Patents Assigned to Vrije Universiteit Brussel
  • Publication number: 20200017556
    Abstract: The invention relates to mutant forms of CsgG. The invention also related to analyte detection and characterisation using CsgG.
    Type: Application
    Filed: July 25, 2019
    Publication date: January 16, 2020
    Applicants: Oxford Nanopore Technologies Ltd., VIB VZW, Vrije Universiteit Brussel
    Inventors: Stefan Howorka, Han Remaut, Lakmal Jayasinghe, Elizabeth Jayne Wallace, James Anthony Clarke, Richard George Hambley, Jonathan Bankes Pugh
  • Patent number: 10530346
    Abstract: An aspect of the disclosure includes a comparator circuit comprising: a master latch comprising a first amplifier circuit and a first latch circuit coupled to an output of the first amplifier circuit; a slave latch comprising a second amplifier circuit having an input coupled to the output of the first amplifier circuit, and a second latch circuit coupled to an output of the second amplifier circuit; and a hysteresis compensation circuit coupled to the output of the second amplifier circuit and configured to cause a first predetermined signal level shift of an output signal of the first amplifier circuit in response to a high signal level at the output of the second amplifier circuit, and configured to cause a second predetermined signal level shift of an output signal of the first amplifier circuit in response to a low signal level at the output of the second amplifier circuit.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: January 7, 2020
    Assignees: IMEC VZW, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Oscar Elisio Mattia, Davide Guermandi
  • Patent number: 10523176
    Abstract: The present disclosure relates to a front-end module for a telecommunication device with an EBD circuit comprising a hybrid transformer for coupling via a transmit port to the telecommunication device transmitting a first frequency transmit signal, to an antenna, via a receive port to the telecommunication device receiving a second frequency receive signal, and to a tunable impedance circuit. In a first configuration the EBD circuit is configured to isolate the transmit port from the receive port at the first frequency, and the FEM comprises a first filter at the transmit port for attenuating the transmit signal with a predetermined amount at the second frequency. In a second configuration the EBD circuit is configured to isolate the transmit port from the receive port at the second frequency, and the FEM comprises a second filter at the receive port for attenuating the receive signal a predetermined amount at the first frequency.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: December 31, 2019
    Assignees: IMEC VZW, Murata Manufacturing Company Ltd., Vrije Universiteit Brussel
    Inventors: Barend Wilhelmus Marinus van Liempd, Ariumi Saneaki
  • Patent number: 10516423
    Abstract: A polar transmitter provided for transmitting a phase/frequency modulated and amplitude modulated transmit signal and a method for generating a transmit signal using a polar transmitter are described. An example polar transmitter comprises a phase locked loop for generating a phase/frequency modulated precursor of the transmit signal. The phase locked loop comprises at its input a phase error detection unit for detecting a phase error of the precursor fed back from the output of the phase locked loop to the phase error detection unit as a feedback signal. The polar transmitter comprises a digital amplitude modulator for amplitude modulation of the precursor, resulting in the transmit signal. The digital amplitude modulator is arranged within the phase locked loop for amplitude modulation of the precursor before being output by the PLL. The phase error detection unit is further provided for detecting the amplitude of the feedback signal.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: December 24, 2019
    Assignees: IMEC VZW, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Nereo Markulic, Jan Craninckx
  • Publication number: 20190309056
    Abstract: The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: September 15, 2017
    Publication date: October 10, 2019
    Applicants: VIB VZW, Vrije Universiteit Brussel
    Inventors: Peter Vanlandschoot, Ines Cabrito, BenoƮt Stijlemans, Amanda Sparkes, Jo Van Ginderachter, Patrick De Baetselier
  • Patent number: 10436796
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: October 8, 2019
    Assignees: LELAND STANFORD JUNIOR UNIVERSITY, VIB VZW, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Jan Steyaert, Els Pardon, Soren G. F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Publication number: 20190288520
    Abstract: A modular management system for balancing, testing and protecting rechargeable energy storage cells connected in series. Different energy storage cell technologies can be connected in the same battery pack and they can be completely balanced by using one or both of two balancing modes. In addition, the modular management system includes bidirectional and unidirectional switches optionally connected to a single ohmic device such as a resistor to efficiently execute a Dual Function Process (DFP) (i.e., passive/active balancing, and testing mode for SoH/SoC estimation) preferably without using any extra or external components (i.e., capacitor or inductor or DC/DC converter or power supply). The systems and methods decrease the balancing time, energy loss, heat loss and complexity needed to monitor, protect and balance energy storage cell systems such as battery systems, and thus decreasing the overall cost.
