Patents Assigned to University
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Patent number: 8633161Abstract: The invention provides for methods of treating a mammal who has a BCR/ABL-mediated leukemia, including chronic myelogenous leukemia (CML), particularly the blast crisis stage of CML, Philadelphia-positive acute lymphoblastic leukemia (Ph?-ALL), and refractory leukemias. The invention also provides for compounds for the treatment of these leukemias and methods of identifying anti-leukemic agents.Type: GrantFiled: March 24, 2006Date of Patent: January 21, 2014Assignee: The Ohio State University Research FoundationInventors: Danilo Perrotti, Paolo Neviani, Ramasamy Santhanam, John C. Byrd, Guido Marcucci, Natarajan Muthusamy, Ching-Shih Chen
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Patent number: 8634579Abstract: A thermoacoustic device includes a sound wave generator and a signal input device. The sound wave generator includes a graphene layer. The graphene layer includes at least one graphene. The signal input device inputs signals to the sound wave generator.Type: GrantFiled: December 26, 2011Date of Patent: January 21, 2014Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.Inventors: Kai-Li Jiang, Xiao-Yang Lin, Lin Xiao, Shou-Shan Fan
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Patent number: 8631759Abstract: An elastomeric stamp is used to deposit material on a non-planar substrate. A vacuum mold is used to deform the elastomeric stamp and pressure is applied to transfer material from the stamp to the substrate. By decreasing the vacuum applied by the vacuum mold, the elasticity of the stamp may be used to apply this pressure. Pressure also may be applied by applying a force to the substrate and/or the stamp. The use of an elastomeric stamp allows for patterned layers to be deposited on a non-planar substrate with reduced chance of damage to the patterned layer.Type: GrantFiled: February 1, 2010Date of Patent: January 21, 2014Assignees: The Trustees Of Princeton University, The Regents Of The University Of MichiganInventors: Stephen Forrest, Xin Xu, Xiangfei Qi, Marcelo Davanco
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Patent number: 8633181Abstract: This invention concerns a method of treating hemangiomas with a beta blocker by applying the beta blocker onto the hemangiomas directly. The invention also concerns a combination therapy by using a beta blocker along with a corticosteroid or an alpha adrenergic receptor agonist for the treatment of hemangiomas.Type: GrantFiled: April 9, 2010Date of Patent: January 21, 2014Assignee: Rutgers, The State University of New JerseyInventor: Suqin Guo
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Patent number: 8633029Abstract: Provided is an efficiency improving agent for gene transfer to mammalian cells, a method for improving efficiency of gene transfer to mammalian cells, and a method for transforming mammalian cells. The method is characterized in that tRNA is used in combination with a lipofection reagent. Preferably, the agent may be used so that the tRNA concentration in a lipofection solution falls within the range of 3 to 50 ?g/mL, and the concentration in a culture is approximately 1/10. More preferably, tRNA and PEG may be used in combination with a lipofection reagent. According to the present invention, gene transfer to mammalian cells with high efficiency can be achieved.Type: GrantFiled: March 13, 2011Date of Patent: January 21, 2014Assignee: Yamaguchi UniversityInventors: Rinji Akada, Mikiko Nakamura
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Patent number: 8632811Abstract: A silica-based nanoformulation and method is used to treat citrus canker, inhibit the growth of mold and mildew, and add nutrients to soil used for agricultural purposes. The nanotechnology-enabled copper-loaded, silica nanoformulation (CuSiNP/NG) design is a “revolutionary re-invention” of Cu for safe application because it provides a formulation with maximum abundance of ionic Cu, provides sustained and optimal Cu ion release for long-term disease protection, better adherence to plant surfaces and structural surfaces due to gel-based nanostructure of CuSiNG, thus avoiding multiple spray applications and reducing the amount of Cu used in comparison to existing Cu compounds without compromising antibacterial activity.Type: GrantFiled: June 20, 2012Date of Patent: January 21, 2014Assignee: University of Central Florida Research Foundation, Inc.Inventor: Swadeshmukul Santra
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Patent number: 8632209Abstract: A lighting fixture system, comprising a first illuminant, a secondary illuminant; and a sensor configured to detect a predetermined condition, the sensor being coupled to the first illuminant and the secondary illuminant, the first illuminant and the secondary illuminant comprising different light sources, the sensor configured to cause modulation of the first illuminant and the secondary illuminant in response to detection of the pre-determined condition.Type: GrantFiled: July 28, 2011Date of Patent: January 21, 2014Assignees: Full Spectrum Solutions, The Regents of the University of CaliforniaInventors: Keith E. Graeber, Michael Olen Nevins, Michael Jay Siminovitch, Konstantinos Papamichael
