Patents Assigned to Yissum Research Development Company of the Hebrew
  • Patent number: 11324709
    Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 10, 2022
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Raphael Mechoulam, Vincenzo Di Marzo, Fabiana Piscitelli, Aron H. Lichtman, Imad M. Damaj, Linda Parker, Rami Yaka
  • Patent number: 11319227
    Abstract: The invention provides a process for the preparation of bismuth oxyhalide, comprising a precipitation of bismuth oxyhalide in an acidic aqueous medium in the presence of a reducing agent. Also provided are bismuth oxyhalide compounds doped with elemental bismuth Bi(0). The use of Bi(0)doped-bismuth oxyhalide as photocatalysts in water purification is also described.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: May 3, 2022
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Yoel Sasson, Hani Gnayem
  • Patent number: 11304989
    Abstract: Disclosed are peptides, compositions, combinations, kits and methods for the treatment of viral pathogen infection. Combinations and kits comprise the disclosed peptides together with an additional antiviral therapeutic agent.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: April 19, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raymond Kaempfer, Gila Arad
  • Publication number: 20220112342
    Abstract: The invention relates to a block co-polymer film having different morphologies within said film, uses thereof and processes for its preparation.
    Type: Application
    Filed: July 29, 2019
    Publication date: April 14, 2022
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Roy SHENHAR, Elisheva MICHMAN, Marcus MULLER
  • Patent number: 11298151
    Abstract: Device for accessing a pericardial space of a subject in need thereof, the device including a tubular member having an atraumatic distal end and a thread formed on, and at least partially around, the outer surface of the tubular member, proximally to the distal end; wherein the thread is configured to cut, puncture and/or penetrate a pericardium.
    Type: Grant
    Filed: June 17, 2018
    Date of Patent: April 12, 2022
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Ran Eliaz, Yonathan Avraham Demma, Ziv Menshes, Or Hazan, Eva Abramov, Yaakov Nahmias, Amnon Buxboim, Yoav Kan-Tor, Yoav Mintz, Elchanan Fried
  • Patent number: 11297868
    Abstract: A method of preparing a bacterial composition is disclosed. The method comprises: (a) in vitro co-culturing beneficial bacteria with biofilm-producing bacteria in a growth substrate under conditions that generate a biofilm which comprises the beneficial bacteria and the non-pathogenic bacteria; and (b) isolating the biofilm from the growth substrate.
    Type: Grant
    Filed: May 29, 2017
    Date of Patent: April 12, 2022
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Moshe Shemesh, Ram Reifen
  • Publication number: 20220088099
    Abstract: Provided are methods for extraction of various agents, e.g. active agent, from a plant source, specifically with the use of extraction formulations which are based on micellar liquid systems.
    Type: Application
    Filed: December 7, 2021
    Publication date: March 24, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Nissim GARTI, Sharon GARTI LEVI, Rotem EDRI
  • Patent number: 11267846
    Abstract: The present disclosure relates to solid phase synthesis of organic molecules and particularly to highly efficient methods for synthesizing polymers, such as peptides, nucleotides or saccharides, employing solid phase synthesis.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: March 8, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Chaim Gilon, Moshe Bentolila
  • Patent number: 11261215
    Abstract: The present invention provides prodrugs of somatostatin peptide and peptide analogs that are tissue permeable and oral bioavailable and enable activity of the somatostatin analog at the circulation or target tissue after cleavage of charge-masking lipophilic moieties. Pharmaceutical compositions comprising these prodrugs and their use in therapy and diagnosis are also provided.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 1, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Amnon Hoffman, Chaim Gilon, Adi Klinger, Johnny Naoum
  • Patent number: 11248018
    Abstract: Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived mixture comprising NR may be further used without further processing in a variety of products, particularly in a cosmetic product.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: February 15, 2022
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HIKARI LABORATORIES LTD.
    Inventors: Dmitri Gelman, Amani Zoabi, Assaf Zeira, Raed Abu-Reziq
  • Publication number: 20220042975
    Abstract: Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug.
