Patents Assigned to William Marsh Rice University
  • Patent number: 11504437
    Abstract: A Magnetic Resonance Imaging (MRI) enhancement agent includes a plurality of particles, each particle including: a metal core; a dielectric shell disposed on the metal core comprising at least one MRI contrast agent; and a metal shell disposed on the exterior surface of the dielectric shell that encapsulates the dielectric shell.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 22, 2022
    Assignees: WILLIAM MARSH RICE UNIVERSITY, BAYLOR COLLEGE OF MEDICINE
    Inventors: Nancy J. Halas, Ciceron Ayala-Orozco, Sandra Bishnoi, Luke Henderson, Oara Neumann, Robia Pautler, Peter Nordlander
  • Patent number: 11505819
    Abstract: This present disclosure describes hybridization probes modularly constructed from several oligonucleotides with a pattern of designed complementary interactions, allowing the probes to sequence-specifically capture or analyze nucleic acid target sequences that are long and/or complex.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: November 22, 2022
    Assignee: William Marsh Rice University
    Inventors: David Zhang, Juexiao Wang, Yan Yan
  • Publication number: 20220339436
    Abstract: A method of improving electrical conduction across an impaired region of a tissue (e.g., myocardial tissue), includes applying an electrically conductive wiring carbon nanotube fibers) across the impaired region. The electrically conductive wiring can become associated with non-impaired regions of the tissue on opposite sides of the impaired region by suturing. The method can also be utilized to treat or prevent cardiac arrhythmia in a subject (e.g., ventricular arrhythmia). The electrically conductive wiring includes carbon nanotubes, such as carbon nanotube fibers, Such electrically conductive wiring can be used to transmit electrical signals to a tissue or sense electrical signals from the tissue. Suture threads including carbon nanotubes, such as carbon nanotube fibers, are provided.
    Type: Application
    Filed: July 11, 2022
    Publication date: October 27, 2022
    Applicants: William Marsh Rice University, Baylor College of Medicine, Texas Heart Institute
    Inventors: Matteo Pasquali, Mehdi Razavi, Flavia Vitale, Colin Christopher Young, Mark David McCauley
  • Patent number: 11478489
    Abstract: The disclosure relates to the treatment of primary and metastatic cancer using radiation. Specifically, the disclosure relates to methods providing for the selective accretion of cytoprotective agent in tissues and/or organs, sensitive to radiation that are adjacent to malignant tumors prior to radiation of the tumors at a dose that otherwise would be toxic to the tissues and/or organs, but are necessary to achieve ablative outcome on the tumors.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: October 25, 2022
    Assignees: WILLIAM MARSH RICE UNIVERSITY, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
    Inventors: James Tour, Cullen Taniguchi, Kathy Mason
  • Publication number: 20220333050
    Abstract: Some embodiments of the disclosure disclose a process for adhering cells, beads or particles to a surface of a material. The surface may be flat or curved and can be employed in the context of patterned or 3D printed hollow channels, facilitating the recapitulation of certain aspects of physiological systems. In various embodiments, interfacial cell seeding is accomplished by locally polymerizing a carrier containing a suspension of cells along the surface with a crosslinking molecule incorporated into the target material in advance of the interfacial polymerization. Polymerization of the carrier entraps the cells into controlled configuration along the surface. The techniques disclosed herein can be utilized for tissue engineering to build engineered organs/devices suitable for implanting into living organisms.
    Type: Application
    Filed: April 8, 2022
    Publication date: October 20, 2022
    Applicant: William Marsh Rice University
    Inventors: Jordan MILLER, Ian KINSTLINGER, Bagrat GRIGORYAN, Samantha PAULSEN
  • Publication number: 20220334552
    Abstract: A method for designing lithology-specific drill bits. The method creates an experimentally verified multiphysics model to predict drilling into site-specific rock formations. A physics-based, Eulerian-Lagrangian computational modeling framework to predict particle flow and tribological phenomena. The method uses this multiphysics model to generate virtual drilling data and then generates a machine learning enabled surrogate model of the physics-based model using the data from virtual drilling to provide design charts for drill bits.
