Patents Assigned to Zaidan Hojin
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Patent number: 7482439Abstract: Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1??-amide derivative of the formula (II) and a caprazene-1??-ester derivative of the formula (III) from caprazene. Further, there could be synthesized a caprazol-1??-amide derivative of the formula (V) and a caprazol-1??-amide-3??-ester derivative and a caprazol-3??-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol. The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria.Type: GrantFiled: January 30, 2004Date of Patent: January 27, 2009Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Meiji Seika Kaisha, Ltd.Inventors: Toshiaki Miyake, Masayuki Igarashi, Tetsuo Shitara, Yoshiaki Takahashi, Masa Hamada
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Patent number: 7348318Abstract: There are disclosed a novel ?-amino-N-(diaminophosphinyl)lactam derivative represented by general formula (1): wherein, for example, A is a hydrogen atom or a substituent such as a lower alkyl group or the like; W, X, Y and Z are independently a hydrogen atom or a substituent such as a lower alkyl group, aryl group, arylacyl group, arylaminocarbonyl group or the like; and Q is —(CH2)n— wherein n is 0 to 3, or its salt, and a therapeutic agent and a prophylactic agent for myelosuppression, a therapeutic agent for infectious diseases, an agent for increasing the number of leukocytes and a dipeptidyl peptidase IV inhibitor which comprise the above-mentioned derivative or salt thereof as an active ingredient.Type: GrantFiled: March 24, 2003Date of Patent: March 25, 2008Assignees: Nippon Kayaku Kabushiki Kaisha, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Masatoshi Abe, Masashi Nagai, Keiichirou Yamamoto, Chihiro Nishimura
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Patent number: 7271147Abstract: By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general formula (I): wherein R is 7-methyl-octyl group, 8-methyl-nonyl group, 9-methyl-dodecyl group, 10-methyl-undecyl group or 11-methyl-dodecyl group, is obtained as antibiotics having excellent antibacterial activities against bacteria and having a novel molecular structure. These tripropeptins each have an excellent antibacterial activity against various bacteria and drug-resistant strains thereof, such as methicillin-resistant strains and vancomycin-resistant strains.Type: GrantFiled: March 28, 2001Date of Patent: September 18, 2007Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Hideki Hashizume, Masayuki Igarashi, Hiroshi Naganawa, Masa Hamada
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Patent number: 7247640Abstract: A medicament for prophylaxis or treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes, which comprise as an active ingredient a sulphostin-related compound represented by general formula (I): wherein n is an integer of 0 to 3, or a pharmacologically acceptable salt thereof.Type: GrantFiled: July 22, 2005Date of Patent: July 24, 2007Assignees: Nippon Kayaku Kabushiki Kaisha, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Takumi Yamashita, Chihiro Nishimura, Tetsushi Saino, Yasuhiko Muraoka, Tomio Takeuchi
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Publication number: 20070160093Abstract: An electromagnetic wave generator encompasses a first pump beam emitter (2) configured to emit a first pump beam (hv1) having a wavelength larger than one micrometer; a second pump beam emitter (25) configured to emit a wavelength-tunable second pump beam (hv2) having a wavelength larger than one micrometer, the wavelength of which is different from the wavelength of the first pump beam (hv1); a nonlinear optical crystal (19) configured to generate an electromagnetic wave (hv3) of a difference frequency between the first pump beam (hv1) and second pump beam (hv2); and an optical system (M1, M2, 18) configured to irradiate the first pump beam (hv1) and second pump beam (hv2) to the nonlinear optical crystal (19), by adjusting an external intersection angle between the first pump beam (hv1) and second pump beam (hv2) within 0.5° at the difference frequency of 1 THz.Type: ApplicationFiled: October 29, 2004Publication date: July 12, 2007Applicant: Zaidan Hojin Handotai Kenkyu ShinkokaiInventors: Jun-ichi Nishizawa, Ken Suto, Tetsuo Sasaki, Tadao Tanabe, Tomoyuki Kimura
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Patent number: 7157268Abstract: Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, inexpensive myo-inositol is used as a starting compound which is reacted with a gram-negative bacterium capable of converting myo-inositol into L-epi-2-inosose, and thereby producing L-epi-2-inosose by conversion of myo-inositol into L-epi-2-inosose. A biologically pure culture of Pseudomonas sp. AB 10215 strain is also provided which has a characteristic nature of being capable of converting myo-inositol into L-epi-2-inosose.Type: GrantFiled: May 25, 2004Date of Patent: January 2, 2007Assignees: Hokko Chemical Industry Co., Ltd., Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Atsushi Takahashi, Kenji Kanbe, Tetsuya Mori, Yuichi Kita, Tsuyoshi Tamamura, Tomio Takeuchi
