Abstract: Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. The carrier assembly includes multiple electrodes that are configured to ablate tissue at low power. Additional embodiments include a system that includes an interface unit for delivering one or more forms of energy to the ablation catheter.

Abstract: A cryoprobe for use in cryosurgery and other applications comprising a rigid outer tube, an inner coolant inlet tube. a short rigid penetrating segment extending distally from the distal end of the outer tube and a helical-shaped baffle having a heating element disposed about the outer surface of the inlet tube. The baffle is adapted to produce turbulent fluid flow improving heat transfer and is able to warm target tissue during rapid freezing and thawing cycles.

Abstract: This invention provides a system and method that allows a therapeutic device, such as an atrial fibrillation microwave ablation catheter or ablation tip to be guided to a remote location within a body cavity and then accurately immobilized on the tissue, including that of a moving organ, such as the heart.

Abstract: An endoscopic instrument includes a housing having shaft extending therefrom that defines a longitudinal axis therethrough. The shaft includes an articulating section disposed thereon. The articulating section has a central annulus extending therealong and first and second pluralities of bores. The first plurality of bores configured to receive corresponding tendons therethrough and the second plurality of bores configured to receive corresponding conductive leads therethrough. An end effector assembly operatively connected to a distal end of the shaft including a pair of first and second jaw members. The corresponding conductive leads transition from a first state for enabling articulation of the shaft about the articulating section, to a second state for disabling articulation of the shaft about the articulating section.

Abstract: An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.

Abstract: The invention relates to electrodes used in ablation catheter devices, where the electrodes contain two or more thermal sensors at different positions within the electrode that are capable of detecting temperature differences along the external surface of the electrode. In preferred embodiments, the thermal sensors are separated by one or more thermal insulating members and the thermal sensors are positioned near the external surface of the electrode at about the same distance from the end of the electrode, so that temperature measurements can indicate the position of the electrode with respect to the tissue desired to be ablated.

Abstract: The present invention provides devices, systems and methods for delivering one or more thermal waveforms to the vestibular system and/or the nervous system of a patient. In some embodiments, the present invention provides a vestibular stimulation device configured both to generate a prescription for delivering one or more thermal waveforms and to deliver the prescribed thermal waveforms.

Abstract: A method for purging a cryotreatment system, in particular, for clearing moisture and thus preventing ice blockages within a fluid flow path that may be formed when moisture pockets within the fluid flow path of the system are encountered by a first injection of refrigerant at the beginning of a cryotreatment procedure. The method may include injecting refrigerant from a refrigerant source into a fluid delivery conduit at a preselected pressure for a first period of time, the refrigerant flowing from the fluid delivery conduit through a fluid injection element and into a fluid recovery conduit, and evacuating refrigerant from the fluid recovery conduit by vacuum pressure generated by the vacuum pump for a second period of time. This method may be repeated for a plurality of cycles.

Abstract: Apparatus and methods for determining positioning of a energy delivery element include deploying a energy delivery element at a treatment site proximal to a vessel wall; using a multi-region pressure sensing apparatus to sense pressures applied in a plurality of directions about the energy delivery element; and determining an orientation of the energy delivery element based on the pressures measured in the plurality of directions about the energy delivery element.

Abstract: A treatment device treats a biotissue by heating the biotissue to a target temperature. The device includes a heat-transfer member conveying heat to the biotissue, a heat-generating chip including a heat-generating member, a first temperature-measuring module, a temperature-measuring element disposed on the heat-transfer member, a second temperature-measuring module, and a controller. The heat-generating member heats the heat-transfer member. The first temperature-measuring module obtains a first temperature of the heat-generating member. The second temperature-measuring module obtains a second temperature measured by the temperature-measuring element. The controller determines the supplied electric power based on the first temperature after start of heating and before a transition point in time, and based on the second temperature after the transition point in time.

Abstract: An apparatus and procedure for defining the area for a thermo-electric knife to perform a bloodless intrastromal abdominal hysterectomy procedure while minimizing damage to the pericervical ring. The apparatus is configured to be inserted into the center cavity of the cervix and uterus to engage the uterine wall. The apparatus comprises an elongate member having a first end configured to extend into the center cavity of the uterus and cervix, and a thermo-electric knife guide plate secured concentrically to the elongate member proximal to the second end of the member to define the area for dissection of connective tissue between the cervix and the pericervical ring by a thermo-electric knife. A barb is secured to the elongate member between the first end and the guide plate, and configured to engage the uterine wall so that upon removal of the apparatus when in use the barb becomes attached to the uterus sufficient to remove the uterus and cervix through the abdomen.

