Abstract: Provided is a method of treating asthma. The method is the administering to a patient requiring treatment of an effective dose of a benzoxazole-2-carboxylic acid or an ester or therapeutically-acceptable salt of benzoxazole-2-carboxylic acid.

Abstract: New triazoloquinoxalin-1,4-diones are described as well as the use thereof as anti-allergenic agents.

Abstract: Compounds having the structure: ##STR1## are novel and useful as antiallergic agents. The compounds are formulated with a pharmaceutical carrier for oral, parental, inhalational, or rectal means of administration.

Abstract: A composition for the treatment of acne in the form of a solution, lotion or cream containing from about 1 to 10% by weight of a compound of the formula ##STR1## wherein R is an alkyl having up to 6 carbon atoms or aryl having up to 10 carbon atoms and R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl having up to 6 carbon atoms, phenyl, phenyl-lower alkyl, lower alkylphenyl, halogen, halophenyl, trifluoromethyl, trifluoromethylphenyl, lower alkoxy, methylenedioxy, and lower alkoxyphenyl.

Abstract: Provided are pyridothienopyridazine compounds of the formula ##STR1## wherein R.sub.1 is alkyl, alkenyl, alkynyl, halogen, nitro, cyano, carboxy, carboxyalkyl, carbalkoxy, alkanoyl, trihalomethyl, aryl, aralkyl, hetero, thio, thioalkyl, alkylmercapto, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, alkylamino, sulfinyl, sulfonyl or methylenedioxy,n is an integer from 0 to 3 inclusive, andR.sub.2 and R.sub.3 are independently hydrogen, alkyl, alkenyl, alkinyl, hydroxy, hydroxyalkyl, alkoxy, halogen, amino, aminoalkyl, alkylamino, alkanoylamino, thio, thioalkyl, alkylmercapto, carboxy, carbalkoxy, alkylsulfinyl, alkylsulfonyl, arylsulfinyl, or arylsulfonyl, wherein the alkyl groups contain from 1 to 6 carbon atoms, the alkenyl and alkynyl groups contain from 2 to 6 carbon atoms, and the aryl groups contain from 6 to 10 carbon atoms. These compounds have anti-allergy activity.

Abstract: New substituted triazoloquinoxalin-4-ones are described as well as the use thereof as anti-hypertensive agents.

Abstract: A compound of the formula ##STR1## wherein: R.sub.1 is independently lower alkyl having from 1 to 6 carbon atoms, lower alkenyl having from 2 to 6 carbon atoms, lower alkynyl having from 2 to 6 carbon atoms, hydroxy, hydroxyalkyl, alkoxy, thio, thioalkyl, alkylmercapto, amino, aminoalkyl, alkylamino, nitro, cyano, alkanoyl, carboxy, carboxyalkyl, carbalkoxy, carbalkoxyalkyl, halogen, alkylsulfoxy, alkylsulfonyl, sulfonyl, sulfonamido, trifluoromethyl, or methylenedioxy, wherein the alkyl group in hydroxyalkyl, thioalkyl, aminoalkyl, carboxyalkyl, alkoxy, alkylmercapto, alkylsulfoxy, alkanoyl, carbalkoxy, and carbalkoxyalkyl has from 1 to 6 carbon atoms,n is an integer from 1 to 4 inclusive,R.sub.2 is selected from the group consisting of hydrogen and cycloalkyl, wherein the cycloalkyl group contains from 3 to 16 carbon atoms,R.sub.3 and R.sub.4 are hydrogen, andY is oxygen, sulphur, .dbd.NR.sub.1, .dbd.NOR.sub.1 or .dbd.N--NH.sub.2, R.sub.1 being the same as defined above.

Abstract: Compounds of the formulae: ##STR1## wherein, Z and Y are each alkylene containing one to about five carbon atoms in the principal chain or said alkylene substituted with OH, alkanoyloxy, alkoxy, mercapto or alkylmercapto;each of R.sub.1, R.sub.2 and R.sub.3 is independently H, alkyl, aryl, halo, alkoxy, alkenyloxy, alkylsulfinyl, alkylsulfonyl, alkylmercapto, cyano, carboxy, carbalkoxy, carboxamido, sulfamoyl, trifluoromethyl, hydroxy, hydroxyalkyl, acyloxy, alkylamino, sulfonylamino, or acylamino; and R.sub.1 and R.sub.2, when taken together, form a methylenedioxy or --O--CO--O--;Ar is heteroaryl, cycloalkyl or ##STR2## wherein, R.sub.1, R.sub.2 and R.sub.3 are as hereindescribed; andR is H, alkyl, cycloalkyl, aryl, aralkyl, alkenyl, alkynyl, carboalkoxy, or CONR.sub.4 R.sub.5 wherein each of R.sub.4 and R.sub.5 is H or alkyl; wherein the total number of carbon atoms in each hydrocarbyl group is up to 10;and ##STR3## wherein, each of R.sub.1 and R.sub.

