Patents Assigned to Virginia Commonwealth University
  • Patent number: 9669198
    Abstract: A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: June 6, 2017
    Assignees: University of Virginia Patent Foundation, Virginia Commonwealth University
    Inventors: William C. Broaddus, Rahul Mahajan, George T. Gillies
  • Publication number: 20170136038
    Abstract: Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.
    Type: Application
    Filed: September 23, 2016
    Publication date: May 18, 2017
    Applicant: Virginia Commonwealth University
    Inventor: Shunlin Ren
  • Patent number: 9649316
    Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: May 16, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Ruey-min Lee, Peck-sun Lin
  • Publication number: 20170114106
    Abstract: Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from both Borrelia OspA and Borrelia OspC.
    Type: Application
    Filed: November 25, 2016
    Publication date: April 27, 2017
    Applicant: Virginia Commonwealth University
    Inventors: Christopher G. Earnhart, Richard T. Marconi
  • Patent number: 9616033
    Abstract: Presystemic metabolism in intestine of bioactives such as phenylephrine is avoided by administering a subject (human or animal) the bioactive (e.g., phenylephrine) in combination with one or more inhibitors of sulfation (e.g., sulfotransferase enzymes aka SULTs). This can also be enhanced be co-administering inhibitors of monoamine oxidases aka, MAOs, and uridine diphosphate glucoronysl transferases, aka UGTs. Preferably the inhibitors are GRAS compounds. The one or more inhibitor compounds inhibit the enzymes responsible for rapid presystemic metabolism, thus allowing the bioactives (e.g., phenylephrine) to be more readily absorbed intact into the circulatory system.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: April 11, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Phillip M. Gerk, William H. Barr, Joseph K. Ritter
  • Patent number: 9598384
    Abstract: 3-(2-amino-ethyl)-5-[3-(4-substituted-phenyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-3-alkylidene-1,3-dihydro-indol-2-one and derivatives thereof are provided for use as selective SphK2 inhibitors and for use in the treatment of human diseases, such as cancer.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: March 21, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Shijun Zhang, Sarah Spiegel
  • Publication number: 20170049109
    Abstract: A compound having the formula: wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect are described.
    Type: Application
    Filed: March 24, 2016
    Publication date: February 23, 2017
    Applicant: Virginia Commonwealth University
    Inventors: Kenneth J. Wynne, Souvik Chakrabarty, Wei Zhang, Asima Chakravorty, Olufemi O. Oyesanya
  • Patent number: 9572909
    Abstract: Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: February 21, 2017
    Assignee: Virginia Commonwealth University
    Inventors: David Simpson, Gary Bowlin, Raymond Colello, Woon Chow, Balendu Shekhar Jha
  • Patent number: 9562079
    Abstract: The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of Borrelia burgdorferi. Vaccines incorporating the immunogenic composition of the invention, as well as methods of preventing Lyme disease in dogs and/or protecting dogs from Lyme disease using the vaccines are also provided.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: February 7, 2017
    Assignees: Zoetis Services LLC, Virginia Commonwealth University
    Inventors: Robert M. Lohse, Patrick F. M. Meeus, Jason J. Millership, Zhichang Xu, Richard Thomas Marconi, Christopher G. Earnhart
  • Patent number: 9534021
    Abstract: Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from both Borrelia OspA and Borrelia OspC.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: January 3, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Christopher G. Earnhart, Richard T. Marconi
  • Publication number: 20160375270
    Abstract: A method and apparatus are used to compare an intended treatment plan using a radiation source with a delivered plan. This done by arranging markers at known three-dimensional (3D) positions in a detection reference system between a two dimensional radiation detector configured to acquire images generated by radiation emitted by the radiation source and an area where the radiation source is positioned during a treatment. The positions of projections of the markers on an image detected are determined when the radiation source is at a treatment position in an intended treatment plan reference system. A plurality of lines in the detection reference system are calculated, each line being defined by a 3D position of a marker and a 3D position of a corresponding projection of the marker on the detector according to the image. A 3D position of the radiation source in the detection reference system is inferred based on the calculated lines.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Dorin A. Todor, Aditya A. Bondal
  • Patent number: 9527823
    Abstract: The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: December 27, 2016
    Assignees: Research Triangle Institute, Dignity Health, Virginia Commonwealth University
    Inventors: Frank Ivy Carroll, Bruce E. Blough, Hernan A. Navarro, S. Wayne Mascarella, Ana Zamfira Muresan, M. Imad Damaj, Ronald J. Lukas
  • Patent number: 9522179
    Abstract: Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: December 20, 2016
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Charles A. Dinarello, Antonio Abbate, Eli C. Lewis
  • Patent number: 9517342
    Abstract: The system includes five components: (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The olfactory implant system generates odor fingerprints by detecting odors with an array of chemical sensors and then transmitting variable spatio-temporal stimulation patterns for an electrode array with electrode stimulating points positioned at different locations in the olfactory cortex (e.g., stimulating the olfactory bulb). Different patterns of activity in the olfactory cortex are thereby generated which mimic the sense of smell in a subject. Once trained the system should be usable by a subject to detect or correctly identify one or more odors.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: December 13, 2016
    Assignee: Virginia Commonwealth University
    Inventors: Richard M. Costanzo, Daniel Coelho
  • Publication number: 20160326097
    Abstract: Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.
    Type: Application
    Filed: December 22, 2014
    Publication date: November 10, 2016
    Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Martin K. SAFO, Richmond DANSO-DANQUAH, Mohini GHATGE, Jurgen VENITZ, Martin MANGINO, Kevin R. WARD
  • Publication number: 20160317472
    Abstract: Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management. These compounds are applicable to treating tumors of the central nervous system, such as glioblastoma multiforme (GBM).
    Type: Application
    Filed: June 14, 2016
    Publication date: November 3, 2016
    Applicants: Enzo Therapeutics, Inc. c/o Enzo Biochem, Inc., Virginia Commonwealth University
    Inventors: Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
  • Patent number: 9480692
    Abstract: Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 1, 2016
    Assignee: Virginia Commonwealth University
    Inventor: Shunlin Ren
  • Patent number: 9480439
    Abstract: Provided is a new hierarchical methodology having a series of computational steps such as adaptive window creation, 2-D SWT application, masking, and boundary tracing is proposed. The techniques and systems are able to detect and quantify fracture as well as to generate recommendations for decision-making and treatment planning in traumatic pelvic injuries.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: November 1, 2016
    Assignee: Virginia Commonwealth University
    Inventors: Jie Wu, Rosalyn Hobson Hargraves, Kayvan Najarian, Ashwin Belle, Kevin R. Ward
  • Patent number: D773740
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: December 6, 2016
    Assignee: Virginia Commonwealth University
    Inventors: Sonya Clark, Jordana Kron, John Reavey-Cantwell
  • Patent number: D774700
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: December 20, 2016
    Assignee: Virginia Commonwealth University
    Inventors: Sonya Clark, Jordana Kron, John Reavey-Cantwell