    Type: Application
    Filed: May 15, 2017
    Publication date: September 19, 2019
    Applicants: VITO NV, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Mohamed ABDEL-MONEM, Omar HEGAZY, Noshin OMAR, Khiem TRAD, Joeri VAN MIERLO
  • Patent number: 10398787
    Abstract: The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: September 3, 2019
    Assignee: Vrije Universiteit Brussel
    Inventors: Thierry Vandendriessche, Marinee Chuah
  • Patent number: 10400014
    Abstract: The invention relates to mutant forms of the outer membrane-located lipoprotein CsgG, in particular, modifications at one or more of positions Tyr51; Asn55; and Phe56. The invention also relates to analyte detection and characterisation using said mutant CsgG.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 3, 2019
    Assignees: Oxford Nanopore Technologies Ltd., VIB VZW, Vrije Universiteit Brussel
    Inventors: Stefan Howorka, Han Remaut, Lakmal Jayasinghe, Elizabeth Jayne Wallace, James Anthony Clarke, Richard George Hambley, Jonathan Bankes Pugh
  • Patent number: 10392601
    Abstract: The present invention relates to a composition and method for assisted reproductive technology in mammals. In particular, the present invention provides compositions and methods for in vivo maturation of an immature cumulus oocyte complex (COC), thereby enhancing the embryology outcome.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: August 27, 2019
    Assignee: Vrije Universiteit Brussel
    Inventors: Sergio Romero, Flor Sanchez, Johan Smitz
  • Patent number: 10377834
    Abstract: Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: August 13, 2019
    Assignees: VIB VZW, KATHOLIEKE UNIVERSITEIT LEUVEN. K.U. LEUVEN R&D, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Bart De Strooper, Els Marjaux, Lujia Zhou, Serge Muyldermans
  • Patent number: 10336791
    Abstract: The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such interferor molecules and their use in agrobiotech applications.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: July 2, 2019
    Assignees: VIB VZW, VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Joost Schymkowitz, Frederic Rousseau
  • Patent number: 10332588
    Abstract: In an aspect of the disclosed technology, a SRAM device includes a first stack of transistors and a second stack of transistors arranged on a substrate. Each of the first and second stacks includes a pull-up transistor, a pull-down transistor and a pass transistor, where each of the transistors includes a horizontally extending channel. In each of the first and second stacks, the pull-up transistor and the pull-down transistor have a common gate electrode extending vertically therebetween, and the pass transistor has a gate electrode separated from the common gate electrode. A source/drain of each of the pull-up transistor and the pull-down transistor and a source/drain of the pass transistor included in one of the first stack and the second stack are electrically interconnected with the common gate electrode of the pull-up transistor and the pull-down transistor included in the other of the first stack and the second stack.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: June 25, 2019
    Assignees: IMEC vzw, Vrije Universiteit Brussel
    Inventors: Trong Huynh Bao, Julien Ryckaert, Praveen Raghavan, Pieter Weckx
  • Patent number: 10325647
    Abstract: A memory cell is disclosed, comprising a static random-access memory, SRAM, bit cell, a first resistive memory element and a second resistive memory element. The first resistive memory element is connected to a first storage node of the SRAM bit cell and a first intermediate node, and the second resistive memory element connected to a second storage node of the SRAM bit cell and a second intermediate node. Each one of the first intermediate node and the second intermediate node is configured to be supplied with a first supply voltage via a first transistor and a second supply voltage via a second transistor, wherein the first transistor and the second transistor are complementary transistors separately controllable by a first word line and a second word line, respectively. Methods for operating such a memory cell are also disclosed.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 18, 2019
    Assignees: IMEC VZW, VRIJE UNIVERSITEIT BRUSSEL, Katholieke Universiteit Leuven, KU Leuven R&D
    Inventors: Sushil Sakhare, Trong Huynh Bao, Manu Komalan Perumkunnil
  • Patent number: 10279135
    Abstract: The present invention relates generally to medical devices, methods, and kits. More particularly, the present invention relates to improved endotracheal tubes or patient ventilation tubes which prevent the leakage of proximal secretions to the distal airways.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: May 7, 2019
    Assignee: VRIJE UNIVERSITEIT BRUSSEL
    Inventor: Emiel Suijs
  • Patent number: 10278370
    Abstract: The present invention relates to the dissemination of biological control agents or other substances through the use of bees, in particular bumblebees. It relates to a disseminator device, installable in or in connection to the hive, and which contains biological control agents or other substances which are picked up, carried and disseminated by the bees when leaving the hive.
