Patents Assigned to William Marsh Rice University
  • Publication number: 20210295166
    Abstract: A system may include a processor and a memory. The memory may include program code that provides operations when executed by the processor. The operations may include: partitioning, based at least on a resource constraint of a platform, a global machine learning model into a plurality of local machine learning models; transforming training data to at least conform to the resource constraint of the platform; and training the global machine learning model by at least processing, at the platform, the transformed training data with a first of the plurality of local machine learning models.
    Type: Application
    Filed: February 6, 2017
    Publication date: September 23, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Bita Darvish Rouhani, Azalia Mirhoseini, Farinaz Koushanfar
  • Patent number: 11104936
    Abstract: The present disclosure describes the thermodynamic design and concentrations necessary to design probe compositions with desired optimal specificity that enable enrichment, detection, quantitation, purification, imaging, and amplification of rare-allele-bearing species of nucleic acids (prevalence <1%) in a large stoichiometric excess of a dominant-allele-bearing species (wildtype). Being an enzyme-free and homogeneous nucleic acid enrichment composition, this technology is broadly compatible with nearly all nucleic acid-based biotechnology, including plate reader and fluorimeter readout of nucleic acids, microarrays, PCR and other enzymatic amplification reactions, fluorescence barcoding, nanoparticle-based purification and quantitation, and in situ hybridization imaging technologies.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: August 31, 2021
    Assignee: William Marsh Rice University
    Inventors: David Yu Zhang, Juexiao Wang
  • Patent number: 11104964
    Abstract: The present disclosure is directed to compositions and methods present a universal microbial diagnostic (UMD) platform to screen for microbial organisms in a sample using a small number of random DNA probes that are agnostic to the target DNA sequences. The UMD platform can be used to direct and monitor appropriate treatments, thus minimizing the risk of antibiotic resistance, and enhancing patient care.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: August 31, 2021
    Assignee: William Marsh Rice University
    Inventors: Rebekah A. Drezek, Richard G. Baraniuk, Amirali Aghazadeh, Mona Sheikh, Adam Y. Lin, Allen L. Chen, Pallavi Bugga
  • Publication number: 20210261503
    Abstract: In one aspect, the present disclosure provides methods of preparing a secondary amine. In some embodiments, the secondary amine comprises two different groups or two identifical groups. Also provided herein are compositions for use in the preparation of the secondary amine.
    Type: Application
    Filed: May 17, 2018
    Publication date: August 26, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Padmanabha Venkatesh KATTAMURI, Laszlo KURTI
  • Patent number: 11098233
    Abstract: Various embodiments of the present disclosure provide methods of making wellbore fluids with enhanced electrical conductivities. In some embodiments, such methods comprise: (1) pre-treating a carbon material with an acid; and (2) adding the carbon material to the wellbore fluid. Further embodiments of the present disclosure pertain to wellbore fluids formed by the methods of the present disclosure. Additional embodiments of the present disclosure pertain to methods for logging a subterranean well by utilizing the aforementioned wellbore fluids.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: August 24, 2021
    Assignees: WILLIAM MARSH RICE UNIVERSITY, M-I L.L.C.
    Inventors: James M. Tour, Gabriel Ceriotti, Alexander Slesarev, Ruquan Ye, Katherine Price-Hoelscher, Cara Bovet, Jim Friedheim, Steve Young
  • Publication number: 20210257679
    Abstract: Systems and methods that utilize a separator coated by particles for Li dendrite detection in an ordinary two-electrode battery system. The particles can be red phosphorus (RP) particles and/or other particles that are poor electronic conductors, are able to react with Li, and will form an insoluble product with Li, such as silicon, germanium, arsenic, metal oxides, metal halides, metal chalcogenides, chalcogenides, and LiMxEyOz (M=metal, E=nonmetal, O=oxygen, x?0, y?0, z?0). These other particles can be used by themselves or in combination with one another. No additional electrode is needed, and the presence of Li dendrites can be detected simply based on the voltage profile during the charging step.
    Type: Application
    Filed: June 11, 2019
    Publication date: August 19, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: James M. Tour, Tuo Wang, Rodrigo Villegas Salvatierra
  • Publication number: 20210257616
    Abstract: Embodiments of the present disclosure pertain to electrodes that include a plurality of vertically aligned carbon nanotubes and a metal associated with the vertically aligned carbon nanotubes. The vertically aligned carbon nanotubes may be in the form of a graphene-carbon nanotube hybrid material that includes a graphene film covalently linked to the vertically aligned carbon nanotubes. The metal may become reversibly associated with the carbon nanotubes in situ during electrode operation and lack any dendrites or mossy aggregates. The metal may be in the form of a non-dendritic or non-mossy coating on surfaces of the vertically aligned carbon nanotubes. The metal may also be infiltrated within bundles of the vertically aligned carbon nanotubes. Additional embodiments pertain to energy storage devices that contain the electrodes of the present disclosure. Further embodiments pertain to methods of forming said electrodes by applying a metal to a plurality of vertically aligned carbon nanotubes.
    Type: Application
    Filed: November 20, 2020
    Publication date: August 19, 2021
    Applicant: William Marsh Rice University
    Inventors: James M. Tour, Abdul-Rahman O. Raji, Rodrigo V. Salvatierra
  • Publication number: 20210252166
    Abstract: Embodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo. The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide-based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.
