Patents Assigned to Univerzita Palackeho V Olomouci
-
Patent number: 11797753Abstract: Techniques for customizing multimedia content using data structures adapted to text samples. A method includes dividing a text sample into segments. Unique words are identified within the segments. For each unique word found in the segments, its neighboring words are identified. Based on sentiment values associated with those neighboring words, a sentiment of each unique is determined. Using the sentiments of the unique words, text skeletons are modified by inserting the unique words into corresponding locations within structured data of the text skeletons. The modified text skeletons may be inserted into multimedia content in order to customize that multimedia content to the text sample.Type: GrantFiled: June 27, 2022Date of Patent: October 24, 2023Assignee: UNIVERZITA PALACKÉHO V OLOMOUCIInventors: Dan Faltýnek, Martina Bene{hacek over (s)}ová, Vladimír Matlach, Ond{hacek over (r)}ej Ku{hacek over (c)}era
-
Patent number: 11643413Abstract: The invention relates to N2,N6-disubstituted-9-(2-oxacycloalkyl)-9H-purine-2, 6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.Type: GrantFiled: April 27, 2018Date of Patent: May 9, 2023Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Jana Bibova, Vaclav Mik, Marek Zatloukal, Lucie Plihalova, Jiri Gruz, Lukas Spichal, Karel Dolezal, Miroslav Strnad
-
Publication number: 20230080789Abstract: A system and method for customizing multimedia content using text-based data structures adapted to text samples. A method includes dividing a text sample into segments of approximately the same size. A unique word occurring exactly once in two or more of the segments is identified. Neighboring words within a threshold distance of the unique word in each of the segments are identified. A first sentiment is determined based on the neighboring words for the unique word. A text skeleton is modified by inserting the unique word into the location in the structured dataset based on the determined first sentiment, wherein the text skeleton is a structured dataset including a location having a designated second sentiment matching the first sentiment. The modified text skeleton is inserted into a multimedia content item in order to create a customized multimedia content item for the text sample.Type: ApplicationFiled: June 27, 2022Publication date: March 16, 2023Applicant: Univerzita Palackého v OlomouciInventors: Dan FALTÝNEK, Martina BENESOVÁ, Vladimír MATLACH, Ondrej KUCERA
-
Publication number: 20230039704Abstract: N-(furan-2-ylmethyl)-7H-purin-6-amine, or a pharmaceutically acceptable salt or solvate thereof, for prevention and/or treatment of circadian rhythm disorders, circadian rhythm diseases and/or circadian rhythm dysfunctions is disclosed. The disorders, diseases and dysfunctions include, inter alia, jet-lag, social jet-lag, shift-work disorder, and circadian rhythm disturbance induced by neurodegeneration is also disclosed.Type: ApplicationFiled: December 8, 2020Publication date: February 9, 2023Applicants: UNIVERZITA PALACKEHO V OLOMOUCI, FYZIOLOGICKY USTAV AV CR, V. V. I.Inventors: Jiri VOLLER, Martin SLADEK, Marian HAJDUCH, Alena SUMOVA, Miroslav STRNAD
-
Publication number: 20230028523Abstract: Lipophosphonoxins of general formula I, diastereomers and mixtures of diastereomers of compounds of general formula I and their pharmaceutically acceptable salts and hydrates as antibacterial agents, forming an active ingredient in pharmaceutical compositions for the treatment of resistant bacterial infections, disinfectants and/or selective culture media is disclosed.Type: ApplicationFiled: December 9, 2020Publication date: January 26, 2023Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I., MIKROBIOLOGICKY USTAV AV CR, V. V. I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Dominik REJMAN, Radek POHL, Viktor MOJR, Duy Dinh DO PHAM, Milan KOLAR, Libor KRASNY
-
Publication number: 20220402978Abstract: A polypeptide mimicking epitope of glycoprotein gp120 of HIV-1 virus that is recognized by a paratope of broadly neutralizing antibody VRC01 and has the length up to 100 amino acid residues and contains an amino acid sequence: (SEQ?ID?NO.?1): X1YKNX2INX3AX4X5VX6X7VKRX8IDX9ILAX10LP X1 is selected from amino acids A, N, R; X2 is selected from amino acids A, R, D; X3 is selected from amino acids R, V, P; X4 is selected from amino acids V, L, S; X5 is selected from amino acids T, G, R; X6 is selected from amino acids G, T; X7 is selected from amino acids L, A; X8 is selected from amino acids V, I; X9 is selected from amino acids G, A, R; X10 is selected from amino acids R, A, G; with a directly attached alpha-helical structure at the N-terminus or C-terminus is disclosed.Type: ApplicationFiled: September 8, 2020Publication date: December 22, 2022Applicant: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Petr MALY, Milan RASKA, Milan KUCHAR, Petr KOSZTYU, Jaroslav TURANEK, Hana PETROKOVA