    Type: Application
    Filed: July 30, 2020
    Publication date: October 20, 2022
    Applicants: William Marsh Rice University, Carnegie Mellon University
    Inventors: Fred C. Higgs, III, Prathamesh S. Desai
  • Patent number: 11475979
    Abstract: Embodiments of methods, systems, and tangible non-transitory computer readable medium having instructions are presented. A method includes calculating a plurality of feature values for a number of bioinformatic features of the desired hybridization reaction; and calculating distances between the plurality of feature values and corresponding database rate constant values stored in a database, the database comprising a plurality of hybridization reactions having known rate constants. The method additionally includes calculating a weighted average of a logarithm of the database rate constant values, with larger weights assigned to value instances having values lower in distance to the plurality of feature values of the desired hybridization reaction; and providing the weighted average as a predicted logarithm of the rate constant of the desired hybridization reaction.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: October 18, 2022
    Assignee: William Marsh Rice University
    Inventors: Xuemeng Zhang, Zheng Fang, Ruojia Wu, Wei Duan, David Zhang
  • Publication number: 20220323906
    Abstract: In some embodiments, the present disclosure pertains to systems and methods for distilling a fluid by exposing the fluid to a porous membrane that includes a surface capable of generating heat. In some embodiments, the heat generated at the surface propagates the distilling of the fluid by converting the fluid to a vapor that flows through the porous membrane and condenses to a distillate. In some embodiments, the surface capable of generating heat is associated with a photo-thermal composition that generates the heat at the surface by converting light energy from a light source to thermal energy. In some embodiments, the photo-thermal composition includes, without limitation, noble metals, semiconducting materials, dielectric materials, carbon-based materials, composite materials, nanocomposite materials, nanoparticles, hydrophilic materials, polymers, fibers, meshes, fiber meshes, hydrogels, hydrogel meshes, nanomaterials, and combinations thereof.
    Type: Application
    Filed: April 22, 2022
    Publication date: October 13, 2022
    Applicant: William Marsh Rice University
    Inventors: Qilin Li, Jinjian Wu, Nancy J. Halas, Katherine R. Zodrow, Haoli Guo, Jiarui Xu, Cong Yu
  • Patent number: 11464632
    Abstract: Some embodiments are directed to a transcatheter and serially-expandable artificial heart valve, e.g., to be minimally-invasively implanted into a pediatric patient during a first procedure, and then expanded during a second procedure to accommodate for the pediatric patient's growth. Some embodiments include an expandable frame having a compressed, delivery configuration, and an expanded, deployed configuration, in which the valve is implantable within the patient. The valve can have a first working condition when the frame is expanded to a first diameter and a second working condition when the frame is expanded to a second diameter greater than the first diameter. The valve can include a plurality of leaflets configured to accommodate the expansion of the frame and growth of the patient.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: October 11, 2022
    Assignees: Baylor College of Medicine, William Marsh Rice University
    Inventors: Henri Justino, Daniel Harrington, Kwonsoo Chun
  • Patent number: 11465997
    Abstract: In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: October 11, 2022
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C. Nicolaou, Gabriel Bellavance, Marek Buchman, Kiran Kumar Pulukuri, Stephan Rigol
  • Publication number: 20220313599
    Abstract: The present disclosure relates to implantable constructs designed to deliver antigenic therapeutic reagents to a subject while providing protection from host immune responses. In certain aspects, the constructs are designed to degrade over time or upon a particular signal, thereby providing control of the length of time the therapeutic agent is delivered to the subject.
    Type: Application
    Filed: August 7, 2020
    Publication date: October 6, 2022
    Applicant: William Marsh Rice University
    Inventors: Omid VEISEH, Amanda NASH, Maria Isabel JARVIS-RUOCCO, Sudip MUKHERJEE, Michael David DOERFERT, Samira AGHLARA-FOTOVAT, David Yu ZHANG
  • Patent number: 11447744
    Abstract: The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: September 20, 2022
    Assignee: William Marsh Rice University
    Inventors: Jordan Miller, Anderson Ta, Bagrat Grigoryan
  • Patent number: 11437620
    Abstract: In some embodiments, the present disclosure pertains to methods of producing a graphene material by exposing a polymer to a laser source. In some embodiments, the exposing results in formation of a graphene from the polymer. In some embodiments, the methods of the present disclosure also include a step of separating the formed graphene from the polymer to form an isolated graphene. In some embodiments, the methods of the present disclosure also include a step of incorporating the graphene material or the isolated graphene into an electronic device, such as an energy storage device. In some embodiments, the graphene is utilized as at least one of an electrode, current collector or additive in the electronic device. Additional embodiments of the present disclosure pertain to the graphene materials, isolated graphenes, and electronic devices that are formed by the methods of the present disclosure.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: September 6, 2022
    Assignee: William Marsh Rice University
    Inventors: James M. Tour, Jian Lin, Zhiwei Peng, Wilbur Carter Kittrell
  • Publication number: 20220267848
    Abstract: This disclosure describes methods for enabling accurate detection and quantitation of rare alleles within a DNA sample using low-depth sequencing, through the use of allele-specific enrichment and/or depletion hybridization probes. For example, methods are provided for using competitive probes to apply allele-specific enrichment or depletion to amplicons from multiplex PCR on a biological DNA sample.
