Patents Assigned to Yissum Research Development Company of the Hebrew University
  • Lipid-polymer conjugates, their preparation and uses thereof
    Patent number: 11013811
    Abstract: This invention provides low molecular weight lipid-GAG and phospholipids-GAG conjugates and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: May 25, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Saul Yedgar, Yuval Cohen, Joseph V. Bondi
  • PROCESS FOR FABRICATING CONDUCTIVE PATTERNS ON 3-DIMENSIONAL SURFACES BY HYDRO-PRINTING
    Publication number: 20210153345
    Abstract: Provided is a process for fabricating a conductive pattern on a three-dimensional (3D) object, involving hydroprinting a 2-dimensional (2D) conductive planar pattern on a 2D sacrificial substrate, and transferring the pattern to the 3D object.
    Type: Application
    Filed: March 8, 2018
    Publication date: May 20, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Shlomo MAGDASSI, Michael LAYANI, Gabriel SAADA
  • TOPICAL DELIVERY SYSTEMS FOR ACTIVE COMPOUNDS
    Publication number: 20210137829
    Abstract: Provided concerns viscous or gelled delivery systems based on oily nano-domains dispersed in a viscosified/gelled continuous aqueous phase, and suitable for prolonged and/or sustained topical delivery of various active compounds.
    Type: Application
    Filed: March 7, 2018
    Publication date: May 13, 2021
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Lyotropic Delivery Systems Ltd
    Inventors: Nissim GARTI, Sharon GARTI LEVI
  • 3D POLYMERIZABLE CERAMIC INKS
    Publication number: 20210139720
    Abstract: Provided are formulations and processes for manufacturing 3D objects, the formulations being free of particulate materials and used in low temperature 3D printing processes.
    Type: Application
    Filed: January 19, 2021
    Publication date: May 13, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Shlomo MAGDASSI, Ido COOPERSTEIN, Efrat SHUKRUN
  • SYSTEM AND METHOD FOR USE IN FRET MICROSCOPY
    Publication number: 20210140889
    Abstract: A system and method are presented, for monitoring and/or imaging of a sample. The system comprises: a light unit configured for illuminating the sample in at least two different wavelength ranges; a collection unit configured for collecting a light emitted from the sample in at least a third wavelength range and directing said emitted light towards at least one detector; and an activation unit configured for providing activation signal to selectively activate at least a portion of fluorescent substance in the sample; and a processing circuitry configured for operating the light unit to determine a selected temporal illumination profile of said at least two different wavelength ranges and for operating the activation unit for controllable activation.
    Type: Application
    Filed: January 14, 2021
    Publication date: May 13, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Eilon SHERMAN, Shai TSIPSHTEIN
  • DRUG DELIVERY SYSTEMS
    Publication number: 20210128534
    Abstract: A novel platform for manufacturing storage stable and effective drug delivery systems.
    Type: Application
    Filed: February 26, 2019
    Publication date: May 6, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon BENITA, Taher NASSAR, Leslie REBIBO, Amit BADIHI
  • ANTIBODIES SPECIFIC TO HUMAN POLIOVIRUS RECEPTOR (PVR)
    Publication number: 20210115150
    Abstract: The present invention provides monoclonal antibodies that recognize polio virus receptor (PVR) and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.
    Type: Application
    Filed: December 10, 2020
    Publication date: April 22, 2021
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., UNIVERSITY OF RIJEKA FACULTY OF MEDICINE
    Inventors: Ofer MANDELBOIM, Noa S. KAYNAN, Pinchas TSUKERMAN, Stipan JONJIC
  • Methods of modulating stomata conductance and plant expression constructs for executing same
    Patent number: 10975385
    Abstract: A method of regulating plant stomata conductance is provided. The method comprises modulating in the plant the level and/or activity of a type B hexokinase in a guard cell specific manner, thereby regulating plant conductance.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 13, 2021
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: David Granot, Gilor Kelly, Menachem Moshelion
  • Haploid human embryonic stem cell lines and somatic cell lines and methods of making the same
    Patent number: 10961503
    Abstract: Haploid human embryonic stem cells and cell lines, haploid multipotent human cells, and haploid differentiated human cells are provided. In addition, methods of making and using the haploid human cells are provided.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: March 30, 2021
    Assignees: New York Stem Cell Foundation, Inc., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dietrich M. Egli, Nissim Benvenisty, Ido Sagi
  • Process for treating plastic waste
    Patent number: 10961368
    Abstract: Processes of treating plastic waste that include converting one or more plastic polymers into a liquid form either by dissolving in an organic solvent or by melting, and degrading the polymer(s) with the aid of alkali hydroxide and hydrogen peroxide are described. The processes can be performed in the presence of a phase transfer catalyst.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: March 30, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yoel Sasson, Uri Stoin
  • NANOPARTICLES AND FORMULATIONS FOR PRINTING
    Publication number: 20210087302
    Abstract: A method for generating reactive species in a medium in which light irradiates the medium including a nanoparticle. A photoinitiator composed of semiconductor nanoparticles for photo-polymerization and 2D and 3D printing.
