Patents Examined by Amy M Bunker
  • Patent number: 10719579
    Abstract: A method for validating quantification of biomarkers, the biomarkers being quantified using a quantification technique of a selected type, and the method including determining a plurality of biomarker values, each biomarker value being indicative of a value measured or derived from a measured value, for at least one corresponding biomarker of the biological subject and being at least partially indicative of a concentration of the biomarker in a sample taken from the subject, determining at least one control value by determining a combination of biomarker values, comparing each control value to a respective control reference and determining if the biomarker values are valid using results of the comparison.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: July 21, 2020
    Assignee: IMMUNEXPRESS PTY LTD
    Inventor: Leo Charles McHugh
  • Patent number: 10670605
    Abstract: Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 2, 2020
    Assignee: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Benjamin F. Cravatt, Keriann M. Backus, Bruno E. Correia, Megan M. Blewett, John R. Teijaro
  • Patent number: 10620200
    Abstract: Certain embodiments are directed to paper/polymer hybrid microfluidic devices integrated with nano-biosensors for pathogen detection and infectious disease diagnosis.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: April 14, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: XiuJun Li, Maowei Dou
  • Patent number: 10598642
    Abstract: A method is for the simultaneous identification of one or more chemical compounds contained in a sample, from an analytical measurement of a pool of two or more of the samples. A measured intensity of a first and second signal is representative of an abundance of respectively the first and second chemical compound in the first sample, and a measured intensity of a third and fourth second signal is representative of an abundance of respectively a third and fourth chemical compound in the second sample. The first and third, and the second and fourth compound may be the same or different. The signal intensities are organized in a matrix aij of m columns and n rows, in which n is ?2 and corresponds to the number of chemical compounds in the pool, and m?2 and corresponds to the number of samples in the pool.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 24, 2020
    Assignee: VITO NV
    Inventors: Dirk Valkenborg, Jef Hooyberghs
  • Patent number: 10597700
    Abstract: The present invention relates to a method for screening a molecule of interest by means of nanoparticles comprising a candidate molecule, a tracer, and a single DNA tag specific to said molecule. The present invention also relates to a method for screening biomarkers of a disease and/or of a phenotype feature, more particularly of a cancer or an infection, by means of said nanoparticles. The invention finally relates to the nanoparticles as such as well as to a library of said nanoparticles.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: March 24, 2020
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Fabrice Navarro Y Garcia, Jonathan Bruniaux, Xavier Gidrol, Eric Sulpice
  • Patent number: 10538794
    Abstract: This disclosure relates to libraries of oligosaccharides comprising multiple individual oligosaccharides derived from cells that contain a tag or detectable marker. In certain embodiments, the tag or detectable marker is an oxygen linked to the oligosaccharides through the first carbon of a sugar ring. In certain embodiments, the disclosure relates to methods of generating the libraries of oligosaccharides using saccharides, e.g., monosaccharides, or a disaccharide, in which hydroxyl groups are chemically acetylated.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: January 21, 2020
    Assignee: Emory University
    Inventors: Tongzhong Ju, Richard Cummings, Matthew Kudelka
  • Patent number: 10537889
    Abstract: Disclosed are methods and systems concerning flow cells for sequencing a nucleic acid sample that may be characterized by the following components: (a) a substrate having an inner surface facing a library sequencing region, and an outer surface; (b) a plurality of a plurality of forward and reverse amplification primers immobilized over the inner surface and providing a nucleic acid library capture surface of the library sequencing region; (c) a plurality of electrodes disposed along the inner surface directly under at least some of the forward and reverse amplification primers, and configured to provide, when charged, an electric field through the library capture surface and into the library sequencing region; (d) electrical leads connected to the plurality of electrodes to permit the electrodes to be independently addressable; and (e) fluidic couplings configured to deliver a plurality of nucleic acid libraries to the flow cell during different time periods.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: January 21, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Chenlu Hou, Byoungsok Jung, Yir-Shyuan Wu, Tarun Khurana
  • Patent number: 10495628
    Abstract: Devices and methods for detecting a target molecule are provided herein. The methods entail contacting a sample with a polymer scaffold, the polymer comprising at least one association site configured to associate with the target molecule. The sample is brought into contact with the polymer to determine whether the target molecule is present in the sample under conditions allowing the target molecule, if present, to associate with the polymer scaffold. The methods further involve loading the polymer into a device comprising a pore or channel that connects two volumes, configuring the device to pass the polymer through the pore or channel from one volume to the other volume, and determining, with a sensor configured to detect objects passing through the pore or channel, whether the target molecule is associated with the association site, and thereby detecting the presence or absence of the target molecule in the sample.
