Patents Assigned to World Health Organization
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Patent number: 8887713Abstract: The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/?0.2 ?m (ii) Dv50: 5.0+/?0.5 ?m (iii) Dv90: 10.0+/?1.0 ?m (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 ?m This allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers. Nebulizers identified by the methods of the invention are also claimed.Type: GrantFiled: October 12, 2012Date of Patent: November 18, 2014Assignee: World Health OrganizationInventors: Felicity Cutts, Jorge Fernandez De Castro, John V. Bennett, Beth Laube, Clyde Witham, Ana Maria Henao-Restrepo, Bernard Cohen, David Brown, John Dennis
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Publication number: 20130032140Abstract: The invention provides a method of selecting a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/?0.2 ?m (ii) Dv50: 5.0+/?0.5 ?m (iii) Dv90: 10.0+/?1.0 ?m (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 ?m This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. Nebulisers identified by the methods of the invention are also claimed.Type: ApplicationFiled: October 12, 2012Publication date: February 7, 2013Applicant: World Health OrganizationInventors: Felicity Cutts, Jorge FERNANDEZ DE CASTRO, John V. BENNETT, Beth LAUBE, Clyde WITHAM, Ana Maria HENAO-RESTREPO, Bernard COHEN, David BROWN, John DENNIS
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Patent number: 5011951Abstract: A process for the epimerization of .alpha.- to .beta.-ethyletherartemisininelactol (arteether) or preparation of arteether, useful in the treatment of malaria, from artemisininelactol, comprises reacting starting material in a solvent including an acid catalyst, the reaction of artemisininelactol also including an etherifying ethyl moiety, and isolating the product.Type: GrantFiled: February 27, 1989Date of Patent: April 30, 1991Assignee: World Health OrganizationInventors: Peter Buchs, Arnold Brossi
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Patent number: 4507290Abstract: Esters of 17 .alpha.-ethynyl 19-nor-testosterone and 17 .alpha.-ethynyl-18-homo-19-nor-testosterone and the 3-oximes thereof having long-active contraceptive activity.Type: GrantFiled: April 7, 1981Date of Patent: March 26, 1985Assignee: World Health OrganizationInventors: Sydney Archer, Giuseppe Benagiano, Pierre Crabbe, Egon Diczfalusy, Carl Djerassi, Josef Fried
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Patent number: 4359454Abstract: A method of female sterilization which comprises instilling methyl cyanoacrylate and radiopaque additive in the oviduct, allowing the methyl cyanoacrylate (MCA) to polymerize and induce an inflammatory response on the inside lining of the oviduct such that dense fibrous scar tissue is deposited across the oviduct lumen and the oviduct is occluded by natural scar tissue. The radiopaque additive permits the instillation to be examined by X-ray to insure proper positioning of the formulation and resultant blockage of the oviduct. The polymerized methyl cyanoacrylate degrades and is readily cleared along with other components of the formulation from the oviduct. In one embodiment the MCA and radiopaque additive are instilled together in liquid water-free form although they may also be instilled separately. The latter embodiment permits the use of aqueous systems for the radiopaque material. Acid and free radical polymerization inhibitors should also be used to prevent premature polymerization.Type: GrantFiled: December 16, 1980Date of Patent: November 16, 1982Assignee: World Health OrganizationInventor: Allan S. Hoffman
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Patent number: 4326510Abstract: A barrier contraceptive device and a method for preventing conception utilizing the device. The device comprises a torus of biocompatible material sized to fit in a vagina, structure--such as overlapping flaps--being provided with the torus for providing a primary barrier preventing direct ejaculation into the cervix while allowing fluid drainage from the cervix. The material forming the torus contains a spermicide and is operative to allow release of the spermicide to maintain an effective level of spermicide in the area between the torus and the cervix to kill any sperm that passes the primary barrier. The torus is constructed so that the spermicide is more readily releasable through the inner peripheral surface thereof than the outer peripheral surface thereof.Type: GrantFiled: November 20, 1979Date of Patent: April 27, 1982Assignee: World Health OrganizationInventor: Richard G. Buckles
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Patent number: 4309565Abstract: The present invention is directed to a process for synthesizing A-nor and A-nor-18-homo-steroids. The invention is concerned with providing a total synthesis for the compounds called Dinordin and 18-homo-Dinordin. The preparation of other compounds will also be evident.Type: GrantFiled: April 15, 1980Date of Patent: January 5, 1982Assignee: World Health OrganizationInventor: Pierre Crabbe
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Patent number: 4261969Abstract: A novel, closed loop drug delivery system has been developed where the presence or absence of an external compound determines delivery of a drug from a bioerodible polymer. In the described delivery system hydrocortisone is incorporated into a n-hexyl half ester of a methyl vinyl ether-maleic anhydride copolymer and the polymer-drug mixture fabricated into discs. These are then coated with a hydrogel containing immobilized urease. In a medium of constant pH and in the absence of external urea, the release of hydrocortisone is that normally expected for that polymer at the given pH. In the presence of external urea, ammonium bicarbonate and ammonium hydroxide is generated within the hydrogel which accelerates polymer erosion and hence drug release. Drug delivery rate increase is proportional to the amount of external urea and is reversible, that is, when external urea is removed, the rate of drug release gradually returns to its original value.Type: GrantFiled: May 3, 1979Date of Patent: April 14, 1981Assignee: World Health OrganizationInventor: Jorge Heller