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Patent number: 8633625Abstract: Embodiments of the present invention include a shaft-less energy storage flywheel system. The shaft-less energy storage flywheel system includes a solid cylindrical flywheel having permanent motor magnets mounted about the flywheel. The shaft-less energy storage flywheel system also includes a motor stator having motor windings carrying electrical currents. The motor windings of the motor stator are aligned with the permanent motor magnets of the flywheel such that rotation of the flywheel is induced through interaction of the motor winding currents and the magnetic field of the permanent motor magnets. The flywheel provides a magnetic flux path for the permanent motor magnets. In certain embodiments, the shaft-less energy storage flywheel system includes a magnetic bearing assembly disposed directly adjacent an axial face of the flywheel. The magnetic bearing assembly controls positioning and alignment of the flywheel without physically contacting the flywheel during normal operation.Type: GrantFiled: September 13, 2011Date of Patent: January 21, 2014Assignee: The Texas A&M University SystemInventors: Alan Palazzolo, Randall Tucker, Zhiyang Wang
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Patent number: 8632966Abstract: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.Type: GrantFiled: January 10, 2013Date of Patent: January 21, 2014Assignee: Queen's University at KingstonInventors: R. Stephen Brown, Samir P. Tabash, Igor S. Kozin, Eric J. P. Marcotte, Arthur N. Ley, Kevin R. Hall, Moe Hussain, Peter V. Hodson, Raymond J. Bowers, Robin A. Wynne-Edwards, John G. St. Marseille
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Patent number: 8633395Abstract: A multilayer wiring board 100 comprises a first wiring region 101 where wirings 103a and insulating layers 104a and 104b are alternately laminated, and a second wiring region 102 where a thickness H2 of an insulating layer 104 is twice or more a thickness H1 of the insulating layer in the first wiring region 101 and a width W2 of a wiring 103b is twice or more a width W1 of the wiring in the first wiring region 101. The first wiring region 101 and the second wiring region 102 are integrally formed on the same board.Type: GrantFiled: May 22, 2009Date of Patent: January 21, 2014Assignees: National University Corporation Tohoku University, Foundation For Advancement of International ScienceInventors: Tadahiro Ohmi, Shigetoshi Sugawa, Hiroshi Imai, Akinobu Teramoto
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Patent number: 8632475Abstract: An intracranial pressure monitoring system and method. The system includes an auditory stimulation and recording unit, which includes a stimulation controller, a memory for storing waveforms, a device for comparing received waveforms with stored waveforms, and an alarm operable based upon that comparison. The system includes at least one cranial electrode attachable to a patient, and an auditory stimulation device, operable by the stimulation controller. The stimulation device is a pair of acoustic ear inserts, each of which is connected to and operated by an auditory stimulator activated by the stimulation controller. In the method, a patient is auditorially stimulated to evoke a received waveform indicative of intracranial pressure, a comparison is generated by comparing the received waveform with one of an established patient baseline waveform and an established normal waveform, and an alarm is generated responsive to that comparison.Type: GrantFiled: February 15, 2008Date of Patent: January 21, 2014Assignee: The Board of Trustees of the University of IllinoisInventor: James L. Stone
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Patent number: 8632879Abstract: A flexible sheet of aligned carbon nanotubes includes an array of aligned nanotubes held in a polymer matrix material. The carbon nanotubes have an average length of between about 50 microns and about 500 microns. The polymer matrix has an average thickness of between about 10 microns and about 500 microns. The flexible sheet has a density of about 0.2 to about 1.0 g/cc and includes between about 98 to about 60 weight percent aligned carbon nanotubes and between about 2 and about 40 weight percent polymer. A tape of aligned carbon nanotubes, a method for producing a tape of aligned carbon nanotubes, a method of producing the flexible aligned carbon nanotube sheet material and a method of increasing unidirectional heat conduction from a work piece are also disclosed.Type: GrantFiled: April 25, 2008Date of Patent: January 21, 2014Assignee: The University of Kentucky Research FoundationInventor: Matthew C. Weisenberger
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Patent number: 8632780Abstract: A modified human complement C3 protein (C3) is disclosed comprising a substitution of a portion of a human C3 protein, with a corresponding portion of a Cobra Venom Factor protein (CVF) which results in a human C3 protein with CVF functions, but with substantially reduced immunogenicity. Advantageously, the C3 protein can be manipulated to contain at least one of the following CVF functions: increased stability of the C3 convertase and increased resistance to the actions of factors H and/or I. A large number of hybrid C3 proteins containing substitutions in the C-terminal portion of the alpha chain of C3 are presented and tested for the above functions. Methods of treatment of diseases such as reperfusion injury, autoimmune diseases, and other diseases of increased complement activation are presented as well as methods of increasing the effectiveness of gene therapeutics and other therapeutics.Type: GrantFiled: April 29, 2005Date of Patent: January 21, 2014Assignee: University of HawaiiInventors: Carl-Wilhelm Vogel, David C. Fritzinger
