Patents Examined by Amy C Bonaparte
  • Patent number: 10442762
    Abstract: The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silica gel chromatography and the salt formation is carried out by using solid tromethamine base.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: October 15, 2019
    Assignee: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA ZRT.
    Inventors: Péter Buzder-Lantos, Zsuzsanna Kardos, Irén Hortobágyi, István Lászlófi, Imre Juhász, László Fónagy, Csaba Váradi, Ágnes Nagyné Borkó
  • Patent number: 10442751
    Abstract: The present invention relates to a method for producing a substituted alkyl cycloalkanone, comprising the alkylation of a cycloalkanone with an alkene derivative in the presence of a metal oxide, where n is 2 to 20, m is 0 to 10, and R is a functional group.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: October 15, 2019
    Assignee: SYMRISE AG
    Inventors: Atia Hanan, Reinhard Eckelt, Angela Koeckritz, Johannes Panten, Peter Esser, Oskar Koch
  • Patent number: 10435354
    Abstract: The invention relates to a process for preparing isocyanates by reacting primary amines with phosgene in a solvent, where the solvent comprises a dialkyl carbonate.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: October 8, 2019
    Assignee: BASF SE
    Inventors: Manfred Heilig, Thomas Schulz, Torsten Mattke, Filip Nevejans, Kai Thiele, Stefan Maixner
  • Patent number: 10435351
    Abstract: A convenient method for converting oximes into enamides is disclosed. The process produces enamides without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: October 8, 2019
    Assignee: SUNOVION PHARMACEUTICALS INC.
    Inventors: Charles P. Vandenbossche, John R. Snoonian
  • Patent number: 10433547
    Abstract: The present invention relates generally to peroxyformic acid forming compositions, methods for forming peroxyformic acid, preferably in situ, using the peroxyformic acid forming compositions. The present invention also relates to the peroxyformic acid formed by the above compositions and methods. The present invention further relates to the uses of the peroxyformic acid, preferably in situ, for treating a surface or a target. The present invention further relates to methods for treating a biofilm using peroxyformic acid, including peroxyformic acid generated in situ.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: October 8, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Junzhong Li, Allison Brewster, Richard Staub, Steven J. Lange, Taz Cheritu, Jonathan P. Fast, Catherine Hanson
  • Patent number: 10428011
    Abstract: The present invention relates to a process to prepare ethyleneamines of the formula NH2—(C2H4—NH—)pH wherein p is at least 3 or derivatives thereof wherein one or more units —NH—C2H4—NH— may be present as a cyclic ethylene urea unit or between two units —NH—C2H4—NH— a carbonyl moiety is present, by reacting an ethanolamine-functional compound, an amine-functional compound in the presence of a carbon oxide delivering agent, wherein the molar ratio of ethanolamine-functional compound to amine-functional compound is at least 0.7:1 and the molar ratio of carbon oxide delivering agent to amine-functional compound is at least 0.05:1.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 1, 2019
    Assignee: Nouryon Chemicals International B.V.
    Inventors: Rolf Krister Edvinsson, Eike Nicolas Kantzer, Per Fredrik Olmo Larsson, Karl Fredrik Lake, Antoon Jacob Berend Ten Kate
  • Patent number: 10421713
    Abstract: Process for preparing compound of formula (Ia)
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: September 24, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Taraneh Farida, Hubertus Stakemeier, Jan Vermehren
  • Patent number: 10421706
    Abstract: The invention relates to a conversion method that is fed with a diol feedstock that comprises at least 90% by weight of diol and a carboxylic acid feedstock that comprises at least 80% by weight of carboxylic acid. The method comprising at least: An esterification step which is fed with at least the diol feedstock and at least the carboxylic acid feedstock, wherein the carboxylic acid/diol molar ratio at the inlet of the esterification step is between 2 and 6, the esterification step comprises at least one reactive distillation column that has a mixed reaction/separation zone located between two separation zones; and A water elimination step that is fed with distillate from the esterification step that comprises water and producing at least one water effluent.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: September 24, 2019
    Assignees: IFP Energies Nouvelles, Compagnie Generale des Etablissements Michelin
    Inventors: Romain Richard, Damien Leinekugel Le Cocq, Marc Jacquin, Margarita Dorato, Nuno Pacheco, Claire Rannoux
  • Patent number: 10414714
    Abstract: 2-Acetoxyalkanoic acid esters are made in a reaction of a 3,6-dialkyl-1,4-dioxane-2,5-dione or a poly(?-hydroxyalkanoic acid), an acetate ester and an alcohol or phenol in the presence of a transesterification catalyst. Unlike previous methods for making 2-acetoxyalkanoic acid esters, this process proceeds in high yield and high selectivity to the desired product.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: September 17, 2019
    Assignee: NatureWorks LLC
    Inventors: Aman Kulshrestha, Joseph David Schroeder
  • Patent number: 10414720
    Abstract: The present invention relates to an improved process for the synthesis of (R)-Lacosamide in which free base of O-methyl-N-benzyl-D-Serinamide is not isolated before acylation. The process avoids the use of column chromatography and chiral resolution for the preparation of different stages of Lacosamide.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: September 17, 2019
    Assignee: Unichem Laboratories Ltd.
    Inventors: Dhananjay G. Sathe, Arijit Das, Sanjay Raikar, Rahul Bhagwatkar, Ramdas Ahire
  • Patent number: 10414717
    Abstract: Disclosed is a process for preparing ?-agonist, 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I. The process comprises refluxing 1-(4-amino-3,5-dichlorophenyl) ethanone of Formula II and selenium dioxide in the presence of 1,4-dioxane to form compound of Formula III. Further, compound of Formula III is heated at a temperature below 30° C. in the presence of t-butyl amine to form compound of Formula IV. The compound of Formula IV is treated with sodium borohydride to form compound of Formula I.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: September 17, 2019
    Assignee: Vamsi Lab Ltd.
