Patents Assigned to William Marsh Rice University
  • Publication number: 20190346386
    Abstract: An Electron Paramagnetic resonance (EPR) system and method allows the measurement paramagnetic characteristics of materials in real-time, such as heavy oil, hydrocarbons, asphaltenes, heptane, vanadium, resins, drilling fluid, mud, wax deposits or the like. The EPR systems and methods discussed herein are low cost, small and light weight, making them usable in flow-assurance or logging applications. The EPR sensor is capable of measuring paramagnetic properties of materials from a distance of several inches. In some embodiments, a window will be used to separate the EPR sensor from the materials in a pipeline or wellbore. Since the sensor does need to be in direct contact with the materials, it can operate at a lower temperature or pressure. In other embodiments, the EPR sensor may be placed in the materials.
    Type: Application
    Filed: July 15, 2019
    Publication date: November 14, 2019
    Applicant: William Marsh Rice University
    Inventors: Aydin Babakhani, Xuebei Yang
  • Patent number: 10465212
    Abstract: There is provided a recombinant bacterium comprising at least one overexpressed acyl-ACP thioesterase gene, and wherein at least one gene from the tricarboxylic acid cycle or glycolysis or both is inactivated. There is also provided a method for producing fatty acids, said method comprising culturing bacteria comprising at least one overexpressed acyl-ACP thioesterase gene in a growth medium in a container having walls; allowing said bacteria to secrete fatty acids; and collecting said fatty acids. Acid supplementation is also shown to increase productivity.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: November 5, 2019
    Assignee: William Marsh Rice University
    Inventors: Ka-Yiu San, Mai Li, Xiujun Zhang
  • Publication number: 20190330064
    Abstract: Methods that expand the properties of laser-induced graphene (LIG) and the resulting LIG having the expanded properties. Methods of fabricating laser-induced graphene from materials, which range from natural, renewable precursors (such as cloth or paper) to high performance polymers (like Kevlar). With multiple lasing, however, highly conductive PEI-based LIG could be obtained using both multiple pass and defocus methods. The resulting laser-induced graphene can be used, inter alia, in electronic devices, as antifouling surfaces, in water treatment technology, in membranes, and in electronics on paper and food Such methods include fabrication of LIG in controlled atmospheres, such that, for example, superhydrophobic and superhydrophilic LIG surfaces can be obtained. Such methods further include fabricating laser-induced graphene by multiple lasing of carbon precursors. Such methods further include direct 3D printing of graphene materials from carbon precurors.
    Type: Application
    Filed: November 6, 2017
    Publication date: October 31, 2019
    Applicants: WILLIAM MARSH RICE UNIVERSITY, BEN-GURION UNIVERSITY
    Inventors: James M. TOUR, Yieu CHYAN, Christopher John ARNUSCH, Swatantra Pratap SINGH, Yilun LI, Duy X. LUONG, Carter KITTRELL, Ruquan YE, Jordan MILLER, Ian KINSTLINGER, Savannah COFER
  • Patent number: 10450593
    Abstract: This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the ?-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the ?-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their ?-, ?-, and ?-functionalized derivatives from renewable carbon sources can be achieved.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: October 22, 2019
    Assignee: William Marsh Rice University
    Inventors: Ramon Gonzalez, James M. Clomburg, Jacob E. Vick
  • Patent number: 10442696
    Abstract: In some embodiments, the present disclosure pertains to methods of forming calcium-silicate-hydrate particles by mixing a calcium source with a silicate source. In some embodiments, the mixing comprises sonication. In some embodiments, the mixing occurs in the presence of a surfactant and a solvent. In some embodiments, the methods of the present disclosure further comprise a step of controlling the morphology of the calcium-silicate-hydrate particles. In some embodiments, the step of controlling the morphology of calcium-silicate-hydrate particles comprises selecting a stoichiometric ratio of the calcium source over the silicate source. In some embodiments, the formed calcium-silicate-hydrate particles have cubic shapes. In some embodiments, the formed calcium-silicate-hydrate particles have rectangular shapes. In some embodiments, the formed calcium-silicate-hydrate particles are in the form of self-assembled particles of controlled shapes.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 15, 2019
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Rouzbeh Shahsavari, Sakineh Ebrahimpourmoghaddam, Kenton Herbert Whitmire
  • Publication number: 20190308880
    Abstract: Three-dimensional (3D) printing of graphene materials and methods and apparatuses for making same. In some embodiments, combined metal powder and carbon growth sources (such as powder Ni and sucrose) are utilized in the 3D printing process. In other embodiments, metal powders with binders (such as powder Ni and a polymer bases binder) are utilized in the 3D printing process. The metal in the resulting 3D printed composite material can then be etched or otherwise removed yielding the 3D printed graphene materials.
