Abstract: Systems and methods for blood flow control are described herein. In some variations, a blood flow control system may comprise a blood flow control device. The blood flow control device may be placed within a body of a patient and may comprise an expandable member and a sensor. The sensor may be configured to measure at least one of a physiologic condition of the patient and a pressure associated with the expandable member. The blood flow control system may include at least one controller communicably coupled to the sensor to: receive data indicative of at least one of the physiologic condition of the patient and the pressure associated with the expandable member from the sensor, compare the received data with target data, identify at least one error based on the comparison, and in response to identifying the error, inhibit at least one function of the blood flow control system.
Type:
Grant
Filed:
July 1, 2021
Date of Patent:
April 25, 2023
Assignees:
CERTUS CRITICAL CARE, INC., WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventors:
Michael Austin Johnson, David Poisner, Melanie Mcwade, Timothy Williams, Lucas Neff
Abstract: Described herein are bioink compositions, which may have an elastic modulus similar to a natural tissue and/or tunable mechanical properties, along with methods of preparing and using the compositions. The compositions described herein may be useful as a medium for cell and/or tissue culture and/or for bioprinting, but are not limited thereto.
Abstract: Provided is a composition comprising an isolated Lactobacillus paracasei D3.5 strain or cellular components thereof. In some embodiments, the composition is provided in a pharmaceutically acceptable carrier, which may be a food product, tablet or capsule suitable for enteral administration, etc. Also provided is a composition comprising lipoteichoic acid isolated from Lactobacillus paracasei D3.5 strain, which may be provided in a pharmaceutically acceptable carrier.
Abstract: According to an aspect, a method includes receiving data about a patient, computing geometric characterization of one or more organs at risk proximate to a target volume of a patient or vice versa, and selecting relevant treatment knowledge and experience. The method also includes generating, based on the received data, computed geometric characterization, and available knowledge and experience, a first set of radiation treatment planning parameters that will lead to a high quality plan for the patient. Further, the method includes model-based prediction, based on the data, a second set or more of radiation treatment planning parameters that will lead to alternative achievable plans with different organ sparing objectives for treating the patient. The multiple sets for parameters can be used separately or in conjunction to generate treatment plans.
Type:
Grant
Filed:
October 18, 2019
Date of Patent:
February 21, 2023
Assignees:
Wake Forest University Health Sciences, Duke University
Inventors:
Fang-Fang Yin, Qingrong Jackie Wu, Lulin Yuan, Yaorong Ge
Abstract: The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.
Type:
Grant
Filed:
December 28, 2017
Date of Patent:
January 31, 2023
Assignees:
Wake Forest University Health Sciences, Genethon, Children's Medical Center Corporation
Inventors:
Martin K. Childers, Alan H. Beggs, Ana Maria Buj Bello
Abstract: Methods and compositions are disclosed for repair of shoulder injuries by employing disaggregated muscle fiber fragments to regenerate functional shoulder muscle tissue. In some embodiments, the fragments retain functional satellite cells but exhibit cell wall rupture and have an average size of less than 150 ?m. The methods include the preparation and implantation of compositions by extracting muscle tissue from a donor site, disaggregating muscle fibers from the extracted tissue, and fragmenting disaggregated muscle fibers into fiber fragments that exhibit cell wall rupture and preferably have an average size of less than 150 microns, more preferable less than about 100 microns, while retaining functional satellite cells. Upon injection, e.g., into the supraspinatus or other rotator cuff muscles, the muscle fiber fragment compositions are capable of reconstituting or reconstructing elongated muscle fibers from the fragments and orienting in alignment with native shoulder muscle fibers.
Type:
Application
Filed:
October 26, 2020
Publication date:
December 1, 2022
Applicant:
Wake Forest University Health Sciences
Inventors:
Anthony ATALA, James YOO, Gary G. POEHLING, Brian Robert WATERMAN
Abstract: Disclosed is a waste container comprising a port in communication with a tube where the port is configured to receive a fluid from an implement and the tube is configured to direct the fluid from the implement toward an absorbent material within the waste container.
Abstract: An incremental syringe useful for multiple injections of medications like botulinum toxin is provided. The syringe includes detents on the syringe plunger which provide a tactile feeling, a discrete audible sound or “click,” or preferably both, for every unit of medication aspirated or injected to or from an individual syringe. Hence, there is no need to look at the syringe, or bring it to the eye level, during use thereof. In some embodiments, a second set of detents is included, and in some embodiments a third set of detents is included. Syringe plungers useful for combining with a syringe body to produce such an incremental syringe are also described.
