Patents Assigned to Wakunaga Pharmaceutical Co., Ltd.
  • Publication number: 20090149440
    Abstract: The present invention provides an agent which exhibits excellent antibacterial activity, low toxicity, improved bioavailability, and low binding rate to serum proteins. The present invention is directed to a pyridonecarboxylic acid derivative represented by formula (1): or a salt thereof, wherein R1 represents a methyl group, a fluorine atom, or a chlorine atom; R2 represents a hydrogen atom or a lower alkyl group; R3 represents an isopropyl group or a tert-butyl group; R4 represents a methyl group or a halogen atom; and R5 represents a fluorine atom or a chlorine atom. The present invention is also directed to an antibacterial agent and a medicament containing the derivative or the salt thereof as an active ingredient.
    Type: Application
    Filed: November 17, 2005
    Publication date: June 11, 2009
    Applicant: WAKUNAGA PHARMACEUTICAL CO., LTD
    Inventors: Akira Yazaki, Yasuhiro Kuramoto, Kenji Itoh, Kazusa Yoshikai, Yuzo Hirao, Yoshihiro Ohshita, Norihiro Hayashi, Hirotaka Amano, Takayuki Amago, Hitomi Takenaka
  • Publication number: 20090042856
    Abstract: A pyridazinone derivative compound shown by the following formula (I): wherein R1 is selected from hydrogen, etc.; R2 is selected from substituted or unsubstituted aryl, etc.; R3 is hydrogen, etc.; p is 0, 1 or 2; R4 and R5, are each hydrogen, etc.; R6 and R7, are taken together to form a group of the formula: wherein R8 is hydrogen; X is selected from oxygen, etc; R10 is selected from hydrogen, etc.; R11 is selected from hydrogen, etc.; R12 is selected from hydrogen, etc.; R13 is selected from hydrogen, etc.; R14 is selected from hydrogen, etc.; m and n are each 0, 1, or 2, or a pharmaceutically acceptable salt thereof, which is useful as a medicament.
    Type: Application
    Filed: August 31, 2006
    Publication date: February 12, 2009
    Applicants: Astellas Pharma Inc, Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Hitoshi Yamazaki, Chiyoshi Kasahara, Hirokazu Kubota, Toru Kontani, Toru Asano, Hidekazu Mizuhara, Masaharu Yokomoto, Keiji Misumi, Tomohiko Kinoshita
  • Publication number: 20090012054
    Abstract: The present invention provides a compound of the formula [I]: wherein R1 is lower alkyl, etc. and R2 is hydrogen, etc., or R1 and R2 are bonded together to form lower alkylene; R3 is a group represented by wherein R6 and R7 are independently optionally protected amino, etc.; m and n are independently an integer of 0 to 6; R8 and R9 are independently optionally protected amino, etc., and q and r are independently an integer of 0 to 6, or R8 and R9, together with the adjacent alkylene(s) and the nitrogen atom, form saturated nitrogen-containing heterocycle optionally having substituent(s); R4 is lower alkyl, etc.; and R5 is amino, etc., or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 16, 2007
    Publication date: January 8, 2009
    Applicants: ASTELLAS PHARMA INC., WAKUNAGA PHARMACEUTICAL CO. LTD.
    Inventors: Toshio Yamanaka, Ayako Toda, Hidenori Ohki, Shinya Okuda, Kohji Kawabata, Kenji Murano, Kazuo Hatano, Shinobu Takeda, Toru Nakai, Masaru Oogaki, Satoshi Inoue, Keiji Misumi, Kenji Itoh
  • Publication number: 20080311571
    Abstract: A nucleic acid fragment set according to the present invention comprises a plural number of nucleic acid fragments capable of individually hybridizing with a plural number of target sequences, in which each nucleic acid fragment has a region ligatable with each other and the affinity between such ligatable regions is adjusted to a higher level than the affinity between the target sequence and the nucleic acid fragment. The nucleic acid fragment according to the present invention is for use in a nucleic acid fragment kit. The nucleic acid fragment of the present invention can be used as a probe for detecting nucleic acid or a competitor for detecting nucleic acid. According to the present invention, human leukocyte antigen (HLA) genes, T-cell receptor genes, red blood cell group determining genes, and Rh antigen genes, and the like can be detected at a high accuracy level.
