Abstract: A fluid treatment system is provided which includes a fluid distribution manifold, a multiport connector including a plurality of fluid channels, and at least one discrete fluid treatment cartridge. The distribution manifold includes a plurality of fluid channels, one for each of a plurality of fluid connection tubes with the fluid channels having inlet and outlet ports. The multiport connector is configured such that each one of the fluid channels in the multiport connector aligns with one of the ports in the distribution manifold. The fluid treatment cartridge includes a sump which includes a fluid inlet port and a fluid outlet port. The sump is configured such that the cartridge fluid inlet port aligns with one of the ports in the distribution manifold and the cartridge outlet port aligns with another the ports in the distribution manifold. A replacement treatment cartridge is also provided for a distribution manifold which includes a cartridge receiving aperture.