Type:
Grant
Filed:
August 30, 2019
Date of Patent:
October 11, 2022
Assignee:
Wake Forest University Health Sciences
Inventors:
Majid Mirzazadeh, Phillip J. Brown, Kenneth W. Russell
Abstract: The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique gene expression profiles in children with regressive autism spectrum disorder (ASD) and ileocolitis.
Abstract: The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (CRR) for the subject based on the genotype determined in step (a). A CRR of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early PSA screening, prostate biopsy and/or chemoprevention.
Abstract: A capsule including alginate encapsulating: insulin-secreting cells, a RGD-alginate, mesenchymal stem cells, extracellular matrix, the process for the preparation thereof and the use thereof for treating diabetes.
Type:
Application
Filed:
March 27, 2020
Publication date:
June 2, 2022
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, ETABLISSEMENT FRANCAIS DU SANG, WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventors:
Sandrine LABLANCHE, Pierre-Yves BENHAMOU, Emily TUBBS, Anaïck MOISAN, Harald EGELHOFER, Virginie PERSOONS, Florence RIVERA, Frédéric BOTTAUSCI, Maxime PIERRON, Giuseppe ORLANDO, Riccardo TAMBURRINI
Abstract: Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle cells to said organized skeletal muscle tissue on said solid support, and then repeating said step of cyclically stretching and relaxing said muscle cells in said support in vitro for time sufficient to enhance the density (i.e., increased number of nuclei and/or number of multinucleated cells) of said organized skeletal muscle tissue on said support.
Abstract: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.
Type:
Grant
Filed:
November 21, 2019
Date of Patent:
May 3, 2022
Assignee:
Wake Forest University Health Sciences
Inventors:
Benjamin S. Harrison, James J. Yoo, Anthony Atala
Abstract: Methods are disclosed for forming tissue engineered, tubular gut-sphincter complexes from intestinal circular smooth muscle cells, sphincteric smooth muscle cells and enteric neural progenitor cells. The intestinal smooth muscle cells and neural progenitor cells can be seeded on a mold with a surface texture that induces longitudinal alignment of the intestinal smooth muscle cells and co-cultured until an innervated aligned smooth muscle sheet is obtained. The innervated smooth muscle sheet can then be wrapped around a tubular scaffold to form an intestinal tissue construct. Additionally, the sphincteric smooth muscle cells and additional enteric neural progenitor cells can be mixed in a biocompatiable gel solution, and the gel and admixed cells applied to a mold having a central post such that the sphinteric smooth muscle and neural progenitor cells can be cultured to form an innervated sphincter construct around the mold post.
Abstract: The present application relates to biomimetic three-dimensional (3D) scaffolds, constructs and methods of making the same. The three-dimensional scaffold can include a sacrificial internal cast and a durable external scaffold material, wherein the durable external scaffold material comprises a biocompatible material which completely surrounds the sacrificial internal cast and wherein the sacrificial internal cast be removed to yield a branching 3D network of hollow, vessel-like tubes that substantially mimics a native tissue or organ.
Type:
Grant
Filed:
July 21, 2016
Date of Patent:
April 19, 2022
Assignee:
Wake Forest University Health Sciences
Inventors:
James Yoo, In Kap Ko, Jennifer Huling, Anthony Atala
Abstract: Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present invention may have a structure represented by and/or comprising Formula I, Formula II, Formula III, Formula IV, Formula IV?, Formula V, Formula V?, Formula VI, Formula VII, and/or Formula VIII as described herein. Compositions including compounds of the present invention along with methods of preparing and using the same are also described herein.
Type:
Grant
Filed:
October 26, 2017
Date of Patent:
March 29, 2022
Assignees:
Wake Forest University Health Sciences, Wake Forest University
Inventors:
Mark E. Welker, Aleksander Skardal, Amber N. Weissenfluh, Surya Banks
Abstract: The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique blood-based gene expression profiles in children with regressive autism spectrum disorder (ASD) and ileocolitis.
Abstract: Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.
Type:
Grant
Filed:
August 4, 2017
Date of Patent:
January 25, 2022
Assignee:
Wake Forest University Health Sciences
Inventors:
Robert T. Wicks, Anthony Atala, Goodwell Nzou, Elizabeth E. Wicks
Abstract: The present disclosure provides compositions and methods for treatment of a kidney disease with chemokine protein stromal cell-derived factor 1 (SDF-1), such as methods of treating a subject afflicted with or at risk of developing a kidney disease, comprising administering SDF-1 to a kidney of the subject in a treatment-effective amount.
Abstract: Described herein are gelatin nanoparticles including their use in a composition. The composition may comprise a plurality of gelatin nanoparticles, at least one polymer, and water. In some embodiments, the composition comprises cells. The composition may be in the form of a hydrogel. Methods of using such gelatin nanoparticles and/or compositions are also described.