Patents Assigned to Ustav Organicke Chemie A Biochemie AV CR, V.V.I.
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Patent number: 11744855Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.Type: GrantFiled: March 26, 2019Date of Patent: September 5, 2023Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I, MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE U SV, ANNY V BRNEInventors: Petr Cigler, Lukas Balek, Jan Havlik, Pavel Krejci, Lukas Trantirek, Silvie Trantirkova
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Publication number: 20230192647Abstract: Quinolinecarboxamide compounds of general formula I exceed the previously known FAP inhibitors in affinity and inhibitory effect. These agents can be used to specifically target tumours for diagnostic and therapeutic purposes, or for laboratory purposes in the study of endogenous FAP expression.Type: ApplicationFiled: March 29, 2021Publication date: June 22, 2023Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I.Inventors: Adela SIMKOVA, Pavel SACHA, Natan SIDEJ, Tereza ORMSBY, Jan KONVALINKA
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Publication number: 20230028523Abstract: Lipophosphonoxins of general formula I, diastereomers and mixtures of diastereomers of compounds of general formula I and their pharmaceutically acceptable salts and hydrates as antibacterial agents, forming an active ingredient in pharmaceutical compositions for the treatment of resistant bacterial infections, disinfectants and/or selective culture media is disclosed.Type: ApplicationFiled: December 9, 2020Publication date: January 26, 2023Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I., MIKROBIOLOGICKY USTAV AV CR, V. V. I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Dominik REJMAN, Radek POHL, Viktor MOJR, Duy Dinh DO PHAM, Milan KOLAR, Libor KRASNY
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Patent number: 11534578Abstract: A catheter that has a catheter tube everting inside-out during the process of catheterization. The catheter tube has a plurality of longitudinal protrusions extending from the first end of the catheter tube through at least a portion of the catheter tube, and forming an angle of 0 degrees to 45 degrees with respect to the longitudinal axis of the catheter tube and facing radially inwards, and provides for dilating a circumference of the catheter tube upon everting the catheter tube inside-out from the first end of the catheter tube.Type: GrantFiled: August 30, 2017Date of Patent: December 27, 2022Assignees: RIOCATH MEDICAL DEVICES, A.S., USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.Inventors: Vit Pokorny, Miroslav Svoboda
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Publication number: 20220305235Abstract: A catheter that has a catheter tube everting inside-out during the process of catheterization is disclosed. The catheter tube has a plurality of longitudinal protrusions extending from the first end of the catheter tube through at least a portion of the catheter tube, and forming an angle of 0 degrees to 45 degrees with respect to the longitudinal axis of the catheter tube and facing radially inwards, and provides for dilating a circumference of the catheter tube upon everting the catheter tube inside-out from the first end of the catheter tube.Type: ApplicationFiled: June 13, 2022Publication date: September 29, 2022Applicants: RIOCATH MEDICAL DEVICES, A.S., USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.Inventors: Miroslav Svoboda, Vit Pokorny
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Publication number: 20220259119Abstract: The present invention relates to compounds of general formula (I), wherein —X is selected from a group consisting of H; C1 to C6, alkyl; halogen (F, Cl, Br or I); Y is selected from a group consisting of nitrogen; N-oxide; Z1, Z2, Zm, wherein m is 1 or 2, are independently selected from the group consisting of —CH2—CH2— and —CH2—CH2—CH24 A, Am, wherein m is 1 or 2, are independently selected from H; —CH2COOH; —CH2C(O)NH2; —CH2P(O)(OH)2, and n is 1 or 2; R1, R2, R3 are independently H; C1 to C6, alkyl; C1 to C6 alkyloxy; C6 to C10 aryloxy; benzyloxy; C1 to C6 alkylthio; C6, to C10 arylthio; F; Cl; Br; I; OH; SH; NH2; C1 to C6, alkylamino; di(C1 to C6, alkyl)amino; C1 to C6 acylamino; di(C1 to C6 acyl) amino; C6 to C10 arylamino; di(C6 to C10 aryl)amino; CN; OH; nitro; COORn, C(O)NHRn, C(O)N(Rn)2, wherein Rn is independently H or C1 to C10 alkyl or C6, to C10 aryl; and/or neighboring two of R1, R2, R3 together with neighboring two carbon atoms of the aromatic cycle form a six-membered ring, optionally substType: ApplicationFiled: May 28, 2020Publication date: August 18, 2022Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.IInventor: Miloslav Polasek
