hash function is assigned, so as to maintain hierarchical nature of scalability (L). A key generating unit generates partial keys (K1,1-K2,2) corresponding to respective hierarchies of the scalabilities (R, L), on the basis of the key element matrices (M1-M3). These partial keys (K1,1-K2,2) are outputted to a coding unit or a decoding unit by an output unit.

Abstract: The present invention relates to a method for microfluidic mixing in a “lab-on-a-chip” environment. The methodology focuses on constant acceleration and deceleration about a mean angular speed with a rotating disk serving as the mixing platform. The methodology results in good mixing between different fluids.

Abstract: The present invention relates to a tray for use with a walker. The tray includes a generally rigid tray base having an essentially rectangular shape with a front long side, a back long side, a first short side and a second short side, and wherein the tray has a length that extends to or past the essentially horizontal support member; a ridge extending along the sides of the tray, wherein the ridge has a height of at least about a ½ inch; a strap having a hook and loop fastener wherein the strap is positioned at or near the back long end; and a first hinge and a second hinge, the first and second hinges are positioned, when the tray is in use, at or near the front leg of the first and second support, respectively.

Abstract: One aspect of the instant disclosure is to provide a sensorless adaptive safety actuator. The safety actuator comprises a driving unit, a transmission unit coupled to the driving unit, and an output unit coupled to the transmission unit. The transmission unit comprises a load-adaptable retracting mechanism. When the output unit experiences a mechanical load exceeding a critical value, the load-adaptable retracting mechanism causes the transmission unit to decouple from the driving unit. Thus, responding to an accident where the impact on the output unit causes a force/torque overload, the instant safety actuator is capable of effectively stopping the force/torque transmission to the work output device without the use of active sensors.

Abstract: Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof: (I) in which R1, R2, R3, and R4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).

Abstract: A system and method for monitoring personal protection items of a healthcare worker (gloves, gown, mask and respirator), using a user badge which stores data representing items worn by a worker, wirelessly communicating with the badge before the worker enters a patient zone (such as a patient room, bed area or exam table area), to see whether the worker has the required items. Patient beacons, located near patient room doors, near beds and other locations, store data representing the items required by workers who come in contact with, or close proximity to a patient, and wirelessly communicate with the badge. The patient beacon data can be set for the requirement of the patient, based on patient condition.

Abstract: A transflective liquid crystal display includes a liquid crystal panel including a first substrate, a second substrate, a liquid crystal layer, the first and second substrates arranged to face each other and the liquid crystal layer between the first and second substrates, a reflection polarizer and an absorption polarizer at opposing outer sides of the liquid crystal panel, and a backlight unit at an outer side of the liquid crystal panel and supplying light to the inside of the liquid crystal panel. A reflective axis of the reflection polarizer is parallel with a transmissive axis of the absorption polarizer, the transmissive axis of the reflection polarizer perpendicularly crosses the transmissive axis of the absorption polarize, and the liquid crystal layer includes liquid crystal molecules and a dichroic dye.

Abstract: An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 ?m or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or group of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.