    Type: Application
    Filed: August 22, 2021
    Publication date: February 10, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH, Muneef AYYASH
  • Patent number: 11241147
    Abstract: A guided tracheal intubation system using an autonomous modulated light source, outputting modulated illumination at a constant level, and externally applied to the subject's larynx region. An optical imaging system receives a video stream from within the subject's throat, including modulated illumination from the subject's trachea. A display control system performs signal processing on the modulated content of the images, and outputs frames of those images in which the intensity level of illumination from the trachea can be controlled without any need to change the illumination output from the modulated light source. The light source has no connection with the rest of the system, and need contain no more than a battery, a power supply circuit and a light source. It can therefore be of low cost and can be made disposable, such as in the form of an adhesive patch applied to the subject's neck.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: February 8, 2022
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Itai Hayut, Elchanan Fried, Yaakov Nahmias, Tommy Weiss-Sadan, Ariel Shrem
  • Publication number: 20220030866
    Abstract: Described herein are methods of enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant. The method comprises contacting at least a portion of the plant and/or plant tissue with a compound having Formula I: wherein X, Y and R1-R7 are as defined herein. Further described are compositions for enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant, comprising the abovementioned compound and a horticulturally acceptable carrier. Novel compounds having Formula I are also described herein.
    Type: Application
    Filed: October 18, 2021
    Publication date: February 3, 2022
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Ramot at Tel-Aviv University Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Einat SADOT, Roy WEINSTAIN, Joseph RIOV, Leor ESHED-WILLIAMS
  • Publication number: 20220023308
    Abstract: Provided is based on the discovery of novel agonists for PPAR-? which are proposed for use in medicine.
    Type: Application
    Filed: November 28, 2019
    Publication date: January 27, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Amiram GOLDBLUM, Jianwei CHE, Anwar RAYAN, Binyamin DAADOOSH, David MARCUS
  • Publication number: 20220025129
    Abstract: The inventors of the technology disclosed herein have developed triblock copolymers of lactide-containing polyesters and poly(ethylene glycol), PEG, having thermoresponsive properties.
    Type: Application
    Filed: November 14, 2019
    Publication date: January 27, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Abraham J. DOMB, Noam STEINMAN
  • Publication number: 20220017493
    Abstract: The present invention provides pyrazole derivatives, e.g., a compound of Formula (I), and their uses in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
    Type: Application
    Filed: July 26, 2021
    Publication date: January 20, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dansu Li, Irit Snir-Alkalay, Joseph P. Vacca, Yinon Ben-Neriah, Avanthika Venkatachalam
  • Publication number: 20220016218
    Abstract: The present invention relates to methods of preparing peptide-based prodrugs having enhanced oral bioavailability and intestinal penetration. Said prodrugs are characterized in improved lipophilicity, reduced electric charge and tendency to undergo biotransformation through enzymatic reaction (e.g. in the blood stream) to form biologically active peptides.
    Type: Application
    Filed: July 9, 2021
    Publication date: January 20, 2022
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Amnon HOFFMAN, Chaim GILON, Joseph FANOUS, Adi KLINGER
  • Patent number: 11224628
    Abstract: Provided is a process for extraction of a lipophilic agent from a plant source, the process including: mixing a first quantity of a plant source, the plant source being containing the lipophilic agent and a first quantity of an extraction medium to obtain a first mixture, the extraction medium being in the form of a microemulsion and comprising at least one oil, at least one hydrophilic surfactant, at least one co-surfactant and optionally at least one co-solvent; homogenizing the first mixture under conditions maintaining the microemulsion structure; and separating the homogenized mixture into a biomass slurry and an agent-loaded medium to obtain the agent-loaded medium in a microemulsion form.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 18, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Nissim Garti, Sharon Garti Levi, Rotem Edri
  • Publication number: 20220008381
    Abstract: Provided are cannabinoid-loaded formulations, as well as processes for their preparation.
    Type: Application
    Filed: September 28, 2021
    Publication date: January 13, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Nissim GARTI, Sharon GARTI LEVI, Rotem EDRI
  • Patent number: 11208443
    Abstract: The present invention provides peptides comprising a sequence derived from the human NAF-1 protein, analogs of said sequence or a retro-inverso sequence of said peptide or analog. The conjugates of such peptides are provided as well. The peptides and the conjugates of the present invention are useful in treating cancer, and in particular cancer in which the expression of NAF-1 is enhanced.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: December 28, 2021
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Rachel Nechushtai, Assaf Friedler, Anat Iosub-Amir, Merav Darash-Yahana, Yang-Sung Sohn, Dorit Michaeli