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Publication number: 20140015527Abstract: Example apparatus and methods control a magnetic resonance imaging (MRI) apparatus to acquire, from an object to be imaged, throughout a period of time, a partitioned non-Cartesian fully-sampled calibration data set. Different groups of lines in the calibration data set are acquired at different points in time under different gradient encoding conditions that yield phase encoding in the direction perpendicular to the non-Cartesian encoded plane. The MRI apparatus is controlled to acquire an under-sampled non-Cartesian data set from the object to be imaged and to reconstruct an image from the under-sampled data set based, at least in part, on a through-time GRAPPA calibration. A GRAPPA weight set can be computed from data in different groups of lines in the calibration data set because different groups of lines can be treated as unique calibration time frames due to phase encoding produced by the different gradient encoding conditions.Type: ApplicationFiled: July 13, 2012Publication date: January 16, 2014Applicant: Case Western Reserve UniversityInventors: Mark Griswold, Nicole Seiberlich
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Publication number: 20140014922Abstract: A dibenzo[1,4]azaborine comprising compound, and devices and formulations including the same are described. The compound includes a ligand L1 including wherein E1 is N; E2 is B; and R3 and R4 represent mono, di, tri, tetra substitutions or no substitution; wherein R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; wherein any two adjacent R1, R2, R3, and R4 are optionally joined to form a ring, which may be further substituted; wherein L1 is coordinated to a metal M, provided that the metal M does not form bond with E1 and E2; and wherein L1 may be linked with other ligands to comprise a bidentate, tridentate, tetradentate, pentadentate or hexadentate ligand.Type: ApplicationFiled: March 13, 2013Publication date: January 16, 2014Applicant: Universal Display CorporationInventors: Chun Lin, Chuanjun Xia
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Publication number: 20140016174Abstract: There is provided a cell driven by an electric field including a first electrode and a second electrode spaced from each other and an actuator moving between the first electrode and the second electrode. The actuator does not have permanent electric charges and a DC voltage or a pulse voltage is applied to the first electrode and the second electrode.Type: ApplicationFiled: November 7, 2011Publication date: January 16, 2014Applicant: Korea University Research and Business FoundationInventors: Mun Pyo Hong, Hong Choi, Hyo Joo Park, Ho Won Yoon
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Publication number: 20140018675Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostcs, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.Type: ApplicationFiled: July 18, 2013Publication date: January 16, 2014Applicant: Hampton UniversityInventors: Cynthia E. KEPPEL, Paul Gueye, Christopher Sinesi
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Publication number: 20140017696Abstract: An isolated nucleic acid reporter construct, the protein for which it encodes and methods for its use for the in vivo or in vitro measurement of the concentration of a specific biologically important molecule in a subcellular compartment or locale are provided. Certain constructs described are useful in measuring the local concentration of ATP at synapses.Type: ApplicationFiled: April 12, 2012Publication date: January 16, 2014Applicant: Cornell UniversityInventor: Timothy A. Ryan
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Publication number: 20140017884Abstract: In the present invention, copper(I) selenide (Cu2-xSe) nanoparticles are fabricated by pyrolysis in an inert atmosphere. Uniformly dispersed Cu2-xSe particles are synthesized by altering Cu/Se ratio, the concentration of Se Precursors (TOP Se), reaction time and temperature. Analysis by inductively coupled plasma atomic emission spectroscopy (ICP-AES) of said Cu2-xSe nanoparticles reveals that the composition of the nanoparticles is Cu 1.95Se, wherein x=0.05. In addition, Cu2-xSe is dissolved in ethanol to deposit thin films by electrophoretical deposition (EPD) in an inert atmosphere, wherein a positive electrode and a negative electrode are employed. The positive electrode is made of stainless steel plate and the negative electrode is made of indium tin oxide on a glass substrate. Investigations on properties and surface morphology thereof in different electrophoretical conditions are carried out. The rate of EPD is found to significantly influence the quality of thin films.Type: ApplicationFiled: July 12, 2012Publication date: January 16, 2014Applicant: National Chung Cheng UniversityInventors: Chu-Chi Ting, Wen-Yuan Lee
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Publication number: 20140017338Abstract: A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.Type: ApplicationFiled: September 17, 2013Publication date: January 16, 2014Applicant: Auburn UniversityInventors: Vitaly J. Vodyanoy, Nilmini Viswaprakash, Ludmila Petrovna Globa, Edward E. Morrison