    Type: Application
    Filed: May 2, 2022
    Publication date: August 25, 2022
    Applicant: William Marsh Rice University
    Inventors: David ZHANG, Juexiao WANG
  • Publication number: 20220267153
    Abstract: Methods that expand the properties of laser-induced graphene (LIG) and the resulting LIG having the expanded properties. Methods of fabricating laser-induced graphene from materials, which range from natural, renewable precursors (such as cloth or paper) to high performance polymers (like Kevlar). With multiple lasing, however, highly conductive PEI-based LIG could be obtained using both multiple pass and defocus methods. The resulting laser-induced graphene can be used, inter alia, in electronic devices, as antifouling surfaces, in water treatment technology, in membranes, and in electronics on paper and food Such methods include fabrication of LIG in controlled atmospheres, such that, for example, superhydrophobic and superhydrophilic LIG surfaces can be obtained. Such methods further include fabricating laser-induced graphene by multiple lasing of carbon precursors. Such methods further include direct 3D printing of graphene materials from carbon precurors.
    Type: Application
    Filed: November 1, 2021
    Publication date: August 25, 2022
    Applicants: WILLIAM MARSH RICE UNIVERSITY, B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. AT BEN-GURION UNIVERSITY
    Inventors: James M. Tour, Yieu Chyan, Christopher John Arnusch, Swatantra Pratap Singh, Yilun Li, Duy X. Luong, Carter Kittrell, Ruquan Ye, Jordan Miller, Ian Kinstlinger, Savannah Cofer
  • Publication number: 20220259746
    Abstract: A porous solid electrolyte electrosynthesis cell and corresponding related process for the direct synthesis of high purity liquid products wherein the electrosynthesis cell comprises a cathode compartment including a cathode electrode comprising a gas diffusion layer loaded with a selective reduction reaction electrocatalyst for specific reduction reactions. The electrosynthesis cell further includes an anode compartment including an anode electrode comprising a gas diffusion layer loaded with a catalyst for oxidation reactions; and a solid electrolyte compartment comprising a porous solid electrolyte; a cation exchange membrane; and an anion exchange membrane; (or two cation exchange membranes) wherein the solid electrolyte compartment is separated from the cathode and the anode by the anion exchange membrane and the cation exchange membrane (or by the two cation exchange membranes).
    Type: Application
    Filed: July 15, 2020
    Publication date: August 18, 2022
    Applicant: William Marsh Rice University
    Inventors: Haotian Wang, Chuan Xia
  • Patent number: 11414686
    Abstract: This disclosure describes a method of purifying several full-length oligonucleotide targets from corresponding synthesis truncation products, in a way that ensures roughly stoichiometric equality among the targets.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: August 16, 2022
    Assignee: William Marsh Rice University
    Inventors: David Zhang, Alessandro Pinto
  • Patent number: 11407792
    Abstract: Engineered protein electron carriers, microorganisms expressing the same, and methods detecting regulated electron flow are described.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: August 9, 2022
    Assignee: William Marsh Rice University
    Inventors: Jonathan Silberg, Joshua T. Atkinson, Ian J. Campbell, George N. Bennett
  • Publication number: 20220223352
    Abstract: Described is an integrated device for solar-driven water splitting. The integrated device includes cobalt phosphide (CoP) electrodes, series-connected perovskite solar cells (PSCs) encapsulated in a polymer, and a metal film connecting the CoP electrodes with the series-connected PSCs. Also described is a method for forming an integrated device for solar-driven water splitting.
    Type: Application
    Filed: January 11, 2022
    Publication date: July 14, 2022
    Applicant: William Marsh Rice University
    Inventors: Jun Lou, Jia Liang
  • Patent number: 11371014
    Abstract: The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: June 28, 2022
    Assignee: William Marsh Rice University
    Inventors: Jordan Miller, Anderson Ta, Bagrat Grigoryan