    Type: Application
    Filed: November 21, 2005
    Publication date: December 18, 2008
    Applicant: WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi Jikihara, Shintaro Kawai, Takanori Oka
  • Publication number: 20080274213
    Abstract: It is intended to provide a highly safe pharmaceutical drug or food that inhibits reduction in blood testosterone level and prevents or ameliorates symptoms and so on associated with male climacteric disorders. The present invention provides a drug for inhibiting reduction in blood testosterone level and a drug for ameliorating male climacteric disorders comprising a plant belonging to the genus Codonopsis or an extract thereof.
    Type: Application
    Filed: May 31, 2005
    Publication date: November 6, 2008
    Applicant: WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Setsuko Sekita, Masanori Kuroyanagi, Kayo Yasuda, Ikuko Mizuno, Mitsuyasu Ushijima, Minoru Hayama, Makoto Ichikawa, Masanori Sumihiro
  • Patent number: 7192943
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: March 20, 2007
    Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Toshio Yamanaka, Kenji Murano, Ayako Toda, Hidenori Ohki, Masaru Oogaki, Shinya Okuda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Sato
  • Patent number: 7179801
    Abstract: The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R3 and R5 are independently amino or protected amino; and R4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: February 20, 2007
    Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Hitomi Ogino, legal representative, Tetsuya Ogino, legal representative, Tomomi Takezawa, legal representative, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Hisashi Akamatsu, Kenji Satoh, Takashi Ogino, deceased
  • Publication number: 20070037786
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: October 24, 2006
    Publication date: February 15, 2007
    Applicants: WAKUNAGA PHARMACEUTICAL CO., LTD., Astellas Pharma Inc.
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Patent number: 7129232
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: October 31, 2006
    Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Publication number: 20060194207
    Abstract: The present invention provides a reactor for carrying out in a single container the steps of the extraction of nucleic acids and the amplification of a nucleic acid, the procedures of the steps being usually different to each other. The reactor according to the present invention is a reactor for detecting a target nucleic acid from a sample, comprising at least a first compartment which contains an extraction reagent composition for extracting nucleic acids from said sample, a second compartment which contains an amplification reagent composition for amplifying the target nucleic acid, a separating means for separating the first and second compartments, and an aperture which enables to introduce said sample into only said first compartment.
    Type: Application
    Filed: July 29, 2004
    Publication date: August 31, 2006
    Applicants: Riken, Kabushiki Kaisha Danform, Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Yasumasa Mitani, Takanori Oka, Yoshihide Hayashizaki, Toshizo Hayashi
  • Publication number: 20060124695
    Abstract: This invention relates to a liquid preparation containing a solution, which has a water content of from 10 to 80%, and an active ingredient coated with a coating material comprising a water-soluble cellulose derivative. The liquid preparation can stably retain the water-unstable active ingredient in it and at the same time, can mask its unpleasant taste and/or smell, and is usable as drug, quasi-drug, cosmetic, food or the like.
    Type: Application
    Filed: June 25, 2004
    Publication date: June 15, 2006
    Applicant: WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Yoichi Ikeda, Soko Motoune, Mizuho Ono, Yoshifumi Mohri
  • Publication number: 20050096306
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: September 17, 2004
    Publication date: May 5, 2005
    Applicants: Fujisawa Pharmaceutical Co. Ltd., Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Toshio Yamanaka, Kenji Murano, Ayako Toda, Hidenori Ohki, Masaru Oogaki, Shinya Okuda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Sato
  • Patent number: 6858625
    Abstract: This invention relates to 1-(6-amino-3,5-difluoropyridin-2-yl)-8-bromo-7-(3-ethylaminoazetidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a salt thereof, and also to a medicine containing the same. This compound has characteristic features that, when administered orally, it has extremely high blood half-life and bioavailability while retaining properties that it has extremely high antimicrobial effects and has low toxicity. It can be used widely as preventives, therapeutics and the like for various infectious diseases of human and animals.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: February 22, 2005
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Akira Yazaki, Yoshiko Niino, Yasuhiro Kuramoto, Yuzo Hirao, Yoshihiro Ohshita, Norihiro Hayashi, Hirotaka Amano
  • Publication number: 20050004094
