Patents Assigned to Vysoka skola chemicko-technologicka
  • Patent number: 11492327
    Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: November 8, 2022
    Assignees: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I., APIGENEX S.R.O.
    Inventors: Miroslav Ledvina, Roman Effenberg, Jaroslav Turanek, Elissa Bartheldyova, Ladislav Droz, Josef Masek, Frantisek Hubatka
  • Publication number: 20220192985
    Abstract: A formulation of composites having yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments or food supplements is disclosed. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. A method of preparation of the composites by spray drying is also disclosed.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 23, 2022
    Applicant: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE
    Inventors: Gabriela RUPHUY CHAN, Frantisek STEPANEK, Jaroslav HANUS, Petra SALAMUNOVA, Ivan SALON
  • Publication number: 20210292275
    Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.
    Type: Application
    Filed: November 2, 2017
    Publication date: September 23, 2021
    Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I., APIGENEX S.R.O.
    Inventors: Mirolav LEDVINA, Roman EFFENBERG, Jaroslav TURANEK, Elissa BARTHELDYOVA, Ladislav DROZ, Josef MASEK, Frantisek HUBATKA
  • Patent number: 9932339
    Abstract: Helquat derivatives of general formula I, in which substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1?,2?, S3,4 and S3?,4? are present, each of S1,2, S1?,2?, S3,4 and S3?,4? independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2?, and 4? are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5? with C8?, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1)? and (X2)? independently represent anions of pharmaceutically acceptable salts.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: April 3, 2018
    Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE
    Inventors: Filip Teply, Miroslav Hajek, Erika Kuzmova, Jaroslav Kozak, Veronika Komarkova, Pavla Hubalkova, Paul Eduardo Reyes-Gutierrez, Michael Jirasek, Manoj R. Sonawane, Vishwas D. Joshi, Lukas Severa, Jana Novotna
  • Publication number: 20170096433
    Abstract: Helquat derivatives of general formula I, in which substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1?,2?, S3,4 and S3?,4? are present, each of S1,2, S1?,2?, S3,4 and S3?,4? independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2?, and 4? are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5? with C8?, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1)? and (X2)? independently represent anions of pharmaceutically acceptable salts.
    Type: Application
    Filed: May 26, 2015
    Publication date: April 6, 2017
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE
    Inventors: Filip TEPLY, Miroslav HAJEK, Erika KUZMOVA, Jaroslav KOZAK, Veronika KOMARKOVA, Pavla HUBALKOVA, Paul Eduardo REYES-GUTIERREZ, Michael JIRASEK, Manoj R. SONAWANE, Vishwas D. JOSHI, Lukas SEVERA, Jana NOVOTNA
  • Patent number: 8013190
    Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: September 6, 2011
    Assignees: Vysoka Skola Chemicko-Technologicka V Praze, Ustav Organicke Chemie A Biochemie AV CZ, Ustav Anorganicke Chemie AV CZ, Department of Virology, University of Heidelberg
    Inventors: Vladimír Král, Petr Cigler, Jan Konvalinka, Milan Kozísek, Jana Prejdová, Bohumír Grüner, Jaromír Plesek, Martin Lepsík, Jana Pokorná, Hans-Georg Kräusslich, Jochen Bodem
  • Publication number: 20090012044
    Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.
    Type: Application
    Filed: January 27, 2005
    Publication date: January 8, 2009
    Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CZ, USTAV ANORGANICKE CHEMIE AV CZ, DEPARTMENT OF VIROLOGY, UNIVERSITY OF HEIDELBERG
    Inventors: Vladimir Kral, Petr Cigler, Jan Konvalinka, Milan Kozisek, Jana Prejdova, Bohumir Gruner, Jaromir Plesek, Martin Lepsik, Jana Pokorna, Hans-Georg Krausslich, Jochen Bodem
  • Patent number: 4685935
    Abstract: A process for producing a pure magnesium sulphite from crude crystalline magnesium sulphite. Into a full suspension or flow containing magnesium sulphite crystals at least one further water-containing and heat-supplying flow is led. The heat-supplying flow rapidly increases the temperature of the suspension to above 80.degree. C. in less than 10 seconds, preferably in less than 2 seconds. The solid water-insoluble fraction is then separated from the resulting flow, and the pure product is recrystallized from the solution. The solution may be recycled into the process either for further purification or for use as at least one heat-supplying flow.
