Patents Assigned to Worcester Foundation for Experimental Biology, Inc.
  • Patent number: 5635377
    Abstract: A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: June 3, 1997
    Assignee: Worcester Foundation for Experimental Biology, Inc.
    Inventors: Thoru Pederson, Sudhir Agrawal, Sandra Mayrand, Paul C. Zamecnik