Abstract: This invention is related to a cyclic hydroxamic acid of the formula: ##STR1## wherein R.sup.1 is C.sub.1-24 alkyl and R.sup.2 is benzyl.

Abstract: A control system for rapid fault tolerant control of a multiple control-point apparatus is disclosed. The system comprises: a host subsystem acting as a user interface; a plurality of control-point actuators; a master controller subsystem which receives initialization data from the host terminal and which generates behavior commands; and a control-point controller subsystem which receives behavior commands from the master controller subsystem and generates control-point actuator commands. The control-point controller subsystem is made fault tolerant by using a plurality of control-point processors connected to control-point interfaces through a programmable crossbar switch such that if any of the control-point processors develops a fault, the crossbar switch will connect one of the other control-point processors to the control-point interface previously serviced by the faulty control-point processors.

Abstract: The present invention relates to a method and apparatus for producing uniform polymeric spheres with controllable permeability. This invention may be useful for encapsulating living cells or tissue or chemicals or medicines in uniform polymeric spheres. In particular, this invention relates to polymeric microspheres made from polycation and polyanion polymer solutions. An apparatus includes airtight housing 1 having top 3 and bottom 25 chambers. Top chamber 3 includes pressure regulator means 5, stationary polyanion reservoir tank 7, polycation reservoir tank 27, and feed line 9 to adjustable tank 11. Tank 11 is associated with oscillator 13, nozzle 14 and capacitance means 19. Nozzle 14 and oscillator 3 cooperate to form polyanion droplets. In the bottom chamber 25 annular nozzle 50 is used to form an annular jet of polycation solution. The droplets and polycation jet are mixed at minimal impact velocities to form uniform polymeric sphere.

Abstract: In a model-based dynamically configured system, various processing components are created dynamically, interfaced to each other, and scheduled upon demand. A combination of data driven and demand-driven scheduling techniques are used to enhance the effectiveness of the dynamically configured system.

Abstract: A uniform composite of hypermonotectic composition and a method for producing the same wherein the composition has a plurality of aligned and constrained fibers therein. These fibers serve to uniformly distribute L.sub.11 from the reaction L.sub.I .fwdarw.S.sub.I +L.sub.II.

Abstract: Novel aryl aliphatic acids or derivatives thereof of the general formulaR--(C.sub.x --C.sub.y)--(C.sub.m H.sub.2m)--G--C(R.sup.1).sub.2 --Ar--(C.sub.n H.sub.2n)--COOR.sup.2are described which exhibit inhibiting activity against 12-lipoxygenase. The compounds are characterized by having a low level of toxicity. Also included are salts and esters of the aliphatic acids.

Abstract: RNA has been cloned for the intestinal receptor which recognizes heat stable enterotoxins and has guanylyl cylase activity. The protein sequence has been deduced. The protein has been expressed in cultured cells. Data shows that the protein binds enterotoxin and signals normally through the cyclic GMP second messenger system.

Abstract: An optimization method is used in a real-time diagnostic system that monitors alarm sources and detects possible sources of failure in an industrial process. When the diagnostic system detects one or more alarms, it determines which components are likely sources of failure. The system determines the level of criticality of certain other, currently off-line, alarms sources and schedules the off-line alarms for evaluation according to their levels of criticality. The system refines its analysis of likely sources of failure by evaluating the status of the previously off-line alarm sources Those previously off-line alarm sources are added to the grouping of possible sources of failure prior to repeating the evaluation process. The evaluation process is repeated, with the analysis of likely causes of failure being continually refined.

Abstract: Novel cyclic hydroxamic acids of the general formula: ##STR1## wherein ring A is 5- or 6-membered; R.sup.1, R.sup.2 and R.sup.3 each, ipendently, is hydrogen, C1-24 alkyl, C2-24 alkenyl or a group of the formula: ##STR2## wherein R.sup.4, R.sup.5, R.sup.7 and R.sup.8 each, independently is hydrogen,C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, halogen or nitro; l is 1-3; m is 1-3; n is 1-3; k is 1-3;R.sup.6 and R.sup.9 each, independently is C1-24 alkylene or C2-24 alkenylene;With the proviso that, more than one of R.sup.1, R.sup.2 and R.sup.3 are not hydrogen at the same time; and the pharmaceutically acceptable salts thereof possesses an inhibitory activity against 12-lipoxygenase, and therefore, may be useful for treating and/or preventing inflammation, immune diseases, psoriasis, arteriosclerosis and/or ischaemic cardiovascular diseases and also for suppressing metastasis of cancer.