    Type: Grant
    Filed: June 26, 1986
    Date of Patent: August 11, 1987
    Assignee: Vysoka Skola chemicko-technologicka
    Inventors: Stanislav Najmr, Zdenek Jerman, Jaroslav Kralicek
  • Patent number: 4664810
    Abstract: Method of separating heavy metals from complex-forming substance of aminocarboxylic acid type, or salts thereof in aqueous solutions, as well as a method of removing heavy metals from the solutions containing said complex-forming substance. A solution containing heavy metals in complex form and complex-forming substances of aminocarboxylic acid type is contacted with a ion exchanger having polyethyleneimine active groups, whereupon free non-complexed heavy metal cations are displaced out of said ion exchanger by an acid solution of 0.5-30 percent concentration, and the ion exchanger is converted back into its active form by a solution of an alkali hydroxide, carbonate, or hydrogen carbonate of 0.5-30 percent concentration.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: May 12, 1987
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Zdenek Matejka, Jarcslay Eliasek
  • Patent number: 4624002
    Abstract: A circuit for performing a method melting vitreous materials in an electric furnace wherein the electrodes are supplied with an alternating current of optimal frequency lower than 60 or 50 Hz, respectively, the corrosion of electrodes being minimized. The circuit comprises a cycloconverter which changes a three-phase current supply into a single-phase current with a simultaneous changing of the input mains frequency into an optimal output frequency. The circuit also comprises a device for measuring and/or controlling the direct current component of the low frequency feeding alternating current, in order to stabilize the favorable anticorrosion effect of the low optimal frequency. Further, it comprises a device for the control of the power input of the cycloconverter with respect to the melting temperature in the furnace.
    Type: Grant
    Filed: July 18, 1985
    Date of Patent: November 18, 1986
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Pavel Zahalka, Jaroslav Stanek, Jiri Matej
  • Patent number: 4487841
    Abstract: There is disclosed a material for hot or plasma spraying, especially a material based on oxide ceramics, and a process for the production thereof. The composition of the invention is a mixture of powdered oxides containing at least two fundamental oxides with high melting point, and at least one glass-forming oxide the melting point of which is lower. The invention also includes a process for the production of such composition by the melting and agglomeration of individual components in the oxidizing medium of a plasma stream, including the special treatment of the starting components.
    Type: Grant
    Filed: February 12, 1982
    Date of Patent: December 11, 1984
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Miloslav Bartuska, Petr Kroupa, Josef Szabo, Karel Zverina
  • Patent number: 4343933
    Abstract: Process which accelerates the activated and non-activated polymerization of 2-pyrrolidone. A prepared polymerization charge containing monomer and components of the initiation system is first allowed to polymerize at a temperature above the monomer melting temperature, then is cooled below the melting point of the mixture, and then the crystalline reaction mixture is heated to a polymerization temperature of 25.degree. to 60.degree. C.
    Type: Grant
    Filed: September 26, 1980
    Date of Patent: August 10, 1982
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Jan Roda, Jaroslav Kralicek
  • Patent number: 4338509
    Abstract: Process of radial stabilization and homogenization of a plasma stream and a liquid stabilized plasma burner for the realization of such process. The arc is stabilized by its passage through several orifice plates, stabilized by a whirl or eddy of cooling liquid, then passes through a nozzle and is bent toward the peripheral surface of a rotatable anode lying out of the main outlet plasma stream issuing from the nozzle. The liquid stabilized burner has a rod cathode placed in the arc chamber, the cathode being progressively fed into the arc chamber to from an arc therewithin.
    Type: Grant
    Filed: November 14, 1980
    Date of Patent: July 6, 1982
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Miloslav Bartuska, Karel Zverina, Josef Szabo, Borivoj Pospisil, Petr Kroupa
  • Patent number: 4330568
    Abstract: A method of bonding at least two types of refractory ceramic materials, a first material being, for example, fireclay and a second material being, for example, alumina, to each other in order to enhance both the abrasion and corrosion resistances of heat resistant plates for valve closures of foundry ladles. The second, thermally more resistive material, which is applied to the first material in the form of relatively small particles, is preheated on at least the outer surface layers of the particles, the entire volume of the particles usually being preheated or even molten. The bonding of the two preheated materials occurs in such a way that minute particles up to drops of the second, thermally more resistive material are thrown at high speed (with high kinetic energy) onto the preheated surface of the first material. The source of such a relatively high kinetic energy can be constituted by either an explosion or a plasma beam ejected at a high outlet velocity out of the mouth of a plasma torch.