    Type: Application
    Filed: February 6, 2019
    Publication date: March 25, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Uri BANIN, Shlomo MAGDASSI, Nir WAISKOPF, Lior Efraim VERBITSKY
  • CD247 as a biomarker for assessing the effect of chemotherapeutic and biological drugs
    Patent number: 10955415
    Abstract: The invention relates to methods, kits and compositions using CD247 as a biomarker for assessing the efficacy and selecting an appropriate therapy such as chemotherapeutic, biological therapy or combined therapy for treating a subject suffering from a pathologic disorder that leads to a chronic-inflammatory condition.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: March 23, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Michal Baniyash, Julia Kanterman, Moshe Sade-Feldman, Eliran Ish-Shalom
  • Antibodies specific to human T-cell immunoglobulin and ITIM domain (TIGIT)
    Patent number: 10946095
    Abstract: Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions including them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: March 16, 2021
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., University of Rijeka Faculty of Medicine
    Inventors: Ofer Mandelboim, Noa S. Kaynan, Pinchas Tsukerman, Stipan Jonjic
  • Methods and devices for storage and release of hydrogen
    Patent number: 10944119
    Abstract: The invention relates to a process for generating hydrogen, comprising decomposing in a reaction vessel aqueous alkali formate in the presence of a transition metal-containing catalyst system dissolved in one or more organic solvent(s), characterized in that said organic solvent(s) comprise at least one solvent which is water-immiscible, thereby releasing hydrogen and forming bicarbonate in the aqueous phase, and separating the catalyst-containing organic solvent(s) from said bicarbonate. Also disclosed are apparatuses for carrying out hydrogen generation.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 9, 2021
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Energystoredge Ltd.
    Inventors: Yoel Sasson, Judith Toubiana, Ariel Givant, Sorel Rothschild
  • Attenuated or inactivated pathogenic for treating urogenital cancer
    Patent number: 10918677
    Abstract: The present invention provides attenuated or inactivated pathogenic bacteria having anti-cancer properties, compositions comprising the bacteria, and use thereof for treating cancers of the urogenital system.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: February 16, 2021
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Ofer Mandelboim, Gilad Benjamin Bachrach, Chamutal Gur, Vladimir Yutkin
  • Method and apparatus for CO2 sequestration
    Patent number: 10920249
    Abstract: Processes, methods, and apparatus for carbon sequestration utilizing catalysis schemes configured to provide high concentrations of hydrated CO2 in proximity with a sequestration agent are provided. Reactants are combined with catalyst such that at least two regions of controlled catalytic activity form encompassing at least the interface between a sequestration agent and an aqueous solution containing dissolved CO2. Suitable reactants include various sequestration agents, catalyst, and carbon dioxide dissolved in an aqueous solution (seawater, for example). Possible products include bicarbonate and metal cations.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: February 16, 2021
    Assignees: California Institute of Technology, University of Southern California, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Adam Vinay Subhas, William Max Berelson, Nick Everett Rollins, Jess Firey Adkins, Jonathan Erez
  • Kit for diagnosis, prognosis, and monitoring the immune status, of patients with chronic inflammatory diseases
    Patent number: 10914743
    Abstract: Provided are methods and kits, e.g.; for testing the immune status of patients with chronic inflammatory diseases by measuring the TCR zeta chain (CD247) expression levels, and in particular a method and a kit for testing the selective downregulation of TCR zeta chain expression in T cells, NK cells, or NKT cells. Zeta chain expression is measured using antibodies directed against the intracellular zeta chain region, and these levels are compared with the expression levels of other T cell receptor subunits and NK cell markers. Provided are methods for determining diabetes complications in a diabetic patient. Further provided are kits for diagnosis, prognosis, and monitoring of same.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: February 9, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Michal Baniyash, Ilan Vaknin
  • Process for removing pollutants from a flue gas
    Patent number: 10913030
    Abstract: A process for removing impurities from a flue gas, comprising treating the flue gas with a liquid absorbent comprising (i) a precursor of chlorine dioxide and (ii) an organic ionic liquid, and releasing a purified flue gas into the atmosphere. The process is useful for removing Hg, SO2 and NOx.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: February 9, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Zach Barnea, Yoel Sasson, Benny Bogoslavsky, Yaakov Mines
  • Antibodies specific to human poliovirus receptor (PVR)
    Patent number: 10906987
    Abstract: The present invention provides monoclonal antibodies that recognize polio virus receptor (PVR) and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: February 2, 2021
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., UNIVERSITY OF RUEKA FACULTY OF MEDICINE RIJEKA, CROATIA
    Inventors: Ofer Mandelboim, Noa S. Kaynan, Pinchas Tsukerman, Stipan Jonjic
  • Characterization of plant behavior using transpiration rate and water uptake rate
    Patent number: 10897849
    Abstract: A system for characterizing a plant is disclosed. The system comprises: a plurality of sensors configured to sense a first parameter indicative of a transpiration rate from the whole plant and a second parameter indicative of a water uptake rate into the whole plant. The system also comprises a processor configured to receive signals from the sensors, to process the signals to calculate both the parameters, and to characterize the plant according to the calculated parameters. In some embodiments of the present invention the processor is configured for calculating at least one of the first parameter and the second parameters momentarily.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: January 26, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Menachem Moshelion, Rony Wallach, Ofer Halperin