    Type: Grant
    Filed: May 29, 2010
    Date of Patent: May 7, 2019
    Assignees: Biobest Belgium NV, Vrije Universiteit Brussel
    Inventors: Kurt Hans Put, Kris Cyriel Johan Jans, Guido Mario Karel Michel Sterk, Guy Smagghe, Veerle Mommaerts, Felix Leopold Wackers, Yann Bruno Loic Jacques
  • Patent number: 10261245
    Abstract: A microstructured optical fiber comprises a doped core region embedded in a cladding layer, and a plurality of longitudinal tubes, wherein a radial cross-section of the optical fiber comprises a central hexagonal portion comprising a plurality of holes arranged according to a hexagonal grid surrounding a core section. Each hole corresponds to a respective tube, within a hexagonal boundary of the grid, and the plurality of holes comprises holes of first and second types arranged in a biaxial mirror-symmetric configuration. The holes of the first type are arranged in two side holey structures comprising distinct sub-grids of the hexagonal grid, defined by respective outer boundaries corresponding to portions of the hexagonal boundary of the grid and respective inner boundaries. Outer tangential lines to the respective inner boundaries cross each other at the opposed side of the core with respect to the side of the respective side holey structure.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: April 16, 2019
    Assignee: VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Sanne Sulejmani, Thomas Geernaert, Francis Berghmans, Hugo Thienpont
  • Patent number: 10233241
    Abstract: Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: March 19, 2019
    Assignees: VIB VZW, VRIJE UNIVERSITEIT BRUSSEL, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Jan Steyaert, Toon Laeremans, Els Pardon, Brian Kobilka, Aashish Manglik
  • Patent number: 10230347
    Abstract: A system having a tunable impedance network and a method of tuning a tunable impedance network are disclosed. In one aspect, a telecommunications device comprises an electrical-balance duplexer (EBD) circuit coupled to at least one output node of a transmit path (TXin), an antenna, and at least one input node of a receive path (RXout), wherein the EBD circuit is configured to isolate the transmit path from the receive path by signal cancellation, and a balancing network (Zbal) as part of the EBD circuit. In one embodiment, the balancing network is an integrated tunable impedance network configured to provide an impedance that matches a target impedance (Zant) associated with the antenna at a first frequency and simultaneously at a second, different frequency. The network comprises a first portion and a second portion, the first portion reducing the influence of the tuning of the second portion at the first frequency. In some embodiments, the network preferably comprises no explicit resistors.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 12, 2019
    Assignees: IMEC vzw, Vrije Universiteit Brussel
    Inventors: Benjamin Hershberg, Barend Wilhelmus Marinus Van Liempd, Jan Craninckx
  • Patent number: 10200047
    Abstract: The disclosure provides a phase locked loop, PLL, for phase locking an output signal to a reference signal. The PLL comprises a reference path providing the reference signal to a first input of a phase detector, a feedback loop providing the output signal of the PLL as a feedback signal to a second input of the phase detector, a controllable oscillator generating the output signal based on at least a phase difference between reference and feedback signal, a digital-to-time converter, DTC, delaying a signal that is provided at one of the first and second input, a delay calculation path for calculating a DTC delay value. The PLL further comprises a randomization unit for generating and adding a random offset, i.e. a pseudo-random integer, to the delay value. The offset is such that a target output of the phase detector remains substantially unchanged.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: February 5, 2019
    Assignees: IMEC VZW, Stichting IMEC Nederland, Vrije Universiteit Brussel
    Inventors: Nereo Markulic, Yao-Hong Liu, Jan Craninckx