    Type: Grant
    Filed: July 8, 2018
    Date of Patent: December 3, 2019
    Assignee: Ontera Inc.
    Inventors: Trevor J. Morin, Daniel Alexander Heller, William B. Dunbar
  • Patent number: 10494669
    Abstract: The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: December 3, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen R. Quake, Thomas M. Snyder, Hannah Valantine
  • Patent number: 10479991
    Abstract: A method and reagent for constructing a nucleic acid double-linker single-strand cyclic library.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: November 19, 2019
    Assignee: MGI TECH CO., LTD
    Inventors: Yuan Jiang, Qiaoling Li, Andrei Alexeev, Evan Hurowitz, Xia Zhao, Tong Wang, Chao Dong, Dong Li, Radoje Drmanac, Wenwei Zhang, Hui Jiang
  • Patent number: 10465227
    Abstract: The present disclosure provides for microbial testing devices, methods for making microbial testing devices, methods for growing and testing microbial cultures and methods for testing compounds for antimicrobial activity.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: November 5, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Anand K. Ramasubramanian, Jose L. Lopez-Ribot, Anand Srinivasan
  • Patent number: 10422793
    Abstract: The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to components of the samples can be increased by forming arrays such that multivalent components of the samples (e.g., antibodies or cells) can bind to more than one molecule of a compound at the same time. When a sample is applied to an array under such conditions, the compounds of the array bind to component(s) of the sample with significantly different avidities generating a profile characteristic of the sample.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: September 24, 2019
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Stephen Albert Johnston, Phillip Stafford
  • Patent number: 10379117
    Abstract: Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: August 13, 2019
    Assignee: Robert Bosch GmbH
    Inventors: Nadezda Fomina, Christopher Johnson, Sam Kavusi, Habib Ahmad
  • Patent number: 10330668
    Abstract: Compositions and methods determines post-transfusion survival of platelets and the suitability of platelet units for transfusion by measuring the levels of one or more markers in a platelet sample. A method determines post-transfusion survival of platelets (PL T) prior to transfusion, the method comprising the steps of: a) measuring the levels of one or more markers in a PL T sample selected from the group consisting of adenine, 13-HODE/9-HODE, Caprylate, Laurate, C-glycosyltryptophan, andro steroid monsulfate 2, and Unelucidated Compounds (UC) 1-4; b) comparing the level of the one or more markers in the PLT sample with the level of the one or more markers present in a control sample, wherein a higher or lower level of the one or more markers in the PL T sample is indicative of post-transfusion survival of platelets.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: June 25, 2019
    Assignee: Bloodworks
    Inventors: James Charles Zimring, Sherrill J. Slichter
  • Patent number: 10329607
    Abstract: The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 25, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen R. Quake, Thomas M. Snyder, Hannah Valantine
  • Patent number: 10316354
    Abstract: A two-electrode detection system having target substrates including nucleic acids, proteins, and/or small molecules on specifically defined regions of a single surface. The spatial distribution of the target substrate on the surface allows for more accurate substrate interactions and analysis. Additionally, the detection system of the present invention allows for patterning of different target substrates, thereby affording more accurate analysis of multiple substrate targets.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: June 11, 2019
    Assignee: California Institute of Technology
    Inventors: Ariel L. Furst, Michael G. Hill, Natalie B. Muren, Jacqueline K. Barton
  • Patent number: 10316000
    Abstract: The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: June 11, 2019
    Assignee: Cornell University
    Inventors: Samie R. Jaffrey, Jeremy S. Paige
  • Patent number: 10288607
    Abstract: An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: May 14, 2019
    Assignee: Sentilus Holdco LLC
    Inventors: Ashutosh Chilkoti, Angus Hucknall
  • Patent number: 10274488
    Abstract: Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: April 30, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Susan Y. Tseng
  • Patent number: 10267811
    Abstract: The present invention provides a rapid, sensitive method for forensic drug testing in a post-mortem subject using oral fluid collected from the post-mortem subject. The method comprises collecting a sample of oral fluid from a post-mortem subject, analyzing the oral fluid sample qualitatively to detect the presence of one or more non-naturally occurring drugs, analyzing the oral fluid sample quantitatively to determine concentration of the one or more non-naturally occurring drugs in the post-mortem subject, and identifying the one or more non-naturally occurring drugs in the post-mortem subject. The detection and quantification in oral fluid is more sensitive and faster than detection and quantification of the non-naturally occurring drugs in blood, urine, bile, and liver tissue collected from the same post-mortem subject. Further, the qualitative and quantitative results are obtained in as little as three hours.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: April 23, 2019
    Inventor: Amy J. Reisinger