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Patent number: 7060821Abstract: A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamella sp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I): wherein X represents —O— or —CH2—, and R represents a hydroxyl group when X represents —O—, or a hydrogen atom when X represents —CH2—.Type: GrantFiled: March 6, 2003Date of Patent: June 13, 2006Assignees: Mercian Corporation, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hiroyuki Kumagai, Tomohiro Sameshima, Motoko Matsufuji, Naoto Kawamura, Kunio Isshiki, Hiroyuki Inoue, Tetsuya Someno, Masaaki Ishizuka, Tomio Takeuchi
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Publication number: 20060113298Abstract: An electromagnetic wave irradiation tool encompasses a narrow tube (endoscope probe) (7) defined by an outside diameter of 0.1 mm-20 mm, having an electromagnetic wave irradiation terminal (3) configured to irradiate an electromagnetic wave (2) having a frequency equal to a characteristic frequency of a microorganism (11) at the top of the narrow tube (7) and an electromagnetic wave generation unit (3) configured to generate the electromagnetic wave (2) and to supply the electromagnetic wave (2) to the electromagnetic wave irradiation terminal (3). The electromagnetic wave irradiation tool drives the microorganism (11) into a resonant vibration state selectively so that the microorganism (11) can be destroyed, without giving damages to biological body (1) for medically treating the disease induced by the microorganism (11).Type: ApplicationFiled: November 27, 2003Publication date: June 1, 2006Applicant: ZAIDAN HOJIN HANDOTAI KENKYU SHINKOKAIInventor: Jun-ichi Nishizawa
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Publication number: 20060054940Abstract: The ultra high-speed vertical short channel insulated-gate static induction transistor with uniform operating characteristic which has the drain layer 3 consisting of an epitaxial single crystal layer on the main surface 2 of substrate 1, the channel layer 4 with thickness 1000 ? or less on the drain layer, the source layer 5 consisting of an epitaxial single crystal layer on the channel layer 4, and the insulated-gates 6 and 7 on the sidewalls of the drain, the channel, and the source layers. Since the thickness of 1000 ? or less is accurately controlled using the molecular layer epitaxial method and the channel layer 4 is grown up, the X-ray photolithography is not needed. Since the gate oxide film is formed by low temperature CVD using active oxygen, impurity re-distribution does not occur.Type: ApplicationFiled: September 9, 2005Publication date: March 16, 2006Applicants: Incorporated Administrative Agency, Zaidan Hojin Handotai Kenkyu ShinkokaiInventors: Toru Kurabayashi, Toru Oizumi, Kyouzou Kanamoto, Jun-ichi Nishizawa
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Patent number: 6977406Abstract: The ultra high-speed vertical short channel insulated-gate static induction transistor with uniform operating characteristic which has the drain layer 3 consisting of an epitaxial single crystal layer on the main surface 2 of substrate 1, the channel layer 4 with thickness 1000 ? or less on the drain layer, the source layer 5 consisting of an epitaxial single crystal layer on the channel layer 4, and the insulated-gates 6 and 7 on the sidewalls of the drain, the channel, and the source layers. Since the thickness of 1000 ? or less is accurately controlled using the molecular layer epitaxial method and the channel layer 4 is grown up, the X-ray photolithography is not needed. Since the gate oxide film is formed by low temperature CVD using active oxygen, impurity re-distribution does not occur.Type: GrantFiled: April 26, 2002Date of Patent: December 20, 2005Assignees: National Institute of Information and Communications Technology, Incorporated Administrative Agency, Zaidan Hojin Handotai Kenkyu ShinkokaiInventors: Toru Kurabayashi, Toru Oizumi, Kyouzou Kanamoto, Jun-ichi Nishizawa
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Patent number: 6939892Abstract: An antibiotic SF2487 substance having the formula (I) or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an antimalarial drug.Type: GrantFiled: April 26, 2001Date of Patent: September 6, 2005Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Yusuke Wataya, Munekazu Iinuma, Hye-Sook Kim, Hiroomi Watabe, Hiroshi Naganawa, Yoshikazu Takahashi
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Publication number: 20050131061Abstract: Compounds represented by formula (I) below; a process for producing the compounds by culturing a microorganism belonging to the genus Aspergillus and isolating the above-mentioned compounds from the culture; an angiogenesis inhibitory agent containing as an active ingredient the compounds; and an Aspergillus sp. F-1491 (FERM BP-8288) strain capable of producing the compounds. In formula (I), R represents a methyl group or an ethyl group, R1 represents a hydrogen atom, a chlorine atom, a hydroxyl group or a methoxy group, R2 represents a hydroxyl group, or R1 and R2 taken together form an epoxy ring structure.Type: ApplicationFiled: March 6, 2003Publication date: June 16, 2005Applicants: Mercian Corporation, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hiroyuki Kumagai, Tomohiro Sameshima, Motoko Matsufuji, Naoto Kawamura, Tetsuya Someno, Masaaki Ishiduka, Tomio Takeuchi
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Publication number: 20050124050Abstract: A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamella sp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I): wherein X represents —O— or —CH2—, and R represents a hydroxyl group when X represents —O—, or a hydrogen atom when X represents —CH2—.Type: ApplicationFiled: March 6, 2003Publication date: June 9, 2005Applicant: Mercian Corporation and Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hiroyuki Kumagai, Tomohiro Sameshima, Motoko Matsufuji, Naoto Kawamura, Kunio Isshiki, Hiroyuki Inoue, Tetsuya Someno, Masaaki Sihizuka, Tomio Takeuchi
