Abstract: A fluorescent probe having a capsule of nanometric size and an aggregate of fluorogenic molecules coupled to the capsule is provided. The aggregate emits a fluorescent signal at one or more wavelengths within the fluorescence spectral range when the probe is illuminated by an excitation light beam at one or more wavelengths within the excitation spectral range. Preferably, the fluorescent spectral range is in the near-infrared region of the spectrum. In some embodiments, the capsule is a boron nitride (BN) nanotube and the aggregate comprise 3,6-Bis[2,2?]bithiophenyl-5-yl-2,5-di-n-octylpyrrolo[3,4-c]pyrrole-1,4-dione as fluorogenic molecules. In some embodiments, the 3,6-Bis[2,2?]bithiophenyl-5-yl-2,5-di-n-octylpyrrolo[3,4-c]pyrrole-1,4-dione fluorogenic molecules are in a J-aggregation state.

Abstract: Chalcogen-grafted carbon material as well as their functionalized forms are described along with processes for their preparation. More specifically, the chalcogen is covalently linked to the carbon scaffold of a polyaromatic carbon via C?X and/or C—X—C bonds. Processes for their preparation include a single thermal treatment without the use of strong acids or anhydrous solvents.

Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

Abstract: There is provided a pH responsive optical nanoprobe comprising metallic SWCNTs or graphene coated with a transition metal M. The coated metallic SWCNTs or graphene have an absorption spectrum comprising an optical resonance, and have a Raman scattering spectrum responsive to optical excitation at said optical resonance comprising at least one pH-dependent peak having at least one of a Raman shift value and an intensity that is function of a solution pH, when the nanoprobe is in contact with a solution at said solution pH. There is also provided a method to measure the pH of a solution, by contacting the solution with the nanoprobe; illuminating the nanoprobe with an excitation light beam having a wavelength at said optical resonance, thereby generating a Raman signal from the nanoprobe according to said Raman scattering spectrum; measuring a spectral distribution of the Raman signal; and determining the pH of the solution from the spectral distribution.

Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

Abstract: A system for and a method of processing signals sensed from a user. The method comprises accessing positions of a line of sight of the user over a time frame, a first set of data associated with a first physiological signal and a second physiological signal. The method further comprises executing, by a processor, for at least one position of the positions of the line of sight of the user, identifying a first subset of data from the first set of data, identifying a second subset of data from the second set of data, associating the at least one position with the first subset of data and the second subset of data and causing to generate, by a machine-learning algorithm, a predicted value reflective of a pattern associated with the user. The method also comprises storing the predicted value associated with the at least one position.

Abstract: There is provided a 3D virtual environment interaction system comprising: a processing unit for generating a 3D virtual environment comprising a planar reference frame for allowing a user to perform a user interaction with the 3D virtual environment; a display unit for displaying the generated 3D virtual environment; a portable input device for allowing the user to control the position and orientation of the planar reference frame within the generated 3D virtual environment, the portable input device comprising a planar input surface; a position and orientation sensor for monitoring the position and orientation of the planar input surface in a real-world space, the position and orientation sensor allowing the processing unit to modify at least one of the position and the orientation of the planar reference frame in response to a change in a corresponding one of the position and orientation of the planar input surface.

Abstract: A Raman scattering probe, and a method of making such a probe, uses a capsule of nanometric size, such as a nanotube, to which is coupled at least one Raman-active molecule. The Raman-active molecule may be encapsulated in, or attached on the exterior of, the capsule, and exhibits a Raman scattering response when the probe is illuminated by an excitation light beam. A functionalization chemical group that is attached to an exterior of the capsule provides a connection between the capsule and a target material. This functionalization may include a generic chemical functionalization that bonds with any of a plurality of secondary chemical groups each of which bonds directly with a different target. A method of using the probe for Raman spectroscopy or Raman imaging is also provided.

Abstract: Compounds which inhibit the formation and/or accumulation of RNA foci, such as those due to polynucleotide repeats (e.g., trinucleotide repeats) are described herein. Also described herein are uses of such compounds, such as for the inhibition of the formation and accumulation such RNA foci, as well as for the treatment of polynucleotide repeat disorders (e.g., trinucleotide repeat disorders), such as myotonic dystrophy (e.g., DM1). Such compounds include compounds of formula 1, 1a, 1b, 2, 2a and (3) described herein.