Abstract: Compounds of the formula ##STR1## wherein, Y and Z are each H, alkyl, halo, alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino;X is F, Cl Br or NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl or cycloalkyl; andR is H, alkyl, cycloalkyl or aralkyl; and salts thereof.The compounds have utility as anti-hypertensive and diuretic agents and as intermediates for the preparation of other anti-hypertensive and diuretic agents.

Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, hydroxy, nitro, trifluoromethyl, mercapto, or alkylmercapto, and may be the same or different,n is an integer from 2 to 4, andR.sub.1 and R.sub.2 are hydrogen or alkyl and may be the same or different, or R.sub.1 and R.sub.2 taken together with the nitrogen to which they are attached may be pyrrolidino, piperidino or morpholinoand their pharmaceutically acceptable, non-toxic acid addition salts have anti-arrhythmic activity.

Abstract: Therapeutic compositions containing as active principle, a benzoxazindione or pharmaceutically-acceptable acid addition salt thereof are useful in the treatment of allergy.

Abstract: Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is heterocyclic or heterocyclic alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ZS, or ##STR2## wherein Z is hydrogen, alkyl, kydroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, M and Y are as described above; and where Y is hydroxy their nontoxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.

Abstract: Compounds of the formula ##STR1## wherein each of R, R.sub.1 and R.sub.2 is independently H, alkyl, alkenyl, alkoxy, halo, hydroxy, trifluoromethyl, amino, alkylamino, cyano and nitro;R.sub.3 is carbalkoxy, carboxamide alkanoyl, trifluoromethyl and cyano; andAr is heteroaryl or ##STR2## wherein R.sub.4 and R.sub.5 have the same meaning as each of R, R.sub.1 and R.sub.2 ; and acid addition salts thereof have cardiotonic and hypertensive activity.

Abstract: Iminobenzyl dihydropyridines of the formula ##STR1## wherein, each R is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, sulfonamido, halogen, alkoxy, alkenyloxy, alkynyloxy, cyano, hydroxy, acyloxy, nitro, amino, alkylmercapto, alkylamino, alkanoylamino, carbalkoxyamino, carboxy, methanesulfonyl, carbalkoxy or trifluoromethyl;each R.sub.4 is lower alkoxy;each R.sub.2 is lower alkyl;and R.sub.3 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic or ##STR2## wherein R is as previously defined; have anti-hypertensive activity.

Abstract: Migration of suspended materials in nail enamels is prevented by the addition thereto of from about 0.10 to 5.0% by weight of a phosphatide such as lecithin. Settling and migration of suspended materials in nail enamels is prevented by the addition thereto of from 0.10 to 5.0% by weight of a phosphatide such as lecithin and from about 0.04 to 0.20% by weight of a cosmetically acceptable acid.

Abstract: New benzoxazole-2-carboxylic acid esters are described. These compounds are useful as anti-allergic reagents.

Abstract: Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive,R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, cycloalkyl having from 3 to 16 carbon atoms, phenyl, benzyl, tolyl, naphthyl, phenethyl, indanyl, tetrahydronaphthyl, decanydronaphthyl, pyridyl, quinolyl, pyrrolidyl, pyrrolyl, morpholinyl, thiomorpholinyl, furyl, furfuryl, tetrahydrofurfuryl, benzimidazole, thienyl, imidolyl, or tetrahydroindolyl, and where the R.sub.1 to R.sub.7 groups are alkyl, said groups carrying a substituent selected from hydroxy, alkoxy, amino, carboxy, or carbalkoxy, the alkyl group in alkoxy and carbalkoxy having from 1 to 6 carbon atoms, or R.sub.2 taken together with R.sub.3 and the carbons to which they are attached is tetrahydronaphthyl or phenyl, and when phenyl R.sub.1 and R.sub.4 are absent, or R.sub.6 and R.sub.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl, phenyl or phenyl-lower alkyl,n is an integer from 1 to 5, andm is an integer from 2 to 5 have antiarrhythmic activity.

Abstract: New triazolobenzoxazinones are described as well as the use thereof as anti-allergenic agents.

Abstract: New benzoheterocyclic oxadiazolones and triazolones are described. These compounds are useful as anti-allergic reagents.