    Type: Grant
    Filed: January 21, 1980
    Date of Patent: May 18, 1982
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Valter Boehm, Veslav Marosczyk, Antonin Cieslar, Miloslav Bartuska, Karel Rybak, Karel Zverina, Eduard Zelezny
  • Patent number: 4325642
    Abstract: Kaolin suspension homogenizing and storage tank provided with at least a single mixing device mounted on its side wall. The mixing device includes a propeller or paddle impeller with inclined blades, the diameter of which is 1/15 to 1/30 of the diameter of the tank and the velocity of the blade tips of the impeller range from 6 to 12 m/s. The arrangement includes an alternative circulation pump and at least a single jet.
    Type: Grant
    Filed: September 4, 1980
    Date of Patent: April 20, 1982
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Jiri Kratky, Ivan Fort, Petr Havel, Vaclav Machacek, Bohuslav Masek, Konstantin Hruban
  • Patent number: 4304734
    Abstract: 6-amino-1-hydroxyhexylidene diphosphonic acid (I), salts of acid (I), and a process for the production thereof. Acid (I) has the summary formula ##STR1## Acid (I) and its salts are useful for pharmocologial purposes. In the production of acid (I) a mixture of phosphorous acid and phosphorous trichloride is reacted with the .epsilon.-aminocaproic acid or amide derived therefrom at a temperature from 50.degree. to 150.degree. C. The reaction can be carried out in the presence of an organic solvent, preferably chlorobenzene. Salt of the acid is produced by neutralization with one or two molecular equivalents of alkaline hydroxide, preferably sodium hydroxide.
    Type: Grant
    Filed: October 16, 1980
    Date of Patent: December 8, 1981
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Jiri Jary, Veroslava Rihakova, Alena Zobacova
  • Patent number: 4303778
    Abstract: A method is described for the anionic polymerization and copolymerization of .omega.-aminoacid lactams. This end is attained at elevated temperatures in the presence of a polymerization initiator of the formulaMeZX.sub.m L.sub.nwherein Me is an alkali metal, Z is boron or aluminum, X is an alkoxy group and L is an organic residue derived from a lactam and being of the formula ##STR1## wherein a is an integer in the range 3-11, m is an integer in the range of 0-3, (m+n) is 4 and n is (4-m).
    Type: Grant
    Filed: January 17, 1978
    Date of Patent: December 1, 1981
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Jaroslav Kralicek, Vladimir Kubanek, Jiri Marik, Jaroslava Kondelikova, Jiri Machacek, Bohuslav Casensky
  • Patent number: 4186252
    Abstract: A method for preparing vitamin B.sub.1 in a fermentation process involves cultivating mutants of yeast of the genus Saccharomyces Meyen emend Reess that synthesize this vitamin from sugars and inorganic salts and excrete it from living cells into fermentation media.
    Type: Grant
    Filed: May 2, 1977
    Date of Patent: January 29, 1980
    Assignee: Vysoka skola chemicko-technologicka
    Inventor: Ludmila Silhankova
  • Patent number: 4177295
    Abstract: A method for treating beverages containing turbidity procursors and/or enzymes is described. The technique involves contacting the beverages with a diol or dicarboxylic acid polycondensate at a temperature ranging from 28.4.degree. to 176.degree. F., thereby resulting in separation of deleterious substance. The colloidal and taste qualities of the resultant beverages is thereby enhanced.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: December 4, 1979
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Vladimir Kubanek, Gabriela Basarova, Jaroslav Kralicek, Josef Skach, Zdenek Fencl, Jiri Budin, Jaroslava Kondelikova, Eduard Sittler
  • Patent number: 4150563
    Abstract: Method of and appartus for liquid recirculation in at least substantially closed circuit which is particularly suitable for recycled liquid chromatography. The circulating liquid is brought into motion in the circuit inlet by working fluid supplied under pressure, e.g. from a pump, pressure gas cylinder, or the like. Circulating liquid approaching the end of the circuit beyond the circuit outlet is mechanically and at regular intervals repeatedly transported in the form of slugs into the beginning of the circuit in advance of the circuit inlet where these slugs are again forced into the circuit inlet by means of working fluid. The injection of one slug into the circuit inlet and the pushing of the following slug of equal volume out from the circuit outlet are carried out simultaneously.
    Type: Grant
    Filed: November 15, 1977
    Date of Patent: April 24, 1979
    Assignee: Vysoka skola chemicko-technologicka
    Inventors: Milan Minarik, Milan Popl, Jiri Mostecky