Abstract: An apparatus for the levitation of a liquid drop by a fluid flow comprising a profile generator, a fluid flow supply means operatively connected to the profile generator. The profile generator includes an elongate cylindrical shell in which is contained a profiling means for configuring the velocity profile of the fluid flow exiting the profile generator.

Abstract: This invention relates to a method to treat a heart attack victim to reduce heart muscle damage. In particular, the invention relates to a metGrant StatementThis research was supported in part by the National Institute of Health, Grant R01 HL40892-01.

Abstract: Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medicine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.

Abstract: A charge-based multiplier circuit is provided which generates a charge packet proportional to the product of an input signal and a weight voltage. An exponential pulse is formed which is representative of the input signal. The circuit generates an output charge proportional to the product of the peak magntiude of the exponential pulse and the exponential decay time constant, which is represented by the weight voltage. The output charge can be generated as a charge onto an output bus for positive results, or the amount can be depleted from the bus for negative results.

Abstract: Flaws in an electrically conductive sample object are detected by cancelling the magnetic field generated by a detection current passed through the sample object by passing the current back through an unflawed field cancelling object placed next to the sample object, and measuring the uncancelled field produced by any flaw, preferably with a superconducting quantum interference device (SQUID) magnetometer. Elongated objects such as tubes and rods are fed through a sleeve which forms the field cancelling object, with the current applied to the elongated member and passed to the field cancelling sleeve through sliding contacts.

Abstract: An improved method and related apparatus is provided for magnetic resonance imaging with distortions due to magnetic field inhomogeneities and subject susceptibility corrected. The method includes providing a subject positioned within a main magnetic field, a source of RF signals, a receiver for receiving signals emitted from the subject responsive to the RF pulses and emitting responsive output signals, a computer for receiving the output signals from the receiver and establishing image information related thereto and a visual display for displaying images obtained from the image information. The improved method includes performing a first image generating sequence including generating a 90.degree. RF pulse while simultaneously applying a first slice selection gradient, a phase-encoding gradient and subsequently applying a first preparation gradient after which a 180.degree. refocussing pulse is generated. Subsequently a first read-out gradient is generated while the echo signal is read by the receiver.

Abstract: A method of healing extracellular matrix degradation to reverse glomerular sclerosis includes the steps of administering on angiotension I converting enzyme inhibitor and suppressing extracellular matrix release independent of the blood pressure effects of the enzyme inhibitor.

Abstract: Replication of human immunodeficiency virus (HIV) is inhibited in human patients by administering melanins. L-dopa melanin is preferred, but other water-soluble melanins can be used.

Abstract: Pickup coils for imaging magnetometers are formed from plural turns of a conductor with varying spacing between turns selected so that the Fourier transform of the coil turns function which is the filter function of the coil, has no zeroes within the spatial frequency bandwidth of the magnetic field generated by a two or three dimensional current to be imaged. Various exemplary coil configurations are presented including a Gaussian distribution for the turns of a planar coil.

Abstract: A method and apparatus for determining material properties such as composition and structure of the surfaces of bulk materials and thin film sample members using time-of-flight medium energy particle scattering is provided. The method and apparatus are based upon scattering particles from a sample material or ejecting particles from the sample material. The particles may include both uncharged particles and charged particles. Particles are scattered into a chamber from a sample surface using known methods. The particles pass through the first of two grids which grid is held at ground potential and which limits the electrostatic field. The particles then pass through a very thin carbon foil which is held at a potential of -3kV. On passing through the carbon foil the particles emit secondary electrons. An electric field is created between the carbon foil and the second grid, which accelerates the secondary electrons. The electrons strike a first microchannel plate detector and this generates a start pulse.

Abstract: A method for at least partially inhibiting vascularization of a developing solid tumor. Said method comprising parenterally administering to the patient the polysaccharide toxin produced by group B .beta.-hemolytic Streptococcus bacteria known as GBS toxin in an amount effective for said inhibition.