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Patent number: 11395904Abstract: A catheter that has a catheter tube everting inside-out during the process of catheterization. The catheter tube has a plurality of longitudinal protrusions extending from the first end of the catheter tube through at least a portion of the catheter tube, and forming an angle of 0 degrees to 45 degrees with respect to the longitudinal axis of the catheter tube and facing radially inwards, and provides for dilating a circumference of the catheter tube upon everting the catheter tube inside-out from the first end of the catheter tube.Type: GrantFiled: August 30, 2017Date of Patent: July 26, 2022Assignees: RIOCATH MEDICAL DEVICES, A.S., USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.Inventors: Miroslav Svoboda, Vit Pokorny
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Publication number: 20220218849Abstract: Cyclen based compounds of general formula (I) are disclosed. X is nitrogen and Y, Z are —CH—, or X, Z are —CH— and Y is nitrogen, or X, Y are —CH— and Z is nitrogen. R1 is independently selected from H; COOH; benzyloxycarbonyl; fluorenylmethyloxycarbonyl; tert-butoxycarbonyl; methylcarbonyl; trifluoromethylcarbonyl; benzyl; triphenylmethyl; tosyl; mesyl; benzyloxymethyl; phenylsulfonyl; ethoxycarbonyl; 2,2,2-trichloroethyloxycarbonyl; methoxycarbonyl; methoxymethyloxycarbonyl; R2 is selected from H; methylcarbonyl; tert-butyldimethylsilyl; (C1-C4)alkyl; R3 is independently selected from H; (C1-C6)alkyl.Type: ApplicationFiled: May 27, 2020Publication date: July 14, 2022Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V.V.I.Inventors: Miloslav POLASEK, Jan KRETSCHMER
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Publication number: 20220185822Abstract: A structurally novel class of heterocyclic compounds of general formula I wherein L1 is heteroaryl and L2 is heteroaryl or aryl is disclosed. The novel compounds are useful in a method of prevention or treatment of a condition that is mediated by the action, or by loss of action of Constitutive androstane receptor (CAR) receptor or its endogenous ligands. The present invention provides the novel compounds for medicinal use as well as pharmaceutical composition containing the compounds.Type: ApplicationFiled: April 25, 2020Publication date: June 16, 2022Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA KARLOVAInventors: Radim NENCKA, Ivana MEJDROVA, Petr PAVEK, Jan DUSEK
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Publication number: 20220177514Abstract: A method for functionalization of an aromatic amino acid or a nucleobase with a fluoroalkyl-containing moiety RF, wherein the aromatic amino acid is reacted in the presence of at least one reductant with at least one hypervalent iodine fluoroalkyl reagent carrying the floroalkyl-containing moiety RF is disclosed. Novel hypervalent iodine fluoroalkyl reagents is also disclosed.Type: ApplicationFiled: May 5, 2020Publication date: June 9, 2022Applicants: CF PLUS CHEMICALS S.R.O., USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., MIKROBIOLOGICKY USTAV AV CR, V.V.I.Inventors: Vaclav MATOUSEK, Petr BEIER, Petr NOVAK
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Publication number: 20220162257Abstract: 3?5?-steroid compounds of general formula I is disclosed. These compounds are useful in the treatment of epilepsy or comorbidities associated with epilepsy or conditions associated with convulsions, such as seizures associated with hypoxia, seizures associated with traumatic brain damage, seizures associated with intoxication, pathological changes caused by hyperexcitation, or in treatment of conditions accompanying epilepsy, such as affective disorders, depression, post-traumatic stress disorder (PTSD) and stress-related diseases, anxiety, schizophrenia and psychotic disorders, related ischemic CNS damage, neurodegenerative changes and disorders, multiple sclerosis. The compounds of general formula I also show age-specific efficacy.Type: ApplicationFiled: April 2, 2020Publication date: May 26, 2022Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I., FYZIOLOGICKY USTAV AV CR, V. V. I.Inventors: Eva KUDOVA, Hana CHODOUNSKA, Pavel MARES, Karel VALES
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Patent number: 11299510Abstract: Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl; and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.Type: GrantFiled: March 4, 2019Date of Patent: April 12, 2022Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lucia Veselovska, Michal Hocek, Marian Hajduch, Petr Dzubak