-
Patent number: 11366148Abstract: The present disclosure refers to a method of measuring resistance of the resistive sensor (5), where the value of resistance of the resistive sensor (5) is determined from its series connection with actively controlled resistor network (3) with selectable value of resistance and with a periodic waveform voltage source (7), and further a device for measuring resistance of the resistive sensor (5) including a periodic waveform voltage source (7), actively controlled resistor network (3), and a resistive sensor (5), wherein the terminals of the periodic waveform voltage source (7) are connected to the first node (2) and the third node (6), terminals of actively controlled resistor network (3) are connected to the first node (2) and the second node (4), and terminals of the resistive sensor are connected to the second node (4) and the third node (6), thus forming a connection in a resistive voltage divider with an automatic selection of one resistor of the divider, and usage of this method for measuring time-varyType: GrantFiled: March 29, 2019Date of Patent: June 21, 2022Assignee: Univerzita Palackého v OlomouciInventor: Petr Fry{hacek over (c)}ák
-
Patent number: 11299510Abstract: Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl; and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.Type: GrantFiled: March 4, 2019Date of Patent: April 12, 2022Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lucia Veselovska, Michal Hocek, Marian Hajduch, Petr Dzubak
-
Patent number: 11186583Abstract: 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives of formula I that are effective inhibitors of kinases and exhibit strong antiproliferative and proapoptotic properties on lymphoma cells. Derivatives in the treatment of blood hyperproliferative diseases, such as Non-Hodgkin lymphomas are also disclosed.Type: GrantFiled: February 1, 2019Date of Patent: November 30, 2021Assignees: UNIVERZITA PALACKEHO V OLOMOUCI, USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.Inventors: Libor Havlicek, Antonin Sturc, Eva Reznickova, Radek Jorda, Vladimir Krystof, Miroslav Strnad
-
Patent number: 11028087Abstract: The present invention relates to novel 2,6-disubstituted-9-cyclopentyl-9H-purines of general formula I, capable of inhibiting the activity of kinases such as FLT3, CDKs and PDGFRs in cancer and other related proliferative diseases. The invention further includes pharmaceutical compositions containing the 2,6-disubstituted-9-cyclopentyl-9H-purines. Compounds of the present invention can be used as active ingredients of a pharmaceutical compositions for treating acute myeloid leukemia (AML).Type: GrantFiled: March 19, 2018Date of Patent: June 8, 2021Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Tomas Gucky, Eva Reznickova, Radek Jorda, Vladimir Krystof, Miroslav Strnad, Tereza Radosova Muchova, Vladimir Divoky
-
Publication number: 20210002321Abstract: Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl; and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.Type: ApplicationFiled: March 4, 2019Publication date: January 7, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lucia VESELOVSKA, Michal HOCEK, Marian HAJDUCH, Petr DZUBAK
-
Publication number: 20200361943Abstract: 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives of formula I that are effective inhibitors of kinases and exhibit strong antiproliferative and proapoptotic properties on lymphoma cells. Derivatives in the treatment of blood hyperproliferative diseases, such as Non-Hodgkin lymphomas are also disclosed.Type: ApplicationFiled: February 1, 2019Publication date: November 19, 2020Applicants: UNIVERZITA PALACKEHO V OLOMOUCI, USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.Inventors: Libor HAVLICEK, Antonin STURC, Eva REZNICKOVA, Radek JORDA, Vladimir KRYSTOF, Miroslav STRNAD
-
Patent number: 10774084Abstract: Adenine derivatives substituted at the C2, N6, and N9 purine positions having antisenescent and combined photoprotective UVA/UVB effects. These substances are particularly suitable as anti-senescent and UV-photoprotective component in cosmetic preparations, plant protection preparations and in preparations for the treatment/application of tissue cultures.Type: GrantFiled: August 24, 2016Date of Patent: September 15, 2020Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Martin Hönig, Lucie Plihalova, Karel Dolezal, Jiri Voller, Miroslav Strnad, Lukas Spichal, Jitka Vostalova, Alena Rajnochova Svobodova, Jitka Ulrichova, Alena Kadlecova, Ondrej Plihal
-
