Abstract: Methods and apparatus for the treatment of dermatological conditions, including, for example, viral infections, microbial infections, cancers, dermatological conditions and particularly infections of the skin caused by human papillomavirus (HPV).

Abstract: The utility model discloses a hand warmer with detachable battery, which relates to the hand warmer field, and comprises a shell, wherein the outer side of the shell is provided with a hardware piece, the inner side of the shell is fixedly provided with a PCB motherboard, and the inner side of the shell is also provided with a detachable battery compartment; the bottom of the shell is provided with an opening structure, and a battery cover is clamped at the opening, and the battery cover can be detached from the opening; the outer side of the shell is also provided with silica gel, which is formed by splicing two plastic shells, and the silica gel is arranged outside the connecting seam of the shell. By arranging the battery cover, which can be directly detached from the shell, the utility model is convenient to replace the battery, and can be used for hand warmers all day.

Abstract: Systems and methods are described for devices that may include a nasal assembly comprising: a first support member having a first surface configured to substantially conform to a sinistral contour of a nose when the nasal assembly is being worn; a second support member having a second surface configured to follow a dextral contour of the nose when the nasal assembly is being worn; and a heat source electrically coupled to the first support member and the second support member, the heat source being configured to adjust a surface temperature of the first surface and the second surface to cause warming of the sinistral contour of the nose and the dextral contour of the nose to a predefined temperature range.

Abstract: Methods, apparatuses, systems, and implementations for inductive heating of a foreign metallic implant are disclosed. A foreign metallic implant may be heated via AMF pulses to ensure that the surface of the foreign metallic implant heats in a uniform manner. As the surface temperature of the foreign metallic implant rises, acoustic signatures may be detected by acoustic sensors that may indicate that tissue may be heating to an undesirable level approaching a boiling point. Once these acoustic signatures are detected, the AMF pulses may be shut off for a time period to allow the surface temperature of the implant to cool before applying additional AMF pulses. In this manner, the surface temperature of a foreign metallic implant may be uniformly heated to a temperature adequate to treat bacterial biofilm buildup on the surface of the foreign metallic implant without damaging surrounding tissue.

Abstract: Presented are a method and apparatus for surgical procedures. An exemplary apparatus includes a body having a longitudinal axis, the body comprising a hollow passageway extending through the longitudinal axis from an inlet at a distal end to a port at a proximal end. The apparatus further includes an electrode extending from the distal end of the body adjacent to the inlet. The apparatus also includes a swivel portion moveably coupled to the port, the swivel portion having a second hollow passageway fluidly coupled to the hollow conduit extending from the port to an outlet, wherein the swivel portion comprises a first swivel element operable to rotate around the longitudinal axis relative to the body, and wherein the swivel portion comprises a second swivel element operable to rotate relative to the first swivel element and the body.

Abstract: A process and related assemblies for delivering slush through a tube towards a patient. Obtaining an elongated container partially filled with slush with a port end that has a first port and a second port. Placing the first port in fluid communication with tubing for delivery of slush towards the patient. Placing the second port in fluid communication with a source of gas which may be air. Subjecting the elongated container to automated repetitive movements so that the slush in the partially filled elongated container moves against interior surfaces within the elongated container. Ideally, two different forms of repetitive motion are used to impose complex movement upon the slush within the elongated container. Applying a pressure gradient to cause slush to flow out of the first port towards the patient. The elongated container may be made from a slush bottle with a reversibly engaged cap with the two ports.

Abstract: A device for RF skin treatment includes an outer electrode arranged on an operational side of the device. The outer electrode has an annular or equilateral polygonal shape. An inner electrode is arranged at a center of the outer electrode and is surrounded by the outer electrode. An RF generator is arranged to supply an RF treatment voltage between the inner electrode and the outer electrode. A skin contact surface of the inner electrode has a largest cross-sectional dimension in a range of 200-500 ?m, and the RF treatment voltage is less than 50 V.

Abstract: This document describes methods and materials for reducing incision sizes for improving the treatment of pathological conditions, including arrhythmias and trauma, using temperature modulation via implantable devices. For example, this document describes methods and devices for treating atrial and/or ventricular fibrillation by cooling the epicardium.

Abstract: Wearable heat transfer devices and associated systems and methods are disclosed herein. In some embodiments, a representative heat transfer device can comprise (i) thermoelectric components each having a first side and a second side, (ii) a heat transfer system having a heat exchanger and an array of fluid distribution networks, in which individual fluid distribution networks are thermally coupled to the second side of a corresponding one of the thermoelectric components and fluidically coupled to the heat exchanger, and (iii) a flexible support unit coupled to the first sides of the thermoelectric components and extending at least between individual thermoelectric components, wherein the flexible support unit is a heat spreader configured to enhance heat transfer from a target area.

Abstract: An apparatus used for increasing the level of CD4+T cells in a mammal. The mammal has a cancerous tissue. The apparatus comprises a cold treatment unit and a heat treatment unit. The cold treatment unit is used for cooling the cancerous tissue. The heat treatment unit is used for heating the cancerous tissue. A method for increasing the level of CD4+ T cells in the body of a cancer patient, comprising steps for cold treatment of the cancerous tissue and for heat treatment of the cancerous tissue.

Abstract: An enclosure or plenum that supports a looped pump tube is hingedly connected to a framed thin-walled heat exchange bag through which working fluid from an intravascular heat exchange catheter flows. The frame with bag can be inserted between cold plates to exchange heat with the working fluid flowing through the bag. With the framed bag between the plates, the looped pump tube from the enclosure or plenum is receivable in the raceway of a peristaltic pump, which pumps working fluid through the system.