    Type: Application
    Filed: April 16, 2021
    Publication date: August 19, 2021
    Applicants: William Marsh Rice University, Durham University
    Inventors: James M. Tour, Robert Pal, Victor García López, Lizanne Nilewski
  • Publication number: 20210238187
    Abstract: In one aspect, the present disclosure provides epothilone analogs of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Application
    Filed: April 11, 2018
    Publication date: August 5, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Kyriacos C NICOLAOU, Derek RHOADES, Yangping WANG
  • Publication number: 20210230691
    Abstract: Compositions and methods for highly specific nucleic acid probes and primers are provided. The probe system comprises a complement strand and a protector stand that form a partially double-stranded probe. The reaction standard free energy of hybridization between the probe and target nucleic acid as determined by Expression 1 (?G°rxn=?G°t-TC??G°nh-PC+(?G°v-TC??G°h-PC)) is from about ?4 kcal/mol to about +4 kcal/mol. Alternatively, the reaction standard free energy of hybridization between the probe and target nucleic acid is determined by Expression 1 to be within 5 kcal/mol of the standard free energy as determined by Expression 2 (?R?ln(([P]0?[C]0)/[C]0)]), where the [P]0 term of Expression 2 equals the concentration of the protector strand and the [C]0 term of Expression 2 equals the concentration of the complement strand. In addition, a method for on-the-fly fine tuning of a reaction using the present probe is provided.
    Type: Application
    Filed: December 30, 2020
    Publication date: July 29, 2021
    Applicant: William Marsh Rice University
    Inventors: David Yu ZHANG, Juexiao WANG, Ruojia WU
  • Publication number: 20210230178
    Abstract: In one aspect, the present disclosure provides trioxacarcin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein as well as dimers of the compounds described herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 29, 2021
    Applicant: William Marsh Rice University
    Inventors: Kyriacos C. NICOLAOU, Pengxi CHEN, Shugao ZHU, Quan CAI
  • Patent number: 11071857
    Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: July 27, 2021
    Assignees: William Marsh Rice University, Baylor College of Medicine, Texas Heart Institute
    Inventors: Yuxiang Sun, Aydin Babakhani, Mehdi Razavi, David Burkland, Brian Greet, Mathews John, Hongming Lyu
  • Publication number: 20210206642
    Abstract: Methods for the synthesis of graphene, and more particularly the method of synthesizing graphene by flash Joule heating (FJH). Such methods can be used to synthesize turbostratic graphene (including low-defect turbostratic graphene) in bulk quantities. Such methods can further be used to synthesize composite materials and 2D materials.
    Type: Application
    Filed: August 23, 2019
    Publication date: July 8, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: James Mitchell Tour, Duy X. Luong, Wilbur Carter Kittrell, Wala A. Algozeeb, Weiyin Chen
  • Publication number: 20210205468
    Abstract: Provided herein are compositions comprising multi domain peptide (MDP) hydrogels where the peptides that constitute the hydrogel have at least one N6-(1-iminoethyl)-lysine side chain. Also provided are hydrogels that further comprise a STING agonist, an immune checkpoint inhibitor, and/or an anti-cancer therapy. Also provided are methods of using such compositions in the treatment of cancer.
    Type: Application
    Filed: December 18, 2020
    Publication date: July 8, 2021
    Applicants: William Marsh Rice University, Baylor College of Medicine, The Board of Regents of the University of Texas System
    Inventors: Jeffrey HARTGERINK, Andrew G. SIKORA, David LEACH, Jared M. NEWTON, Simon YOUNG
  • Publication number: 20210202943
    Abstract: Alkali metal-sulfur cells and batteries with cathode layers that store alkali metal charge carriers (e.g., lithium ions) in agglomerates of sulfurized carbon. The cathode layers lack costly and environmentally unfriendly nickel and cobalt. The cathode layers are composites that include agglomerates of sulfurized-carbon particles in a conductive binder and interconnected by sp2-bonded carbon materials, such as carbon nanotubes or nanoribbons, that extend within the agglomerates and between the sulfurized-carbon particles.
    Type: Application
    Filed: September 1, 2020
    Publication date: July 1, 2021
    Applicant: William Marsh Rice University
    Inventors: James M. Tour, Rodrigo Villegas Salvatierra, Gladys Anahi Lopez Silva, Abdul-Ramahn O. Raji
  • Patent number: 11046978
    Abstract: This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: June 29, 2021
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Ramon Gonzalez, James M. Clomburg, Seokjung Cheong
  • Patent number: 11048893
    Abstract: Remote measuring and sensing. Some example embodiment related to optical energy harvesting by identification device, such as infrared identification device GRID devices). Other embodiments relate to RFID device localization using low frequency source signals. Yet still other embodiments related to energy harvesting by RFID in electric fields in both conductive and non-conductive environments.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 29, 2021
    Assignee: William Marsh Rice University
    Inventors: Aydin Babakhani, Seyed Mohammad Kazem Pour, Mahdi Forghani, Yuxiang Sun, Yaswanth Kumar Cherivirala
  • Publication number: 20210188906
    Abstract: In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Application
    Filed: November 28, 2018
    Publication date: June 24, 2021
    Applicant: William Marsh Rice University
    Inventors: Kyriacos C. NICOLAOU, Rohan Diliprao ERANDE, Dionisios VOURLOUMIS, Kiran Kumar PULUKURI, Stephan RIGOL
  • Publication number: 20210171929
    Abstract: Provided herein are systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and cytosine deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided.
    Type: Application
    Filed: November 25, 2020
    Publication date: June 10, 2021
    Applicant: William Marsh Rice University
    Inventors: Xue GAO, Sangsin LEE, Ning DING
  • Publication number: 20210171351
    Abstract: Laser-induced graphene (LIG) and laser-induced graphene scrolls (LIGS) materials and, more particularly to LIGS, methods of making LIGS (such as from polyimide (PI)), laser-induced removal of LIG and LIGS, and 3D printing of LIG and LIGS using a laminated object manufacturing (LOM) process.
    Type: Application
    Filed: November 23, 2020
    Publication date: June 10, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: James M. Tour, Duy X. Luong, Ajay Subramanian