Patents Assigned to Vipont Pharmaceutical, Inc.
  • Free amine benzophenanthridine alkaloid compositions
    Patent number: 5395615
    Abstract: A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: March 7, 1995
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Kenneth C. Godowski, Ronald J. Harkrader, Richard L. Dunn, Arthur J. Tipton
  • Intragingival delivery systems for treatment of periodontal disease
    Patent number: 5324520
    Abstract: A polymeric controlled delivery system is provided for use in treating periodontal disease. The delivery system in a variety of forms is placed directly in the infected gingival tissue where the chemotherapeutic agent is slowly released into the tissue and into the infected periodontal pocket by means of the gingival crevicular fluid originating in the gingival tissue.
    Type: Grant
    Filed: April 13, 1993
    Date of Patent: June 28, 1994
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Richard L. Dunn, Arthur J. Tipton, Ronald J. Harkrader, Jack A. Rogers
  • Free amine benzophenanthridine alkaloid compositions
    Patent number: 5175000
    Abstract: A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: December 29, 1992
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Kenneth C. Godowski, Ronald J. Harkrader, Richard L. Dunn, Arthur J. Tipton
  • Biodegradable system for regenerating the periodontium
    Patent number: 5077049
    Abstract: Methods are described for assisting the restoration of periodontal tissue in a periodontal pocket and for retarding migration of epithelial cells along the root surface of a tooth. The methods involve placement of an in-situ forming biodegradable barrier adjacent the surface of a tooth. The barrier is microporous and includes pores of defined size. The barrier can include a biologically active agent.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: December 31, 1991
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Richard L. Dunn, Arthur J. Tipton, George L. Southard, Jack A. Rogers
  • Oral rinse compositions
    Patent number: 5066483
    Abstract: Mouthrinses containing sanguinarine of superior efficacy and increased uptake into dental plaque are attained by the development of stable mouthrinses adjusted to a pH in the range of 4.0 to 5.6, preferably about 4.5. The compositions may contain a zinc salt as an optional ingredient. Various types of buffer systems are described.
    Type: Grant
    Filed: September 17, 1990
    Date of Patent: November 19, 1991
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Ronald J. Harkrader, Richard R. Jones, Kenneth S. Peterson
  • Drug delivery devices
    Patent number: 5013553
    Abstract: Drug delivery devices and techniques are described for use in treatment of periodontal disease and the like. The delivery device includes benzo (c) phenanthridine alkaloid in a bioerodable and biocompatible material. The alkaloid is slowly released from the bioerodable material in the oral cavity. The bioerodable material may be polymeric and may be natural or synthetic. The delivery device may be inserted subgingivally (e.g., in a periodontal pocket) where the alkaloid is released slowly over a period of days.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: May 7, 1991
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: G. Lee Southard, Ronald J. Harkrader
  • Muscosal delivery systems for treatment of periodontal disease
    Patent number: 4975271
    Abstract: A muscosal delivery system is provided for use in treating periodontal disease. The system is composed of a chemotherapeutic agent dissolved in a skin-penetration enhancer. The solution of chemotherapeutic agent and skin-penetration enhancer is placed into the periodontal pocket where the agent is transported into the surrounding gingival tissue by means of the penetration enhancer.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: December 4, 1990
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Richard L. Dunn, Kenneth C. Godowski, Ronald J. Harkrader, George L. Southard
  • Production of high purity alkaloids
    Patent number: 4818533
    Abstract: A method for extracting valuable alkaloid materials from plants containing the same comprising slurrying the comminuted plant material in a mixture of water and a cosolvent at a pH of 8.5, adding a nonpolar, water-insoluble, solvent to dissolve the alkaloid, washing the nonpolar phase with acidulated water to convert the alkaloid to the imminium ion or acid salt form, precipitating the alkaloids, and recovering and drying the alkaloid.
    Type: Grant
    Filed: September 4, 1987
    Date of Patent: April 4, 1989
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Richard T. Boulware, George Schlowsky