    Type: Application
    Filed: July 12, 2017
    Publication date: October 10, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: James M. Tour, Junwei Sha, Yilun Li, Jordan Miller, Ian Kinstlinger, Savannah Cofer, Yieu Chyan
  • Publication number: 20190290785
    Abstract: Embodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo. The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide-based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.
    Type: Application
    Filed: July 14, 2017
    Publication date: September 26, 2019
    Applicants: William Marsh Rice University, Durham University
    Inventors: James M. Tour, Robert Pal, Victor Garcia, Lizanne Nilewski
  • Patent number: 10422214
    Abstract: Systems and methods for fracture mapping may utilize frequency changing to aid in providing high-resolution mapping. Integrated chips may be injected into a well and dispersed into a formation. A downhole tool that provides a transmitter and receiver may be positioned in the well. The transmitter may transmit electromagnetic (EM) signals into the formation. The dispersed integrated chips may receive the transmitted EM signal and return a frequency-changed signal to the receiver of the downhole tool. Utilizing the returned frequency changed signal, the system is able to determine the locations of the integrated chips that have been dispersed into the formation and provide fracture mapping.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: September 24, 2019
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventor: Aydin Babakhani
  • Publication number: 20190284596
    Abstract: This disclosure describes a method of purifying several full-length oligonucleotide targets from corresponding synthesis truncation products, in a way that ensures roughly stoichiometric equality among the targets.
    Type: Application
    Filed: May 5, 2017
    Publication date: September 19, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: David ZHANG, Alessandro PINTO
  • Patent number: 10408774
    Abstract: An Electron Paramagnetic resonance (EPR) system and method allows the measurement paramagnetic characteristics of materials in real-time, such as heavy oil, hydrocarbons, asphaltenes, heptane, vanadium, resins, drilling fluid, mud, wax deposits or the like. The EPR systems and methods discussed herein are low cost, small and light weight, making them usable in flow-assurance or logging applications. The EPR sensor is capable of measuring paramagnetic properties of materials from a distance of several inches. In some embodiments, a window will be used to separate the EPR sensor from the materials in a pipeline or wellbore. Since the sensor does need to be in direct contact with the materials, it can operate at a lower temperature or pressure. In other embodiments, the EPR sensor may be placed in the materials.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: September 10, 2019
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Aydin Babakhani, Xuebei Yang
  • Patent number: 10403894
    Abstract: Embodiments of the present disclosure pertain to electrodes that include a plurality of vertically aligned carbon nanotubes and a metal associated with the vertically aligned carbon nanotubes. The vertically aligned carbon nanotubes may be in the form of a graphene-carbon nanotube hybrid material that includes a graphene film covalently linked to the vertically aligned carbon nanotubes. The metal may become reversibly associated with the carbon nanotubes in situ during electrode operation and lack any dendrites or mossy aggregates. The metal may be in the form of a non-dendritic or non-mossy coating on surfaces of the vertically aligned carbon nanotubes. The metal may also be infiltrated within bundles of the vertically aligned carbon nanotubes. Additional embodiments pertain to energy storage devices that contain the electrodes of the present disclosure. Further embodiments pertain to methods of forming said electrodes by applying a metal to a plurality of vertically aligned carbon nanotubes.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: September 3, 2019
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: James M. Tour, Abdul-Rahman O. Raji, Rodrigo V. Salvatierra
  • Publication number: 20190262605
    Abstract: Inducing hyperthermia in cancer cells. At least some of the example embodiments are methods including: charging a capacitor of a microchip device proximate to cells within the body, the charging by harvesting ambient energy by the microchip device; and when the energy on the capacitor reaches or exceeds a predetermined value inducing hyperthermia in the cells proximate to the microchip device using energy from the capacitor.