    Inventors: G Pratap Reddy, M. Kesava Reddy
  • Patent number: 10414723
    Abstract: Process for converting a carboxamide to a thiocarboxamide includes reacting (a) a substrate that comprises a heteroatom-containing moiety and a carboxamide moiety with (b) a dialkyl dithiophosphate and/or a salt thereof. The heteroatom-containing moiety includes a heteroatom selected from the group consisting of N, O, and S. Processes for preparing piperidine-4-thiocarboxamide are described.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: September 17, 2019
    Assignee: VERTELLUS HOLDINGS LLC
    Inventors: Martin P. Grendze, Ramiah Murugan
  • Patent number: 10407448
    Abstract: The purpose of the present invention is to provide an N,N-bis(2-dialkylphosphinoethyl)amine-borane complex which is a ruthenium complex that exhibits excellent catalytic activity in a hydrogenation reaction, etc., and a production method therefor, and a method for efficiently producing a ruthenium complex containing N,N-bis(2-dialkylphosphinoethyl)amine as a ligand. The present invention is capable of efficiently producing an amine-borane complex (3) by reacting an oxazolidinone compound (1) with a dialkylphosphine-borane compound (2) in the presence of a base. The present invention is also capable of efficiently producing a ruthenium complex (5) by reacting the amine-borane complex (3) with a ruthenium compound (4) in the presence of an amine. (In the formula, a solid line, a dashed line, B, C, H, L1-L3, LG, n, N, O, P, Ru, X, and R1-R10 are as defined in the description.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: September 10, 2019
    Assignee: Takasago International Corporation
    Inventors: Yuji Nakayama, Hikaru Nakajima
  • Patent number: 10407387
    Abstract: Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (SO2F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FSO2NMe2), tetramethylsulfamide (SO2(NMe2)2), or a combination thereof. A second phase, which may include dimethylamine hydrofluoride (Me2NH2F), may be also formed and separated from the first phase. FSO2NMe2 or SO2(NMe2)2 is then isolated from the first phase. For example, the first phase may be a liquid phase, and FSO2NMe2 and SO2(NMe2)2 are separated by distillation, optionally under reduced pressure.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: September 10, 2019
    Assignee: Trinapco, Inc.
    Inventor: Martin Reid Johnson
  • Patent number: 10407379
    Abstract: A molecular species is covalently attached to elemental carbon by exposing the carbon to a reaction mixture containing a strong base and a compound of the formula or in which X denotes a covalently attached atom or group capable of forming an X? anion and each Z is a moiety comprising a plurality of atoms, but which does not have a hydrogen atom directly attached to the atom which itself is directly attached to the —CH2X or —CHX group. The carbon substrate may be graphite or carbon nanotubes.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: September 10, 2019
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Fenglou Zou, Nathan Lawrence, Timothy Jones
  • Patent number: 10399928
    Abstract: The method of the present invention for converting a nitrile functional group into a hydroxamic acid functional group can be easily performed at room temperature and under normal pressure by using a peroxocobalt complex. The final hydroxamic acid functional group produced through the intermediate Hydroximatocobalt (III) compound or the derivative comprising the same has been known to be able to inhibit the growth of cancer cells, so that the conversion method of the present invention can be applied to the preparation of a pro-drug for anticancer treatment.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: September 3, 2019
    Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jaeheung Cho, Hyeon Ju Noh
  • Patent number: 10385004
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: August 20, 2019
    Assignee: Novartis AG
    Inventors: Benjamin Martin, Francesca Mandrelli, Francesco Venturoni
  • Patent number: 10385002
    Abstract: 2-Acetoxyalkanoic acid esters are made in a reaction of a 3,6-dialkyl-1,4-dioxane-2,5-dione or a poly(?-hydroxyalkanoic acid), an acetate ester and an alcohol or phenol in the presence of a transesterification catalyst. Unlike previous methods for making 2-acetoxyalkanoic acid esters, this process proceeds in high yield and high selectivity to the desired product.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: August 20, 2019
    Assignee: NatureWorks LLC
    Inventors: Aman Kulshrestha, Joseph David Schroeder
  • Patent number: 10364262
    Abstract: A method for synthesis of N-phosphonoalkyliminodiacetic acid or derivatives thereof by forming a reaction mixture having an acid catalyst, a compound of the following general formula R1—CH2—NX—CH2—R2 and a compound having one or more P—O—P anhydride moieties to form a compound having a formula R1—CH2—N(—CH2PO3R32)(—CH2—R2) wherein in R1—CH2—NX—CH2—R2: X is —CH2—OH or —CH2—COOH; R1 and R2 are independently selected from the group consisting of nitrile, C1-C4 alkyl carboxylate, and carboxylic acid for when X is —CH2—OH, or R1 and R2 are both carbonyl groups linked by a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom; and R3 is H, an alkyl group, or an aryl group; the anhydride moieties in the P—O—P anhydride compound have one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V); and 2) hydrolyzing the mixture to form N-phosphonomethyliminodiacetic acid or one of its derivatives.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: July 30, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Albert Devaux, Sebastian Burck, Patrick Notte
  • Patent number: 10351518
    Abstract: Processes for separating carbon dioxide from CO2-containing gases and an apparatus for providing carbon dioxide for the synthesis of urea.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: July 16, 2019
    Assignees: THYSSENKRUPP INDUSTRIAL SOLUTIONS AG, THYSSENKRUPP AG
    Inventors: Yevgeny Makhynya, Joachim Johanning, Daniela Dostal