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Patent number: 11168153Abstract: Compounds of general formulae 6 and 13 where X is —NH—C(NH2)?N+H2 or —N+H3, Y is a linear oligomer of arginine units terminated with an aminodimethylenamide unit (-Arg)n-NH—(CH2)2—NH2, where n=6-10, or arginine-aminocaproic units (-Arg-Aca)n-NH2, where n=6 to 10, A-?CF3COO— or Cl— and m=1-2. Preparation and use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membranes for the purpose of incorporation of modified nucleoside triphosphates into cellular DNA or RNA. Use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membrane for determining the virostatic activities of modified nucleoside triphosphates. Use of compounds of general formula 6 and 13 as carriers of modified nucleoside triphosphates across the cell membrane for determining cell proliferation and S phase of the cell cycle.Type: GrantFiled: March 15, 2017Date of Patent: November 9, 2021Assignee: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.Inventors: Tomas Kraus, Zbigniew Zawada
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Patent number: 11135237Abstract: Lipophosphonoxins of general Formula I are described, in which R1 is C8-C22, preferably C10-C18 and more preferably C12-C16 alkyl, or hexadecyloxypropyl, tetradecyloxypropyl, tetradecyloxyethyl or hexadecyloxyethyl, R2 is uracil, thymine, or cytosine, and R3 is selected from a group which contains compounds of general formulas II and III.Type: GrantFiled: April 19, 2017Date of Patent: October 5, 2021Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., TRIOS, SPOL. S R.O.Inventors: Dominik Rejman, Radek Pohl, Eva Zbornikova, Libor Krasny, Tomas Latal, Milan Kolar
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Publication number: 20210283568Abstract: The present invention relates to a process for ion irradiation of a particulate substrate containing the steps of embedding particulate substrate in a solid matrix having 10B atoms, and exposing the matrix obtained in the previous step to a neutron flux to give irradiated particulate substrate. The process is extremely effective and amenable to large scale and is particularly suitable for producing irradiated nanodiamonds and irradiated SiC particles.Type: ApplicationFiled: July 8, 2019Publication date: September 16, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V. V. I.Inventors: Petr CIGLER, Jan HAVLIK, Martin HRUBY, Jan KUCKA
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Patent number: 11111219Abstract: The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E2. In concentrations lowering production of this factor by 50%, these compounds have no negative effect on the cell viability and they are not cytotoxic. Furthermore, the method of production of the compounds of the general formula I is provided. A pharmaceutical composition comprising the polysubstituted pyrimidines according to the invention and the use of these compounds for the treatment of the inflammatory diseases are also provided.Type: GrantFiled: May 23, 2018Date of Patent: September 7, 2021Assignee: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.Inventors: Viktor Kolman, Filip Kalcic, Zlatko Janeba, Zdenek Zidek
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Publication number: 20210220383Abstract: Lipophosphonoxins of general Formula I are described, in which R1 is C8-C22, preferably C10-C18 and more preferably C12-C16 alkyl, or hexadecyloxypropyl, tetradecyloxypropyl, tetradecyloxyethyl or hexadecyloxyethyl, R2 is uracil, thymine, or cytosine, and R3 is selected from a group which contains compounds of general formulas II and III.Type: ApplicationFiled: April 19, 2017Publication date: July 22, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., MIKROBIOLOGICKY USTAV AV CR, V.V.I., TRIOS, SPOL. S R. O.Inventors: DOMINIK REJMAN, Radek POHL, Eva ZBORNIKOVA, Libor KRASNY, Tomas LATAL, Milan KOLAR
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Patent number: 10927146Abstract: Compounds useful for the treatment of malaria, cancer, Parkinson's disease, diabetes, and bacterial infection.Type: GrantFiled: June 12, 2018Date of Patent: February 23, 2021Assignee: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.Inventors: Kvido Strisovsky, Pavel Majer, Stanco Stancev, Anezka Ticha
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Publication number: 20210015856Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.Type: ApplicationFiled: March 26, 2019Publication date: January 21, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE U SV. ANNY V BRNEInventors: Petr CIGLER, Lukas BALEK, Jan HAVLIK, Pavel KREJCI, Lukas TRANTIREK, Silvie TRANTIRKOVA
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Publication number: 20210002321Abstract: Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl; and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.Type: ApplicationFiled: March 4, 2019Publication date: January 7, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lucia VESELOVSKA, Michal HOCEK, Marian HAJDUCH, Petr DZUBAK