Patents Assigned to Velico Medical, Inc.
  • Patent number: 8697411
    Abstract: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique ?-N-acetylgalactosaminidases and ?-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique ?-N-acetylgalactosaminidases and ?-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: April 15, 2014
    Assignee: Velico Medical, Inc.
    Inventors: Henrik Clausen, Humberto de la Vega, Cheryl Hill, Qiyong Peter Liu
  • Publication number: 20140099629
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 10, 2014
    Applicants: The Brigham and Women's Hospital, Inc., Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Patent number: 8601712
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: December 10, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8595950
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: December 3, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8533972
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: September 17, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8533971
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: September 17, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8517967
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: August 27, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Keith Rosiello, Henrik Clausen
  • Patent number: 8469202
    Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: June 25, 2013
    Assignee: Velico Medical, Inc.
    Inventor: Keith M. Rosiello
  • Publication number: 20130126101
    Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
    Type: Application
    Filed: January 17, 2013
    Publication date: May 23, 2013
    Applicant: VELICO MEDICAL, INC.
    Inventors: Dennis Brian Hubbard, JR., Michael Haley, Keith Rosiello
  • Patent number: 8434242
    Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: May 7, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Michael Haley
  • Patent number: 8407912
    Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: April 2, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley
  • Publication number: 20130078324
    Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
    Type: Application
    Filed: November 19, 2012
    Publication date: March 28, 2013
    Applicant: VELICO MEDICAL, INC.
    Inventor: Velico Medical, Inc.
  • Publication number: 20130056158
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Application
    Filed: October 25, 2012
    Publication date: March 7, 2013
    Applicant: VELICO MEDICAL, INC.
    Inventor: Velico Medical, Inc.
  • Patent number: 8387270
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: March 5, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8387269
    Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: March 5, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley
  • Publication number: 20130048225
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Application
    Filed: October 25, 2012
    Publication date: February 28, 2013
    Applicant: VELICO MEDICAL, INC.
    Inventor: Velico Medical, Inc.
  • Patent number: 8359767
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: January 29, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8359766
    Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: January 29, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley
  • Patent number: 8356421
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: January 22, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Publication number: 20130000774
    Abstract: A system for transferring blood product between a blood storage bag and a processing bag. The system includes an airtight containment chamber for supporting therein one or more blood storage bags. A door is provided for access to the chamber and there is included an airtight fixture that allows tubing from the blood storage bag to exit the chamber. A fluid pump is coupled to the containment chamber for establishing either pressure or vacuum within the containment chamber. A controller controls the air pump to, in turn, control the transfer of a blood product.
    Type: Application
    Filed: April 5, 2012
    Publication date: January 3, 2013
    Applicant: VELICO MEDICAL, INC.
    Inventor: Keith Rosiello