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl which may have suitable substituent(s), R2 is amino, protected amino or guanidino, R3 is carboxy or protected carboxy, R4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 28, 2004
    Publication date: January 6, 2005
    Applicants: Fujisawa Pharmaceutical Co., Ltd., WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Toshio Yamanaka, Hidenori Ohki, Masaru Ohgaki, Shinya Okuda, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Publication number: 20040132994
    Abstract: The present invention relates to a compound of the formula [I]: 1
    Type: Application
    Filed: October 30, 2003
    Publication date: July 8, 2004
    Applicants: Fujisawa Pharmaceutical Co., Ltd, WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Patent number: 6586420
    Abstract: The present invention relates a 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-hydroxyazetidin-1-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid or salt thereof; and drugs containing the same as the active ingredient. Since this compound or salt thereof is highly stable to light while sustaining the excellent properties inherent to quinolone antibacterial agents, an antibacterial agent comprising, as an active ingredient, the invention compound or salt thereof can be stored over a long period of time without suffering from any decrease in the drug effect and can therefore be supplied as stable preparations such as injections, eye drops and surgical medicines.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: July 1, 2003
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Akira Yazaki, Yoshiko Niino, Yasuhiro Kuramoto, Yuzo Hirao, Yoshihiro Oshita, Norihiro Hayashi, Hirotaka Amano
  • Patent number: 6239111
    Abstract: The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1): CH2═CH—CH2—S(O)n—R  (1) [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl group, a substituted alkenyl group, an alkylthio group, an alkenylthio group, a phenyl group, a substituted phenyl group, a heterocyclic group, or a group derived from an amino acid or an oligopeptide by deletion of one hydrogen atom, and which group may have a protective group; and n is 0, 1, or 2], a glycoside thereof, or a salt of the compound or the glycoside. The drug of the present invention for ameliorating brain diseases, inhibiting reduction of brain neurons and promoting branching of neurites, is useful for the prevention and treatment of brain diseases such as dementia in association with degeneration and sloughing of brain neurons.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: May 29, 2001
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Toru Moriguchi, Hiromichi Matsuura, Hiroshi Saito
  • Patent number: 6211375
    Abstract: A novel pyridonecarboxylic acid derivative or its salt exhibiting satisfactory antibacterial activities, intestinal absorption, metabolic stability, and reduced side effects, in particular, phototoxicity and cytotoxicity, as well as an antibacterial agent containing such pyridonecarboxylic acid derivative or its salt are provided. For such an object, a pyridonecarboxylic acid derivative represented by the following formula (1): (wherein R1 represents hydrogen atom, a halogen atom or a lower alkyl group; R2 represents hydrogen atom or a lower alkyl group; R3 represents substituted or unsubstituted amino group or hydroxyl group; and R4 represents hydrogen atom, a lower alkyl group, amino group or nitro group) or its salt is provided.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: April 3, 2001
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Akira Yazaki, Yoshiko Niino, Yoshihiro Ohshita, Norihiro Hayashi, Hirotaka Amano, Yuzo Hirao, Tamae Yamane
  • Patent number: 6156903
    Abstract: A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R.sup.1 represents hydrogen atom or a carboxyl protective group; R.sup.2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R.sup.3 represents hydrogen atom or a halogen atom; R.sup.4 represents hydrogen atom or a halogen atom; R.sup.5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R.sup.6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH.dbd. or --CR.sup.7 .dbd. (wherein R.sup.7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR.sup.8 .dbd. (wherein R.sup.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: December 5, 2000
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Akira Yazaki, Yoshiko Niino, Yoshihiro Ohshita, Yuzo Hirao, Hirotaka Amano, Norihiro Hayashi, Yasuhiro Kuramoto
  • Patent number: 6146638
    Abstract: The present invention relates to a composition prepared by fermenting enzymatically-deactivated garlic with Aspergillus and/or Monascus, to a process for preparing the same, and also to foods and drugs containing the same. The composition is free from any unpleasant odor and is useful as a prophylactic or therapeutic agent for diabetes, hepatic diseases, cancer, immunopathy, hyperlipemia, and the like.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: November 14, 2000
    Assignee: Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Masanori Kakimoto, Ayumi Suzuki, Isao Nishimoto, Sumihiro Shiraishi, Yoichi Itakura