Patents Assigned to Vectura Limited
  • Patent number: 10238601
    Abstract: The invention provides a method of making a composition for inhalation which includes the step of mixing particles of additive material having a diameter of not more than 2 ?m with active particles, wherein the additive material is suitable for promoting the dispersal of active particles upon aerolisation of a dry powder in a dry powder inhaler.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: March 26, 2019
    Assignee: VECTURA LIMITED
    Inventors: John Nicholas Staniforth, David Alexander Vodden Morton
  • Patent number: 10188612
    Abstract: The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: January 29, 2019
    Assignee: Vectura Limited
    Inventors: John Nicholas Staniforth, Haggis Harris, David Alexander Vodden Morton, Robin Bannister
  • Patent number: 10155757
    Abstract: The invention relates to novel co-crystals of a drug substance and their use to treat respiratory diseases such as asthma and COPD.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: December 18, 2018
    Assignee: Vectura Limited
    Inventor: Joanne Holland
  • Patent number: 10087196
    Abstract: The invention relates to a polymorphic forms of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and their use as a therapeutic agent for the treatment of respiratory diseases.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: October 2, 2018
    Assignee: VECTURA LIMITED
    Inventor: Alexander Munro
  • Patent number: 10022323
    Abstract: The present invention concerns a method for making an inhaled pharmaceutical composition with improved powder handling properties comprising a stearate, a method of preparing such a composition, and the use of such a stearate in a composition when dispensed into a receptacle for use in a dry powder inhaler receptacle.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: July 17, 2018
    Assignee: VECTURA LIMITED
    Inventor: Matthew Green
  • Patent number: 9962338
    Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: May 8, 2018
    Assignee: VECTURA LIMITED
    Inventors: John Nicholas Staniforth, Matthew Michael Green, David Alexander Vodden Morton
  • Patent number: 9931304
    Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: April 3, 2018
    Assignee: VECTURA LIMITED
    Inventors: John Nicholas Staniforth, Matthew Michael Green, David Alexander Vodden Morton
  • Patent number: 9907754
    Abstract: The invention discloses spray-dried compositions for inhalation and methods for preparing such powder compositions. The compositions of the invention are produced by spray-drying taurine under conditions that (i) retain the physical and chemical stability of the composition during spray drying and upon storage, (ii) protect the powder composition from aggregation and (iii) provide particles suitable for aerosolization.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: March 6, 2018
    Assignee: VECTURA LIMITED
    Inventors: David Farrow, Katie Coggins
  • Patent number: 9642800
    Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: May 9, 2017
    Assignee: VECTURA LIMITED
    Inventor: David Morton
  • Patent number: 9585834
    Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: March 7, 2017
    Assignee: VECTURA LIMITED
    Inventor: David Morton
  • Patent number: 9585839
    Abstract: The invention provides a method of making a composition for inhalation which includes the step of mixing particles of additive material having a diameter of not more than 2 ?m with active particles, wherein the additive material is suitable for promoting the dispersal of active particles upon aerolization of a dry powder in a dry powder inhaler.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: March 7, 2017
    Assignee: VECTURA LIMITED
    Inventors: John Nicholas Staniforth, David Alexander Vodden Morton
  • Patent number: 9566239
    Abstract: A powder for use in a dry powder inhaler comprises: i) a fraction of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: February 14, 2017
    Assignee: VECTURA LIMITED
    Inventors: John Nicholas Staniforth, David Alexander Vodden Morton, Rajbir Gill, Gaetano Brambilla, Rossella Musa, Lorenzo Ferrarini
  • Patent number: 9381189
    Abstract: A method of processing an active ingredient, the method comprising submitting a pharmaceutically active ingredient in the absence of excipients and/or additives to compression and shearing forces. The invention also relates to compositions comprising an active prepared by the method.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: July 5, 2016
    Assignee: VECTURA LIMITED
    Inventors: Matthew Michael James Green, Richard Michael Poole
  • Patent number: 9351928
    Abstract: A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: May 31, 2016
    Assignee: VECTURA LIMITED
    Inventors: John Nicholas Staniforth, David Alexander Vodden Morton, Rossella Musa
  • Patent number: 9011923
    Abstract: The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurized metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: April 21, 2015
    Assignees: Innovata Biomed Limited, Vectura Limited
    Inventors: David Andrew Lewis, Christina Alexandra Keeble, Nicola Kim Whitfield, Tanya Church
  • Patent number: 8956661
    Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: February 17, 2015
    Assignee: Vectura Limited
    Inventors: John Nicholas Staniforth, Matthew Michael James Green, David Alexander Vodden Morton
  • Patent number: 8946257
    Abstract: N-containing heteroaryl derivatives of formula I or II, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK, particularly JAK3, kinase inhibitors.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: February 3, 2015
    Assignee: Vectura Limited
    Inventor: Jorge Salas Solana
  • Patent number: 8932635
    Abstract: The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: January 13, 2015
    Assignee: Vectura Limited
    Inventors: John Nicholas Staniforth, Haggis Harris, David Alexander Vodden Morton, Robin Bannister
  • Patent number: 8920781
    Abstract: A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material in the powder has been found to give an increased respirable fraction of the active material.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: December 30, 2014
    Assignee: Vectura Limited
    Inventor: John Nicholas Staniforth
  • Patent number: 8871274
    Abstract: A powder for use in a dry powder inhaler comprises: i) a fraction of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: October 28, 2014
    Assignee: Vectura Limited
    Inventors: John Nicholas Staniforth, David Alexander Vodden Morton, Rajbir Gill, Gaetano Brambilla, Rossella Musa, Lorenzo Ferrarini