Abstract: A surgical ablation system employing an ablation probe having a deployable ground plane is disclosed. The disclosed system includes a source of ablation energy and a source of electrosurgical energy, and a switching assembly configured to select between ablation and electrosurgical modes. The probe includes a cannula having a shaft slidably disposed therein. The shaft includes a deployable ground plane electrode assembly and a needle electrode disposed at distal end of the shaft. As the shaft is extended distally from the cannula, the ground plane electrode unfolds, and the needle electrode is exposed. Electrosurgical energy is applied to tissue via the needle electrode to facilitate the insertion thereof into tissue. Ablation energy is applied to tissue via the needle electrode to achieve the desired surgical outcome. The shaft, ground plane electrode and needle electrode are retracted into the cannula, and withdrawn from the surgical site.

Abstract: In an embodiment a sheath allows one to simultaneously ablate tissue, using a catheter located in the sheath, and remove fluid from a patient's pericardial space, via the same sheath, all without withdrawing the ablation catheter from the sheath. Applying pressure (positive or negative) to fenestrations in the sheath may allow one to withdraw fluid from the space, navigate the sheath within the space, and/or adhere the sheath to tissue in the space. Other embodiments are described herein.

Abstract: A catheter includes a flexible shaft having a lumen arrangement and a length sufficient to access a target vessel of a patient. A balloon at the distal end of the shaft is fluidly coupled to the lumen arrangement. The balloon body comprises a first material and a second material different from the first material. The second material comprises a hydrophilic polymer that becomes electrically conductive in response to absorption of the conductive fluid. The fluid conductive regions facilitate perfusion of the conductive fluid through the balloon body to an inner wall of the target vessel during ablation of perivascular tissues. A cooling arrangement is configured for one of receiving a thermal transfer fluid from the lumen arrangement or facilitating perfusion of blood passing through the target vessel to cool the balloon body during ablation of the perivascular tissues.

Abstract: An electrosurgical instrument includes a housing, an elongated shaft, and an end-effector assembly. The proximal end of the shaft is operably associated with the housing. The end-effector assembly is operably coupled to the distal end of the shaft and includes first and second jaw members. Each of the first and second jaw members includes a sealing plate and a bipolar electrode. Either one or both of the first and second jaw members is movable from a position in spaced relation relative to the other jaw member to at least one subsequent position wherein the sealing plates cooperate to grasp tissue therebetween. The electrosurgical instrument includes a semiconductor switch operably coupled to at least one of the sealing plates and at least one of the bipolar electrodes. The semiconductor switch is configured to enable user selection between energizing the at least one sealing plate or the at least one bipolar electrode.

Abstract: Tissue treatment systems include an actuator handle assembly coupled with a clamp assembly having a first jaw mechanism and a second jaw mechanism. A first jaw mechanism includes a first flexible boot, a first flexible ablation member coupled with the first flexible boot, and a first rotatable jawbone disposed within the first flexible boot. A second jaw mechanism comprises a second flexible boot, a second flexible ablation member coupled with the second flexible boot, and a second rotatable jawbone disposed within the second flexible boot.

Abstract: Systems and methods of electrical stimulation for intra and extra vascular treatment of a subject are provided. The device includes a first electrode, a second electrode, and a controller. The controller is configured to apply an electrical current between the first and second electrodes. The electrical current follows a path between the first and second electrodes and through a portion of the subject that includes a blockage.

Abstract: A catheter includes a flexible shaft having a distal end dimensioned for deployment within a patient's renal artery. A number of elongated resilient members are mounted along a longitudinal length of the distal end of the shaft, and are extensible radially from the shaft at regions defined between longitudinally spaced-apart engagement locations. One or more electrodes are mounted on each of the resilient members at the radially extensible regions. A number of conductors are electrically coupled to the electrodes and extend along the shaft of the catheter. The elongated resilient members are collapsible when encompassed within a lumen of an outer sheath and extensible radially outward from the shaft at the regions defined between the longitudinally spaced-apart engagement locations when the catheter and the resilient members are axially extended beyond the distal tip of the sheath. RF energy is delivered to the electrodes for ablating perivascular renal nerves.

Abstract: Various embodiments are described herein that generally relate to catheter probes for diagnostic and/or therapeutic purposes. The catheter probes described herein generally comprise a proximal hub comprising a hub housing and at least one wire, a catheter body connected to the proximal hub, the catheter body comprising a channel member and an insulator, the channel member being adapted to provide a housing for a portion of the catheter body and a conductive pathway, and the insulator being adapted to cover at least a portion of the channel member; and a catheter distal end comprising at least one electrode connected to the at least one wire.

Abstract: A medical device may include one or more operable components and one or more limited-use portions. The limited-use portion(s) is configured to transition from a first state to a second state upon being subjected to sterilization above a sterilization threshold. In the second state, the limited-use portion(s) inhibit the operability of the one or more operable components.