    Type: Application
    Filed: September 19, 2017
    Publication date: August 29, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Aydin BABAKHANI, Hongming LYU
  • Patent number: 10376861
    Abstract: The present disclosure pertains to methods of capturing CO2 from an environment at pressures above 1 bar by associating the environment with a porous material that has a surface area of at least 2,800 m2/g, and a total pore volume of at least 1.35 cm3/g, where a majority of pores of the porous material have diameters of less than 2 nm. The present disclosure also pertains to methods for the separation of CO2 from natural gas in an environment at partial pressures of either component above 1 bar by associating the environment with a porous material that has a surface area of at least 2,200 m2/g, and a total pore volume of at least 1.00 cm3/g, where a majority of pores of the porous material have diameters of greater than 1 nm and less than 2 nm.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: August 13, 2019
    Assignees: WILLIAM MARSH RICE UNIVERSITY, APACHE CORPORATION
    Inventors: Saunab Ghosh, Andrew R. Barron, Jason Ho
  • Patent number: 10373512
    Abstract: Mechanisms for automatically grading a large number of solutions provided by learners in response to an open response mathematical question. Each solution is mapped to a corresponding feature vector based on the mathematical expressions occurring in the solution. The feature vectors are clustered using a conventional clustering method, or alternatively, using a presently-disclosed Bayesian nonparametric clustering method. A representative solution is selected from each solution cluster. An instructor supplies a grade for each of the representative solutions. Grades for the remaining solutions are automatically generated based on their cluster membership and the instructor supplied grades. The Bayesian method may also automatically identify the location of an error in a given solution. The error location may be supplied to the learner as feedback. The error location may also be used to extract information from correct solutions. The extracted information may be supplied to a learner as a solution hint.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: August 6, 2019
    Assignee: William Marsh Rice University
    Inventors: Shiting Lan, Divyanshu Vats, Andrew E. Waters, Richard G. Baraniuk
  • Patent number: 10364265
    Abstract: Improved methods of making anhydrosugars by pyrolysis of a substrate sugar to remove at least one water molecule thereby producing a desired anhydrosugar and side products, the improvement being either 1) protecting one hydroxyl group of the substrate sugar before pyrolysis; or (2) pretreating the substrate sugar with a metal salt and optional acid before pyrolysis, wherein lower amounts of said side products are produced by said improved method.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: July 30, 2019
    Assignee: William Marsh Rice University
    Inventors: Li Chen, Michael S Wong, Zongchao Zhang
  • Publication number: 20190224476
    Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.
    Type: Application
    Filed: August 22, 2017
    Publication date: July 25, 2019
    Applicants: WILLIAM MARSH RICE UNIVERSITY, TEXAS HEART INSTITUTE, BAYLOR COLLEGE OF MEDICINE
    Inventors: Yuxiang SUN, Aydin BABAKHANI, Mehdi RAZAVI, David BURKLAND, Brian GREET, Mathews JOHN, Hongming LYU
  • Publication number: 20190202866
    Abstract: Provided herein are recombinant viral nanoparticles (VNPs) which comprise truncated viral proteins. The VNPs may be mosaic VNPs which are activatable at desired levels. The VNPs may be used to administer therapeutic agents to target cells.
    Type: Application
    Filed: December 12, 2018
    Publication date: July 4, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Junghae SUH, Nicole THADANI, Christopher DEMPSEY
  • Publication number: 20190202774
    Abstract: In one aspect, the present disclosure provides diaryl compounds of the formula presented herein. The application also provides compositions and methods of treatment thereof. In some embodiments, these compounds are used in the treatment of bacterial infections or in the treatment of cancer.
    Type: Application
    Filed: November 11, 2016
    Publication date: July 4, 2019
    Applicants: WILLIAM MARSH RICE UNIVERSITY, THE TEXAS A&M UNIVERSITY SYSTEM, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hongyin GAO, Laszlo KURTI, Kush SHAH, Parth SHAH, Carolyn L CANNON
  • Publication number: 20190185933
    Abstract: This disclosure describes methods for enabling accurate detection and quantitation of rare alleles within a DNA sample using low-depth sequencing, through the use of allele-specific enrichment and/or depletion hybridization probes. For example, methods are provided for using competitive probes to apply allele-specific enrichment or depletion to amplicons from multiplex PCR on a biological DNA sample.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: David Zhang, Juexiao Wang
  • Publication number: 20190184063
    Abstract: Graphene compositions used for neuronal repair and treatments, and, in particular neuronal scaffold-water soluble graphene for treatment of severed spinal cords and other neuronal repairs. The neuronal scaffold-water soluble graphene can be PEGylated GNR used in combination with a fusogen agent, such as PEG600.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 20, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: James M. Tour, William Sikkema