Abstract: A self-heating warming blanket includes a pliable outer shell forming a liquid impermeable enclosure. A heat generation layer disposed inside the enclosure has a plurality of liquid permeable heater compartments containing an exothermic reactant. The blanket also has a heater activation system including a sealed bladder containing an activator liquid inside the enclosure. An activation strip extends from outside the outer shell into the enclosure. One segment of the strip is an unsealing segment connected to the bladder. Another segment of the strip is a handle segment outside the outer shell. Pulling on the handle segment opens the bladder and releases the activator liquid into the enclosure where at least a portion of it permeates at least one heater compartment and combines with the exothermic reactant contained therein to initiate an exothermic chemical reaction that heats the warming blanket.

Abstract: According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

Abstract: Polymers, hydrogels, and thermochromic agents, including products embodying them, methods of using them, and processes for making them. In certain embodiments, temperature therapy packs which utilize thermochromic agents integrated into solid, semi-solid, or liquid hydrogels. In preferred (but optional) embodiments, the thermochromic agents are integrated into the composition used as the temperature exchange material of the therapy pack. In certain other embodiments, methods of using the thermochromic integrated temperature exchange materials, or processes for manufacturing such thermochromic integrated temperature exchange materials and/or methods or processes for manufacturing or using thermal packs embodying such materials. In certain particularly preferred embodiments, novel polymer compositions and/or processes for making polymers, which improve product durability or longevity and/or which improve use cycles or usage times.

Abstract: Proposed is a filter fixing module mounted to a handpiece cooling device having a connecting unit such that a refrigerant supply unit is coupled thereto, the filter fixing module including a body having a support surface formed in a plate shape, and a receiving surface formed on an edge of the support surface and protruding in a first direction relative to the support surface so as to prevent removal of a filter received in the support surface, and a grip unit connected to the body, wherein the grip unit comprises a first grip member and a second grip member extending in directions opposite to the protruding direction of the receiving surface relative to the body.

Abstract: A variable length interstitial probe apparatus includes: a probe for effecting thermal therapy and/or cryotherapy to a tissue; a flexible umbilical sheath permanently affixed to the probe, including at least one interface for supplying energy, cooling fluid, cooling gas, heating fluid, and/or heating gas to the probe; and an adjustable depth stop configured to slide along a length of a shaft region of the probe, and lock to the shaft region at a selected position. The adjustable depth stop is configured to engage a probe driver and/or a skull mount apparatus to stabilize positioning of the probe and to control a depth of entry of the probe into a patient. The probe may be configured to effect temperature modulation therapy, where processing circuitry activates a modulation pattern of thermal therapy emission and cryogenic therapy emission for applying a thermal dose to the tissue.

Abstract: A method of improving brain function in a hypothermic patient is provided. The method comprises administering to the patient an amount of a fibroblast growth factor 21 (FGF21) effective to increase RNA binding motif 3 (RBM3) production in nerve cells of the patient. The method is useful, for example, where the patient is or will be undergoing cardiac surgery or spinal surgery, such as requiring deep hypothermia circulatory arrest (DHCA), or is subject to an emergency preservation and resuscitation (EPR) method, or where a patient suffers from mild/moderate/severe traumatic brain injury (TBI), ventricular fibrillation cardiac arrest (VFCA), subarachnoid hemorrhage (SAH), subdural hematoma (SH), cerebral vasospasm, neonatal abusive head trauma (a.k.a. shaken baby syndrome), neonatal hypoxic ischemic encephalopathy (HIE), asphyxia cardiac arrest (ACA), treatment of spinal injury, prophylaxis in spinal surgery, stroke, and drug overdose.

Abstract: Devices, systems, and methods herein relate to cooling a head of a patient. These systems and methods may comprise a cooling cap assembly comprising a heat exchanger configured to be wrapped around a head of a patient and a compression assembly releasably coupled to the heat exchanger. The compression assembly may comprise an enclosure and an inflatable member coupled to an internal surface of the enclosure. When coupled, the inflatable member may be positioned between the enclosure and the heat exchanger. The heat exchanger may be separate from and moveable relative to the inflatable member.

Abstract: A temperature modulation assembly and a multi-layer retention mechanism for such a temperature therapy device are disclosed. According to one embodiment, a temperature modulation assembly for a temperature therapy device has a heat spreader and a mounting plate coupled to a bottom portion of a spacer, wherein the heat spreader is disposed between the mounting plate and the spacer. The temperature modulation assembly has a heatsink and a fan coupled to a top portion of the spacer, wherein the heatsink is disposed between the top portion of the spacer and the fan. The temperature modulation assembly further includes a heating and/or cooling device disposed within a central opening of the spacer, wherein the heating and/or cooling device is located between the heatsink and the heat spreader.

Abstract: The present disclosure generally relates to intelligent garments that provide thermal regulation in a variety of environments. The garments may include different layers such as a hydrophobic layer in direct contact with a wearer's skin surface and saturated with an aqueous mixture, a spacer layer, a reflective layer, and an outer hydrophobic layer. The layers of the garment may work together to reduce the metabolic expenditure of the wearer in extreme environmental conditions or during demanding physical activity. A variety of sensors may be displaced throughout the garments so as to enable the collection of data associated with wearers as well as environmental conditions. Wearers may control the thermal balance and other properties of the garments as desired.