Abstract: The present invention relates to a peptide comprising (A) (i) a first domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence PDDRTLQ (SEQ ID NO:1); and (ii) a second domain covalently linked to the first domain and comprising an amino acid sequence having at least 60% sequence similarity with the sequence QNPVYLIPETVPYIKWDN (SEQ ID NO:2) or (B) (i) a first domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence GSAKPGNGSYF (SEQ ID NO: 41); and (ii) a second domain covalently linked to the first domain, said second domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence SVKTEMLGNEID (SEQ ID NO: 42), wherein the peptide binds to monoclonal antibody clone 72A1.

Abstract: A method for generating a 360 degree view. N input images are captured from N cameras fixed at a baseline height equidistantly about a circle in an omnipolar camera setup where N?3. Two epipolar lines are defined per field of view from the cameras to divide the field of view of each one of the cameras into four parts. Image portions from each one of the cameras are stitched together along vertical stitching planes passing through the epipolar lines. Regions corresponding to a visible camera are removed from the image portions using deviations performed along the epipolar lines. Output images are formed for left and right eye omnistereo views by stitching together the first one of the four parts from each one of the fields of view and the second one of the four parts from each one of the fields of view, respectively.

Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.

Abstract: An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B ??I.

Abstract: There is described a camera setup for capturing omnistereo images using a minimum of three cameras with ultra wide angle lenses and a method for generating a substantially 360 degree view from images taken from the cameras. The field of view covered in stereo may be a dome. The baseline between pairs of cameras defines epipoles which can be used for stitching without any horizontal misalignments due to parallax. The method comprises capturing the images from a plurality of cameras fixed at a baseline height substantially equidistantly about a circle; and stitching together portions of the images from each one of the plurality of cameras along first and second borders corresponding at least in part to lines joining center points of neighboring ones of the plurality of cameras.

Abstract: There are provided non-destructive methods for incorporating an atom such as N into a material such as graphene. The methods can comprise subjecting a gas comprising the atom to conditions to obtain a flowing plasma afterglow then exposing the material to the flowing plasma afterglow. There are also provided materials such as N-doped graphene produced by such methods.

Abstract: A Raman scattering probe, and a method of making such a probe, uses a capsule of nanometric size, such as a nanotube, to which is coupled at least one Raman-active molecule. The Raman-active molecule may be encapsulated in, or attached on the exterior of the capsule, and exhibits a Raman scattering response when the probe is illuminated by an excitation light beam. A functionalization chemical group that is attached to an exterior of the capsule provides a connection between the capsule and a target material. This functionalization may include a generic chemical functionalization that bonds with any of a plurality of secondary chemical groups each of which bonds directly with a different target. A method of using the probe for Raman spectroscopy or Raman imaging is also provided.

Abstract: An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B??I.

Abstract: A measurement device for measuring activity of the spinal cord of a vertebrate. The device includes at least one main probe (1) shaped to be fastened to a spinous process (2) of a vertebra (3) and to hold in position on opposite sides of the vertebra at least one emitter (6) for emitting a wave capable of interacting with the spinal cord (7) and at least one associated receiver (8) for receiving the wave that has interacted with the spinal cord and for generating a signal representative of the activity of the spinal cord.

Abstract: The present invention relates to the field of Streptococcus. More specifically, the present invention relates to the identification of polypeptides and polynucleotide sequences encoding the same which are involved in the pathogenic mechanism of S. suis. The present invention also relates to the use of such polypeptides in compositions and methods for the prevention, the treatment and diagnosis of S. suis-associated diseases and infections caused by S. suis.

Abstract: The present invention relates to the field of Streptococcus. More specifically, the present invention relates to the identification of polypeptides and polynucleotide sequences encoding the same which are involved in the pathogenic mechanism of S. suis. The present invention also relates to the use of such polypeptides in compositions and methods for the prevention, the treatment and diagnosis of S. suis-associated diseases and infections caused by S. suis.