Patent number: 10759826Abstract: 15?-substituted derivatives of estrone of general formula I wherein R1, R2, R3, R4, R5 are independently selected from the group consisting of: C1-C4 alkyl, C1-C4 alkoxy, C1-C4 halogenalkyl, halogen, COOR6 wherein R6 is C1-C4 alkyl; H, OH; optionally, R3, R4 and R5 are each formed by a hydrogen atom, while R1 and R2 together form an aryl group, preferably naphthyl, in which the aromatic ring in position C-15 can be mono-, di-, tri-, tetra- and penta-substituted with substituents R1-R5. Compounds of the invention may be used for diagnosis and possibly also for the treatment of estrogen-dependent diseases.Type: GrantFiled: June 7, 2017Date of Patent: September 1, 2020Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MOLEKULARNI GENETIKY AKADEMIE VED CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCI, HELMHOLTZ ZENTRUM MUNCHENInventors: Martin Kotora, Eva Prchalova, Jerzy Adamski, Gabriele Moeller, Ondrej Stepanek, Petr Bartunek, David Sedlak, Marian Hajduch, Petr Dzubak
-
Publication number: 20200249626Abstract: The invention relates to an add-on imaging module for the off-axis recording of polarization coded waves, that might be connected to any polarization adapted interferometric system, and which incorporates the first polarization sensitive beam splitter, the first optical system of the module and the detector, wherein the first optical system of the module includes the first imaging system and the linear polarizer.Type: ApplicationFiled: September 21, 2018Publication date: August 6, 2020Applicants: Vysoké Ucení Technické v Brne, Univerzita Palackeho V OlomouciInventors: Petr BOUCHAL, Radim CHMELIK, Zdenek BOUCHAL, Radek CELECHOVSKY
-
Patent number: 10730905Abstract: Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides of general formula I, where R is selected from the group comprising furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl or chloro, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers.Type: GrantFiled: July 31, 2017Date of Patent: August 4, 2020Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Michal Hocek, Anna Tokarenko, Sabina Smolen, Marian Hajduch, Petr Dzubak
-
Patent number: 10662194Abstract: The invention relates to substituted 6-anilino-9-heterocyclylpurine derivatives of formula I wherein R denotes one to five substituents independently selected from the group hydrogen, halogen, hydroxy, amino, alkyloxy and alkyl group, R2 is selected from the group comprising amino, halogen, hydroxy, thio, and alkylthio group, Cyc is five- or six-membered heterocyclic ring containing one oxygen atom. The derivatives are useful for inhibition of plant stress.Type: GrantFiled: December 9, 2015Date of Patent: May 26, 2020Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Marek Zatloukal, Lucie Plihalova, Jana Klaskova, Lukas Spichal, Radoslav Koprna, Karel Dolezal, Miroslav Strnad
-
Publication number: 20200157105Abstract: The invention relates to N2,N6-disubstituted-9-(2-oxacycloalkyl)-9H-purine-2, 6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.Type: ApplicationFiled: April 27, 2018Publication date: May 21, 2020Applicant: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Jana BIBOVA, Vaclav MIK, Marek ZATLOUKAL, Lucie PLIHALOVA, Jiri GRUZ, Lukas SPICHAL, Karel DOLEZAL, Miroslav STRNAD
-
Publication number: 20200087306Abstract: The present invention relates to novel 2,6-disubstituted-9-cyclopentyl-9H-purines of general formula I, capable of inhibiting the activity of kinases such as FLT3, CDKs and PDGFRs in cancer and other related proliferative diseases. The invention further includes pharmaceutical compositions containing the 2,6-disubstituted-9-cyclopentyl-9H-purines. Compounds of the present invention can be used as active ingredients of a pharmaceutical compositions for treating acute myeloid leukemia (AML).Type: ApplicationFiled: March 19, 2018Publication date: March 19, 2020Applicant: UNIVERZITA PALACKEHO V OLOMOUCIInventors: TOMAS GUCKY, Eva REZNICKOVA, Radek JORDA, Vladimir KRYSTOF, Miroslav STRNAD, Tereza RADOSOVA MUCHOVA, Vladimir DIVOKY
-
Patent number: 10550144Abstract: 6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents ?-D-arabinofuranosyl or ?-D-2?-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use for regulation, in particular inhibition, of aging in plants in vivo or plant cells in vitro, and for regulation of growth and development of plants in vivo, plant tissues, plant organs and plant cells in vitro.Type: GrantFiled: December 2, 2015Date of Patent: February 4, 2020Assignee: UNIVERZITA PALACKEHO V OLOMOUCIInventors: Karel Dolezal, Lucie Plihalova, Hana Vylicilova, Marek Zatloukal, Ondrej Plihal, Jiri Voller, Miroslav Strnad, Johannes Van Staden, Ponnusamy Baskaran, Aloka Kumari, Adeyemi Oladapo Aremu