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Patent number: 6852735Abstract: A compound of the formula (I): and a compound of the formula (V): as well as a compound of the formula (X): which are each a novel siastatin B derivative having a potent inhibitory activity against a glycosidase, are now synthesized by new processes. The compound of the formula (I), the compound of the formula (V) and the compound of the formula (X) have a potent enzyme-inhibitory activity to a glycosidase, which is particularly N-acetyl-galactosaminidase, galactosidase, glucosidase and mannosidase.Type: GrantFiled: December 24, 1999Date of Patent: February 8, 2005Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Meiji Seika Kaisha, Ltd.Inventors: Yoshio Nishimura, Eiki Shitara, Tomio Takeuchi
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Patent number: 6818430Abstract: Provided are novel processes for the efficient production of L-epi-2-inosose and epi-inositol which are useful either as various medicines or intermediates for the syntheses of various medicines. In the processes, there is used inexpensive myo-inositol as a starting compound. That is, there is now developed a new process which comprises reacting myo-inositol with a gram-negative bacterium capable of converting myo-inositol into L-epi-2-inosose, and thereby producing L-epi-2-inosose by conversion of myo-inositol into L-epi-2-inosose. Further, a novel process is provided, which comprises reacting the so produced L-epi-2-inosose with a reducing agent made of an alkali metal boron hydride or any other alkali metal hydride in an aqueous reaction medium, to produce epi-inositol and myo-inositol, and then isolating epi-inositol from the resulting reaction product composed of the epi-inositol and myo-inositol.Type: GrantFiled: February 12, 2002Date of Patent: November 16, 2004Assignees: Hokko Chemical Industry Co., Ltd., Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Atsushi Takahashi, Kenji Kanbe, Tetsuya Mori, Yuichi Kita, Tsuyoshi Tamamura, Tomio Takeuchi
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Patent number: 6780616Abstract: There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I) wherein R is tridecyl group, 11-methyl-dodecyl group, and others. These caprazamycins have excellent antibacterial activities against various acid-fast bacteria and various bacteria as well as their drug-resistant strains.Type: GrantFiled: May 9, 2002Date of Patent: August 24, 2004Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Corp., Meiji Seika Kaisa, Ltd.Inventors: Tomio Takeuchi, Masayuki Igarashi, Hiroshi Naganawa, Masa Hamada
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Patent number: 6610709Abstract: This invention relates to (2R,3S,4R,5R)-2-amino-5-methylpiperidine-3,4-diol or a (2S,3S,4R,5R)-2-N-substituted-2-amino-5-methylpiperidine-3,4-diol represented by the general formula (I): wherein R1 and R2 each are a hydrogen atom, or R1 is a hydrogen atom and R2 is a lower alkanoyl group or a lower &ohgr;-trihaloalkanoyl group, or R1 and R2 together denote phthaloyl group, and a pharmaceutically acceptable salt thereof. Said compound can be prepared from a (2S,3S,4R)-5-N-protected-2,3,4-O-tri-protected-5-aminopentane-1,2,3,4-tetraol by multi-steps of reactions.Type: GrantFiled: August 1, 2001Date of Patent: August 26, 2003Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Meiji Seika Kaisha, Ltd.Inventors: Yoshio Nishimura, Eiki Shitara, Tomio Takeuchi
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Patent number: 6579989Abstract: A sulphostin analogue represented by the general formula, wherein n is an integer of from 0 to 3, provided that a case where n is 2 and steric configurations of C* and P* are S and R, respectively, is excluded, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 13, 2001Date of Patent: June 17, 2003Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Yasuhiko Muraoka, Masatoshi Abe, Tetsuo Akiyama, Shigeko Harada
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Patent number: 6566394Abstract: Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) and (1b) are useful as anti-inflammatory agents and immunosuppressive agents which exert an effect of inhibiting the activation of NF-&kgr;B with little side effects.Type: GrantFiled: May 30, 2002Date of Patent: May 20, 2003Assignees: Mercian Corporation, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Kazuo Umezawa, Sakino To-E, Naoki Matsumoto, Tsutomu Sawa, Takeo Yoshioka, Naoki Agata, Shin-ichi Hirano, Kunio Isshiki
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Patent number: 6548695Abstract: Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula: (wherein Rc, R2 and R are mainly protecting groups) with a malonic acid derivating represented by a formula: (wherein R is an organic group including a lower alkyl group; R3 is a protecting group for a carboxyl group; and X is a halogen atom or a —OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.Type: GrantFiled: April 11, 2002Date of Patent: April 15, 2003Assignees: Mercian Corporation, Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Toshio Tsuchida, Hazuki Nagai, Takashi Nakashima, Masashi Yoshida, Kaname Konuki, Asako Kuroda, Kunio Isshiki, Tomio Takeuchi